Family C8

Family

Summary Holotypes Alignment Tree Genomes Literature Architecture

Summary for family C8

Family type peptidase	C08.001 - chestnut blight fungus virus p48 peptidase (Cryphonectria hypovirus 1), MEROPS Accession MER0000822 (peptidase unit: 271-418)
Content of family	Peptidase family C8 contains only the p48 proteinase of the chestnut blight hypovirus.
History	Identifier created: Biochem.J. 290:205-218 (1993)
Catalytic type	Cysteine
Active site residues	C341 H388
Active site	The active site residues have been identified by site directed mutagenesis as Cys341 and His388 (Shapira & Nuss, 1991)
Activities and specificities	The p48 endopeptidase is autocatylitically released from the small polyprotein, through cleavage of a single GlyAla bond (Shapira & Nuss, 1991).
Inhibitors	Inhibitors have not been described.
Molecular structure	No structure is yet available for any peptidase in family C8.
Clan	unassigned
Basis of clan assignment	Active site residues for members of this family and family C1 occur in the same order in the sequence: C, H.

Distribution of family	Bacteria	-
	Archaea	-
	Protozoa	-
	Fungi	-
	Plants	-
	Animals	-
	Viruses	details

Biological functions	The virus encodes two polyproteins, with the p48 peptidase found at the N-terminus of the larger p48 polyprotein. The role of the p48 petidase once it is released from the polyprotein is uncertain.
Statistics for family C8	Sequences:	7
	Identifiers:	1
	Identifiers with PDB entries:	0
Downloadable files	Sequence library (FastA format)
	Sequence alignment (FastA format)
	Phylogenetic tree (Newick format)

Other databases	INTERPRO	IPR005315
	PFAM	PF03569

Peptidases and Homologues	MEROPS ID	Structure
chestnut blight fungus virus p48 peptidase	C08.001	-
Family C08 unassigned peptidases	unassigned	-