Alignment for family C2A
8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32
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
# # # #
1 WERAEKK-----FK-----------------GREFEKTCQPNEIVQG-YFGDCYLVTS-LSSI--C-QNSR---IIKNLFY-------------------------------KSELAVSNGVSCVSFNAMD--TNLY----------------VLV---DTMIPVS----------------------------KE----GKPKM-VS--------P-------------------------------------------------------------------------------------------------LN--------------------------ENSPWWFCMVEK-----------TFCKLV----G-SLSESE-----GGAPSNALYRLVGGYPMVI---------------ELN---------------------------------------------------------------------------------------------------------------------------------TLDVREKFKS---------------------------------------------------------------------------------------------------------------------------------------------------GALFDQ---------INEIFMNGGYLVSG--------------------------------------------------SMEGNN-SS-----VKHGIVQGHAYNILDV----------VD------------------------------Y----------------------------------RGIK----LLKLRNP--WG--K-TEWNGDWSDDSD-LWDRYPAVKNR-----------CKFEK---ADDGMFWI- 1
2 WVRAEQL-----YE-----------------KQKFIDTCRPNDLVQG-YFGDCYVVTA-MASI--C-RSIS---NIKNLFY-------------------------------IPDIAVKNGLCCVVFKAMN--KEMS----------------VNV---DTLIPL-----------------------------LN----GKPRM-VH--------P-------------------------------------------------------------------------------------------------AT--------------------------ERSPYWFCIVEK-----------AYAKIV----G-SYSAAT-----GGTPDEALYRLLGGFPINI---------------DLT---------------------------------------------------------------------------------------------------------------------------------DLDVRESITS---------------------------------------------------------------------------------------------------------------------------------------------------GELFKQ---------MVEWNKRGSHLIAG--------------------------------------------------SPEGSHFKK-----NKDGIVQGHAYNILDV----------VE------------------------------F----------------------------------HGVQ----LLKLRNP--WG--E-QEWKGDWSAESS-MWKKYPAVASK-----------CNFDKDRTQTDGVFWM- 2
3 WKRAEDE-----FK------------------EAPTGHVNANDLCQG-ALGDCYLVSA-MAAI--C-AAPH---DVVDIFE-------------------------------DHTKIQKTGAACISFYSMG--KRGH----------------VIV---DTQLPFS-------------------------T--KS----GKGKF-VH--------P-------------------------------------------------------------------------------------------------RDP-------------------------ETNGWWFTLVEK-----------AYAKQN----G-SYSAIE-----GGNSHLALYRLVGGWPEIF---------------NLD---------------------------------------------------------------------------------------------------------------------------------SLEMKERINN---------------------------------------------------------------------------------------------------------------------------------------------------GTLWKR---------ILQWHQDKDYICCG--------------------------------------------------SHPGSDTTK-----SKTNIVQGHAYSVLQA----------VE------------------------------V----------------------------------KGFQ----LLQLRNP--WG--D-SEWNGDWSDKSP-LWTKHPDIAKQ-----------LGHTD---VDDGMFWIT 3
4 WKRIEEV-----YG-----------------TNIFDD-INEYGICQG-ELSDCYLLST-LIQM--T-NKPA---NVRALFQ-------------------------------DP-IDINTGCVCVKFQIFE--KPAY----------------VII---DTLIPFT-------------------------Q--SKDDQPGQPIF-SY--------P-------------------------------------------------------------------------------------------------RT--------------------------ENDSYWFALIEK-----------AYVKML----G-SCRAVK-----GCAAITSCYHILGYSPTSI---------------KLQ---------------------------------------------------------------------------------------------------------------------------------DLKETPS----------------------------------------------------------------------------------------------------------------------------------------------------------EQ---------IQKLLDINGDVYAS--------------------------------------------------IDKNEEA-------VKLGLIEDHTYAVVGL----------NQ------------------------------V----------------------------------GGYK----LIHLRNP--WG--RMDDWNGNFSAMSD-KW----AIGFK-----------RQVGY---KEGGHFWIS 4
5 WLRPVEL-----SR---Y-------PRFV--ADG----VSRFDIKQG-ELGNCWVIAA-LASL--S-MYPE---LFNQVVP--P----------------D----Q-SFEKSSK--YPYVGMFWFRFWRFG--DWYD----------------VVV---DDRLPTR-------------------------N--GH--------L-VF--------M-------------------------------------------------------------------------------------------------HSA-------D-----------------S-NEFWSALLEK-----------AYAKLV----S-SYDALR-----GGCTAEAMEDFTGGLTELV---------------DLG-----------------------------------------------------------------------------------------------------------------------------------AKAP---T---------------------------------------------------------------------------------------------------------------------------------------------------N-LFGI---------MEHALNRASLMACS-ID--------------------------------------------------ADPHE--IEANGPLGLILGHAYSVTDI----------RQ---------------------------VH-T---------NYG----------S-----------QSIR----LIRLRNP--WGN-E-SEWSGPWSDQS----------------------------------------- 5
6 WLRPHEI-----SP---D-------AVFD--VDG----FSRFDIQQG-LLGDCWLLAA-AANL--T-TFPV---LFSRVVP--D----------------DNDRIQ-GGRK-G---VDYAGIFHFRFWRFG--QWYD----------------VVV---DDRLPTI-------------------------R--GQ--------L-VY--------I-------------------------------------------------------------------------------------------------KSS-------T-----------------K-HEFWSALLEK-----------AYAKLF----G-SYEALS-----GGSASEAMEDFTGGLTEGY---------------EMK------------------------------------------------------------------------------------------------------------------------------------DAP---E---------------------------------------------------------------------------------------------------------------------------------------------------G-LFEM---------IEKGCNNYAMFACS-IE--------------------------------------------------AGAGE--MEQVTPQGLVKGHAYSITKA----------QA------------------------------V---------DIE----------T-----------PRVKGKIQLLRLRNP--WGN-E-NEWNGAWSDKSP-EWRFINEDTKR--SI------GLTFEV-----DGEFWMS 6
7 --------------------------------------ASRFDVAQG-QLGDCWFLAA-TAGL--S-LDDH---LLKKVIP--P----------------D----Q-NFDL---------GVVKFNFWQYG--KWVT----------------VVI---DDQLPTY-------------------------N--NE--------L-VF--------V-------------------------------------------------------------------------------------------------HSK-------E-----------------K-NEFWSALLEK-----------AYAKLH----G-SYECLK-----GGNVIEAMEDFTGGVSESI---------------DLN------------------------------------------------------------------------------------------------------------------------------------QNP---P---------------------------------------------------------------------------------------------------------------------------------------------------KGLFKI---------LKSSYDRDSQLGCS-IN--------------------------------------------------AKPGV--TEAKLPSGLIAGHAYTITDV----------KK------------------------------V---------NVK----------G-----------RDVR----LIRIRNP--WG--A-VEWNGRWSDNAR-EWDDINQRERK--NL------GLVSGD-----DGEFWME 7
8 WKRPSEI-----VQ---N-------PQLF--VGG----ASRFDVAQG-QLGDCWFLAA-TAGL--S-LDDH---LLKKVIP--P----------------D----Q-NFDL---------GVVKFNFWQYG--KWVT----------------VVI---DDQLPTY-------------------------N--NE--------L-VF--------V-------------------------------------------------------------------------------------------------HSK-------E-----------------K-NEFWSALLEK-----------AYAKLH----G-SYECLK-----GGNVIEAMEDFTGGVSESI---------------DLN------------------------------------------------------------------------------------------------------------------------------------QNP---P---------------------------------------------------------------------------------------------------------------------------------------------------KGLFKI---------LKSSYDRDSQLGCS-IN--------------------------------------------------AKPGV--TEAKLPSGLIAGHAYTITDV----------KK------------------------------V---------NVK----------G-----------RDVR----LIRIRNP--WG--A-VEWNGRWSDNAR-EWDDINQRERK--NL------GLVSGD-----DGEFWME 8
9 WKRPHEI-----VS---D-------PKMF--VGG----ASRFDITQG-MLGDCWLLAA-VAAL--C-QYEG---LLYQVVP--P----------------D----Q-DFKT-N-----YCGLIRFRFWQYG--DWNE----------------IVI---DDRLPTY-------------------------N--NK--------L-VF--------L-------------------------------------------------------------------------------------------------HSA-------Q-----------------N-NEFWSALLEK-----------AYAKLC----G-SYESLK-----GGQTSEAMEDFTGGVTESF---------------NTQ------------------------------------------------------------------------------------------------------------------------------------KAP---K---------------------------------------------------------------------------------------------------------------------------------------------------R-FFKL---------LQKAQERQSLMCCS-IE--------------------------------------------------AAPNE--VEAKLDNGLIKGHAYTITDI----------KK------------------------------L---------HEH----------K-------------------LIRVRNP--WGN-D-REWTGAWSDKSN-EWHRVSQADKE--SL------GITYDD-----DGEFWMS 9
10 WKRPHEI-----CD---N-------PVFI--ADG----ASRFDVQQG-ELGDCWLLAA-IASL--T-VNQR---LFAKVVP--P----------------D----Q-SFED-G-----YCGMFRFHFWRQG--EWVE----------------VVV---DDRLPTY-------------------------Y--GQ--------L-TF--------M-------------------------------------------------------------------------------------------------HSV-------D-----------------K-NEFWSALLEK-----------AYAKLE----G-SYESLK-----GGSTCEAMVDFTGGVSEFF---------------DLR------------------------------------------------------------------------------------------------------------------------------------KAP---P---------------------------------------------------------------------------------------------------------------------------------------------------N-LFSI---------MLKASQRGSLMGCS-ID--------------------------------------------------ADPNQ--LEARLANGLVMGHAYSITSV----------IL------------------------------M---------DIE----------T-----------PTMSGKIPMVRIRNP--WGN-E-AEWKGRWSDQSR-EWSLIPDSQKD--SI------GLTFDD-----DGEFWMS 10
11 WKRPTEI-----TD---N-------PQWF--VGG----ASRFDVKQG-ELGDCWLLAA-VSGL--C-GCKE---LLYRVVP--P----------------D----Q-DFTT-K-----YCGIFRFQFWQYG--KWTE----------------ILV---DDRLPTY-------------------------N--NK--------L-VF--------M-------------------------------------------------------------------------------------------------HSQ-------D-----------------M-NEFWSPLLEK-----------AYAKLC----G-SYEALK-----GGSTCEAMEDFTGGVTEMF---------------DLR-----------------------------------------------------------------------------------------------------------------------------------Q-AP---P---------------------------------------------------------------------------------------------------------------------------------------------------N-LFQI---------MLKAYERNSQMGCS-ID--------------------------------------------------ADPNQ--TEAKLTNGLIMGHAYTITRV----------AF------------------------------V---------DIK----------T-----------SRTEGRLPMIRVRNP--WGD-D-HEWNGAWSDKSR-EWSLISEEERE--EH------GLNFSD-----DGEFWMA 11
12 WLRPHEI-----CP---N-------PEFI--TGG----ASRFDVRQG-ELGDCWLLAA-IACL--S-MDKK---LFEQVVA--I----------------D----Q-NFTK-E-----YCGLFRFHFWNYG--EWKE----------------VVV---DDRLPTY-------------------------Q--KS--------L-VY--------I-------------------------------------------------------------------------------------------------HST-------E-----------------K-NEFWSALLEK-----------AYAKLC----G-SYEALK-----GGTTSEALEDFTGGISEMF---------------DLK-----------------------------------------------------------------------------------------------------------------------------------KDTP---S---------------------------------------------------------------------------------------------------------------------------------------------------N-LLQV---------MLKSQELSSLMACS-IQ--------------------------------------------------ADPNT--FEARLPNGLIMGHAYSITSV----------KM------------------------------L---------DIS----------I-----------PNKTGKIPLVRVRNP--WGD-E-SEWKGAWSDKSK-EWSLISPEQRQ--QL------GLTFDD-----DGEFWMS 12
13 WLRPTEI-----VE---D-------PQLF--VEG----ASRFDVKQG-KLGDCWLLAA-MASL--T-LNER---LFHKVIP--E----------------D----Q-SFTD-N-----YAGIFHFRIWQYG--NWVD----------------VVV---DDRLPTC-------------------------D--GE--------L-VF--------L-------------------------------------------------------------------------------------------------KSH-------A-----------------K-NEFWSALLEK-----------AYAKVH----G-GYEALD-----FGHTYEAMVDFTGGVSEMY---------------KLH------------------------------------------------------------------------------------------------------------------------------------ESP---P---------------------------------------------------------------------------------------------------------------------------------------------------N-LFEI---------LLKAHERSSLMSCG-IK--------------------------------------------------SDPNQ--LEAKTPMGLIKGHAYTITSV----------KM------------------------------M---------DIN----------T-----------PEMSEQLPMIRIRNP--WGN-E-AEWKGAWSDQSP-EWQFVPEEEKE--EV------GLTFDR-----DGEFWMS 13
14 WLRPTEI-----VG---D-------PQLF--VEG----ASRFDVQQG-ELGDCWLLAA-MASL--T-LNER---LFHQVVP--E----------------D----Q-SFTD-N-----YAGIFHFRIWQYG--SWVD----------------VVV---DDRLPTC-------------------------D--GK--------L-VF--------L-------------------------------------------------------------------------------------------------QSH-------T-----------------K-NEFWSALLEK-----------AYAKLH----G-GYEALK-----GGTTCEAMEDFTGGVSEMY---------------ELN------------------------------------------------------------------------------------------------------------------------------------QSP---P---------------------------------------------------------------------------------------------------------------------------------------------------N-LFKI---------LLKAHERSSLMSCA-IE--------------------------------------------------PDPDQ--LEAETPMGLIKGHAYSITSV----------KM------------------------------M---------DIR----------T-----------PRMSGQIPMIRIRNP--WGN-E-AEWKGAWSDQSP-EWQFIPAEEKE--EV------GLTFDR-----DGEFWMS 14
15 WKRPHEI-----TD---E-------PQLF--IDG----ATRFDVKQG-ELGDCWLLAA-VANL--T-LNRR---LFYQIVP--S----------------D----Q-GFGD-N-----YAGIFHFRFWQYG--RWVD----------------VVV---DDRLPTF-------------------------Y--GR--------L-VF--------M-------------------------------------------------------------------------------------------------HSE-------E-----------------K-NEFWSALAEK-----------AYAKLH----G-SYEALK-----GGTTCEAMEDFTGGVSEIY---------------DLT------------------------------------------------------------------------------------------------------------------------------------KAP---P---------------------------------------------------------------------------------------------------------------------------------------------------N-LFNI---------MLKAYQRGSLMGCS-ID--------------------------------------------------PDPNV--VEARCDNGLIRGHAYSITRI----------KY------------------------------C---------DIE----------T-----------PRVSGKIPLVRIRNP--WGN-E-AEWVGSWSDKSP-EWQFIPPEEKE--EM------GLTFEH-----DGEFWMS 15
16 WLRPGDI-----AD---D-------PQFF--VEG----YSRFDVQQG-ELGDCWLLAA-AANL--T-QDST---LFFRVIP--P----------------D----Q-DFQE-N-----YAGIFHFKFWQYG--KWVE----------------VVI---DDRLPTY-------------------------N--GE--------L-IY--------M-------------------------------------------------------------------------------------------------HST-------E-----------------K-NEFWSALLEK-----------AYAKLH----G-SYEALK-----GGTTCEAMEDFTGGVTEWY---------------DIK------------------------------------------------------------------------------------------------------------------------------------EAP---P---------------------------------------------------------------------------------------------------------------------------------------------------N-LFSI---------MMKAAERGSMMGCS-LE--------------------------------------------------PDPHV--LEAETPQGLIRGHAYSITKV----------CL------------------------------M---------DIS----------T-----------PNRQGKLPMIRMRNP--WGN-D-AEWSGPWSDSSP-EWRFIPEHTKE--EI------GLNFDR-----DGEFWMS 16
17 WLRPHEI-----AE---N-------PQFF--VEG----YSRFDVQQG-ELGDCWLLAA-TANL--T-QESN---LFFRVIP--A----------------E----Q-SFEE-N-----YAGIFHFRFWQYG--KWVD----------------VII---DDRLPTY-------------------------N--GE--------L-MY--------M-------------------------------------------------------------------------------------------------HST-------E-----------------K-NEFWSALLEK-----------AYAKLH----G-SYEALK-----GGSTCEAMEDFTGGVSEWY---------------DLK------------------------------------------------------------------------------------------------------------------------------------EAP---G---------------------------------------------------------------------------------------------------------------------------------------------------N-LFTI---------LQKAAERNSMMGCS-IE--------------------------------------------------PDPNV--TEAETPQGLIRGHAYSITKV----------CL------------------------------I---------DIV----------T-----------PNRQGKIPMIRMRNP--WGN-E-AEWNGPWSDSSP-EWRYIPEEQKA--EI------GLTFDR-----DGEFWMS 17
18 WLRPHEI-----CD---G-------PEFF--VEG----FSRFDVQQG-ELGDCWLLAA-CANL--T-QDHK---MFLRVVP--E----------------D----N-SFED-G-----YAGVFHFRFWQYG--KWVD----------------VVI---DDRLPTY-------------------------R--GQ--------L-IY--------M-------------------------------------------------------------------------------------------------RSS-------E-----------------Q-NEFWSALLEK-----------AYAKLH----G-SYESLR-----GGTTCEAMEDFTGGVAEMY---------------DLK-----------------------------------------------------------------------------------------------------------------------------------DQTP---P---------------------------------------------------------------------------------------------------------------------------------------------------N-LFEI---------IEKGFKRNSMFGCS-IE--------------------------------------------------ADPHV--LEAETPEGLIRGHAYSITKI----------QL------------------------------V---------DIE----------T-----------PGRSGKIPLIRLRNP--WGN-E-AEWNGPWSDKSP-EWRYIPDEQKQ--EL------GLNFDH-----DGEFWMS 18
19 WKRPGEL-----SK---N-------PKLF--VDG----ASRLDICQG-MLGDCWFLAA-ISSL--A-GEKS---LLYRVVP--P----------------D----Q-SFSR-N-----YAGIFHFQFWRFG--QWTD----------------VII---DDLLPTY-------------------------N--GR--------L-IF--------V-------------------------------------------------------------------------------------------------HSA-------D-----------------T-NEYWSALLEK-----------AYAKLA----G-SYEALK-----GGHSSEALEDFTGGVTEVI---------------DLK------------------------------------------------------------------------------------------------------------------------------------KPP---N---------------------------------------------------------------------------------------------------------------------------------------------------N-LFDQ---------ILKSFERHSLMGCS-IE--------------------------------------------------ASPNQ--IEHKLDNGLVMGHAYSVSKA----------VR------------------------------V---------KVR----------G-----------RIEED---LIRIRNP--WGN-E-KEWRGAWGDGSP-EWKTISEAEKA--KM------ELSFDD-----DGEFWMA 19
20 WKRPHEI-----TD---N-------PELF--VGG----ASRFDICQG-ELGDCWFLAA-IACL--S-MNES---LLFGVVP--P----------------D----Q-SFDKGD-----YVGCFRFNFWHYG--TWTE----------------VVV---DDQLPTF-------------------------N--NR--------L-TF--------V-------------------------------------------------------------------------------------------------HSA-------E-----------------E-NEYWSALLEK-----------AYAKLY----G-SYEALK-----GGSVTEAMEDFTGGVTEGM---------------DLR------------------------------------------------------------------------------------------------------------------------------------NAP---K---------------------------------------------------------------------------------------------------------------------------------------------------D-LLKI---------VEKAMMRNSLMGCS-VE--------------------------------------------------ADPNA--IDSKMDNGLVMGHAYSITGL----------QK------------------------------V---------NVQ----------G-----------QEIN----LIRVRNP--WG--S-VEWMGDWSDESP-KWDLLSSEQKA--KLNTDDDGDLNFGD-----DGEFWMD 20
21 WKRPHDI-----SN---D-------PQLF--VGG----ASRFDIMQG-ELGDCWLLAA-IASL--S-LNDD---LLYRIIP--P----------------D----Q-SFSQ-D-----YCGMFHFQFWQYG--EWID----------------VMV---DDLLPTV-------------------------R--GK--------L-VY--------L-------------------------------------------------------------------------------------------------HSA-------Q-----------------N-NEFWSALLEK-----------AYAKLN----G-SYEALK-----GGSTTEAMEDFTGGVTEVI---------------DLK------------------------------------------------------------------------------------------------------------------------------------EAP---N---------------------------------------------------------------------------------------------------------------------------------------------------N-LYSV---------MHKSLKKGALMGCA-VE-------------------------------------------------TTSKSQ--REAKLSNGLLMGHAYSITG-------------------------------------------L---------DIL----------R-----------NGVK----LVRVRNP--WG--Q-VEWNGAWSDGSS-SWNRV-PDEKQ--RL------DVEFGE-----DGEFWMS 21
22 WKRPGEI-----YE---N-------PQLI--VGE----KSRFDVKQG-ALGDCWLLAA-VANL--T-LRDE---LFYRVVP--P----------------D----Q-SFTE-N-----YAGIFHFQFWRYG--QWVD----------------VVI---DDRLPTV-------------------------D--GR--------L-CY--------M-------------------------------------------------------------------------------------------------RSQ-------E-----------------N-NEFWSALLEK-----------AYAKLY----G-GYEHLD-----GGTTAEALEDFTGGLTEFF---------------DLE------------------------------------------------------------------------------------------------------------------------------------KGD---K---------------------------------------------------------------------------------------------------------------------------------------------------STILAM---------LVRGMQMGSLFGCS-ID--------------------------------------------------ADENV--KEAQLTNGLVRGHAYSITAI----------QT------------------------------V---------NTY----------S-----------GQTP----LLRIRNP--WGN-S-KEWNGAWSDGAS-EWNQIDPSQRE--QM------NVQFAK-----DGEFWM- 22
23 WKRPGEI-----YE---N-------PQLI--VGE----KSRFDVKQG-ALGDCWLLAA-VANL--T-LRDE---LFYRVVP--P----------------D----Q-SFTE-N-----YAGIFHFQFWRYG--QWVD----------------VVI---DDRLPTV-------------------------D--GR--------L-CY--------M-------------------------------------------------------------------------------------------------RSQ-------E-----------------N-NEFWSALLEK-----------AYAKLY----G-GYENLD-----GGTTAEALEDFTGGLTEFF---------------DIS------------------------------------------------------------------------------------------------------------------------------------KGD---K---------------------------------------------------------------------------------------------------------------------------------------------------STTLAM---------LVRGMQMGSLFGCS-ID--------------------------------------------------ADENV--KEAQLTNGLVRGHAYSITAI----------QT------------------------------V---------NTY----------G-----------GQVP----LLRIRNP--WGN-S-KEWNGAWSDGSS-EWSQVDPQQRE--QM------GVQFAK-----DGEFWM- 23
