Family S72

Family

Summary Holotypes Alignment Tree Genomes Structure Literature H-seq M-seq Architecture

Summary for family S72

Family type peptidase	S72.001 - dystroglycan (Homo sapiens), MEROPS Accession MER0054741 (peptidase unit: 603-712)
Content of family	Peptidase family S72 contains autolytic serine-type endopeptidases.
History	Identifier created: MEROPS 8.2 (4 August 2008) Dystroglycan is a component of the dystrophin-associated protein complex which may link the extracellular matrix to the cytoskeleton. Dystroglycan is a type I membrane protein which is synthesized as a precursor that is proteolytically processed into an alpha and a beta chain which remain non-covalently attached (Jayasinha et al., 2003). Cleavage occurs within a SEA domain, and is assumed to be autolytic because self-processing is known to occur in other proteins with SEA domains, such as mucin 1 (S71.001) (Akhavan et al., 2008).
Catalytic type	Serine
Active site residues	S654
Active site	The N-terminal residue of the beta chain, Ser654, is assumed to be the only active site residue.
Activities and specificities	Cleavage occurs at Gly653Ser within the endoplasmic reticulum (Akhavan et al., 2008).
Molecular structure	No tertiary structure has been solved for any member of the family. The dystroglycan precursor is assumed to be an N-terminal nucleophile hydrolase and family S72 may be a member of clan PB.
Clan	unassigned

Distribution of family	Bacteria	details
	Archaea	-
	Protozoa	-
	Fungi	-
	Plants	-
	Animals	details
	Viruses	-

Biological functions
Pharmaceutical and biotech relevance	Mutation in the gene is associated with muscular dystrophy, and disruption of the cleavage leads to dystrophy in mouse models (Jayasinha et al., 2003). Site-directed mutations that prevent processing result in an increased capacity to bind laminin (Akhavan et al., 2008).
Statistics for family S72	Sequences:	367
	Identifiers:	2
	Identifiers with PDB entries:	1
Downloadable files	Sequence library (FastA format)
	Sequence alignment (FastA format)
	Phylogenetic tree (Newick format)

Other databases	INTERPRO	IPR008465
	PANTHER	PTHR21559
	PFAM	PF05454

Peptidases and Homologues	MEROPS ID	Structure
dystroglycan	S72.001	Yes
dystroglycan type I (Drosophila melanogaster)	S72.A01	-
Family S72 non-peptidase homologues	non-peptidase homologue	-
Family S72 unassigned peptidases	unassigned	-