Family U57

Family

Summary Holotypes Alignment Tree Genomes Literature Architecture

Summary for family U57

Family type peptidase	U57.001 - yabG protein (Bacillus-type) (Bacillus subtilis), MEROPS Accession MER0013579 (peptidase unit: 1-290)
Content of family	Peptidase family U57 contains endopeptidases involved in bacterial sporulation.
History	Identifier created: MEROPS 5.3 (4 December 2000) Sporulation in Bacillushas been divided into stages numbered I-VII, and the stage number is included in the name of any gene that is active at that particlar stage. During stage II, the precursor of the spore, or prespore, develops and is separated from the mother cell by a septum; both mother cell and prespore each have a complete genome. During stage III the prespore becomes a forespore when the chromosome is surrounded by inner and outer membranes. Stage IV is characterized by cortex formation in which a multi-layered peptidoglucan forms between these inner and outer membranes. Sporulation is controlled by a number of σ transcription factors, principally σ^E, σ^F, σ^G and σ^K. Proteolytic processing of the precursors of σ factors occurs during stages II and IV. Other families of peptidases involved in aspects of spore production are M50, S55 and A36.
Catalytic type	Peptidase of unknown catalytic type
Active site	The nature of the active site is unknown.
Activities and specificities	Proteins SpoIVA and YrbA are degraded during stage IV of the sporulation process. Degradation does not occur in the presence of a mutant form of YabG, consistent with the possibility that YabG is a peptidase (Takamatsu et al., 2000).
Inhibitors	Preliminary experiments conducted by Takamatsu et al. (2000) suggest that aprotinin and antipain inhibit YabG.
Molecular structure
Clan	unassigned
Basis of clan assignment	Protein fold and active site residues are not known for any members of this family.

Distribution of family	Bacteria	details
	Archaea	-
	Protozoa	-
	Fungi	-
	Plants	-
	Animals	-
	Viruses	-

Biological functions	Mutational studies suggest that YabG has an important post-transcriptional role in the modification of the coat proteins of bacterial spores (Takamatsu et al., 2000).
Statistics for family U57	Sequences:	205
	Identifiers:	1
	Identifiers with PDB entries:	0
Downloadable files	Sequence library (FastA format)
	Sequence alignment (FastA format)
	Phylogenetic tree (Newick format)

Other databases	INTERPRO	IPR008764
	PFAM	PF05582

Peptidases and Homologues	MEROPS ID	Structure
yabG protein (Bacillus-type)	U57.001	-
Family U57 unassigned peptidases	unassigned	-