Family C62

Family

Summary Holotypes Alignment Tree Genomes Literature Architecture

Summary for family C62

Family type peptidase	C62.001 - gill-associated virus 3C-like peptidase (gill-associated virus), MEROPS Accession MER0014143 (peptidase unit: 2832-3126)
Content of family	Peptidase family C62 contains a viral polyprotein-processing endopeptidase.
History	Identifier created: MEROPS 6.20 (24 March 2003) The first peptidase in the family was discovered in a virus that affects the Black Tiger Prawn (Penaeus monodon) (Cowley et al., 2000).
Catalytic type	Cysteine
Active site residues	H2879 C2968
Active site	Residues His2879 and Cys2968 (see the Alignment) were identified by mutagenesis and suggested to form a simple catalytic dyad; no evidence was obtained for a catalytic triad involving an Asp residue (Ziebuhr et al., 2003).
Activities and specificities	A tentative cleavage consensus site has been defined as -Val-Xaa-His-GluYaa, in which Yaa is Leu or Val (Ziebuhr et al., 2003). The specificity is quite distinctive, but the P2 His specificity is seen also in some plant potyvirus NIa peptidases (family C4).
Molecular structure	In sequence, the peptidase is closest to the viral 'main' endopeptidases of coronaviruses (family C30), but the specificity is more like that of enzymes from plant potyviruses.
Clan	PA
Subclan	PA(C)

Distribution of family	Bacteria	-
	Archaea	-
	Protozoa	-
	Fungi	-
	Plants	-
	Animals	-
	Viruses	details

Biological functions	The peptidase is predicted to be the key enzyme in the processing of the GAV replicase polyprotein precursors, pp1a and pp1ab (Ziebuhr et al., 2003).
Statistics for family C62	Sequences:	2
	Identifiers:	1
	Identifiers with PDB entries:	0
Downloadable files	Sequence library (FastA format)
	Sequence alignment (FastA format)

Other databases	INTERPRO	IPR024348
	PFAM	PF12380

Peptidases and Homologues	MEROPS ID	Structure
gill-associated virus 3C-like peptidase	C62.001	-
Family C62 unassigned peptidases	unassigned	-