24 WKRPGEI-----IA---N-------PQLI--TQG----ESRFDVKQG-ALGDCWFLAA-LANI--T-LYDA---LFYRIVP--P----------------N----Q-SFTE-N-----YAGIFHFQFWHYG--KWVD----------------VVV---DDRLPTV-------------------------N--NQ--------L-YY--------L-------------------------------------------------------------------------------------------------HSA-------D-----------------N-TEFWSALVEK-----------AYAKLH----G-GYENLD-----GGTTAEALEDFTGGLTEYF---------------DLR------------------------------------------------------------------------------------------------------------------------------------KSE---K---------------------------------------------------------------------------------------------------------------------------------------------------AAVLAA---------LVKGMEMGSLFGCS-ID--------------------------------------------------ADANI--KEAQLRNGLVCGHAYSITAI----------HS------------------------------I---------TYY----------G-----------EDTT----LLRLRNP--WGN-E-KEWNGAWSDGSS-EWSKIDEATKK--QI------DVQFAR-----DGEFWM- 24
25 WLRPAKI-----FA---N-------PRLI--VNG----KSRFDVRQG-SLGNCWFLAA-AATL--A-QRDE---LFYRVVP--P----------------D----Q-SFTE-N-----YAGIFHFQFWRYG--EWVD----------------VVI---DDRLPTV-------------------------N--GK--------L-IY--------M-------------------------------------------------------------------------------------------------SSQ-------D-----------------G-DECWGPLLEK-----------AYAKLY----G-TYEHLD-----GGTTTEALEDFTGGLTEFY---------------DLT------------------------------------------------------------------------------------------------------------------------------------STD---K---------------------------------------------------------------------------------------------------------------------------------------------------TMILAM---------IMKGMQMGSLFACS-ID--------------------------------------------------PDPRE--KEAQLANGLVRGHAYSVTGV----------HT------------------------------V---------ETD----------K-----------EKVA----LLRIRNP--WGD-T--EWNGDWSDKSS-LWEQVDQEQRE--KM------EFRIKE-----DGEFWM- 25
26 WLRPGEI-----VR---E-------PQLI--TEG----HSRFDVIQG-ELGDCWLLAA-AANL--T-LKDE---LFYRVVP--P----------------D----Q-SFTE-N-----YAGIFHFQFWQYG--KWVD----------------VVI---DDRLPTS-------------------------N--GE--------L-LY--------M-------------------------------------------------------------------------------------------------HSA-------S-----------------N-NEFWSALLEK-----------AYAKLF----G-SYEALK-----GGTTSEALEDMTGGLTEFI---------------DLK------------------------------------------------------------------------------------------------------------------------------------NPP---R---------------------------------------------------------------------------------------------------------------------------------------------------N-LMQM---------MMRGFEMGSLFGCS-IE--------------------------------------------------ADPNV--WEAKMSNGLVKGHAYSITGC----------RI------------------------------V---------DGP----------N-----------GQTC----ILRIRNP--WGN-E-QEWNGAWSDNSR-EWRNVPDSVKQ--DM------GLKFDH-----DGEFWMS 26
27 WLRPGEI-----TR---E-------PQLI--TEG----HSRFDVIQG-ELGDCWLLAA-AANL--T-LKDE---LFYRVVP--P----------------D----Q-SFTE-N-----YAGIFHFQFWQYG--KWVD----------------VVI---DDRLPTS-------------------------N--GE--------L-LY--------M-------------------------------------------------------------------------------------------------HSA-------S-----------------N-NEFWSALLEK-----------AYAKLF----G-SYEALK-----GGTTSEALEDMTGGLTEFI---------------DLK------------------------------------------------------------------------------------------------------------------------------------NPP---R---------------------------------------------------------------------------------------------------------------------------------------------------N-LMQM---------MMRGFEMGSLFGCS-IE--------------------------------------------------ADPNV--WEAKMSNGLVKGHAYSITGC----------RI------------------------------V---------DGP----------N-----------GQTC----ILRIRNP--WGN-E-QEWNGPWSDNSR-EWRSVPDSVKQ--DM------GLKFDH-----DGEFWMS 27
28 WKRPSEI-----CD---D-------PQMF--VGG----ATRFDVVQG-ELGNCWFLAA-VGSLCAT-KSKE---LLHRVIP--L----------------D----N-SFAKGQ-----YAGVFHFKIWQYG--KWMD----------------VVV---DDRLPTL-------------------------N--GR--------L-QY--------L-------------------------------------------------------------------------------------------------HSP-------S-----------------N-NEFWAALLEK-----------AYAKLC----A-SYEALS-----GGSSSEAMEDFTGGIVEHY---------------ELT-----------------------------------------------------------------------------------------------------------------------------------KNVP---D---------------------------------------------------------------------------------------------------------------------------------------------------D-LFNI---------MKKCYERQSLLCTS-ID--------------------------------------------------VSRMA--LESELPTGLVVGHAYSVTAV----------KS------------------------------L---------KVR----------G-----------HDVQ----LVRIRNP--WGN-K-VEWNGAWSDKSS-EWNMLGENERQ--EL------GLSFED-----DGEFWMS 28
29 WLRASEI-----HD---D-------PQMF--VDG----ACRLDINQG-VLGDCWLLAA-VSCL--A-THPR---LLKRVVP--E----------------D----Q-SFQE-D-----YAGVFRFEIWQFG--RWVE----------------VCI---DDRLPTC-------------------------N--GK--------L-IY--------M-------------------------------------------------------------------------------------------------HSD-------N-----------------T-NEFWSAMLEK-----------AYAKLC----G-CYESLS-----GGLTSEALTDFTGGIAEKF---------------ELR-----------------------------------------------------------------------------------------------------------------------------------ENAP---E---------------------------------------------------------------------------------------------------------------------------------------------------D-LFKI---------MAKAHSKRNLLGCS-ID--------------------------------------------------ATPDS--MEAQLDNGLIIGHAYSVTDV----------RY------------------------------V---------EVE----------T-----------PRVSGRIPMVRVRNP--WGD-S-HEWKGAWSDDSE-EWTLVPEEEKE--EM------GLTYSH-----DGEFWMA 29
30 -KRPGQL-----TS---S-------PEFI--VGG----ATRTDICQG-ALGDCWLLAA-IASL--T-LNED---VLARVVP--S----------------D----Q-GFGQ-D-----YAGIFHFQFWQFG--EWVD----------------VVV---DDRLPTR-------------------------D--GE--------L-LF--------V-------------------------------------------------------------------------------------------------HSV-------T-----------------G-SEFWSALLEK-----------AYAKVN----G-CYEALS-----GGSTTEGFEDFTGGIAEMY---------------ELK------------------------------------------------------------------------------------------------------------------------------------SAP---T---------------------------------------------------------------------------------------------------------------------------------------------------N-LFQI---------IKKALDSGALLGCS-ID-------------------------------------------------ITSAAD--SEAVTYQKLVKGHAYSLTGA----------TE------------------------------V---------NYR----------S-----------RKEK----LVRVRNP--WG--Q-VEWTGAWSDNSS-EWNAVDPSERE--NV--------KS-E-----DGEFWMS 30
31 WKRPGQL-----NS---S-------PEFI--VGG----ATRTDICQG-ALGDCWLLAA-IASL--T-LNED---VLARVVP--S----------------D----Q-GFGQ-D-----YAGIFHFQFWQFG--EWVD----------------VVV---DDRLPTR-------------------------D--GE--------L-LF--------V-------------------------------------------------------------------------------------------------HSV-------T-----------------G-SEFWSALLEK-----------AYAKVN----G-CYEALS-----GGSTTEGFEDFTGGIAEMY---------------ELK------------------------------------------------------------------------------------------------------------------------------------SAP---T---------------------------------------------------------------------------------------------------------------------------------------------------N-LFQI---------IKKALDSGALLGCS-ID-------------------------------------------------ITSAAD--SEAVTYQKLVKGHAYSLTGA----------TE------------------------------V---------NYR----------S-----------RKEK----LVRVRNP--WG--Q-VEWTGAWSDNSS-EWNAVDPSERE--NV--------KS-E-----DGEFWMS 31
32 WKRPGEL-----CQ---K-------PRFI--VGG----ATKTDICQG-ALGDCWLLAA-IASL--T-QNED---VLARVVP--N----------------G----Q-EFDG-T-----YAGIFHFQFWQFG--EWVD----------------VVI---DDRLPVK-------------------------D--GE--------L-LF--------V-------------------------------------------------------------------------------------------------YSA-------E-----------------K-NEFWSALLEK-----------AYAKVN----G-CYEALS-----GGSTSEGFEDFTGGIAESY---------------EIR------------------------------------------------------------------------------------------------------------------------------------KAP---T---------------------------------------------------------------------------------------------------------------------------------------------------N-LFQI---------IQKALEAGALLGCS-ID-------------------------------------------------ITSAAD--SEAITRQKLVKGHAYSLTGA----------TE------------------------------V---------NYR----------G-----------RKEK----LVRMRNP--WG--Q-VEWTGAWSDNSP-EWNSVAASERP--DA--------SA-E-----DGEFWMA 32
33 WLRPKQL-----TS---N-------PTFI--SGG----ATRTDICQG-ALGDCWLLAA-IASL--T-LNQD---VFARVVP--A----------------G----Q-SFDG-D-----YAGIFHFQFWQFG--EWVD----------------VVI---DDRLPAR-------------------------N--GE--------L-LF--------V-------------------------------------------------------------------------------------------------HSA-------E-----------------G-SEFWSALLEK-----------AYAKLN----G-CYEALS-----GGTTTEGFEDFTGGIAEVH---------------ELA------------------------------------------------------------------------------------------------------------------------------------KAG---P---------------------------------------------------------------------------------------------------------------------------------------------------N-LFKT---------IQKALSWGSLLGCS-ID-------------------------------------------------ITSSSD--SEAITSQKLVKGHAYSVTGA----------EE------------------------------V---------EYR----------G-----------DLTK----LIRIRNP--WG--Q-VEWTGPWSDGSS-EWRQISDNDRE--RL------SSKA-E-----DGEFWMS 33
34 WKRPKEL-----CS---N-------PEFI--MDG----ANRTDICQG-ALGDCWLLAA-IASL--T-LDKE---ILERVVP--S----------------G----Q-SFTE-D-----YAGIFHFQFWQYG--EWVD----------------VVI---DDRLPTR-------------------------D--GK--------L-LF--------V-------------------------------------------------------------------------------------------------HSA-------E-----------------G-SEFWSALLEK-----------AYAKVN----G-SYEALT-----GGSTTEGFEDFTGGITENY---------------ELS------------------------------------------------------------------------------------------------------------------------------------KAP---P---------------------------------------------------------------------------------------------------------------------------------------------------N-LFKL---------VQKALALGSLLGCS-ID-------------------------------------------------ITSSYE--TEAVTSLKLVKGHAYSVTAA----------EE------------------------------V---------HFR----------G-----------SLVQ----LVRIRNP--WG--E-VEWTGAWSDNSK-EWDSVPPEEKA--KL------DYSA-E-----DGEFWMA 34
35 WKRPTEL-----CS---N-------PQFI--VGG----ATRTDICQG-ALGDCWLLAA-IASL--T-LNEE---ILARVVP--S----------------D----Q-SFQD-R-----YAGIFHFQFWQYG--EWTD----------------VVV---DDRLPTK-------------------------N--GE--------L-LF--------V-------------------------------------------------------------------------------------------------HSA-------E-----------------G-TEFWSALLEK-----------AYAKVN----G-SYEALS-----GGSTTEGFEDFTGGIAEWY---------------ELR------------------------------------------------------------------------------------------------------------------------------------KAP---P---------------------------------------------------------------------------------------------------------------------------------------------------N-LFRI---------IQKALQKGSLLGCS-ID-------------------------------------------------ITSAAE--TEAVTTQKLVKGHAYSVTGA----------EE------------------------------V---------SFR----------G-----------SLQK----LIRIRNP--WG--E-VEWTGKWNDNCP-SWSNVDPEVRD--RL------TKKH-E-----DGEFWMS 35
36 WCRPTEL-----CS---C-------PRFI--AGG----ATRTDICQG-ALGDCWLLAA-IASL--T-LNEE---ILARVVP--R----------------D----Q-SFQD-E-----YAGIFHFQFWQYG--EWVD----------------VVV---DDRLPTK-------------------------N--GE--------L-LF--------V-------------------------------------------------------------------------------------------------HSA-------E-----------------G-SEFWSALLEK-----------AYAKLN----G-SYEALS-----GGTTTEGFEDFTGGIAEWY---------------ELQ------------------------------------------------------------------------------------------------------------------------------------KAP---P---------------------------------------------------------------------------------------------------------------------------------------------------N-LFKI---------IQKALQKGSLLGCS-ID-------------------------------------------------ITSAAE--TEAVTSQKLVKGHAYSVTGA----------EE------------------------------V---------NFR----------G-----------SIQK----LIRIRNP--WG--E-VEWTGKWNDNCP-NWSGVDPEVRE--RL------TRRH-E-----DGEFWMA 36
37 WKRALEL-----CN---D-------PQFI--VGG----ATRTDICQG-ALGDCWLLAA-IASL--T-LNEE---ILARVVP--L----------------N----Q-SFQE-N-----YAGIFHFQFWQYG--EWVE----------------VVV---DDRLPTK-------------------------D--GE--------L-LF--------V-------------------------------------------------------------------------------------------------HSA-------E-----------------G-SEFWSALLEK-----------AYAKIN----G-CYEALS-----GGATTEGFEDFTGGIAEWY---------------ELR------------------------------------------------------------------------------------------------------------------------------------KAP---S---------------------------------------------------------------------------------------------------------------------------------------------------N-LFKI---------IQKALQKGSLLGCS-ID-------------------------------------------------ITSAAD--SEAITFQKLVKGHAYSVTGA----------EE------------------------------V---------ESS----------G-----------SLQK----LIRIRNP--WG--E-VEWTGRWNDNCP-NWNTVDPEVRE--RL------TRRH-E-----DGEFWMS 37
38 WKRPTEI-----CA---D-------PQFI--IGG----ATRTDICQG-ALGDCWLLAA-IASL--T-LNEE---ILARVVP--L----------------N----Q-SFQE-N-----YAGIFHFQFWQYG--EWVE----------------VVV---DDRLPTK-------------------------D--GE--------L-LF--------V-------------------------------------------------------------------------------------------------HSA-------E-----------------G-SEFWSALLEK-----------AYAKIN----G-CYEALS-----GGATTEGFEDFTGGIAEWY---------------ELK------------------------------------------------------------------------------------------------------------------------------------KPP---P---------------------------------------------------------------------------------------------------------------------------------------------------N-LFKI---------IQKALQKGSLLGCS-ID-------------------------------------------------ITSAAD--SEAITFQKLVKGHAYSVTGA----------EE------------------------------V---------ESN----------G-----------SLQK----LIRIRNP--WG--E-VEWTGRWNDNCP-SWNTIDPEERE--RL------TRRH-E-----DGEFWMS 38
39 -----EI-----CD---D-------PQFI--VGG----ATRTDICQG-ALGDCWLLAA-IASL--T-LNEE---VLARVVP--P----------------N----Q-SFQE-N-----YAGIFHFQFWQYG--EWVE----------------VVV---DDRLPTK-------------------------N--GE--------L-LF--------V-------------------------------------------------------------------------------------------------HSA-------E-----------------G-SEFWSALLEK-----------AYAKIN----G-CYEALS-----GGATTEGFEDFTGGIAEWY---------------ELR------------------------------------------------------------------------------------------------------------------------------------KAP---P---------------------------------------------------------------------------------------------------------------------------------------------------D-LFRI---------IQKALQKGSLLGCS-ID-------------------------------------------------ITSMAD--SEAITFQKLVKGHAYSVTGA----------EE------------------------------V---------ESG----------G-----------SLQK----LIRIRNP--WG--E-VEWTGKWNDNCP-NWNTVDPEVRE--RL------TRRH-E-----DGEFWMS 39
40 WKRPTEI-----CD---N-------PQFI--TGG----ATRTDICQG-ALGDCWLLAA-IASL--T-LNEE---ILARVVP--L----------------D----Q-SFQE-N-----YAGIFHFQFWQYG--EWVE----------------VVV---DDRLPTK-------------------------D--GE--------L-LF--------V-------------------------------------------------------------------------------------------------HSA-------E-----------------G-SEFWSALLEK-----------AYAKIN----G-CYEALS-----GGATTEGFEDFTGGIAEWY---------------ELR------------------------------------------------------------------------------------------------------------------------------------KAP---P---------------------------------------------------------------------------------------------------------------------------------------------------N-LFRI---------IQKALQKGSLLGCS-ID-------------------------------------------------ITSAAD--SEAITFQKLVKGHAYSVTGA----------EE------------------------------V---------ESR----------G-----------SLQK----LIRIRNP--WG--E-VEWTGQWNDNCP-NWNTVDPEVRE--TL------TRQH-E-----DGEFWMS 40
41 WKRPTEI-----CA---D-------PQFI--IGG----ATRTDICQG-ALGDCWLLAA-IASL--T-LNEE---ILARVVP--P----------------D----Q-SFQE-N-----YAGIFHFQFWQYG--EWVE----------------VVV---DDRLPTK-------------------------D--GE--------L-LF--------V-------------------------------------------------------------------------------------------------HSA-------E-----------------G-SEFWSALLEK-----------AYAKIN----G-CYEALS-----GGATTEGFEDFTGGIAEWY---------------ELR------------------------------------------------------------------------------------------------------------------------------------KPP---P---------------------------------------------------------------------------------------------------------------------------------------------------N-LFKI---------IQKALEKGSLLGCS-ID-------------------------------------------------ITSAAD--SEAVTYQKLVKGHAYSVTGA----------EE------------------------------V---------ESS----------G-----------SLQK----LIRIRNP--WG--Q-VEWTGKWNDNCP-SWNTVDPEVRA--NL------TERQ-E-----DGEFWMS 41
42 ---PTEI-----CD---D-------PEFI--VGG----ATRTDICQG-ALGDCWLLAA-IASL--T-LNEE---ILARVVP--L----------------N----Q-SFQE-N-----YAGIFHFQ----------E----------------IFG---RPRGG------------------------------------------------------------------------------------------------------------------------------------------------------ESE-------RRVPGAARNGGPGQRGTQG-QRLPSPL-----------------RVN----G-CYEALS-----GGATTEGFEDFTGGIAEWY---------------ELR------------------------------------------------------------------------------------------------------------------------------------KAP---P---------------------------------------------------------------------------------------------------------------------------------------------------N-LFKI---------IQKALQKGSLLGCS-ID-------------------------------------------------ITSMAD--SEAITFQKLVKGHAYSVTGA----------EE------------------------------V---------ESG----------G-----------SLQK----LIRIRNP--WG--E-VEWTGRWNDNCP-NWNSVDPEVRE--RL------TRRH-E-----DGEFWMS 42
43 --RVQEI-----CD---D-------PEFI--VGG----ATRTDICQG-ALGDCWLLAA-IASL--T-LNEE---ILARVVP--L----------------N----Q-SFQE-N-----YAGIFHFQ-----------------------------A---GHKGA------------------------------------------------------------------------------------------------------------------------------------------------------ESA-------DEGPVPCGPCGEEGRGPHG--RLGEPLLSRGSRRRSRKPRATTGRVN----G-CYEALS-----GGATTEGFEDFTGGIAEWY---------------ELR------------------------------------------------------------------------------------------------------------------------------------KAP---P---------------------------------------------------------------------------------------------------------------------------------------------------N-LFKI---------IQKALQKGSLLGCS-ID-------------------------------------------------ITSMAD--SEAITFQKLVKGHAYSVTGA----------EE------------------------------V---------ESG----------G-----------SLQK----LIRIRNP--WG--E-VEWTGRWNDNCP-NWNSVDPEVRE--RL------TRRH-E-----DGEF--- 43
44 --RSQEI-----CD---D-------PEFI--VGG----ATRTDICQG-ALGDCWLLAA-IASL--T-LNEE---ILARVVP--L----------------N----Q-SFQE-N-----YAGIFHFQ----------A----------------TLP---PDRPGFW-------------------------G--EQ--------V-VF--------K-------------------------------------------------------------------------------------------------DHL-------EQEP----------RSTQG------PLWPELGSR-------AAGRVN----G-CYEALS-----GGATTEGFEDFTGGIAEWY---------------ELR------------------------------------------------------------------------------------------------------------------------------------KAP---P---------------------------------------------------------------------------------------------------------------------------------------------------N-LFKI---------IQKALQKGSLLGCS-ID-------------------------------------------------HGLCC----------KLVKGHAYSVTGA----------EE------------------------------V---------ESG----------G-----------SLQK----LIRIRNP--WG--E-VEWTGRWNDNCP-NWNSVDPEVRE--RL------TRRH-E-----DGEFWM- 44
45 WIRPTEL-----SE---N-------PQFI--VGG----ATRTDICQG-ALGDCWLLAA-IASL--T-LNDK---LLHRVVP--H----------------G----Q-SFTN-E-----YAGIFHFQFWQFG--EWVD----------------IVI---DDRLPVK-------------------------D--KE--------L-MF--------V-------------------------------------------------------------------------------------------------HSA-------E-----------------G-NEFWSALLEK-----------AYAKLN----G-SYEALS-----GGSTTEGFEDFTGGVAEMY---------------ELR------------------------------------------------------------------------------------------------------------------------------------SAP---K---------------------------------------------------------------------------------------------------------------------------------------------------D-LHRI---------IAKALERGSLLGCS-ID-------------------------------------------------ITSAFD--MEAVTFKKLVKGHAYSVTAL----------RE------------------------------V---------NFR----------G-----------NRER----LIRIRNP--WG--Q-VEWTGAWSDNSS-EWNGIDPSERE--EL------NNHM-E-----DGEFWMS 45
46 WMRPTEL-----CD---D-------PQFI--VGG----ATRTDICQG-ALGDCWLLAA-IGSL--T-LNER---LLHRVVP--H----------------G----Q-SFQD-D-----YAGIFHFQFWQFG--EWVD----------------IVI---DDRLPVK-------------------------D--GE--------L-MF--------V-------------------------------------------------------------------------------------------------HSA-------E-----------------G-NEFWSALVEK-----------AYAKLN----G-SYEALS-----GGSTTEGFEDFTGGVSEMY---------------ELR------------------------------------------------------------------------------------------------------------------------------------KAP---R---------------------------------------------------------------------------------------------------------------------------------------------------D-LYRI---------ISKALDRGSLLGCS-ID-------------------------------------------------ITSAFD--MESVTFKKLVKGHAYSVTAL----------KQ------------------------------V---------EYR----------G-----------RMER----LIRIRNP--WG--Q-VEWTGAWSDNSP-EWDEIDPSEKD--DL------HLQM-E-----DGEFWMS 46
