Family U57
Summary for family U57
Family type peptidase | U57.001 - yabG protein (Bacillus-type) (Bacillus subtilis), MEROPS Accession MER0013579 (peptidase unit: 1-290) |
Content of family | Peptidase family U57 contains endopeptidases involved in bacterial sporulation. |
History |
Identifier created: MEROPS 5.3 (4 December 2000) Sporulation in Bacillushas been divided into stages numbered I-VII, and the stage number is included in the name of any gene that is active at that particlar stage. During stage II, the precursor of the spore, or prespore, develops and is separated from the mother cell by a septum; both mother cell and prespore each have a complete genome. During stage III the prespore becomes a forespore when the chromosome is surrounded by inner and outer membranes. Stage IV is characterized by cortex formation in which a multi-layered peptidoglucan forms between these inner and outer membranes. Sporulation is controlled by a number of σ transcription factors, principally σE, σF, σG and σK. Proteolytic processing of the precursors of σ factors occurs during stages II and IV. Other families of peptidases involved in aspects of spore production are M50, S55 and A36. |
Catalytic type | Peptidase of unknown catalytic type |
Active site | The nature of the active site is unknown. |
Activities and specificities | Proteins SpoIVA and YrbA are degraded during stage IV of the sporulation process. Degradation does not occur in the presence of a mutant form of YabG, consistent with the possibility that YabG is a peptidase (Takamatsu et al., 2000). |
Inhibitors | Preliminary experiments conducted by Takamatsu et al. (2000) suggest that aprotinin and antipain inhibit YabG. |
Molecular structure | |
Clan | unassigned |
Basis of clan assignment | Protein fold and active site residues are not known for any members of this family. |
Distribution of family
|
Bacteria |
details |
|
|
Archaea |
- |
|
|
Protozoa |
- |
|
|
Fungi |
- |
|
|
Plants |
- |
|
|
Animals |
- |
|
|
Viruses |
- |
|
Peptidases and Homologues |
MEROPS ID |
Structure |
yabG protein (Bacillus-type) | U57.001 | - |
Family U57 unassigned peptidases | unassigned | - |