47 WKRPSEI-----VD---D-------PQFI--VGG----ATRTDICQG-TLGNCWLLAA-IGSL--T-LNED---LLHRVVP--Q----------------D----Q-TFQK-D-----YAGIFHFQIWQFG--KWVD----------------VVI---DDRLPTK-------------------------D--GK--------L-VF--------V-------------------------------------------------------------------------------------------------HSA-------E-----------------C-QEFWSALLEK-----------AYAKLN----G-SYEALS-----GGSTTEGFEDFTGGVAEVY---------------NLK------------------------------------------------------------------------------------------------------------------------------------KPP---S---------------------------------------------------------------------------------------------------------------------------------------------------N-IARI---------ICKALERGSLLGCS-ID-------------------------------------------------ITSARD--VEAVTFRKLVKGHAYSVTGF----------KN------------------------------V---------DYR----------G-----------QQES----LIRIRNP--WG--E-VEWTGAWSDSSS-EWNEVDPDQRE--EL------HLKK-E-----DGEFWMS 47
48 WKRPSEI-----VD---D-------PQFI--VGG----ATRTDICQG-ALGDCWLLAA-IGSL--T-LNED---LLHRVVP--H----------------G----Q-SFQE-D-----YAGIFHFQIWQFG--EWVD----------------VVV---DDRLPTK-------------------------D--GE--------L-VF--------V-------------------------------------------------------------------------------------------------HSA-------E-----------------C-QEFWSALLEK-----------AYAKLN----G-SYEALS-----GGSTTEGFEDFTGGVAEMY---------------DLK------------------------------------------------------------------------------------------------------------------------------------KPP---R---------------------------------------------------------------------------------------------------------------------------------------------------N-IAQI---------ICKALERGSLLGCS-ID-------------------------------------------------ITSAFD--MEAVTFKKLVKGHAYSVTGF----------KN------------------------------V---------DYR----------G-----------QQES----LIRIRNP--WG--Q-VEWTGAWSDSSS-EWNEVDPDQRE--EL------HLKM-E-----DG----- 48
49 WKRPSEL-----VD---D-------PQFI--VGG----ATRTDICQG-ALGDCWLLAA-IGSL--T-LNEE---LLHRVVP--H----------------G----Q-SFQE-D-----YAGIFHFQIWQFG--EWVD----------------VVV---DDLLPTK-------------------------D--GE--------L-LF--------V-------------------------------------------------------------------------------------------------HSA-------E-----------------C-TEFWSALLEK-----------AYAKLN----G-CYESLS-----GGSTTEGFEDFTGGVAEMY---------------DLK------------------------------------------------------------------------------------------------------------------------------------RAP---R---------------------------------------------------------------------------------------------------------------------------------------------------N-MGHI---------IRKALERGSLLGCS-ID-------------------------------------------------ITSAFD--MEAVTFKKLVKGHAYSVTAF----------KD------------------------------V---------NYR----------G-----------QQEQ----LIRIRNP--WG--Q-VEWTGAWSDGSS-EWDNIDPSDRE--EL------QLKM-E-----DGEFWMS 49
50 WKRPTEL-----CR---N-------PLFI--IDG----ATRTDVCQG-ALGDCWLLAA-IASL--T-LNDP---LLHRVVP--H----------------G----Q-SFQN-G-----YAGIFHFQIWQFG--EWVD----------------VVV---DDLLPTK-------------------------D--GK--------L-VF--------V-------------------------------------------------------------------------------------------------HSA-------E-----------------G-NEFWSALLEK-----------AYAKLN----G-CYEALS-----GGSTSEGFEDFTGGVTEWY---------------DLR------------------------------------------------------------------------------------------------------------------------------------KPP---S---------------------------------------------------------------------------------------------------------------------------------------------------D-LFQI---------ILKALERGSLMGCS-ID-------------------------------------------------ITSAFD--MEAVTFKKLVKGHAYSVTGG----------EQ------------------------------I---------TYR----------G-----------QRVS----LIRIRNP--WG--E-VEWTGAWSDNSA-EWNTVDPSVGQ--QL------RIKM-E-----DGEFWMS 50
51 WKRPTEL-----CR---H-------PQFI--VDG----ATRTDICQG-ALGDCWLLAA-IASL--T-LNET---ILHRVVP--H----------------G----Q-SFQN-G-----YAGIFHFQIWQFG--EWQD----------------VVV---DDYLPTK-------------------------D--GK--------L-LF--------V-------------------------------------------------------------------------------------------------HSA-------E-----------------G-TEFWSALLEK-----------AYAKVN----G-CYEALS-----GGSTSEGFEDFTGGVTEWY---------------DLR------------------------------------------------------------------------------------------------------------------------------------KPP---A---------------------------------------------------------------------------------------------------------------------------------------------------D-LYQI---------ILKALERGSLLGCS-ID-------------------------------------------------ITSAFD--MEAVTFKKLVKGHAYSVTGA----------KQ------------------------------I---------SYR----------G-----------QSLG----LIRMRNP--WG--E-VEWTGAWSDNSS-EWNAVEPALRQ--QL------MVRM-E-----DGEFWMS 51
52 WKRPTEL-----FS---N-------PQFI--VDG----ATRTDICQG-ALGDCWLLAA-IACL--T-LNDT---LLHRVVP--H----------------G----Q-SFQN-G-----YAGIFHFQLWQFG--EWVD----------------VVV---DDLLPTK-------------------------D--EK--------L-VF--------V-------------------------------------------------------------------------------------------------HSA-------Q-----------------G-NEFWSALLEK-----------AYAKVN----G-SYE-LS-----GGSTSEGFEDFTGGVTEWY---------------E-R------------------------------------------------------------------------------------------------------------------------------------KAP---S---------------------------------------------------------------------------------------------------------------------------------------------------D-LYHI---------ILKALERGSLLGCS-ID-------------------------------------------------ISSVLD--MEAVTFKKLVKGHAYSVTGA----------KQ------------------------------V---------NYQ----------G-----------QMVS----LIRMRNP--WG--E-VEWTGAWSDGSS-EWNNVDPYERE--QL------RVKM-E-----DGEFWMS 52
53 WKRPTEL-----FS---N-------PQFI--VDG----ATRTDICQG-ALGDCWLLAA-IASL--T-LNDT---LLHRVVP--H----------------G----Q-SFQD-G-----YAGIFHFQLWQFG--EWVD----------------VVV---DDLLPTK-------------------------D--GK--------L-VF--------V-------------------------------------------------------------------------------------------------HSA-------Q-----------------G-NEFWSALLEK-----------AYAKVN----G-SYEALS-----GGSTSEGFEDFTGGVTEWY---------------ELR------------------------------------------------------------------------------------------------------------------------------------KAP---S---------------------------------------------------------------------------------------------------------------------------------------------------D-LYNI---------ILKALERGSLLGCS-ID-------------------------------------------------ISSILD--MEAVTFKKLVKGHAYSVTGA----------KQ------------------------------V---------NYQ----------G-----------QMVN----LIRMRNP--WG--E-VEWTGAWSDGSS-EWNGVDPYMRE--QL------RVKM-E-----DGEFWMS 53
54 WKRPTEL-----LS---N-------PQFI--VDG----ATRTDICQG-ALGDCWLLAA-IASL--T-LNDT---LLHRVVP--H----------------G----Q-SFQN-G-----YAGIFHFQLWQFG--EWVD----------------VVV---DDLLPIK-------------------------D--GK--------L-VF--------V-------------------------------------------------------------------------------------------------HSA-------Q-----------------G-NEFWSALLEK-----------AYAKVN----G-SYEALS-----GGSTSEGFEDFTGGVTEWY---------------ELR------------------------------------------------------------------------------------------------------------------------------------KAP---S---------------------------------------------------------------------------------------------------------------------------------------------------D-LYQI---------ILKALERGSLLGCS-ID-------------------------------------------------ITSVLD--MEAITFKKLVKGHAYSVTGA----------KQ------------------------------V---------NYQ----------G-----------QMVS----LIRMRNP--WG--E-VEWTGAWSDGSS-EWNNVDPYERE--QL------RIKM-E-----DGEFWM- 54
55 WKRPTEL-----LS---N-------PQFI--VDG----ATRTDICQG-ALGDCWLLAA-IASL--T-LNDT---LLHRVVP--H----------------G----Q-SFQN-G-----YAGIFHFQLWQFG--EWVD----------------VVV---DDLLPIK-------------------------D--GK--------L-VF--------V-------------------------------------------------------------------------------------------------HSA-------Q-----------------G-NEFWSALLEK-----------AYAKVN----G-SYEALS-----GGSTSEGFEDFTGGVTEWY---------------ELR------------------------------------------------------------------------------------------------------------------------------------KAP---S---------------------------------------------------------------------------------------------------------------------------------------------------D-LYQI---------ILKALERGSLLGCS-ID-------------------------------------------------ITSVLD--MEAITFKKLVKGHAYSVTGA----------KQ------------------------------V---------NYQ----------G-----------QMVS----LIRMRNP--WG--E-VEWTGAWSDGSS-EWNNVDPYERE--QL------RIKM-E-----DGEFWMS 55
56 WKRPTEL-----LS---N-------PQFI--VDG----ATRTDICQG-ALGDCWLLAA-IASL--T-LNDT---LLHRVVP--H----------------G----Q-SFQN-G-----YAGIFHFQLWQFG--EWVD----------------VVV---DDLLPIK-------------------------D--GK--------L-VF--------V-------------------------------------------------------------------------------------------------HSA-------Q-----------------G-NEFWSALLEK-----------AYAKVN----G-SYEALS-----GGSTSEGFEDFTGGVTEWY---------------ELR------------------------------------------------------------------------------------------------------------------------------------KAP---S---------------------------------------------------------------------------------------------------------------------------------------------------D-LYQI---------ILKALERGSLLGCS-ID-------------------------------------------------ISSVLD--MEAITFKKLVKGHAYSVTGA----------KQ------------------------------V---------NYQ----------G-----------QMVS----LIRMRNP--WG--E-VEWTGAWSDGG----NNVDPSERE--QL------RVKM-E-----DGEFWMS 56
57 WKRPTEL-----LS---N-------PQFI--VDG----ATRTDICQG-ALGDCWLLAA-IASL--T-LNDT---LLHRVVP--H----------------G----Q-SFQN-G-----YAGIFHFQLWQFG--EWVD----------------VVV---DDLLPIK-------------------------D--GK--------L-VF--------V-------------------------------------------------------------------------------------------------HSA-------E-----------------G-NEFWSALLEK-----------AYAKVN----G-SYEALS-----GGSTSEGFEDFTGGVTEWY---------------ELR------------------------------------------------------------------------------------------------------------------------------------KAP---S---------------------------------------------------------------------------------------------------------------------------------------------------D-LYQI---------ILKALERGSLLGCS-ID-------------------------------------------------ISSVLD--MEAITFKKLVKGHAYSVTGA----------KQ------------------------------V---------NYR----------G-----------QVVS----LIRMRNP--WG--E-VEWTGAWSDSSS-EWNNVDPYERD--QL------RVKM-E-----DGEFWMS 57
58 WKRPTEL-----MS---N-------PQFI--VDG----ATRTDICQG-ALGDCWLLAA-IASL--T-LNET---ILHRVVP--Y----------------G----Q-SFQD-G-----YAGIFHFQLWQFG--EWVD----------------VVI---DDLLPTK-------------------------D--GK--------L-VF--------V-------------------------------------------------------------------------------------------------HSA-------Q-----------------G-NEFWSALLEK-----------AYAKVN----G-SYEALS-----GGCTSEAFEDFTGGVTEWY---------------DLQ------------------------------------------------------------------------------------------------------------------------------------KAP---S---------------------------------------------------------------------------------------------------------------------------------------------------D-LYQI---------ILKALERGSLLGCS-IN-------------------------------------------------ISDIRD--LEAITFKNLVRGHAYSVTGA----------KQ------------------------------V---------TYQ----------G-----------QRVN----LIRMRNP--WG--E-VEWKGPWSDSSY-EWNKVDPYERE--QL------RVKM-E-----DGEFWMS 58
59 WMRPTEF-----CS---D-------PHFI--VDG----ATRTDICQG-ALGDCWLLAA-IACL--T-LNEP---LLRRVVP--H----------------G----Q-SFHQ-Q-----YAGIFHFQFWQFG--DWVD----------------VVI---DDRLPVR-------------------------D--GK--------L-LF--------V-------------------------------------------------------------------------------------------------HSA-------E-----------------G-SEFWSALVEK-----------AYAKLN----G-CYEALS-----GGSTSEGFEDFTGGVTEMY---------------ELK------------------------------------------------------------------------------------------------------------------------------------NAP---P---------------------------------------------------------------------------------------------------------------------------------------------------N-LFSI---------ITRAVERGSLMGCS-ID-------------------------------------------------ITSFFD--MEAITFKKLVKGHAYSITGV----------DE------------------------------V---------EYR----------R-----------SQTK----LLRIRNP--WG--E-VEWTGPWSDESK-EWREIDASVRS--RL------HNCQ-E-----DGEFWMA 59
60 WMRPKEM-----CA---R-------PQFI--VDG----ATRTDICQG-ALGDCWLLAA-IASL--T-LNDN---LLHRVVP--H----------------G----Q-DFDS-R-----YAGIFHFQFWQFG--EWVD----------------VVI---DDRLPTK-------------------------D--GK--------L-LF--------V-------------------------------------------------------------------------------------------------HSA-------E-----------------G-GEFWSALLEK-----------AYAKLN----G-CYEALS-----GGSTCEGFEDFTGGVTEMY---------------ELK------------------------------------------------------------------------------------------------------------------------------------KAP---A---------------------------------------------------------------------------------------------------------------------------------------------------D-LFSI---------IGRAIERGSLLGCS-ID-------------------------------------------------ITSKFD--MEAVTFKKLVKGHAYSVTGA----------EE------------------------------V---------VYR----------G-----------NMTK----LVRIRNP--WG--E-VEWTGAWSDNSR-EWDNVDRSVRG--RL------QNRS-E-----DGEFWMS 60
61 -KRPPEL-----CA---N-------PQFI--VGG----ATRTDICQG-SLGDCWLLAA-LASL--T-LNQE---LLHRVVP--R----------------G----Q-DFQQ-N-----YAGIFHFQFWQYG--EWVE----------------VVV---DDRLPSK-------------------------D--GE--------L-LF--------L-------------------------------------------------------------------------------------------------HSE-------T-----------------G-NEFWGALLEK-----------GLGGLN----G-SYEALT-----GGSTVEGFEDLTGGISEYY---------------DLK------------------------------------------------------------------------------------------------------------------------------------KPP---A---------------------------------------------------------------------------------------------------------------------------------------------------R-LFQI---------IQKALRAGSLLACS-IH-------------------------------------------------VSSAAEAGAEVTTRHKLVKSHAYSVTGV----------IE------------------------------V---------DFR----------G-----------RPEK----LIRLRNP--WG--E-VEWTGAWSDDAP-EWNDIDPRQKE--EL------DRRA-E-----DGEFWMS 61
62 WKRPPEL-----CA---N-------PQFI--VGG----ATRTDICQG-SLGDCWLLAA-LASL--T-LNQE---LLHRVVP--R----------------G----Q-DFQQ-N-----YAGIFHFQFWQYG--EWVE----------------VVV---DDRLPSK-------------------------D--GE--------L-LF--------L-------------------------------------------------------------------------------------------------HSE-------T-----------------G-NEFWGALLEK-----------GLGGLN----G-SYEALT-----GGSTVEGFEDLTGGISEYY---------------DLK------------------------------------------------------------------------------------------------------------------------------------KPP---A---------------------------------------------------------------------------------------------------------------------------------------------------R-LFQI---------IQKALRAGSLLACS-IH-------------------------------------------------VSSAAEAGAEVTTRHKLVKSHAYSVTGV----------IE------------------------------V---------DFR----------G-----------RPEK----LIRLRNP--WG--E-VEWTGAWSDDAP-EWNDIDPRQKE--EL------DRRA-E-----DGEFWM- 62
63 WKRPPEL-----CA---N-------PQFI--VGG----ATRTDICQG-SLGDCWLLAA-LASL--T-LNQE---LLHRVVP--R----------------G----Q-DFQQ-N-----YAGIFHFQFWQYG--EWVE----------------VVV---DDRLPSK-------------------------D--GE--------L-LF--------L-------------------------------------------------------------------------------------------------HSE-------T-----------------G-NEFWGALLEK-----------AYAKLN----G-SYEALT-----GGSTVEGFEDLTGGISEYY---------------DLK------------------------------------------------------------------------------------------------------------------------------------KPP---A---------------------------------------------------------------------------------------------------------------------------------------------------R-LFQI---------IQKALRAGSLLACS-IH-------------------------------------------------VSSAAEAGAEVTTRHKLVKSHAYSVTGV----------IE------------------------------V---------DFR----------G-----------RPEK----LIRLRNP--WG--E-VEWTGAWSDDAP-EWNDIDPRQKE--EL------DRRA-E-----DGEFWMS 63
64 WKRPPEL-----CA---S-------PQFI--VDG----ARRTDICQG-DLGDCWLLAA-LASL--T-LNEE---LLYRVVP--R----------------D----Q-DFQQ-N-----YAGIFHFQFWRYG--EWMD----------------VVV---DDRLPTE-------------------------D--GE--------L-LF--------L-------------------------------------------------------------------------------------------------RSG-------T-----------------G-GEFWGALLEK-----------AYAKLN----G-SYEALT-----GGSLVEGLQDLTGGICECY---------------DLR------------------------------------------------------------------------------------------------------------------------------------KPP---A---------------------------------------------------------------------------------------------------------------------------------------------------G-LFQI---------IRKALRAGSLLACS-ID-------------------------------------------------VSSAAEAEAETTTCQKLVKSHAYSVTGV----------EE------------------------------V---------DFW----------G-----------HPEK----LVRLRNP--WG--E-VEWTGAWSDSAP-EWNHIDPRRKE--EL------DKRA-E-----DGEFWMS 64
65 WKRPPEL-----CA---S-------PQFI--VDG----ARRTDICQG-DLGDCWLLAA-LASL--T-LNEE---LLYRVVP--R----------------D----Q-DFQQ-N-----YAGIFHFQFWRYG--EWMD----------------VVV---DDRLPTE-------------------------D--GE--------L-LF--------L-------------------------------------------------------------------------------------------------RSG-------T-----------------G-GEFWGALLEK-----------AYAKLN----G-SYEALT-----GGSLVEGLQDLTGGICECY---------------DLR------------------------------------------------------------------------------------------------------------------------------------KPP---A---------------------------------------------------------------------------------------------------------------------------------------------------G-LFQI---------IRKALRAGSLLACS-ID-------------------------------------------------VSSAAEAEAETTTCQKLVKSHAYSVTGV----------EE------------------------------V---------DFW----------G-----------HPEK----LVRLRNP--WG--E-VEWTGAWSDSAP-EWNHIDPRRKE--EL------DKRA-E-----DGEFWMS 65
66 WRRPTEL-----CS---S-------PQFI--VGG----ATRTDICQG-GLGDCWLLAA-IASL--T-LNEE---LLYRVVP--R----------------D----Q-NFQK-N-----YAGIFHFQFWQYG--EWVE----------------VVV---DDRLPTR-------------------------N--GK--------L-LF--------L-------------------------------------------------------------------------------------------------HSE-------E-----------------G-NEFWSALLEK-----------AYAKLN----G-SYEALA-----GGSTVEGFEDFTGGISEFY---------------DLK------------------------------------------------------------------------------------------------------------------------------------KPP---P---------------------------------------------------------------------------------------------------------------------------------------------------S-LYHI---------IRKALRSSSLLACS-ID-------------------------------------------------VSSVAE--TEAITRQKLVKGHAYSVTGV----------EE------------------------------V---------DFQ----------G-----------HPEK----LIRLRNP--WG--E-VEWTGAWSDDAP-EWSYIDPRQKE--KL------DKKA-E-----DGEFWMS 66
67 WRRPTEL-----CS---S-------PQFI--VGG----ATRTDICQG-GLGDCWLLAA-IASL--T-LNEE---LLYRVVP--R----------------D----Q-NFQK-N-----YAGIFHFQFWQYG--EWVE----------------VVV---DDRLPTR-------------------------N--GK--------L-LF--------L-------------------------------------------------------------------------------------------------HSE-------E-----------------G-NEFWSALLEK-----------AYAKLN----G-SYEALA-----GGSTVEGFEDFTGGISEFY---------------DLK------------------------------------------------------------------------------------------------------------------------------------KPP---P---------------------------------------------------------------------------------------------------------------------------------------------------S-LYHI---------IRKALRSSSLLACS-ID-------------------------------------------------VSSVAE--TEAITRQKLVKGHAYSVTGV----------EE------------------------------V---------DFQ----------G-----------HPEK----LIRLRNP--WG--E-VEWTGAWSDDAP-EWSYIDPRQKE--KL------DKKA-E-----DGEFWMS 67
68 WKRPMEL-----CP---S-------PQFI--VGG----ATRTDICQG-ALGDCWLLAA-IASL--T-LNRE---LLYRVVP--R----------------D----Q-SFQE-N-----YAGIFRFQFWQYG--EWVE----------------VVV---DDRLPTK-------------------------N--GK--------L-LF--------L-------------------------------------------------------------------------------------------------HSE-------E-----------------G-SEFWSALLEK-----------AYAKLN----G-SYEALT-----GGSTVEGFEDFTGGISEFY---------------NLK------------------------------------------------------------------------------------------------------------------------------------KPP---A---------------------------------------------------------------------------------------------------------------------------------------------------S-LFQI---------IQKALRSGSLLACS-ID-------------------------------------------------ISSAAE--TEAITSQKLVKGHAYSVTGV----------EE------------------------------V---------DFR----------G-----------CPER----LIRLRNP--WG--E-VEWKGAWSDDAP-EWNYIDPRQKE--QL------GKKA-E-----DGEFWMS 68
69 WKRPTEL-----CS---N-------PQFI--VGG----ATRTDIRQG-GLGDCWLLAA-IASL--T-LNEK---LLYRVVP--R----------------D----Q-SFQK-N-----YAGIFHFQFWQYG--EWVE----------------VVI---DDRLPTK-------------------------N--GQ--------L-LF--------L-------------------------------------------------------------------------------------------------HSE-------E-----------------G-NEFWSALLEK-----------AYAKLN----G-SYEALA-----GGSTIEGFEDFTGGISEFY---------------DLR------------------------------------------------------------------------------------------------------------------------------------KPP---G---------------------------------------------------------------------------------------------------------------------------------------------------N-LYYT---------IQKALRKGSLLGCS-ID-------------------------------------------------VSNAAE--AEATTRQKLVKGHAYSVTGV----------EE------------------------------V---------DFR----------G-----------LPEK----LIRLRNP--WG--E-VEWTGAWSDSAP-EWNYIDPQKKG--EL------DKRA-E-----DGEFWMS 69
70 WKRPTEL-----CP---N-------PQFI--VGG----ATRTDIRQG-GLGDCWLLAA-IASL--T-LNEK---LLYRVLP--R----------------D----Q-SFQK-D-----YAGIFHFQFWQYG--EWVE----------------VVI---DDRLPTK-------------------------N--GQ--------L-LF--------L-------------------------------------------------------------------------------------------------HSE-------E-----------------G-NEFWSALLEK-----------AYAKLN----G-SYEALV-----GGSTIEGFEDFTGGISEFY---------------DLK------------------------------------------------------------------------------------------------------------------------------------KPP---E---------------------------------------------------------------------------------------------------------------------------------------------------N-LYYI---------IQKALRKGSLLGCS-ID-------------------------------------------------VSTAAE--AEATTRQKLVKGHAYSVTGV----------EE------------------------------V---------NFH----------G-----------RPEK----LIRLRNP--WG--E-VEWSGAWSDNAP-EWNYIDPRRKE--EL------DKKA-E-----DGEFWMS 70
71 WKRPTEL-----CP---S-------PQFI--VGG----ATRTDICQG-GLGDCWLLAA-IASL--T-LNEE---LLYRVVP--R----------------D----Q-DFQE-N-----YAGIFHFQFWQYG--EWVE----------------VVI---DDRLPTK-------------------------N--GQ--------L-LF--------L-------------------------------------------------------------------------------------------------HSE-------Q-----------------G-NEFWSALLEK-----------AYAKLN----G-CYEALA-----GGSTVEGFEDFTGGISEFY---------------DLK------------------------------------------------------------------------------------------------------------------------------------KPP---A---------------------------------------------------------------------------------------------------------------------------------------------------N-LYQI---------IRKALCAGSLLGCS-ID-------------------------------------------------VSSAAE--AEAITSQKLVKSHAYSVTGV----------EE------------------------------V---------NFQ----------G-----------HPEK----LIRLRNP--WG--E-VEWSGAWSDDAP-EWNHIDPRRKE--EL------DKKV-E-----DGEFWMS 71
72 -KRPTEL-----CD---N-------PQFI--VGG----ATRTDVCQG-ELGDCWLLAA-IASL--T-LNPD---VLHQVVP--K----------------A----Q-SFQE-N-----YAGIFHFQFWQYG--EWVD----------------VVV---DDRLPTK-------------------------N--GE--------L-LF--------V-------------------------------------------------------------------------------------------------HSE-------E-----------------G-NEFWSALLEK-----------AYAKLN----G-SYEALA-----GGSTIEGFEDFTGGISESY---------------DLR------------------------------------------------------------------------------------------------------------------------------------RAP---A---------------------------------------------------------------------------------------------------------------------------------------------------N-LFQI---------VQKALRAGSLLGCS-ID-------------------------------------------------ITRASE--TEAITSLKLVKGHAYSVTGA----------EE------------------------------V---------YYR----------G-----------RPEK----LVRLRNP--WG--E-IEWTGAWSDNAP-EWNYIDPKQKQ--AL------DKQV-D-----DGEF--- 72
73 WKRPTEL-----CD---N-------PQFI--VGG----ATRTDVCQG-ELGDCWLLAA-IASL--T-LNPD---VLHQVVP--K----------------A----Q-SFQE-N-----YAGIFHFQFWQYG--EWVD----------------VVV---DDRLPTK-------------------------N--GE--------L-LF--------V-------------------------------------------------------------------------------------------------HSE-------E-----------------G-NEFWSALLEK-----------AYAKLN----G-SYEALA-----GGSTIEGFEDFTGGISESY---------------DLR------------------------------------------------------------------------------------------------------------------------------------RAP---A---------------------------------------------------------------------------------------------------------------------------------------------------N-LFQI---------VQKALRAGSLLGCS-ID-------------------------------------------------ITRASE--TEAITSLKLVKGHAYSVTGA----------EE------------------------------V---------YYR----------G-----------RPEK----LVRLRNP--WG--E-IEWTGAWSDNAP-EWNYIDPKQKQ--AL------DKQV-D-----DGEFWMA 73
74 WKRPSEL-----VP---N-------PQFI--VGG----ATRTDIRQG-ALGDCWLLAA-IASL--T-LDQE---ILDRVVP--K----------------D----Q-SFQK-D-----YAGIFHFQIWQYG--EWVD----------------VVV---DDRLPTK-------------------------N--GQ--------L-LF--------L-------------------------------------------------------------------------------------------------HSE-------E-----------------G-NEFWSALLEK-----------AYAKLN----G-SYEALT-----GGSTIEGFEDFTGGIAESY---------------DLR------------------------------------------------------------------------------------------------------------------------------------KAP---S---------------------------------------------------------------------------------------------------------------------------------------------------N-LYQI---------IQKALRSGSLLGCS-ID-------------------------------------------------IASAAE--TEAITRLKLVKGHAYSVTGA----------EE------------------------------V---------NYR----------G-----------QPVK----LLRIRNP--WG--E-VEWTGAWSDNAP-EWNYIDPKEKN--AL------DKQA-D-----DGEFWMS 74
75 WQRPTQI-----TS---N-------PQFI--VDG----VGPTDICQG-VLGDCWLLAA-IGSL--T-TYPK---LLNRVVP--K----------------G----Q-SFKK-N-----YAGIFHFQIWQFG--QWVD----------------VVV---DDRLPTK-------------------------N--GK--------L-VF--------V-------------------------------------------------------------------------------------------------HSP-------E-----------------R-TEFWSALLEK-----------AYAKLN----G-SYEALS-----GGNTVEGFEDFTGGVTQSL---------------QLQ------------------------------------------------------------------------------------------------------------------------------------RPP---R---------------------------------------------------------------------------------------------------------------------------------------------------N-LLRM---------LRKAIERSSLLGCS-IE-------------------------------------------------ITSNSD--LESLTQKMLVRGHAYSVTGL----------QD------------------------------V---------LYQ----------G-----------KMET----LIRVRNP--WG--R-IEWNGSWSDNAR-EWEEVDLDIQK--QL------LHKK-E-----DGEFWMS 75
76 WQRPSQI-----TS---N-------PQFI--VNG----VSPTDICQG-VLGDCWLLAA-IGSL--T-AYPK---LLSRVVP--K----------------G----Q-SFKK-N-----YAGIFHFQIWQFG--EWMD----------------VVV---DDRLPTK-------------------------N--GK--------L-VF--------V-------------------------------------------------------------------------------------------------HSA-------E-----------------R-TEFWSALLEK-----------AYAKLN----G-SYEALS-----GGNTVEGFEDFTGGVTQSF---------------QLQ------------------------------------------------------------------------------------------------------------------------------------NPP---R---------------------------------------------------------------------------------------------------------------------------------------------------N-LQRI---------LRKAVERSSLMGCS-IE-------------------------------------------------VTHEHE--LESLTQGMLVRGHAYSVTGL----------QD------------------------------V---------SYQ----------G-----------RTET----LIRVRNP--WG--R-IEWNGAWSDNAK-EWEEVAPDVQR--QL------LHRK-E-----DGEFWMS 76
77 WQRPSEI-----TS---N-------PHFI--MNG----ISPTDICQG-VLGDCWLLAA-IGSL--T-TCPK---LLYRVVP--K----------------G----Q-SFKK-N-----YAGIFHFQIWQFG--QWMD----------------VVV---DDRLPTK-------------------------N--GK--------L-VF--------V-------------------------------------------------------------------------------------------------HSA-------E-----------------R-AEFWSALLEK-----------AYAKLN----G-SYEALS-----GGNTVEGFEDFTGGVTYSL---------------QLQ------------------------------------------------------------------------------------------------------------------------------------KPP---R---------------------------------------------------------------------------------------------------------------------------------------------------N-LLRI---------LRKAIERSSLMGCC-IE-------------------------------------------------VTSDSE--LEAMTQRMLVKGHAYSVTGL----------HD------------------------------V---------FYR----------G-----------RTET----LIRVRNP--WG--R-IEWNGAWSDNAS-EWDKVAPETQK--QL------LQKR-E-----DGEFWMS 77
78 WQRPKDI-----IN---N-------PLFI--MDG----ISPTDICQG-ILGDCWLLAA-IGSL--T-TCPK---LLYRVVP--R----------------G----Q-SFKK-N-----YAGIFHFQIWQFG--QWVN----------------VVV---DDRLPTK-------------------------N--DK--------L-VF--------V-------------------------------------------------------------------------------------------------HST-------E-----------------R-SEFWSALLEK-----------AYAKLS----G-SYEALS-----GGSTMEGLEDFTGGVAQSF---------------QLQ------------------------------------------------------------------------------------------------------------------------------------RPP---Q---------------------------------------------------------------------------------------------------------------------------------------------------N-LLRL---------LRKAVERSSLMGCS-IE-------------------------------------------------VTSDSE--LESMTDKMLVRGHAYSVTGL----------QD------------------------------V---------HYR----------G-----------KMET----LIRVRNP--WG--R-IEWNGAWSDSAR-EWEEVASDIQM--QL------LHKT-E-----DGEFWMS 78
79 -QRPGQI-----TS---S-------PHFI--VNG----FSPTDICQG-VLGDCWLLAA-IGSL--T-TCPK---LLHRVVP--K----------------G----Q-SFRK-N-----YAGIFHFQFWQFG--QWVD----------------VVV---DDRLPTK-------------------------N--GK--------L-VF--------V-------------------------------------------------------------------------------------------------HSA-------E-----------------R-TEFWSALLEK-----------AYAKLN----G-SYEALS-----GGSTVEGFEDFTGGVTYTI---------------QLQ------------------------------------------------------------------------------------------------------------------------------------KPP---R---------------------------------------------------------------------------------------------------------------------------------------------------N-LLRM---------LRKAVERSSLMGCS-IE-------------------------------------------------IVSESE--LETMTQKMLVRGHAYSVTDL----------QE------------------------------V---------WYQ----------G-----------RTET----LIRVRNP--W---R-VEWNGAWSDNAS-EWDKVDVDTIE--QQ------LNEK-E-----DGALWSV 79
80 WQRPGQI-----TS---S-------PHFI--VNG----FSPTDICQG-VLGDCWLLAA-IGSL--T-TCPK---LLHRVVP--K----------------G----Q-SFRK-N-----YAGIFHFQFWQFG--QWVD----------------VVV---DDRLPTK-------------------------N--GK--------L-VF--------V-------------------------------------------------------------------------------------------------HSA-------E-----------------R-TEFWSALLEK-----------AYAKLN----G-SYEALS-----GGSTVEGFEDFTGGVTYTI---------------QLQ------------------------------------------------------------------------------------------------------------------------------------KPP---R---------------------------------------------------------------------------------------------------------------------------------------------------N-LLRM---------LRKAVERSSLMGCS-IE-------------------------------------------------IVSESE--LETMTQKMLVRGHAYSVTDL----------QE------------------------------V---------WYQ----------G-----------RTET----LIRVRNP--W---R-VEWNGAWSDNAS-EWDKVDVDTIE--QQ------LNEK-E-----DGALW-- 80
81 WQRPGQI-----TS---S-------PHFI--VNG----FSPTDICQG-VLGDCWLLAA-IGSL--T-TCPK---LLHRVVP--K----------------G----Q-SFRK-N-----YAGIFHFQFWQFG--QWVD----------------VVV---DDRLPTK-------------------------N--GK--------L-VF--------V-------------------------------------------------------------------------------------------------HSA-------E-----------------R-TEFWSALLEK-----------AYAKLN----G-SYEALS-----GGSTVEGFEDFTGGVTYTI---------------QLQ------------------------------------------------------------------------------------------------------------------------------------KPP---R---------------------------------------------------------------------------------------------------------------------------------------------------N-LLRM---------LRKAVERSSLMGCS-IE-------------------------------------------------IVSESE--LETMTQKMLVRGHAYSVTDL----------QE------------------------------V---------WYQ----------G-----------RTET----LIRVRNP--WG--R-VEWNGAWSDNAS-EWDKVDVDTIE--QQ------LNEK-E-----DGALW-- 81
82 WQRPKDI-----IH---N-------PQFI--TND----FSPTDICQG-ILGDCWLLAA-IGSL--T-TCPK---LLYRVVP--R----------------N----Q-SFKK-N-----YAGIFHFQLWQFG--HWLN----------------VVV---DDRLPTR-------------------------N--NK--------L-VF--------V-------------------------------------------------------------------------------------------------HAS-------H-----------------R-QDFWSALLEK-----------AYAKLI----G-SYGALS-----GGSTLEGLEDFTGGVAQCI---------------PLQ------------------------------------------------------------------------------------------------------------------------------------KPP---G---------------------------------------------------------------------------------------------------------------------------------------------------N-MLRL---------LKKALEKSSLMGCS-IE-------------------------------------------------VTDNSE--VETMTHNMLVRGHAYAVTGL----------ED------------------------------V---------YYR----------D-----------KLET----LIRIQNP--WG--R-VEWNGAWSDKAT-EWEEVSPDVRV--QL------LHKK-D-----DGDFWMS 82
83 WKRPGEI-----VK---N-------PEFI--LGG----ATRTDICQG-ELGDCWLLAA-IASL--T-LNEK---ALARVVP--Q----------------D----Q-SFGP-G-----YAGIFHFQFWQHS--EWLD----------------VVI---DDRLPTF-------------------------R--DR--------L-IF--------L-------------------------------------------------------------------------------------------------HSA-------D-----------------H-SEFWSALLEK-----------AYAKLN----G-SYEALK-----GGSTIEAMEDFTGGVAETF---------------ATK------------------------------------------------------------------------------------------------------------------------------------EAP---E---------------------------------------------------------------------------------------------------------------------------------------------------N-FYEI---------LEKALKRGSLVGCS-ID-------------------------------------------------TRNAAE--SEARTPFGLIKGHAYSVTGI----------DQ------------------------------V---------NFR----------G-----------QKME----LIRVRNP--WG--Q-VEWNGSWSDSSS-EWRSVGPAEQK--RL------CHTALD-----DGEFWMA 83
84 WKRPGEI-----VK---N-------PEFI--LGG----ATRTDICQG-ELGDCWLLAA-IASL--T-LNQK---ALARVIP--Q----------------D----Q-SFGP-G-----YAGIFHFQFWQHS--EWLD----------------VVI---DDRLPTF-------------------------R--DR--------L-VF--------L-------------------------------------------------------------------------------------------------HSA-------D-----------------H-NEFWSALLEK-----------AYAKLN----G-SYEALK-----GGSAIEAMEDFTGGVAETF---------------QTK------------------------------------------------------------------------------------------------------------------------------------EAP---E---------------------------------------------------------------------------------------------------------------------------------------------------N-FYEI---------LEKALKRGSLLGCF-ID-------------------------------------------------TRSAAE--SEARTPFGLIKGHAYSVTGI----------DQ------------------------------V---------SFR----------G-----------QRIE----LIRIRNP--WG--Q-VEWNGSWSDSSP-EWRSVGPAEQK--RL------CHTALD-----DGEFWMA 84
85 WKRPGEI-----VE---N-------PEFI--LGG----ATRTDICQG-ELGDCWLLAA-IASL--T-LNEK---ALARVVP--Q----------------D----Q-GFGP-G-----YAGIFHFQFWQHS--EWLD----------------VVI---DDRLPTF-------------------------R--DR--------L-IF--------L-------------------------------------------------------------------------------------------------HSA-------D-----------------H-NEFWSALLEK-----------AYAKLN----G-SYEALK-----GGNAIEAMEDFTGGVAETF---------------ETK------------------------------------------------------------------------------------------------------------------------------------EAP---E---------------------------------------------------------------------------------------------------------------------------------------------------N-FYEI---------LEKALKRSSLVGCS-ID-------------------------------------------------IRNAAE--SEARTPFGLIKGHAYTVTGI----------DQ------------------------------V---------NCR----------G-----------QKIE----LIRVRNP--WG--H-VEWNGSWSD------------------------------------------- 85
86 WKRPGEI-----VE---N-------PEFI--LGG----ATRTDICQG-ELGDCWLLAA-IASL--T-LNEK---ALVRVVP--Q----------------D----Q-SFGP-G-----YAGIFHFQFWQHS--EWLD----------------VVI---DDRLPTF-------------------------R--DR--------L-IF--------L-------------------------------------------------------------------------------------------------HSA-------N-----------------H-REFWSALLEK-----------AYAKLS----G-SYEALK-----GGSAIEAMEDFTGGVAETF---------------ATK------------------------------------------------------------------------------------------------------------------------------------EAP---E---------------------------------------------------------------------------------------------------------------------------------------------------N-FYEI---------LEKALKRGSLVGCS-ID-------------------------------------------------IRNATE--SEARTPFGLIKGHAYSVTGI----------DQ------------------------------V---------NFQ----------G-----------RNVE----LIRVRNP--WG--Q-VEWNGSWSDSSS-EWLSVGPAEQK--RL------CHTSLD-----DGEFWMA 86
87 WKRPGEI-----VE---K-------PEFI--LGG----ATRTDICQG-ELGDCWLLAA-IASL--T-LNQK---ALTRVVP--Q----------------D----Q-GFGS-G-----YAGIFHFQFWQHS--EWLD----------------VVI---DDRLPTF-------------------------K--DR--------L-VF--------L-------------------------------------------------------------------------------------------------HSA-------D-----------------H-NEFWSALLEK-----------AYAKLN----G-SYEALE-----GGSAIEAMEDFTGGVAENF---------------QIR------------------------------------------------------------------------------------------------------------------------------------EAP---E---------------------------------------------------------------------------------------------------------------------------------------------------D-FFEI---------LEKALKRGSLLGCS-ID-------------------------------------------------TLNASE--SEARTSLGLIKGHAYTVTGL----------DQ------------------------------V---------NFH----------G-----------QRIK----LIRVRNP--WG--Q-VEWNGPWSDSSP-EWRSVDLEEQK--RL------GHTALD-----DGEFW-- 87
88 WKRPGEI-----VK---D-------PQFI--IGG----ATRTDICQG-DLGDCWLLAA-IASL--T-LNEK---TLARVVP--Q----------------D----Q-DFGP-G-----YAGIFHFQFWQHN--EWLD----------------VVI---DDRLPTF-------------------------K--DR--------L-VF--------L-------------------------------------------------------------------------------------------------HSA-------D-----------------H-NEFWSALLEK-----------AYAKLN----G-SYEALK-----GGSTIEAMEDFTGGVAEMY---------------EVK------------------------------------------------------------------------------------------------------------------------------------KAP---E---------------------------------------------------------------------------------------------------------------------------------------------------N-FYEI---------LEKALNRGSMVGCS-ID-------------------------------------------------TRSAAE--TEARTPYGLIKGHAYSVTGI----------NE------------------------------V---------NYQ----------G-----------RKVK----LIRIRNP--WG--Q-VEWNGPWSDNSP-EWNSISQSEKK--RL------YQTALD-----DGEFWM- 88
89 WKRPGDI-----VK---D-------PKFI--LEG----ATRTDICQG-DLGDCWLLAA-IASL--T-LNEK---TLARVVP--L----------------D----Q-NFGP-G-----YAGIFHFQFWQHN--EWLD----------------VVI---DDRLPTF-------------------------K--DR--------L-VF--------V-------------------------------------------------------------------------------------------------HSA-------E-----------------H-NEFWSALLEK-----------AYAKLN----G-SYEALK-----GGSTIEAMEDFTGGVGEMY---------------EVK------------------------------------------------------------------------------------------------------------------------------------KAP---D---------------------------------------------------------------------------------------------------------------------------------------------------N-FYEI---------LEKALKRSSMVGCS-ID-------------------------------------------------TSSAAE--SEARTPFGLIKGHAYSVTGI----------DE------------------------------V---------SYQ----------G-----------QKVQ----LIRIRNP--WG--Q-VEWNGPWSDNSL-EWRLVSPSEQK--RL------AQTALD-----DGEFWM- 89
90 ----GEI-----CK---E-------PQFI--TGG----ATRTDICQG-QLGDCWLLAA-IASL--T-LKEE---TLNRVVP--N----------------D----Q-TFDR-G-----YAGIFHFQFWQHN--KWMD----------------VVV---DDRLPCV-------------------------R--DK--------L-VF--------L-------------------------------------------------------------------------------------------------HSA-------D-----------------N-NEFWSALLEK-----------AYAKLN----G-SYEALK-----GGSTMEAMEDFTGGVGEMY---------------ETK------------------------------------------------------------------------------------------------------------------------------------NGP---N---------------------------------------------------------------------------------------------------------------------------------------------------N-LFLI---------LKKAIERGSMLGCS-ID-------------------------------------------------ITSSAE--SEAQTSTGLVKGHAYSVTGV----------EE------------------------------V---------NYR----------G-----------AKVQ----LIRVRNP--WG--Q-VEWNGPWSDNSR-EWTVIDSSEKK--RL------LQNSLD-----DGEFWME 90
91 WKRPGEI-----CK---E-------PQFI--TGG----ATRTDICQG-QLGDCWLLAA-IASL--T-LKEE---TLNRVVP--N----------------D----Q-TFDR-G-----YAGIFHFQFWQHN--KWMD----------------VVV---DDRLPCV-------------------------R--DK--------L-VF--------L-------------------------------------------------------------------------------------------------HSA-------D-----------------N-NEFWSALLEK-----------AYAKLN----G-SYEALK-----GGSTMEAMEDFTGGVGEMY---------------ETK------------------------------------------------------------------------------------------------------------------------------------NGP---S---------------------------------------------------------------------------------------------------------------------------------------------------N-LFLI---------LKKAIERGSMLGCS-ID-------------------------------------------------ITSSAE--SEAQTSTGLVKGHAYSVTGV----------EE------------------------------V---------NYR----------G-----------AKVQ----LIRVRNP--WG--Q-VEWNGPWSDNSR-EWTVIDSSEKK--RL------LQNSLD-----DGEFWM- 91
92 WKRPPEI-----CE---N-------PRFI--IGG----ANRTDICQG-ELGDCWFLAA-IACL--T-LNEK---LLFRVIP--H----------------D----Q-TFIK-D-----YAGIFHFQFWRYG--SWVE----------------VII---DDRLPTY-------------------------G--KQ--------L-VF--------T-------------------------------------------------------------------------------------------------KSS-------Q-----------------Q-NEFWSALLEK-----------AYAKLH----G-SYEALK-----GGNTTEAMEDFTGGVTEFY---------------EIK------------------------------------------------------------------------------------------------------------------------------------DAP---K---------------------------------------------------------------------------------------------------------------------------------------------------D-IYKI---------MKHAIERGSLMASS-IEDDAGIIYGTPTT--NIGLLINRMLNNMNFKTENDSTPP----VEEKISQAIAPVV--FERRMANGLVLSHAYSVTGV----------EE------------------------------I---------TFK----------R-----------EKLK----LIRLRNP--WG--Q-VEWNGAWSDSSD-E-------------------------------------- 92
93 WKRPREI-----CE---N-------PRFI--IGG----ANRTDICQG-ELGDCWFLAA-IACL--T-LNKK---LLCRVIP--H----------------D----Q-SFIQ-N-----YAGIFHFQFWRYG--DWVD----------------VII---DDCLPTY-------------------------N--NQ--------L-VF--------T-------------------------------------------------------------------------------------------------KSS-------Q-----------------R-NEFWSALLEK-----------AYAKLH----G-SYEALK-----GGNTTEAMEDFTGGVIEFY---------------EIK------------------------------------------------------------------------------------------------------------------------------------DAP---K---------------------------------------------------------------------------------------------------------------------------------------------------D-IYKI---------MKHAIARGSLMASS-IDDNLGFHYGAAPRS-DIGELIARMVKNLENAQMTYSTVDYQG-TDERPAWTIMPMQ--YETRMSCGLVKGHAYSVTAV----------EE------------------------------T---------TYK----------G-----------EKMR----LVRLRNP--WG--Q-VEWNGPWSDKSE-EWNFIDEEEKI--RL------QHKIAE-----DGEFWIS 93
94 WKRPPEI-----CE---N-------PRFI--IGG----ANRTDICQG-DLGDCWFLAA-IACL--T-LNER---LLFRVIP--H----------------D----Q-SFTE-N-----YAGIFHFQFWRYG--DWVD----------------VVI---DDCLPTY-------------------------N--NQ--------L-VF--------T-------------------------------------------------------------------------------------------------KSN-------H-----------------R-NEFWSALLEK-----------AYAKLH----G-SYEALK-----GGNTTEAMEDFTGGVTEFF---------------EIK------------------------------------------------------------------------------------------------------------------------------------DAP---R---------------------------------------------------------------------------------------------------------------------------------------------------D-MYKI---------MKKAIERGSLMGCS-IDDGTNMTYGTSPSGLKMGELIARMVRNMDNSLLRDSDLIPRD-SDDRPTRTIVPVQ--YETRMACGLVKGHAYSVTGL----------EE------------------------------T---------LFK----------G-----------EKVK----LVRLRNP--WG--Q-VEWNGSWSDSWK-DWSFVDKAEKA--RL------QHQVTE-----DGEFWMS 94
95 WKRPPEI-----CE---N-------PRFI--IGG----ANRTDICQG-DLGDCWFLAA-IACL--T-LNER---LLFRVIP--H----------------D----Q-SFTE-N-----YAGIFHFQFWRYG--DWVD----------------VVI---DDCLPTY-------------------------N--NQ--------L-VF--------T-------------------------------------------------------------------------------------------------KSN-------H-----------------R-NEFWSALLEK-----------AYAKLH----G-SYEALK-----GGNTTEAMEDFTGGVTEFF---------------EIK------------------------------------------------------------------------------------------------------------------------------------DAP---R---------------------------------------------------------------------------------------------------------------------------------------------------D-MYKI---------MKKAIERGSLMGCS-IDDGTNMTYGTSPSGLKMGELIARMVRNMDNSLLRDSDLIPRD-SDDRPTRTIVPVQ--YETRMACGLVKGHAYSVTGL----------EE------------------------------T---------LFK----------G-----------EKVK----LVRLRNP--WG--Q-VEWNGSWSDSWK-DWSFVDKAEKA--RL------QHQVTE-----DGEFWMS 95
96 WKRPPEI-----CE---N-------PRFI--IGG----ANRTDICQG-DLGDCWFLAA-IACL--T-LNER---LLFRVIP--H----------------D----Q-SFTE-N-----YAGIFHFQFWRYG--DWVD----------------VVI---DDCLPTY-------------------------N--NQ--------L-VF--------T-------------------------------------------------------------------------------------------------KSN-------H-----------------R-NEFWSALLEK-----------AYAKLH----G-SYEALK-----GGNTTEAMEDFTGGVTEFF---------------EIK------------------------------------------------------------------------------------------------------------------------------------DAP---R---------------------------------------------------------------------------------------------------------------------------------------------------D-MYKI---------MKKAIERGSLMGCS-IDDGTNMTYGTSPSGLKMGELIARMVRNMDNSQLRDSDLVPRG-SDDRPTRTIVPVQ--YETRMACGLVKGHAYSVTGL----------EE------------------------------A---------LFK----------G-----------EKVK----LVRLRNP--WG--Q-VEWNGSWSDGWK-DWSFVDKAEKA--RL------QHQVTE-----DGEFWMS 96
97 WKRPPEI-----CE---N-------PRFI--IGG----ANRTDICQG-DLGDCWFLAA-IACL--T-LNER---LLFRVIP--H----------------D----Q-SFTE-N-----YAGIFHFQFWRYG--DWVD----------------VVI---DDCLPTY-------------------------N--NQ--------L-VF--------T-------------------------------------------------------------------------------------------------KSN-------H-----------------R-NEFWSALLEK-----------AYAKLH----G-SYEALK-----GGNTTEAMEDFTGGVTEFF---------------EIK------------------------------------------------------------------------------------------------------------------------------------DAP---R---------------------------------------------------------------------------------------------------------------------------------------------------D-MYKI---------MKKAIERGSLMGCS-IDDGTNMTYGTSPSGLKMGELIARMVRNMDNSQLRDSDLVPRG-SDDRPTRTIVPVQ--YETRMACGLVKGHAYSVTGL----------EE------------------------------A---------LFK----------G-----------EKVK----LVRLRNP--WG--Q-VEWNGSWSDGWK-DWSFVDKAEKA--RL------QHQVTE-----DGEFWMS 97
98 WKRPKEI-----CE---N-------PRFI--IGG----ANRTDICQG-DLGDCWFLAA-IACL--T-LNER---LLFRVIP--H----------------D----Q-SFTE-N-----YAGIFHFQFWRYG--DWVD----------------VVI---DDCLPTY-------------------------N--NQ--------L-VF--------T-------------------------------------------------------------------------------------------------KSN-------H-----------------R-NEFWSALLEK-----------AYAKLH----G-SYEALK-----GGNTTEAMEDFTGGVTEFF---------------EIK------------------------------------------------------------------------------------------------------------------------------------DAP---S---------------------------------------------------------------------------------------------------------------------------------------------------D-MYKI---------MRKAIERGSLMGCS-IDTIV-------------------------------------------------PVQ--YETRMACGLVKGHAYSVTGL----------EE------------------------------A---------LFK----------G-----------EKVK----LVRLRNP--WG--Q-VEWNGSWSDGWK-DWSFVDKDEKA--RL------QHQVTE-----DGEFWM- 98
99 WKRPPEI-----CE---N-------PRFI--IGG----ANRTDICQG-DLGDCWFLAA-IACL--T-LNER---LLFRVIP--H----------------D----Q-SFTE-N-----YAGIFHFQFWRYG--DWVD----------------VVI---DDCLPTY-------------------------N--NQ--------L-VF--------T-------------------------------------------------------------------------------------------------KSN-------H-----------------R-NEFWSALLEK-----------AYAKLH----G-SYEALK-----GGNTTEAMEDFTGGVTEFF---------------EIK------------------------------------------------------------------------------------------------------------------------------------DAP---S---------------------------------------------------------------------------------------------------------------------------------------------------D-MYKI---------MRKAIERGSLMGCS-IDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLRDSDLDPRG-SDDRPSRTIVPVQ--YETRMACGLVKGHAYSVTGL----------EE------------------------------A---------LFK----------G-----------EKVK----LVRLRNP--WG--Q-VEWNGSWSDGWK-DWSFVDKDEKA--RL------QHQVTE-----DGEFWMS 99
100 WKRPKEI-----CE---N-------PRFI--IGG----ANRTDICQG-DLGDCWFLAA-IACL--T-LNER---LLFRVIP--H----------------D----Q-SFTE-N-----YAGIFHFQFWRYG--DWVD----------------VVI---DDCLPTY-------------------------N--NQ--------L-VF--------T-------------------------------------------------------------------------------------------------KSN-------H-----------------R-NEFWSALLEK-----------AYAKLH----G-SYEALK-----GGNTTEAMEDFTGGVTEFF---------------EIK------------------------------------------------------------------------------------------------------------------------------------DAP---S---------------------------------------------------------------------------------------------------------------------------------------------------D-MYKI---------MRKAIERGSLMGCS-IDDGT-------------------------------------------------N-Q--YETRMACGLVKGHAYSVTGL----------EE------------------------------A---------LFK----------G-----------EKVK----LVRLRNP--WG--Q-VEWNGSWSDGWK-DWSFVDKDEKA--RL------QHQVTE-----DGEFWM- 100
101 WKRPPEI-----CE---N-------PRFI--IGG----ANRTDICQG-DLGDCWFLAA-IACL--T-LNER---LLFRVIP--H----------------D----Q-SFTE-N-----YAGIFHFQFWRYG--DWVD----------------VVI---DDCLPTY-------------------------N--NQ--------L-VF--------T-------------------------------------------------------------------------------------------------KSN-------H-----------------R-NEFWSALLEK-----------AYAKLH----G-SYEALK-----GGNTTEAMEDFTGGVTEFF---------------EIK------------------------------------------------------------------------------------------------------------------------------------DAP---R---------------------------------------------------------------------------------------------------------------------------------------------------D-MYKI---------MKKAIERGSLMGCS-ID--------------------------------------------VSPGQDLEGIS--YETRMACGLVKGHAYSVTGL----------EE------------------------------A---------LFK----------G-----------EKVK----LVRLRNP--WG--Q-VEWNGSWSDGWK-DWSFVDKAEKA--RL------QHQVTE-----DGEFWMS 101
102 WKRPPEI-----CK---N-------PRFI--IGG----ANRTDICQG-DLGDCWFLAA-IACL--T-LNER---LLFRVIP--H----------------D----Q-SFTE-N-----YAGIFHFQFWRYG--DWVD----------------VVI---DDCLPTY-------------------------N--NQ--------L-VF--------T-------------------------------------------------------------------------------------------------KSN-------H-----------------R-NEFWSALLEK-----------AYAKLH----G-SYEALK-----GGNTTEAMEDFTGGVTEFF---------------EIK------------------------------------------------------------------------------------------------------------------------------------EAP---R---------------------------------------------------------------------------------------------------------------------------------------------------D-MYKI---------MKKAIERGSLMGCS-IDDGTNMTYGTSPSGLKMGDLIARMVRNMDNSRLRDSDLIPRD-SDDRPTRTIVPVQ--YETRMACGLVRGHAYSVIGL----------EE------------------------------A---------WFK----------N-----------EKVK----LVRLRNP--WG--Q-VEWNGSWSDGWK-DWSFVDKEEKA--RL------QHQVTE-----DGEFWMS 102
103 WKRPPEI-----CK---N-------PRFI--IGG----ANRTDICQG-DLGDCWFLAA-IACL--T-LNER---LLFRVIP--H----------------D----Q-SFTE-N-----YAGIFHFQFWRYG--DWVD----------------VVI---DDCLPTY-------------------------N--NQ--------L-VF--------T-------------------------------------------------------------------------------------------------KSN-------H-----------------R-NEFWSALLEK-----------AYAKLH----G-SYEALK-----GGNTTEAMEDFTGGVTEFF---------------EIK------------------------------------------------------------------------------------------------------------------------------------EAP---R---------------------------------------------------------------------------------------------------------------------------------------------------D-MYKI---------MKKAIERGSLMGCS-ID-------------------------------------------------TIVPVQ--YETRMACGLVRGHAYSVIGL----------EE------------------------------A---------WFK----------N-----------EKVK----LVRLRNP--WG--Q-VEWNGSWSDGWK-DWSFVDKEEKA--RL------QHQVTE-----DGEFWMS 103
104 WKRPKEI-----CE---N-------PRFI--VGG----ANRTDICQG-DLGDCWFLAA-IACL--T-LNKR---LLFRVIP--H----------------D----Q-SFTE-N-----YAGIFHFQFWRYG--DWVD----------------VVI---DDCLPTY-------------------------N--NQ--------L-VF--------T-------------------------------------------------------------------------------------------------KSN-------H-----------------R-NEFWSALLEK-----------AYAKLH----G-SYEALK-----GGNTTEAMEDFTGGVTEFF---------------EIK------------------------------------------------------------------------------------------------------------------------------------DAP---R---------------------------------------------------------------------------------------------------------------------------------------------------D-MYKI---------MKKAIERGSLMGCS-ID-------------------------------------------------MIVPVQ--FETRMACGLVKGHAYSVTGL----------EE------------------------------A---------LYK----------G-----------EKVK----LVRLRNP--WG--Q-VEWNGSWSDSWK-DWSYVDKDEKA--RL------QHQVTE-----DGEFWM- 104
105 WKRPPEI-----CE---N-------PRFI--VGG----ANRTDICQG-DLGDCWFLAA-IACL--T-LNKR---LLFRVIP--H----------------D----Q-SFTE-N-----YAGIFHFQFWRYG--DWVD----------------VVI---DDCLPTY-------------------------N--NQ--------L-VF--------T-------------------------------------------------------------------------------------------------KSN-------H-----------------R-NEFWNALLEK-----------AYAKLH----G-SYEALK-----GGNTTEAMEDFTGGVTEFF---------------EIK------------------------------------------------------------------------------------------------------------------------------------DAP---R---------------------------------------------------------------------------------------------------------------------------------------------------D-MYKI---------MKKAIERGSLMGCS-IDDGTNMTYGTSPSGLKMGELIERMVRNMDNSRLRDSDLIPEGCSDDRPTRMIVPVQ--FETRMACGLVKGHAYSVTGL----------EE------------------------------A---------LYK----------G-----------EKVK----LVRLRNP--WG--Q-VEWNGSWSDSWK-DWSYVDKDEKA--RL------QHQVTE-----DGEFWMS 105
106 WKRPPEI-----CE---N-------PRFI--IDG----ANRTDICQG-ELGDCWFLAA-IACL--T-LNQH---LLFRVIP--H----------------D----Q-SFIE-N-----YAGIFHFQFWRYG--EWVD----------------VVI---DDCLPTY-------------------------N--NQ--------L-VF--------T-------------------------------------------------------------------------------------------------KSN-------H-----------------R-NEFWSALLEK-----------AYAKLH----G-SYEALK-----GGNTTEAMEDFTGGVAEFF---------------EIR------------------------------------------------------------------------------------------------------------------------------------DAP---S---------------------------------------------------------------------------------------------------------------------------------------------------D-MYKI---------MKKAIERGSLMGCS-IDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRG-SDERPTRTIIPVQ--YETRMACGLVRGHAYSVTGL----------DE------------------------------V---------PFK----------G-----------EKVK----LVRLRNP--WG--Q-VEWNGSWSDRWK-DWSFVDKDEKA--RL------QHQVTE-----DGEFWMS 106
107 WKRPKEI-----CD---N-------PQFI--VGG----ASRTDICQG-DLGDCWLLAA-IACL--T-LNDK---LLYRVIP--Q----------------E----Q-SFSE-Q-----YAGIFHFQFWRYG--DWVD----------------VVV---DDRIPTF-------------------------N--NQ--------L-VF--------T-------------------------------------------------------------------------------------------------KSA-------E-----------------R-NEFWSALLEK-----------AYAKLH----G-SYEALK-----GGNTAEGMEDFTGGVTEFY---------------EMK------------------------------------------------------------------------------------------------------------------------------------EAP---K---------------------------------------------------------------------------------------------------------------------------------------------------E-LYKI---------MQKALERGSLMGCS-ID-------------------------------------------------SLVPAR--FETRTATGLVKGHAYSVTAV----------EE---------------------------CKQS---------QQK----------E-----------SRVR----LVRLRNP--WG--Q-VEWNGPWSDNSK-EWESLSKAEKE--KL------QQQNAE-----DGEFWMS 107
108 WKRPLEM-----VQ---N-------PQFF--IDG----ATRFDIQQG-ELGDCWLLAA-VSNL--T-LHPH---LFHVVVP--R----------------D----Q-GFTH-L-----YAGIFHFKFWQYG--RWQE----------------VVI---DDLLPTH-------------------------N--GR--------L-VF--------M-------------------------------------------------------------------------------------------------HSR-------N-----------------S-SEFWCALLEK-----------AYAKLY----G-GYEALR-----GGNINESMVDLTGGVVELI---------------DLR------------------------------------------------------------------------------------------------------------------------------------SPA---S---------------------------------------------------------------------------------------------------------------------------------------------------N-LFPR---------LLKACRRGSLIGCA-IE--------------------------------------------------SDHLGVRPESIMSNGLIVRHAYSITRV----------TA------------------------------I--------SLAT----------A-----------PKLKGEAHLVRLHNP--WGN-E-TEWKGSWSDKSP-EWNAVPPGERQ--RL------GLTFND-----DGEFWMS 108
109 WMRPGEI-----VG---N-------PEFIDASEG----ASRFDVCQG-CVGDCWMLAA-TATL--A-QKPY---LFKRVCC--E----------------D----N-SYSD-D-----YCGAFHFRFWQYG--EWVD----------------VVI---DDRIPMVVFD--------------------WGD--PQ--------Y-FS--------L-------------------------------------------------------------------------------------------------HSN-------D-----------------K-NEFWSALLEK-----------AYAKLH----G-SYESLE-----GGHTSDALVDFTGGMTERY---------------DTT-----------DP----------------------------------------------------------------------------------------------------------------------SKLP---G---------------------------------------------------------------------------------------------------------------------------------------------------D-LYKI---------LQKAFERGSTMGCSGIK--------------------------------------------------GGSAG--LEAIQDNGLVQQHAYSITGF----------AE------------------------------V----------------------------------EGTQ----LVRIRNP--WG--K-TEWKGPWGD------------------------------------------- 109
110 WMRPQDI-----CD---N-------PLFI--SDG----VSRFDVVQG-VVGDCWMLAA-TAAL--T-TLPG---LFKRVVP--S----------------G----Q-GFQD-N-----YAGIFHFKFWRYG--EWID----------------VVV---DDRIPMVM-DPV------------------QGR--PA--------F-FS--------L-------------------------------------------------------------------------------------------------HSD-------Q-----------------Q-NEFWSALLEK-----------AYAKVH----G-SYEALE-----GGHTSDALVDFTGGVTETY----------------ML-----------DP----------------------------------------------------------------------------------------------------------------------NNVP---P---------------------------------------------------------------------------------------------------------------------------------------------------K-FYQI---------LKKAHDRGSLMGVSGIK--------------------------------------------------GGTAG--LEAVQSNGLVQQHAYSVTGF----------AT------------------------------VSLVLNRTYTHIR----------S-----------SRTQ----IVRVRNP--WG--K-IEWKGPWSDESP-QWEGVTEERKE--EL------GVVKRD-----DGEFWMS 110
111 WKRPKEI-----VS---D-------PQMF--TGG----SSRFDVVQG-MLGDCWLVAA-IASL--T-QDKK---LINKVIP--Q----------------N----Q-GWGK-G-----YAGIFRFHFWHFG--EWID----------------IVI---DDRLPTY-------------------------N--GK--------L-IF--------I-------------------------------------------------------------------------------------------------HST-------D-----------------E-NEFWSALLEK-----------AYAKLY----G-GFEALK-----GGKTSEALTDFTGGVVETY---------------DLK------------------------------------------------------------------------------------------------------------------------------------KCD---A---------------------------------------------------------------------------------------------------------------------------------------------------T-LFDT---------ITRNATRSCLMSCS-IK-------------------------------------------------IEGRDE--VEAKLDSGLIKGHAYSVTGA----------KT------------------------------L---------NMK----------G-----------KVIK----LLRIRNP--WG--Q-KEWNGDWSDNSP-SWNQISADKRK--EI----LEGESAKE-----DGEFYM- 111
112 WMRPHEF-----CA---E-------PQFI--CED----MSRTDVCQG-RLGNCWFLAA-AASL--T-LYPR---LLSRVVP--P----------------G----Q-GFQD-G-----YAGVFHFQLWQFG--RWVD----------------VVV---DDRLPVR-------------------------E--GK--------L-MF--------V-------------------------------------------------------------------------------------------------RSD-------Q-----------------R-NEFWAPLLEK-----------AYAKLH----G-SYEVMR-----GGHMNEAFVDFTGGVGEVL---------------YLR------------------------------------------------------------------------------------------------------------------------------------QDT---P---------------------------------------------------------------------------------------------------------------------------------------------------G-LFSA---------LRHALAKESLVGAT-AL----------------------------------------------------SDR--GESRTEDGLVKGHAYSVTGT----------YK------------------------------V---------TLG----------F-----------TKVR----LLRLRNP--WG--R-VEWTGAWSDSCP-RWDALPTEWRD--AL------LVKK-E-----DGEFWM- 112
113 WLRPHEF-----CA---E-------PQFI--CED----MSRTDVCQG-RLGNCWFLAA-AASL--T-LYPR---LLCRVVP--P----------------G----Q-GFQG-G-----YAGVFHFQLWQFG--RWVD----------------VVV---DDRLPVR-------------------------D--GK--------L-MF--------V-------------------------------------------------------------------------------------------------RSD-------Q-----------------R-NEFWAPLLEK-----------AYAKLH----G-SYEVMR-----GGHMNEAFVDFTGGVGEVL---------------YLR------------------------------------------------------------------------------------------------------------------------------------RDT---P---------------------------------------------------------------------------------------------------------------------------------------------------G-LFSA---------LRHALAKESLVGAT-AL----------------------------------------------------SDR--GEYRTEDGLVKGHAYSVTGT----------YK------------------------------V---------SLG----------F-----------TKVR----LLRLRNP--WG--R-VEWTGAWSDSCP-RWDALPAECRD--AL------LVKK-E-----DGEFWM- 113
114 WMRPHEF-----CA---E-------PQFI--CED----MSRTDVCQG-SLGNCWILAA-AASL--T-LYPR---LLSRVVP--P----------------G----Q-GFQD-G-----YAGVFHFQLWQFG--RWVD----------------VVV---DDRLPVR-------------------------E--GK--------L-MF--------V-------------------------------------------------------------------------------------------------RSA-------Q-----------------R-NEFWAPLLEK-----------AYANL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AQ----------------------------------------------------SDR--GEYRTEDGLVKGHAYSVTGT----------HK------------------------------V---------SLG----------F-----------TKVR----LLRLRNP--WG--R-VEWTGAWSDSCP-RWDALPAEWRE--AL------LVKK-E-----DGEFW-- 114
115 WKRPHEF-----CT---E-------PQFI--CED----MSRTDVCQG-RLGNCWFLAA-AASL--T-LYPR---LLSRVVP--P----------------G----Q-GFQH-G-----YAGVFHFQLWQFG--HWVD----------------VVV---DDRLPVC-------------------------K--GK--------L-MF--------V-------------------------------------------------------------------------------------------------CSD-------Q-----------------R-NEFWAPLLEK-----------AYAKLH----G-SYEVMR-----GGHMNEAFVDFTGGVGEVL---------------YLK------------------------------------------------------------------------------------------------------------------------------------KDTPNPP---------------------------------------------------------------------------------------------------------------------------------------------------G-IFSI---------LRHALAKESLVGAT-AL----------------------------------------------------SDR--GEYRTEDGLVKGHAYSVTGT----------HK------------------------------V---------SLG----------F-----------TRVR----LLRLRNP--WG--R-VEWNGAWSDSCP-RWDALPTEWRD--AL------LVKK-E-----DGEFWM- 115
116 WMRPHEF-----CA---E-------PKFI--CED----MSRTDVCQG-SLGNCWFLAA-AASL--T-LYPR---LLRRVVP--P----------------G----Q-DFQH-G-----YAGVFHFQLWQFG--RWMD----------------VVV---DDRLPVR-------------------------E--GK--------L-MF--------V-------------------------------------------------------------------------------------------------RSE-------Q-----------------R-NEFWAPLLEK-----------AYAKLH----G-SYEVMR-----GGHMNEAFVDFTGGVGEVL---------------YLR------------------------------------------------------------------------------------------------------------------------------------QNS---M---------------------------------------------------------------------------------------------------------------------------------------------------G-LFSA---------LRHALAKESLVGAT-AL----------------------------------------------------SDR--GEYRTEEGLVKGHAYSITGT----------HK------------------------------V---------FLG----------F-----------TKVR----LLRLRNP--WG--C-VEWTGAWSDSCP-RWDTLPTECRD--AL------LVKK-E-----DGEFWM- 116
117 WKRPHEF-----CA---E-------PQFI--CED----MSRTDVCQG-SLGNCWLLAA-AASL--T-LYPR---LLYRVVP--P----------------G----Q-GFQD-G-----YAGVFHFQLWQFG--RWVD----------------VVV---DDKLPVR-------------------------E--GK--------L-MF--------V-------------------------------------------------------------------------------------------------RSE-------Q-----------------R-NEFWAPLLEK-----------AYAKLH----G-SYEVMR-----GGHMNEAFVDFTGGVGEVL---------------YLR------------------------------------------------------------------------------------------------------------------------------------QNT---P---------------------------------------------------------------------------------------------------------------------------------------------------G-VFAA---------LRHALAKESLVGAT-AL----------------------------------------------------SDR--GEIRTDEGLVKGHAYSVTGT----------HK------------------------------M---------SLG----------F-----------TKVR----LLRLRNP--WG--R-VEWSGPWSDSCP-RWDMLPSEWRD--AL------LVKK-E-----DGEFWM- 117
118 WKRPHEF-----CA---E-------PHFI--CED----VSRTDVCQG-RLGNCWLLAA-AASL--T-LYPR---LLRRVVP--L----------------G----Q-GFRN-G-----YAGVFHFQLWQFG--RWVD----------------VVV---DDRLPVR-------------------------N--GK--------L-MF--------V-------------------------------------------------------------------------------------------------RSE-------Q-----------------R-NEFWAPLXXX-----------XXXXXX----X-XXXXXX-----XXXXXXXXXXXXXXXXXXX---------------XXX------------------------------------------------------------------------------------------------------------------------------------XXX---X---------------------------------------------------------------------------------------------------------------------------------------------------X-XXXX---------XXXXXXXXXXXXXX-XX----------------------------------------------------SNR--GEYRTDEGLVKGHAYSVTGT----------HK------------------------------V---------TLG----------F-----------TKLQ----LLRLRNP--WG--H-VEWNGAW--------------------------------------------- 118
119 WKRPKDI-----CK---H--G---TPHFI--CKG----MNRTDVCQG-QLGDCWFLAA-AASL--T-LYPE---LLYRVVP--Q----------------D----Q-HFGGTE-----YAGIFHFQFWQYG--QWVD----------------VVV---DDLLPTI-------------------------N--NE--------L-LF--------V-------------------------------------------------------------------------------------------------RSP-------E-----------------H-DEFWMPLLEK-----------AYAKLN----G-SYEAMN-----GGYMNEAFVDFTGGIGETL---------------SLK-------------------------------------------------------------------------------------------------------------------------------------IP---N---------------------------------------------------------------------------------------------------------------------------------------------------TKLFKT---------IRAALSRNSLMGAH-IE-------------------------------------------------VKRPED--IEKPTPEGLVKGHAYSITGI----------HK------------------------------I---------DFG----------E-----------KVVR----LLRLRNP--WG--Y-QEWTGRWSDKSP-LWSSLDPELLK--KL------HVRDRK-----DGEFWM- 119
120 WKRPKDI-----CK---H--G---TPHFI--CKG----MNRTDVCQG-QLGDCWFLAA-AASL--T-LYPE---LLYRVVP--Q----------------D----Q-HFGGTE-----YAGIFHFQFWQYG--QWVD----------------VVV---DDLLPTI-------------------------N--NE--------L-LF--------V-------------------------------------------------------------------------------------------------RSP-------E-----------------H-DEFWMPLLEK-----------AYAKLN----G-SYEAMN-----GGYMNEAFVDFTGGIGETL---------------SLK-------------------------------------------------------------------------------------------------------------------------------------IP---N---------------------------------------------------------------------------------------------------------------------------------------------------TKLFKT---------IRAALSRNSLMGAH-IE-------------------------------------------------VKRPED--IEKPTPEGLVKGHAYSITGI----------HK------------------------------I---------DFG----------E-----------KVVR----LLRLRNP--WG--Y-QEWTGRWSDKSP-LWSSLDPELLK--KL------HVRDRK-----DGEFWM- 120
121 WKRPTEI-----AA---QHQL---KPAFF--LDN----ATKFDVIQG-DLGDCWVVSA-IACLTSP-DHRE---LFRRVVP--A----------------D----Q-GFQDGW-----YAGIFRFNFWHFG--RWVE----------------VVV---DDRLPTY-------------------------R--GQ--------L-MF--------V-------------------------------------------------------------------------------------------------HSW-------H-----------------K-NEFWAALMEK-----------AYAKLY----G-SYEALK-----GGNVADALTDFTGGICEGY---------------TLRG----------VN----------------------------------------------------------------------------------------------------------------------ANVP---R---------------------------------------------------------------------------------------------------------------------------------------------------N-IVNI---------LFKALDRQSLIGCG-IN-------------------------------------------------PVKGNQ--GEQKLPSGLVAGHAYSVTDL----------RE------------------------------I---------LLM----------S-----------DNRETPITLIRVRNP--WGN-K-VEWKGSWGDRSR-EWNSIPADDRE--KM------GLIFRD-----DGEFWM- 121
122 WRRPKEI-----CL---F-------PQFI--VDG----ATRMDICQV-VLGDCWFLSA-VASL--S-LYPA---LLDRVVP--A----------------G----Q-GFQQ-G-----YNGCFCFQFWQYG--EWIS----------------VKI---DDLLPTC-------------------------N--NQ--------L-IY--------L-------------------------------------------------------------------------------------------------HSA-------S-----------------R-DEFWSALLEK-----------AYAKLK----G-GYSALN-----MGFPHEAMVDMTGGITEVF---------------MVA------------------------------------------------------------------------------------------------------------------------------------SLP---R---------------------------------------------------------------------------------------------------------------------------------------------------A-LGSF---------LRSLLEKGALINCA-------------------------------------------------------NSQGPLEKSNEFGILFRHAYSVTAL----------ET------------------------------V----------------------------------KSTIGPVQLVRIRNP--WG--K-AEWEGPWSDKKGIEWHMVTAEEQR--RV------QRIQQE-----DGEFWMS 122
123 WLRPKEI-----TS---N-------AVFV--EGT----MGTTDICQG-QLGNCWLLAA-LSCL--T-MHPT---LFVKVVP--A----------------G----Q-SLSE-S-----YAGIFRFKFWQYG--EWVE----------------VVV---DDRLPVR-------------------------E--GR--------L-LF--------S-------------------------------------------------------------------------------------------------YSR-------T-----------------S-NEFWSALVEK-----------AYAKLI----G-SYGSLK-----GGIISEGMEDFTGGIAYSL---------------PVS------------------------------------------------------------------------------------------------------------------------------------SRP---P---------------------------------------------------------------------------------------------------------------------------------------------------RMLWKA---------ITAALARNSLLSCF-IH-------------------------------------------------ATTVKD--IGTVTPEGLIKGHAYAITET----------GK------------------------------V----------------------------------KKASEEVFLLRLRNP--WG--F-VEYCGPWSDKCK-DWDFVDNTEKT--KL------ELAKVE-----DGEFWI- 123
124 WKRPYEL-----VP---N-------PVYI--AQG----TSRFDFIQG-RLGNCWFLAS-VGAL--T-FQKR---IMKQVIQ--D----------------D----Q-TFSV-D-----YAGIFHFRFWRFG--SWVD----------------VVI---DDKLPTI-------------------------D--NQ--------L-VF--------V-------------------------------------------------------------------------------------------------QSK-------T-----------------P-NEFWPALLEK-----------AYAKVC----G-SYADMD-----AGNISEALMDFTGGPHMTI---------------KLS------------------------------------------------------------------------------------------------------------------------------------QAS---D---------------------------------------------------------------------------------------------------------------------------------------------------K-LWDI---------MRRAGQSESLMGCG-TP--------------------------------------------------GGQAGVLQNTVLPNGLVEMHAYTVTGV----------TE------------------------------V---------VCK----------G-----------RPVK----LVRIFNP--WG--S-GEWNRDWSDRSP-LWELVRPEDQK--Y--------NDVLD-----NGEFWMS 124
125 WIRPTKL-----YP---E------AAEFV--VDT----VSRFDYAQG-FIGNCWFLAS-VGAL--T-FQSK---LLQKVVP--D----------------G----Q-SLRH-N-----YTGLFHFRFWRFG--KWFD----------------VVI---DDKLPTI-------------------------N--RQ--------L-IF--------V-------------------------------------------------------------------------------------------------KSK-------T-----------------Y-NEFWPALLEK-----------AYAKVC----G-SYADMH-----TGRVSEALLDFTGGVHMHY---------------DLK------------------------------------------------------------------------------------------------------------------------------------TAP---T---------------------------------------------------------------------------------------------------------------------------------------------------D-LWEI---------MYRASQSEVLMGCE-SP--------------------------------------------------AGN-----EERLPNGIVLGHAYTVTKV----------YQ------------------------------V---------MSG----------R-----------NPVQ----LVRLFNP--WG--D-SEWNGDWSDNSP-LWNTVDDEDRK--QL-------L-VSD-----NGEFWMS 125
126 WKRPSEL-----VS---D-------PNLI--VDD----VSRFDYAQGSVLGNCWFLAS-IGAL--T-FEKD---IMKQVLP--A----------------E----Q-SFTK-D-----YAGIFHFRFWRFE--KWID----------------VVI---DDQLPTI-------------------------D--DE--------L-LF--------V-------------------------------------------------------------------------------------------------CSK-------T-----------------S-NEFWPALLEK-----------AYAKVC----G-SYADLN-----AGFISEALMDFTGGTHMYY---------------TLS------------------------------------------------------------------------------------------------------------------------------------SAP---A---------------------------------------------------------------------------------------------------------------------------------------------------D-LWKI---------MECAFISKTLIGCG-SN--------------------------------------------------SEGSP--EENELLHGIIADHAYTVTGV----------FE------------------------------V---------ISE----------E-----------NPVQ----LVRLLNP--WG--E-EEWQGDWSDESP-LWETVCEEARK--CC-------REVLN-----DGEFWMS 126
127 WLRPSKI-----VA---D-------PQFI--VKG----VSRFDYSQGSFLGNCWFLAS-VGTL--T-FQKD---VLYQVMP--E----------------G----Q-SFGK-D-----YAGIFHFRFWRFG--KWID----------------VVI---DDKLPTI-------------------------K--GD--------L-IF--------V-------------------------------------------------------------------------------------------------HSK-------T-----------------S-NEFWPALLEK-----------AYAKVC----G-SYSDMD-----AGVVSEALLDFTGGIHVRF---------------ELE------------------------------------------------------------------------------------------------------------------------------------KPP---L---------------------------------------------------------------------------------------------------------------------------------------------------D-LWSL---------MDRAAKCKALMACG-TY--------------------------------------------------PGKTS--ANTELPNGIVQGHAYSVTGI----------FK------------------------------V---------TWQ----------G-----------APVR----LVRVLNP--WG--K-REWTGAWCDKSS-MWNKVSESERT--KC-------WSLAN-----DGEFWMS 127
128 WLRPSKI-----VA---D-------PQFI--VKG----VSRFDYSQGSFLGNCWFLAS-VGTL--T-FQKD---VLYQVMP--E----------------G----Q-SFGK-D-----YAGIFHFRFWRFG--KWID----------------VVI---DDKLPTI-------------------------K--GD--------L-IF--------V-------------------------------------------------------------------------------------------------HSK-------T-----------------S-NEFWPALLEK-----------AYAKVC----G-SYSDMD-----AGVVSEALLDFTGGIHVRF---------------ELE------------------------------------------------------------------------------------------------------------------------------------KPP---L---------------------------------------------------------------------------------------------------------------------------------------------------D-LWSL---------MDRAAKCKALMACG-TY--------------------------------------------------PGKTS--ANTELPNGIVQGHAYSVTGI----------FK------------------------------V---------TWQ----------G-----------APVR----LVRVLNP--WG--K-REWTGAWCDKSS-MWNKVSESERT--KC-------WSLAN-----DGEFWMS 128
129 WKRPHAL-----HR---T-------PVFY--AAN----RKQLDLCQG-LVGNCWFLAA-LQAL--T-FHQD---ILAAVVP--Q----------------N----Q-SFE-RK-----YAGIFHFRFWHFG--EWVD----------------VVV---DDRLPVNE------------------------A--GE--------L-VF--------V-------------------------------------------------------------------------------------------------SSV-------Y-----------------K-NVFWGALLEK-----------AYAKLY----G-SYEDLQ-----IGQVSEALVDFTGGVNIRI---------------KLP------------------------------------------------------------------------------------------------------------------------------------AAP---P---------------------------------------------------------------------------------------------------------------------------------------------------D-LWDI---------LTRATYSRSLMCCQ-TQ-------------------------------------------------LVKFSSAETTKVLKNGLVAGHAYTVTGI----------RK------------------------------V----------------------------------TCQYGPENLVRLRNP--WG--K-IEWNGDWSDSSY-KWELLSPKEKI--LL-------RKKKE-----DGEFWM- 129
130 WKRPHEL-----CK---T-------PVFF--SSK----KISCMLCQG-ELDDCWFLAA-VEAL--T-FHQD---ILFKVVP--Q----------------N----Q-SFEKKK-----YAGIFHFKFWHFG--EWVD----------------VVV---DDRLPVNE------------------------F--GQ--------F-IF--------L-------------------------------------------------------------------------------------------------SCI-------Y-----------------K-NIFWGALLEK-----------AYAKLC----G-SYGDLQ-----IGYVSEALVDFTGGVNITI---------------KLA------------------------------------------------------------------------------------------------------------------------------------EAP---P---------------------------------------------------------------------------------------------------------------------------------------------------D-LWNI---------LTRAIYSRSFIGCQ-TQ-------------------------------------------------QG-----IPIRVLENGLATCHAYTMTAI----------QK------------------------------V----------------------------------TCKHGTENLVRLRNP--WG--K-TEWKGDWSDKSE-KWELLNPKEKI--LL-------RRDFE-----DGEFWM- 130
131 WKRPHEL-----CK---T-------PVFF--SSK----KISCMLCQG-ELDDCWFLAA-VEAL--T-FHQD---ILFKVVP--Q----------------N----Q-SFEKKK-----YAGIFHFKFWHFG--EWVD----------------VVV---DDRLPVNE------------------------F--GQ--------F-IF--------L-------------------------------------------------------------------------------------------------SCI-------Y-----------------K-NIFWGALLEK-----------AYAKLC----G-SYGDLQ-----IGYVSEALVDFTGGVNITI---------------KLA------------------------------------------------------------------------------------------------------------------------------------EAP---P---------------------------------------------------------------------------------------------------------------------------------------------------D-LWNI---------LTRAIYSRSFIGCQ-TQ-------------------------------------------------QG------PIRVLENGLATCHAYTMTAI----------QK------------------------------V----------------------------------TCKHGTENLVRLRNP--WG--K-TEWKGDWSDKSE-KWELLNPKEKI--LL-------RRDFE-----DGEFWMS 131
132 WRRPPEL-----HS---N-------PQFY--SAD----TKRLDLCQG-VVGDCWFLAA-LQAL--T-LHQD---ILSRVVP--L----------------N----Q-NFT-EN-----YAGIFQFWFWHFG--KWVP----------------VVI---DDRLPVNT------------------------A--GQ--------L-VF--------V-------------------------------------------------------------------------------------------------SST-------Y-----------------K-NVFWGALLEK-----------AYAKLS----G-SYEDLQ-----RGQVSEALVDFTGGVTMTI---------------KPA------------------------------------------------------------------------------------------------------------------------------------EAP---G---------------------------------------------------------------------------------------------------------------------------------------------------N-LWDI---------LTWATYSRTLIGCQ-TH-------------------------------------------------SGVLLPPQKERVLENGLVGGHAYTLTGI----------RK------------------------------V----------------------------------TCRHGPEYLVKLRNP--WG--K-VEWKGDWSDSSG-MWELLSPKEKI--LL-------LRKSN-----DGEFWMT 132
133 WRRPPEL-----HS---N-------PQFY--SAD----TKRLDLCQG-VVGDCWFLAA-LQAL--T-LHQD---ILSRVVP--L----------------N----Q-NFT-EN-----YAGIFQFWFWHFG--KWVP----------------VVI---DDRLPVNT------------------------A--GQ--------L-VF--------V-------------------------------------------------------------------------------------------------SST-------Y-----------------K-NVFWGALLEK-----------AYAKLS----G-SYEDLQ-----RGQVSEALVDFTGGVTMTI---------------KPA------------------------------------------------------------------------------------------------------------------------------------EAP---G---------------------------------------------------------------------------------------------------------------------------------------------------N-LWDI---------LTWATYSRTLIGCQ-TH-------------------------------------------------SG------KERVLENGLVGGHAYTLTGI----------RK------------------------------V----------------------------------TCRHGPEYLVKLRNP--WG--K-VEWKGDWSDSSG-MWELLSPKEKI--LL-------LRKSN-----DGEFWMT 133
134 WRRPPEL-----HS---N-------PQFY--SAK----GKRLDLCQG-VVGDCWFLAA-LQAL--T-LHRD---ILSRVVP--L----------------N----Q-SFT-EK-----YAGIFQFWFWHFG--KWVP----------------VVI---DDRLPVNE------------------------A--GQ--------L-VF--------V-------------------------------------------------------------------------------------------------SST-------Y-----------------K-NLFWGALLEK-----------AYAKLS----G-SYEDLQ-----LGQVSEALVDFTGGVTVTI---------------NLA------------------------------------------------------------------------------------------------------------------------------------EVP---G---------------------------------------------------------------------------------------------------------------------------------------------------N-LWDI---------LTQATYSRTLIGCQ-TH-------------------------------------------------SG-------ERVLETGLVGGHAYTLTGI----------RK------------------------------V----------------------------------TWKHGPEYLVKLRNP--WG--K-VEWKGDWSDSSS-TWELLSPKEKI--LL-------LRKD------DGEFWMT 134
135 WKRPPEL-----HS---N-------PQFY--SPN----AKRLDLCQG-VVGDCWFLAA-LQAL--T-LHQD---ILSRVVP--L----------------N----Q-NFT-EK-----YAGIFRFWFWHFG--KWVP----------------VVI---DDRLPVNA------------------------A--GQ--------L-VF--------V-------------------------------------------------------------------------------------------------SSI-------Y-----------------K-NLFWGALLEK-----------AYAKLS----G-SYEDLH-----RGQVSEALVDFTGGVTMTI---------------IPA------------------------------------------------------------------------------------------------------------------------------------EAS---G---------------------------------------------------------------------------------------------------------------------------------------------------N-LWDI---------LTRATCSRTLIGCQ-TH-------------------------------------------------SGVRLD--KERVLENGLVGGHAYTLTGI----------RK------------------------------V----------------------------------TCKHGPEYLVKLRNP--WG--K-VEWKGDWSDSSS-TWELLSPKEKI--LL-------LRKSD-----DGEFWMT 135
136 WKRPPEL-----HS---N-------PQFY--SPN----AKRLDLCQG-VVGDCWFLAA-LQAL--T-LHQD---ILSRVVP--L----------------N----Q-NFT-EK-----YAGIFRFWFWHFG--KWVP----------------VVI---DDRLPVNA------------------------A--GQ--------L-VF--------V-------------------------------------------------------------------------------------------------SSI-------Y-----------------K-NLFWGALLEK-----------AYAKLS----G-SYEDLH-----RGQVSEALVDFTGGVTMTI---------------IPA------------------------------------------------------------------------------------------------------------------------------------EAS---G---------------------------------------------------------------------------------------------------------------------------------------------------N-LWDI---------LTRATCSRTLIGCQ-TH-------------------------------------------------SG------KERVLENGLVGGHAYTLTGI----------RK------------------------------V----------------------------------TCKHGPEYLVKLRNP--WG--K-VEWKGDWSDSSS-TWELLSPKEKI--LL-------LRKSD-----DGEFWMT 136
137 WKRPPEL-----HS---N-------PQFY--FAK----AKRLDLCQG-IVGDCWFLAA-LQAL--A-LHQD---ILSRVVP--L----------------N----Q-SFT-EK-----YAGIFRFWFWHYG--NWVP----------------VVI---DDRLPVNE------------------------A--GQ--------L-VF--------V-------------------------------------------------------------------------------------------------SST-------Y-----------------K-NLFWGALLEK-----------AYAKLS----G-SYEDLQ-----SGQVSEALVDFTGGVTMTI---------------NLA------------------------------------------------------------------------------------------------------------------------------------EAH---G---------------------------------------------------------------------------------------------------------------------------------------------------N-LWDI---------LIEATYNRTLIGCQ-TH-------------------------------------------------SG-------EKILENGLVEGHAYTLTGI----------RK------------------------------V----------------------------------TCKHRPEYLVKLRNP--WG--K-VEWKGDWSDSSS-KWELLSPKEKI--LL-------LRKDN-----DGEFWMT 137
138 WRRPPEL-----HS---N-------PLFY--SAK----AKRLDLCQG-LVGDCWFLAA-LQAL--S-LHQD---ILSRVVP--L----------------N----Q-SFT-KK-----YAGIFQFWFWHFG--KWVP----------------IVV---DDRLPVNE------------------------A--GQ--------L-VF--------V-------------------------------------------------------------------------------------------------SST-------Y-----------------K-NLFWGALLEK-----------AYAKLS----G-SYEDLQ-----RGQVSEALVDFTGGVTMTI---------------KLS------------------------------------------------------------------------------------------------------------------------------------EAP---D---------------------------------------------------------------------------------------------------------------------------------------------------S-LWDV---------LTRAMYSRTLIGCQ-TH-------------------------------------------------CG------KERVLENGLVDGHAYTLTGL----------RK------------------------------V----------------------------------TTRHGPEYLVRLRNP--WG--K-IEWKGDWSDSSS-MWDLLSPKEKI--LL-------LRKDD-----DGEFWMS 138
139 --------------------------------DG----TKSGDVSQG-QLGNCWFVAA-TANL--A-QEKE---LWETVVPNAK----------------D----Q-DWDADNK--EKYAGIFHFRFWRFG--KWTD----------------VVI---DDRLPTH-------------------------G--NK--------L-IY--------T-------------------------------------------------------------------------------------------------HSE-------E-----------------G-NEFWSALLEK-----------AYAKIS----G-CYENLD-----GGNTADALVDFTGGVAEQI---------------NLAD----------PE----------------------------------------------------------------------------------------------------------------------FQADQNKK---------------------------------------------------------------------------------------------------------------------------------------------------KELHSQ---------MKKYSERRFQMSAS-IK-------------------------------------------------VTNAEE--MEARTDVGLVKGHAYGVTAV----------KS------------------------------V---------KLG----------SSG----FFKK-EKEY----LVRLRNP--WG--E-KEWNGPWSDGSP-EWQNISESQRK--SI------GIVNED-----DGEFWYV 139
140 WKRPGEL-----TS---D-------PHLV--VDG----TKSGDVSQG-QLGNCWFVAA-TANL--A-QEKE---LWETVVPNAK----------------D----Q-DWDADNK--EKYAGIFHFRFWRFG--KWTD----------------VVI---DDRLPTH-------------------------G--NK--------L-IY--------T-------------------------------------------------------------------------------------------------HSE-------E-----------------G-NEFWSALLEK-----------AYAKIS----G-CYENLD-----GGNTADALVDFTGGVAEQI---------------NLAD----------PE----------------------------------------------------------------------------------------------------------------------FQADQNKK---------------------------------------------------------------------------------------------------------------------------------------------------KELHSQ---------MKKYSERRFQMSAS-IK-------------------------------------------------VTNAEE--MEARTDVGLVKGHAYGVTAV----------KS------------------------------V---------KLG----------SSG----FFKK-EKEY----LVRLRNP--WG--E-KEWNGPWSDGSP-EWQNISESQRK--SI------GIVNED-----DGEFWM- 140
141 ------I-----SN---D-------PKLF--VEG----ASSGDVSQG-SLGNCWFVAA-CSSL--A-QQQE---LWTKVVPTHE----------------E----Q-EWDSENP--QKYAGIFHFRFWRFG--EWLD----------------VVV---DDRLPTI-------------------------N--NQ--------L-IF--------V-------------------------------------------------------------------------------------------------HSQ-------T-----------------K-NEFWSALLEK-----------AYAKIS----G-CYENLD-----GGNTADALVDFTGGVAENI---------------DLME----------P------------------------------------------------------------------------------------------------------------------------AVDEEKR---------------------------------------------------------------------------------------------------------------------------------------------------NVLFKE---------MQKCLDRNSLMSSS-IK-------------------------------------------------VTSASE--MEAKTEVGLIKGHAYGVTDV----------RN------------------------------V---------KIG----------DTGLLS-YFKGIEKIA----MIRLRNP--WG--E-KEWNGAWSDQSP-EWSKVGKSERE--KM------GLTFDD-----DGEFWMT 141
142 WKRPREL-----CD---N-------PRLF--VEG----VSSNDLNQG-QLGNCWFVAA-VASL--T-LEKD---LWKEVIPDYK----------------E----Q-EWDTEHP--ENYQGIFRFRFWRFG--TWTE----------------VVV---DDLLPTI-------------------------N--GQ--------L-VY--------N-------------------------------------------------------------------------------------------------RSK-------D-----------------Q-NELWSSLLEK-----------AYAKLA----G-CYEALQ-----GGNTLDALVDFTGGVAEPI---------------ALDK----------GG----------------------------------------------------------------------------------------------------------------------YREDEEKK---------------------------------------------------------------------------------------------------------------------------------------------------EKLFKV---------MHKAAERGSLLTCS-IR-------------------------------------------------VTSRDE--MEASTESGLVKGHAYSVTAV----------KK------------------------------V---------KVG----------ESGMLSGILGNQEKIY----MIRMRNP--WG--Q-KEWRGPWSDDSP-EWQQVSSSEKE--KL------GLVKED-----DGEFWM- 142
143 WKRPKEL-----CE---D-------PHLF--VNG----ISSHDLHQG-KLGNCWFVAA-CACL--A-LRGN---LWRKVIPNVK----------------E----Q-DWDRKRP--EKHAGMFHFRFWCLG--EWTD----------------VVI---DDRLPTL-------------------------N--NE--------L-VF--------C-------------------------------------------------------------------------------------------------HSN-------D-----------------R-NEFWSALLEK-----------AYAKMA----G-CYEALD-----GGSTAEAIVDFTGAVAESI---------------DMAE----------GK----------------------------------------------------------------------------------------------------------------------YSRDIIEQ---------------------------------------------------------------------------------------------------------------------------------------------------AKLFED---------LLKVQRRGGLISCY-IK-------------------------------------------------PTSSRD--FEGQTTMGLIMGHAYSVTSI----------LM------------------------------M---------SLG----------K-KLTT-FTKT-KKLF----MIRLRNP--WG--Q-KEWNGAWSDASE-EWKNVSQAERK--KL------GLTVEN-----DGEFWMT 143
144 WKRPKDL-----CQ---D-------PYLF--VNG----ISSHDLHQG-SLGNCWFVAA-CSCL--A-LRKK---LWQQVIPDFQ----------------E----Q-EWDPKTP--EKYAGIFRFRFWCFG--IWTE----------------VVI---DDLLPTI-------------------------D--GT--------L-IY--------C-------------------------------------------------------------------------------------------------HSN-------V-----------------E-NEFWSALLEK-----------AYAKLA----G-SYEALD-----GGSAADAIVDFTGAVAESI---------------DLVQ----------GK----------------------------------------------------------------------------------------------------------------------YSETISEQ---------------------------------------------------------------------------------------------------------------------------------------------------MKLFED---------LLKVHKRGGLISCF-IA-------------------------------------------------SSSGRA--NEVEAKTGLVTGHAYSVTAI----------RK------------------------------V---------HLG----------E-RLTF-SFKA-EKLF----MVRLRNP--WG--N-REWNGAWSDNSE-EWKKVSNAERK--SL------GLTVEN-----DGEFWMT 144
145 ---------------------------------------SAHDLNQG-QLGNCWFVAA-CSSL--A-SREA---LWQKVIPDWK----------------D----Q-EWDKNKP--ESYAGIFHFRFWRFG--DWVD----------------VVI---DDRLPTA-------------------------N--GK--------L-IY--------C-------------------------------------------------------------------------------------------------HSN-------D-----------------S-NEFWSALVEK-----------AYAKMC----G-CYEALD-----GGNTADALVDFTGGVSEPM---------------DLLE----------GK----------------------------------------------------------------------------------------------------------------------FAQDEEAR---------------------------------------------------------------------------------------------------------------------------------------------------HQLFDR---------VLKVHNRGGLISCS-IR-------------------------------------------------ATTQAD--MEARLDCGLVKGHAYAVTDV----------RK------------------------------V---------RLG----------S-GLLA-FFKS-EKLS----MIRMRNP--WG--Q-REWNGAWSDSSE-EWKRVSKGERE--RL------GVTVED-----DGEFWMD 145
146 WKRPKDL-----CE---D-------PHLF--VNG----ISAHDLNQG-QLGNCWFVAA-CSSL--A-SREA---LWQKVIPDWK----------------D----Q-EWDKNKP--ESYAGIFHFRFWRFG--DWVG----------------VVI---DDRLPTA-------------------------N--GK--------L-IY--------C-------------------------------------------------------------------------------------------------HSN-------D-----------------S-NEFWSALVEK-----------AYAKMC----G-CYEALD-----GGNTADALVDFTGGVSEPM---------------DLLE----------GK----------------------------------------------------------------------------------------------------------------------FAQDEEAR---------------------------------------------------------------------------------------------------------------------------------------------------HQLFDR---------VLKVHNRGGLISCS-IR-------------------------------------------------ATTQAD--MEARLDCGLVKGHAYAVTDV----------RK------------------------------V---------RLG----------S-GLLA-FFKS-EKLS----MIRMRNP--WG--Q-RGWNGAWSDSSE-EWKRVSKGERE--RL------GVTVED-----DGEFWM- 146
147 WKRPEEL-----CD---D-------PHLF--VDG----ISAHDLHQG-QLGNCWFVAA-CSSL--A-SRES---LWQKVIPDWK----------------E----Q-EWDPEKA--DSYAGIFHFRFWRFG--EWVD----------------VVI---DDRLPTV-------------------------D--NQ--------L-VY--------C-------------------------------------------------------------------------------------------------HSN-------D-----------------S-NEFWSALVEK-----------AYAKVY----G-CYEALD-----GGNTADALVDFTGGVSEPM---------------DLLE----------GQ----------------------------------------------------------------------------------------------------------------------FAQDETAR---------------------------------------------------------------------------------------------------------------------------------------------------NQLFER---------VLKVHNRDGLISCS-IR-------------------------------------------------ATTVED--MEARLDCGLVKGHAYAVTDV----------RK------------------------------V---------RLG----------H-GLLA-YFKS-EKLH----MIRMRNP--WG--E-KEWSGPWSDSSE-EWKKVSKSERE--KL------GVTVQD-----DGEFWM- 147
148 ---------------------------------------SSHDLHQG-QVGNCWFVAA-CSSL--A-SRES---LWQKVIPDWK----------------E----Q-EWDPEKP--NAYAGIFHFHFWRFG--EWVD----------------VVI---DDRLPTV-------------------------N--NQ--------L-IY--------C-------------------------------------------------------------------------------------------------HSS-------S-----------------R-NEFWCALVEK-----------AYAKLA----G-CYQALD-----GGNTADALVDFTGGVSEPI---------------DLTE----------GD----------------------------------------------------------------------------------------------------------------------FANDEAKR---------------------------------------------------------------------------------------------------------------------------------------------------NQLFER---------VLKVHSRGGLISAS-IK-------------------------------------------------AVTAAD--MEARLACGLVKGHAYAITDV----------RK------------------------------V---------RLG----------H-GLLA-FFKS-EKLD----MIRLRNP--WG--E-REWNGPWSDTSE-EWQKVSKSERE--KL------GVTVQD-----DGEFWMT 148
149 ----KDI-----CE---D-------PRLF--VDG----ISSHDLHQG-QVGNCWFVAA-CSSL--A-SRES---LWQKVIPDWK----------------E----Q-EWDPEKP--NAYAGIFHFHFWRFG--EWVD----------------VVI---DDRLPTV-------------------------N--NQ--------L-IY--------C-------------------------------------------------------------------------------------------------HSS-------S-----------------R-NEFWCALVEK-----------AYAKLA----G-CYQALD-----GGNTADALVDFTGGVSEPI---------------DLTE----------GD----------------------------------------------------------------------------------------------------------------------FANDEAKR---------------------------------------------------------------------------------------------------------------------------------------------------NQLFER---------VLKVHSRGGLISAS-IK-------------------------------------------------AVTAAD--MEARLACGLVKGHAYAITDV----------RK------------------------------V---------RLG----------H-GLLA-FFKS-EKLD----MIRLRNP--WG--E-REWNGPWSDTSE-EWQKVSKSERE--KL------GVTVQD-----DGEFWMT 149
150 ----KDI-----CE---D-------PRLF--VDG----ISSHDLHQG-QVGNCWFVAA-CSSL--A-SRES---LWQKVMP-----------------------------PNMSFTNAYAGIFHFHFWRFG--EWVD----------------VVI---DDRLPTV-------------------------N--NQ--------L-IY--------C-------------------------------------------------------------------------------------------------HSS-------S-----------------R-NEFWCALVEK-----------AYAKLA----G-CYQALD-----GGNTADALVDFTGGVSEPI---------------DLTE----------GG----------------------------------------------------------------------------------------------------------------------FAHDEAKR---------------------------------------------------------------------------------------------------------------------------------------------------NQLFER---------VLKVHSRGGLISAS-IK-------------------------------------------------AVTAAD--MEARLACGLVKGHAYAITDV----------RK------------------------------V---------RLG----------H-GLLA-FFKS-EKLD----MIRLRNP--WG--E-REWNGPWSDT------------------------------------------ 150
151 WKRPKDI-----CE---D-------PRLF--VDG----ISSHDLHQG-QVGNCWFVAA-CSSL--A-SRES---LWQKVIPDWK----------------E----Q-EWDPEKP--SAYAGIFHFHFWRFG--EWVD----------------VVI---DDRLPTV-------------------------N--NQ--------L-IY--------C-------------------------------------------------------------------------------------------------HSN-------S-----------------R-SEFWCALVEK-----------AYAKLA----G-CYQALD-----GGNTADALVDFTGGVSEPI---------------DLTE----------GG----------------------------------------------------------------------------------------------------------------------FANDEAKR---------------------------------------------------------------------------------------------------------------------------------------------------NQLFER---------VLKVHSRGGLISAS-IK-------------------------------------------------AVTAAD--MEARLACGLVKGHAYAITDV----------RK------------------------------V---------RLG----------H-GLLA-FFKS-EKLD----MIRLRNP--WG--E-REWNGPWSDTSE-EWQKVSKSERE--KM------GVTVQD-----DGEFWMT 151
152 ----KGI-----CE---D-------PRLF--VDG----ISSHDLHQG-QVGNCWFVAA-CSSL--A-SRES---LWQKVIPDWK----------------E----Q-EWDPEKP--NAYAGIFHFHFWRFG--EWVD----------------VVI---DDRLPTV-------------------------N--NQ--------L-IY--------C-------------------------------------------------------------------------------------------------HSN-------S-----------------R-NEFWCALVEK-----------AYAKLA----G-CYQALD-----GGNTADALVDFTGGVSEPI---------------DLTE----------GD----------------------------------------------------------------------------------------------------------------------FANDETKR---------------------------------------------------------------------------------------------------------------------------------------------------NQLFER---------MLKVHSRGGLISAS-IK-------------------------------------------------AVTAAD--MEARLACGLVKGHAYAVTDV----------RK------------------------------V---------RLG----------H-GLLA-FFKS-EKLD----MIRLRNP--WG--E-REWNGPWSDTSE-EWQKVSKSERE--KM------GVTVQD-----DGEFWMT 152
153 ---------------------------LF--VDG----ISSHDLHQG-QVGNCWFVAA-CSSL--A-SREA---LWQKVIPDWK----------------E----Q-EWDPKKP--DAYAGIFHFHFWRFG--EWVD----------------VVI---DDRLPTV-------------------------N--NQ--------L-IY--------C-------------------------------------------------------------------------------------------------HSS-------S-----------------R-NEFWCALVEK-----------AYAKLA----G-CYQALD-----GGNTADALVDFTGGVSEPI---------------DLTE----------GG----------------------------------------------------------------------------------------------------------------------FAHDEAKR---------------------------------------------------------------------------------------------------------------------------------------------------NELFER---------VLKVHSRGGLISAS-IK-------------------------------------------------AVTAED--MEARLACGLVKGHAYAITDV----------RK------------------------------V---------RLG----------H-GLLT-LFKS-EKLD----MIRLRNP--WG--E-REWNGPWSDTSE-EWQQVSKSERE--KM------GMTVQD-----DGEFWMT 153
154 ----KDI-----CE---D-------PRLF--VDG----ISSHDLHQG-QVGNCWFVAA-CSSL--A-SREA---LWQKVIPDWK----------------E----Q-EWDPKKP--DAYAGIFHFHFWRFG--EWVD----------------VVI---DDRLPTV-------------------------N--NQ--------L-IY--------C-------------------------------------------------------------------------------------------------HSS-------S-----------------R-NEFWCALVEK-----------AYAKLA----G-CYQALD-----GGNTADALVDFTGGVSEPI---------------DLTE----------GG----------------------------------------------------------------------------------------------------------------------FAHDEAKR---------------------------------------------------------------------------------------------------------------------------------------------------NELFER---------VLKVHSRGGLISAS-IK-------------------------------------------------AVTAED--MEARLACGLVKGHAYAITDV----------RK------------------------------V---------RLG----------H-GLLT-LFKS-EKLD----MIRLRNP--WG--E-REWNGPWSDTSE-EWQQVSKSERE--KM------GMTVQD-----DGEFWMT 154
155 WKRPKDI-----CD---D-------PRLF--VDG----ISSHDLHQG-QVGNCWFVAA-CSSL--A-SRES---LWQKVIPDWK----------------E----Q-EWNPEKP--DSYAGIFHFNFWRFG--EWVD----------------VIV---DDRLPTV-------------------------N--NQ--------L-IY--------C-------------------------------------------------------------------------------------------------HSN-------S-----------------K-NEFWCALVEK-----------AYAKLA----G-CYQALD-----GGNTADALVDFTGGVSEPI---------------DLTE----------GD----------------------------------------------------------------------------------------------------------------------LATDEAKR---------------------------------------------------------------------------------------------------------------------------------------------------NQLFER---------VLKVHSRGGLISAS-IK-------------------------------------------------AVTAAD--MEARLACGLVKGHAYAVTDV----------RK------------------------------V---------RLG----------H-GLLA-FFKS-EKLD----MIRLRNP--WG--E-REWTGPWSDTSE-EWQKVSKSERE--KM------GVTVQD-----DGEFWMT 155
156 WKRPKEI-----CS---D-------PHLF--VDG----ISSHDLHQG-QVGNCWFVAA-CSSL--A-SREA---LWQKVIPDWK----------------E----Q-EWNAEKP--ESYAGIFHFQFWRFG--QWLD----------------VVI---DDRLPTL-------------------------H--NQ--------L-IY--------C-------------------------------------------------------------------------------------------------HSN-------S-----------------K-NEFWCALVEK-----------AYAKLS----G-CYEALD-----GGNTADALVDFTGGVSEPI---------------DLTE----------GD----------------------------------------------------------------------------------------------------------------------YTTDEAKR---------------------------------------------------------------------------------------------------------------------------------------------------NLLFER---------VLKVHNRGGLISCS-IK-------------------------------------------------AMSAAD--MEARLACGLVKGHAYAVTDV----------RK------------------------------V---------RLG----------H-GLLS-FFKS-EKLD----MIRMRNP--WG--E-REWNGPWSDTSE-EWQKVSKSERE--KM------GMTVED-----DGEFWMT 156
157 WKRPKQI-----CE---N-------PKFF--VEG----TSSGDVKQG-RLGNCWFVAA-SSCL--A-IHKD---IWHKVIPDAK----------------D----Q-EWDENNP--NNYQGIFHFHFWRFG--EWID----------------VVI---DDFLPTQ-------------------------N--NQ--------L-IY--------I-------------------------------------------------------------------------------------------------HSQ-------T-----------------K-NEFWSALLEK-----------AYAKLF----G-CYEALD-----GGELSEALEDFTGGVSVTV---------------NMVK----------LN----------------------------------------------------------------------------------------------------------------------LANDAQER---------------------------------------------------------------------------------------------------------------------------------------------------AALFTR---------MQKEAGRKALMAAS-IP-------------------------------------------------AESSEE--MEASTETGLVKGHAYGVTAV----------KN------------------------------V---------ALE----------GSGLFS-FFKT-EKIA----MVRLRNP--WG--Q-GEWNGPFSDGSP-EWQKISKDERE--KI------GLTFEE-----DGEFWM- 157
158 WKRPKDI-----AE---N-------PSLF--VDG----VTCSDLNQG-ELGNCWFVAA-CSCL--A-TNKE---IWRKVIPNHK----------------D----Q-EWDPEKP--EKYAGIYYFRFWRFG--EWTD----------------VVI---DDLLPTR-------------------------N--GD--------L-VY--------A-------------------------------------------------------------------------------------------------HSK-------D-----------------R-NEFWSALLEK-----------AYAKLY----G-SYESLD-----GGELAEALEDFTGGVSEPL---------------NLVD----------LK----------------------------------------------------------------------------------------------------------------------VGIEEEAR---------------------------------------------------------------------------------------------------------------------------------------------------NDLYKV---------MRKAMDNHAMMAAA-IP-------------------------------------------------SATKEE--QEEVMDMGLVKGHAYGITAV----------KR------------------------------I---------ALE----------GTGIFN-MFNK-EKIA----MIRLRNP--WG--G-TEWKGAFSDESE-EWKKIDKESRE--KI------GLTFDD-----DGEFWM- 158
159 WKRPGEI-----CS---N-------PKLI--VDG----LDPSDLNQG-AVGNCWFVAA-CSAL--A-LERR---LWNKVVVDVN----------------E----Q-EWDANHP--ERYAGIFHFRFWQFG--EWVD----------------VVI---DDWLPTQ-------------------------G--GK--------L-IY--------N-------------------------------------------------------------------------------------------------KSK-------S-----------------G-NEFWSALLEK-----------AYAKLA----G-SYEALS-----GGLTGDALVDFTGGVTETI---------------TLQS----------GD----------------------------------------------------------------------------------------------------------------------LADDEEKR---------------------------------------------------------------------------------------------------------------------------------------------------KQLFDE---------LIRAHEHHAMMSCS-IE-------------------------------------------------VKEGES--PETKLDCGLVKGHAYTITDI----------RR------------------------------M---------KLT----------S-GLSS-LFGNKEKLM----MIKMRNP--WG--Q-KEWNGAWSDDSE-EWKRVPKGEKD--KM------DLKVED-----DGEFWM- 159
160 WKRPTEI-----TD---N-------PKFF--VDG----TSPSDVTQG-HLGNCWFVAA-CASL--S-QEKS---LVNKVIPNVG----------------E----Q-DYDTSD---GEHSGIVHFRFWRFG--EWVD----------------VVI---DDRLPMV-------------------------D--GK--------L-IY--------V-------------------------------------------------------------------------------------------------HSK-------Q-----------------K-NEFWSALLEK-----------AYAKLA----G-SYESLE-----AGNTADALVDFTGGIAETI---------------KMDG----------ED----------------------------------------------------------------------------------------------------------------------YSDD-NNR---------------------------------------------------------------------------------------------------------------------------------------------------DQLFKL---------MDKSMDRHALICCS-IR-------------------------------------------------TADQTK--REERTDMGLILLHAYGVTKV----------TN------------------------------F---------KLG----------E-GLRS-FFRS-EKVP----MVRMRNP--WG--K-GEWKGAWSDGSE-EWNRVKKSERE--KV------GLTFEE-----DGEFWMS 160
161 -----EI-----CD---D-------PQMF--VDG----ASSADVTQG-RVGNCWFVAA-AASL--A-LEKD---LYTKNFILSK--------------------------------EYYHGIFRFRFWRFG--EWIE----------------VVI---DDRLPTI-------------------------N--GE--------L--------------------------------------------------------------------------------------------------------------------------------------------------------------------LS----G-SYEALE-----SGNPGDALVDFTGGVSERI---------------DLVE----------GD----------------------------------------------------------------------------------------------------------------------YHNNLEKK---------------------------------------------------------------------------------------------------------------------------------------------------KLLHVK---------LSKLMSRKSMISAS-IQ-------------------------------------------------VQNRDE--MELQMDHGLVKGHAYSILAV----------KK------------------------------I---------KIG----------N-DHIS-IFNA-NRLF----MVKLRNP--WG--D-TEWNGPWSDGSP-QWNLLSAQERE--KY------GLVNEN-----SGEFWMS 161
162 WKRPGEI-----CD---D-------PQMF--VDG----ASSADVTQG-RVGNCWFVAA-AASL--A-LEKD---LYTKVIPNHK----------------T----L-TFKSVKP--EDYLGIFRFRFWRFG--DWIE----------------VVI---DDRLPTI-------------------------N--GE--------L-IY--------V-------------------------------------------------------------------------------------------------KSK-------S-----------------K-NEFWSALLEK-----------AYAKLA----G-SYEALE-----AGNPADALVDFTGGVSETI---------------DLVK----------ED----------------------------------------------------------------------------------------------------------------------YHNNFEKK---------------------------------------------------------------------------------------------------------------------------------------------------MALHAK---------LRKLMERKSMSSAS-IK-------------------------------------------------VTNRNE--MELQLDTGLIKGHAYGISAV----------KK------------------------------I---------TLG----------Q-NFFS-SFNT-ETLY----LVKLRNP--WG--E-KEWNGAWSDGSA-EWKKLSVKERE--KL------GIKNEN-----DGEFWMS 162
163 ---------------------------------------STRDLHQG-SLGNCWMVAA-TSCL--A-AESS---LWKKVIPDHT----------------E----Q-EWHPKRP--DLYAGIFHFRFWRLG--QWTD----------------VVV---DDRLPVSG------------------------D--GT--------L-LF--------C-------------------------------------------------------------------------------------------------RSA-------T-----------------P-REFWSALLEK-----------AYAKLN----G-CYEALE-----GGNTAEALVDFTGGVSEPL---------------SLNQ----------EE----------------------------------------------------------------------------------------------------------------------LIQHADQR---------------------------------------------------------------------------------------------------------------------------------------------------KILFQT---------LAHAHSHKALITCS-IR-------------------------------------------------PAEGEA--LESVLDCGLIKGHAYGVTAV----------KK------------------------------L---------RMS----------E-TLHS-MCNA-SRLY----MVRIRNP--WG--T-TDWTGAWGLGSP-EWQQFNRKEKE--KM------GLIVRD-----VGEFWME 163
164 WKRPSEL-----CK---D-------PRLF--VDG----ISTRDLHQG-SLGNCWMVAA-TSCL--A-AESS---LWKKVIPDHT----------------E----Q-EWHPKRP--DLYAGIFHFRFWRLG--QWTD----------------VVV---DDRLPVSG------------------------D--GT--------L-LF--------C-------------------------------------------------------------------------------------------------RSA-------T-----------------P-REFWSALLEK-----------AYAKLN----G-CYEALE-----GGNTAEALVDFTGGVSEPL---------------SLNQ----------EE----------------------------------------------------------------------------------------------------------------------LIQHADQR---------------------------------------------------------------------------------------------------------------------------------------------------KILFQT---------LAHAHSHKALITCS-IR-------------------------------------------------PAEGEA--LESVLDCGLIKGHAYGVTAV----------KK------------------------------L---------RMS----------E-TLHS-MCNA-SRLY----MVRIRNP--WG--T-TDWTGAWGLGSP-EWQQFNRKEKE--KM------GLIVRD-----VGEFW-- 164
165 WKRPSEL-----CK---D-------PRLF--VDG----ISTRDLHQG-SLGNCWMVAA-TSCL--A-AESS---LWKKVIPDHT----------------E----Q-EWHPKRP--DLYAGIFHFRFWRLG--QWTD----------------VVV---DDRLPVSG------------------------D--GT--------L-LF--------C-------------------------------------------------------------------------------------------------RSA-------T-----------------P-REFWSALLEK-----------AYAKLN----G-CYEALE-----GGNTAEALVDFTGGVSEPL---------------SLNQ----------EE----------------------------------------------------------------------------------------------------------------------LIQHSDHR---------------------------------------------------------------------------------------------------------------------------------------------------KILFQT---------LAHAHSHKALITCS-IR-------------------------------------------------PAEGEA--LESVLDCGLIKGHAYGVTAV----------KK------------------------------L---------RMS----------E-TLHS-MCNA-SRLY----MVRIRNP--WG--T-TDWTGAWGLGSP-EWQQFNRKEKE--KM------GLIVRD-----VGEFWM- 165
166 WKRPGDI-----VS---N-------PRFF--TEG----RGADDFSQG-SLGNCWFVAA-FACI--A-ERKN---LLRKIVPDIE----------------K----Q-DW--AKG--RKYAGIFHFKFWQCG--EWVD----------------VVI---DDFLPTR-------------------------Q--GR--------L-IF--------M-------------------------------------------------------------------------------------------------HSK-------S-----------------R-NEFWSALLEK-----------AYAKLF----G-DYEALV-----AGKAKDAMVDMTGGVAEGI---------------EIR------------D----------------------------------------------------------------------------------------------------------------------Y-KNEEER---------------------------------------------------------------------------------------------------------------------------------------------------KKLFKI---------LRKSKENMSLISTS-IA-------------------------------------------------AV-GKE--MEEKLSCGLVKGHAYSVTNV----------RK------------------------------L---------KLG----------T-GLKS-IFSR-EKIH----MIRCRNP--WG--G-SDWKGAWSNGSP-EWKKVSDSEKK--EL------GLTFAD-----NGEFWMS 166
167 WKRPGEI-----AS---D-------PKFF--DEG----ASADDFAQG-SLGNCWFVAA-CACI--A-EDKS---LLKKIVPDYE----------------E----Q-EW--SKD--NKYAGIFHFRFWQMG--EWID----------------VVI---DDRLPTR-------------------------H--GE--------L-VY--------V-------------------------------------------------------------------------------------------------QSR-------S-----------------K-NEFWSALLEK-----------AYAKIF----G-DYESLK-----GGQAKDAMVDMTGGVGEAL---------------ELR------------D----------------------------------------------------------------------------------------------------------------------YTKTEEDK---------------------------------------------------------------------------------------------------------------------------------------------------LKLFKI---------LRKCKEHHSLISAA-IP-------------------------------------------------VTSAND--MEAQLSCGLVKGHAYSVNAV----------KK------------------------------V---------RLG----------K-GLMS-HFNK-EKIL----MIRCRNP--WG--G-TEWKGAWSDGSP-EWEKISSSEKK--DM------GLTFDE-----DGDFWMT 167
168 WKRPGEI-----AA---E-------PKFF--VDG----ASTDDFHQG-SLGNCWFVAA-AACI--A-EKPK---LLKKIIPDIE----------------K----Q-EWLPENK--NKYAGIFHFRFWICG--EWSD----------------VVV---DDYLPTR-------------------------N--GN--------L-IY--------I-------------------------------------------------------------------------------------------------HSK-------T-----------------R-NEFWSALLEK-----------AYAKIF----G-SYEALE-----GGHARDALVNMTGGVGEDI---------------TMA------------D----------------------------------------------------------------------------------------------------------------------YTDSGEKK---------------------------------------------------------------------------------------------------------------------------------------------------EKLFKI---------LKSSIKDGSLISAS-IS-------------------------------------------------AK-GDE--MEAKTNTGLVKGHAYSVTAV----------RN------------------------------I---------KLG----------Q-GLLS-FFKR-EHIE----MVRCRNP--WG--G-TEWKGAWSDGSE-EWSKVSDGEKK--EL------GITIDD-----NGEFWMS 168
169 WKRPAEL-----HP---D-------PHLF--VEG----ASPNDVTQG-ILGNCWFVSA-CSAL--T-HNLK---LLAQVIPEAD----------------D----Q-EWSTKHT----YAGIFRFRFWRFG--KWVE----------------VVI---DDLLPTR-------------------------D--GK--------L-LF--------A-------------------------------------------------------------------------------------------------RSK-------T-----------------P-NEFWSALLEK-----------AFAKLY----G-CYENLV-----GGHLSDALQDVSGGVAETL---------------HVRK----------FL----------------------------------------------------------------------------------------------------------------------KDDPTDKD---------------------------------------------------------------------------------------------------------------------------------------------------LKLFND---------LKTAFDKGALIVAA-IA-------------------------------------------------ARTKEE--IEESLDCGLVKGHAYAVSAV----------CT---------------------------IDVS---------NPQ----------QRSLTSFIMGSKQKQN----LIRLQNP--WG--E-KEWNGEWSDDSS-EWQNVSDSQLS--AM--GVQRDNSDNN-----DGDFWMP 169
170 WKRPGEL-----HP---D-------PHLF--VEG----ASPNDVTQG-ILGNCWFVSA-CSAL--T-HNFK---LLAQVIPDAD----------------D----Q-EWSTKHA----YAGIFRFRFWRFG--KWVE----------------VVI---DDLLPTR-------------------------D--GK--------L-LF--------A-------------------------------------------------------------------------------------------------RSK-------T-----------------P-NEFWSALLEK-----------AFAKLY----G-CYENLV-----GGHLSDALQDVSGGVAETL---------------HVRK----------FL----------------------------------------------------------------------------------------------------------------------KDDPNDTE---------------------------------------------------------------------------------------------------------------------------------------------------LKLFND---------LKTAFDKGALVVAA-IA-------------------------------------------------ARTKEE--IEESLDCGLVKGHAYAVSAV----------CT---------------------------IDVT---------NPN----------ERSFTSFIMGSKRKQN----LIRLQNP--WG--E-KEWNGAWSDDSP-EWQNVSASQLS--TM--GVQPANSDSD-----DGDFWMP 170
171 WKRPTEL-----SR---N-------PKFI--VRN----ATRFDLDQG-YLGNCWFIAG-AALV--A-TNKK---LLERVVP--Q----------------D----Q-NFDR-N-----YAGIFHFNFWWYG--RWVE----------------VIV---DDFLPTD-------------------------G--YR--------L-VY--------A-------------------------------------------------------------------------------------------------SNR-------E-----------------EPNEFWAALLEK-----------AYAKLR----G-CYEGVD-----GGKLQDSVVDLTGGISETI---------------DIK------------------------------------------------------------------------------------------------------------------------------------DKAQIPV---------------------------------------------------------------------------------------------------------------------------------------------------D-IYEI---------LWRSWKMNSFLGCS-IS------------------------------------------------LPQNVAVSSREVRRPNGLYMGHAYSITAL----------AV------------------------------I---------PYQ----------G-----------SNVR----LCRLRNP--WG--R-SEWNGDWSDNSY-QLRNLSQDARQ--RL------GIVVQD-----EGEFWI- 171
172 WKRPKEI-----SS---D-------PKFI--DKK----STRFDLDQG-DLGDCWFIAG-AASL--AVSNRK---LFERCVP--H----------------N----Q-TFDD-----EDYAGIFMFRFWHFS--AWTE----------------VVI---DDLLPTV-------------------------N--GR--------L-LY--------A-------------------------------------------------------------------------------------------------HNR-------D-----------------QPNEFWAALLEK-----------AYAKLY----G-CYENID-----GGHINDSLVDFTGGISEVI---------------HLN----------------------------------------------------------------------------------------------------------------------------------------EAP---------------------------------------------------------------------------------------------------------------------------------------------------ANLFQL---------MYRTLRMNSMVGCA-IN-------------------------------------------------ATSHR----EEDLGNGLYAGHAYSVTNI----------IQ------------------------------A---------TVD----------G-----------DVIQ----LIRLRNP--WG--R-DEWKGAWSDYSP-EWRKMTETMRK--KI------GLVKDD-----DGEFWMA 172
173 WKRPAEI-----CE---N-------PMFA--QDG----ATIFDLDQG-DLGNCWFLSA-AGTI--A-LNPD---LFARVVP--I----------------D----Q-TFT------EGYAGIFRFNFWRYG--VWTE----------------VVV---DDRLPTK-------------------------N--NR--------L-VF--------C-------------------------------------------------------------------------------------------------RNR-------E-----------------SLNEFWSALLEK-----------AYAKIF----G-SYQALE-----TGFSHEALVDMTGGIGEFI---------------DV--------------------------------------------------------------------------------------------------------------------------------------KNIPDR---------------------------------------------------------------------------------------------------------------------------------------------------SKFFKL---------IKRLHKRGSLICSA-IE-------------------------------------------------TGDDGT--YESRLDNGLVTGHAYSLTNI----------SE------------------------------V---------TVN----------E-----------AKVQ----LVRLRNP--WG--F-KEWNGAWSDSSE-EWTSLSEEQRQ--TF------DLTVDN-----DGEFWIT 173
174 WKRPYEI-----AA---H-------PKFT--ADG----FSRFDLLQG-KLGNCWLVAA-FSCL--T-LTPK---LLGRCIP--E----------------D----Q-GFTH-K-----YAGIFHFRFWRYG--EWID----------------AVI---DDRLPTI-------------------------N--GE--------L-IY--------L-------------------------------------------------------------------------------------------------RSS-------D-----------------R-QEFWPALFEK-----------AYAKCY----G-SYENTS-----GGLTNWALQDLTGGVTENH---------------QVY------------------------------------------------------------------------------------------------------------------------------------ENP-------------------------------------------------------------------------------------------------------------------------------------------------------RLIQRL---------LDVSMTNASLVGTY----------------------------------------------------ISTNMTQGQRRRLSNGLVTGHAYSVTGY----------AQ------------------------------I----------------------------------PVKNGMIILIRLRNP--WG--H-FEWNGAWSDGSP-HWEALSEDLRK--RL------RPDKAD-----DGEFWMS 174
175 WKRPHEI-----NP---N-------AKFF--AGG----ASRFDIEQG-ALGDCWLLAV-VASI--S-GYPQ---LFDQVVP--K----------------D----Q-ELKGPE-----YVGVVRFRFWRFG--HWVE----------------VLI---DDRLPVRQG-----------------------R--NT--------L-VF--------M-------------------------------------------------------------------------------------------------HSN-------D-----------------P-TEFWSALLEK-----------AYAKLN----G-CYAHLS-----GGSQSEAMEDLTGGICLSL---------------ELN------------Q----------------------------------------------------------------------------------------------------------------------KERP---S---------------------------------------------------------------------------------------------------------------------------------------------------D-LIDQ---------LKIYAQRCCLMGCS-ID------------------------------------------------------SSVMEQKMDNGLIGSHAYSLTGV----------YP------------------------------V---------NYR----------G-----------RTQW----LMRLRNP--WGD-S-HEWKGAWCDGSP-QWREISEQEKK--NI------NLSFTA-----DGEFWMS 175
176 WKRPHEI-----NP---N-------AKFF--AGG----ASRFDIEQG-ALGDCWLLAV-VASI--S-GYPQ---LFDQVVP--K----------------D----Q-ELKGPE-----YVGVVRFRFWRFG--HWVE----------------VLI---DDRLPVRQG-----------------------R--NT--------L-VF--------M-------------------------------------------------------------------------------------------------HSN-------D-----------------P-TEFWSALLEK-----------AYAKLN----G-CYAHLS-----GGSQSEAMEDLTGGICLSL---------------ELN------------Q----------------------------------------------------------------------------------------------------------------------KERP---S---------------------------------------------------------------------------------------------------------------------------------------------------D-LIDQ---------LKIYAQRCCLMGCS-ID------------------------------------------------------SSVMEQKMDNGLIGSHAYSLTGV----------YP------------------------------V---------NYR----------G-----------RTQW----LMRLRNP--WGD-S-HEWKGAWCDGSP-QWREISEQEKK--NI------NLSFTA-----DGEFWMS 176
177 WKRPKDI-----NP---L-------AAFC--TKS----YSRFDVDQG-ALGDCWFASV-MATV--T-KYPS---LMSNIIP--P----------------N----Q-TFKGSG-----YTGAFVFNFWRFG--EWVE----------------VVV---DDRIPVVKG-----------------------T--CN--------P-VF--------I-------------------------------------------------------------------------------------------------HST-------D-----------------N-SEFWSCLLEK-----------AYAKLC----G-SYAHLT-----GGFQSEAMEDFTGGICTTL---------------ILN------------K----------------------------------------------------------------------------------------------------------------------KERP---P---------------------------------------------------------------------------------------------------------------------------------------------------N-LLKM---------MEHYTKTCCVMGAD-VG------------------------------------------------------GDKNKRREELGLIGSHAYSVTGV----------GK------------------------------V---------NYM----------G-----------KDVY----LVRCRNP--WGE-R-HEWKGPWSDNSP-EWKDVKSKDKR--AL------QYKPKE-----DGEF--- 177
178 WKRPGEI-----VP---S-------PKFV--TEG----FSRFDVRQG-IIGNCWFISS-CSAL--T-SHQE---LFERVVP--L----------------D----N-GQF----EADHYAGLFHFRFWQYG--QWVE----------------VIV---DDRLPVG-------------------------K--NN--------QLLF--------I-------------------------------------------------------------------------------------------------SSS-------E-----------------K-DEFWGALLEK-----------AYAKLH----G-SYEALD-----SGTGREGMVDLTGGITEFY---------------QLK------------------------------------------------------------------------------------------------------------------------------------GNE---P---------------------------------------------------------------------------------------------------------------------------------------------------DDLFER---------LESNLARRSLITAG-IN--------------------------------------------GNERERVQS----------VNLVPQHEYSVTKV----------TR------------------------------L---------DATLHMLDFGAGNA-----------VDVR----LICVRNP--WGR-G--EWSGAWGDHSL-EWIMVRDEKME--EL------NIVKE------DGEFWMN 178
179 WKRPKEL-----TP---T-------ARFF--IDG----ASRLDICQG-ALNDCWLLTA-ATNL--T-SHPW---LFRRVLP--G----------------D----N-SFREEQQ----YAGAFHFRFWEFG--QWVE----------------VVI---DDRLPTDA------------------------T--GK--------L-LF--------G-------------------------------------------------------------------------------------------------RSA-------N-----------------G-DEYWSALLEK-----------AYAKFY----G-SYGALD-----GGTAREAMQDLTGGLTEFY---------------QPK------------------------------------------------------------------------------------------------------------------------------------KMADGQE---------------------------------------------------------------------------------------------------------------------------------------------------DQLWDI---------LRSGSEMGSLFACN-LK--------------------------------------------------SDPTG--ENVATKEGLLRGHSYSITKV----------CS---------------------------IPGL---------VSG----------S-----------DDIR----LLRIRNP--WGT-G-IEWNGRWSDKSR-EWKSLNQAERK--RV------GLTVEN-----DGEFWI- 179
180 WLRPKEI-----TD---D-------PKLY--VDG----GDRLDMRQG-RLGDCWFVAS-LSSL--A-TEKN---LLYRVIP--N----------------D----Q-TFDKD------YAGILHVRFWRMG--QWAD----------------IVI---DDRLPCFE------------------------K--SK--------RPCY--------V-------------------------------------------------------------------------------------------------HPS-------D-----------------K-HEFWGCFIEK-----------AYAKVN----N-SYEALV-----GGVNWEALETFTGGIHEDY---------------HMP------------------------------------------------------------------------------------------------------------------------------------SMP---A---------------------------------------------------------------------------------------------------------------------------------------------------D-GFQR---------IFNALARHSLLGCFGVT-----------------------------------------------------QLRVKGHVLPNGLVWGHAYSVDKA----------AK------------------------------I----------------------------------EGNDEEVPLVRIRNP--WG--C-GEWKGAWSDGSA-EWDTVSEETKK--AI------GMAVAN-----NGEFWMS 180
181 WLRPIDI-----MR---Y-------PRLF--VDG----VNRADILQG-QIGDCWVLAA-LGSL--T-RQQR---FLKNVIP--K----------------D----Q-GFED-S-----YAGIFHFRFWQFG--DWVD----------------VVI---DDRLPFL-------------------------D--DN--------F-LF--------V-------------------------------------------------------------------------------------------------HPR-------S-----------------K-NEFWPPLLEK-----------AYAKLR----G-SYTNLD-----QGYLTEALVDFTGGVEMPF---------------NLK------------------------------------------------------------------------------------------------------------------------------------NPP---D---------------------------------------------------------------------------------------------------------------------------------------------------S-LFEM---------LKTAAESGCLMGCT-TP--------------------------------------------------KGKFP--GNIQLENGIVQLHAYTVIWA----------TE------------------------------V---------PYM----------D-----------GKER----LVRLWNP--YG--N-TEWKGAWSDRSV-EWQHVPIPYRK--KL-------YEDKD-----DGEFWIS 181
182 WKRPREL-----LR---N-------PCLI--MDG----VSRFDIIQG-EIGDCWMLAA-LGSL--T-MQKQ---FLEKVLP--K----------------D----Q-GFQS-D-----YAGIFHFRFWQFG--DWVD----------------VVI---DDRLPFL-------------------------N--GN--------Y-LS--------V-------------------------------------------------------------------------------------------------HAR-------T-----------------S-NEFWPSLLEK-----------AYAKLQ----G-SYQNLH-----GGYISDALVDFTGGVQMQF---------------SLK------------------------------------------------------------------------------------------------------------------------------------DPP---P---------------------------------------------------------------------------------------------------------------------------------------------------D-LEDV---------LKAASKSRCLMGCS-T----------------------------------------------------SGWM--RNTVLRNGIVQGHAYTVTGA----------VK------------------------------I---------RFK----------N-----------QWEH----IIRVWNP--WG--H-GEWRGPWSDGSP-EWDYVEPEIKE--EL-------YRKKN-----DGEFWMS 182
183 WKRPTSK-----DL---P-FY---PPHFI--LEG----ASRFDIHQG-IAGDCWFLAA-LGSL--T-QNPQ---CLQKIL---M----------------D----Q-SYSH-Q-----YAGIFQFRFWQCG--QWVE----------------VVI---DDQLPVI-------------------------G--DN--------F-LF--------V-------------------------------------------------------------------------------------------------HPR-------G-----------------GNKEFWPCLMEK-----------AYAKLL----G-SYSQLH-----YGYLPDALVDLTGGVVTII---------------NLH------------------------------------------------------------------------------------------------------------------------------------SSP---F---------------------------------------------------------------------------------------------------------------------------------------------------D-LLTT---------VKTAIQAGSMVACA-TE--------------------------------------------------NGLTE--EAKVMENGLVSQHAYTVTGA----------EK------------------------------I----------------------------------QYQGRWEDIIRLWNP--WG--K-TEWKGRWKDGSK-EW------------------------------------- 183
184 WKRPQDL-----PG---G------PPHFI--LDD----ISRFDIQQG-GAADCWFLAA-LGSL--T-QNPQ---YRQKIL---M----------------V----Q-SFSH-Q-----YAGIFRFRFWQCG--QWVE----------------VVI---DDRLPVQ-------------------------G--DK--------C-LF--------V-------------------------------------------------------------------------------------------------RPR-------H-----------------QNQEFWPCLLEK-----------AYAKLL----G-SYSDLH-----YGFLEDALVDLTGGVITNI---------------HLH------------------------------------------------------------------------------------------------------------------------------------SSP---V---------------------------------------------------------------------------------------------------------------------------------------------------D-LVKA---------VKTATKAGSLITCA-TP--------------------------------------------------SGPTD--TAQAMENGLVSLHAYTVTGA----------EQ------------------------------I----------------------------------QYRRGWEEIISLWNPWGWG--E-AEWRGRWSDGSQ-EWEETCDPRKS--QL------H-KKRE-----DGEFWMS 184
185 --------------------------HFI--LEG----ASRFDIQQG-KAGDCWFLAA-LGSL--T-QNLQ---QLQKIL---M----------------D----Q-SFSH-Q-----YAGIFRFRFWQCG--QWVE----------------VVV---DDRLPVL-------------------------N--KE--------C-LF--------V-------------------------------------------------------------------------------------------------HPR-------K-----------------NNQEFWPCLLEK-----------AYAKFH----G-SYVNLH-----YGFLPDALVDLTGGVVTSI---------------NPN------------------------------------------------------------------------------------------------------------------------------------SIP---S---------------------------------------------------------------------------------------------------------------------------------------------------D-LVMM---------VKTAVKTGSLMACG-TL--------------------------------------------------ADPTG--EARRMENGLVTQHAYTVTGA----------ER------------------------------I----------------------------------QYGRGWEDLIRLWNP--WG--H-TEWIGRWSDRSP-EWQKIRSQHKR--LL------Y-KDKE-----DGEFWMS 185
186 WMRPKDI-----LE---G-KS---EPHFI--LEG----ASRFDIQQG-KAGDCWFLAA-LGSL--T-QNLQ---QLQKIL---M----------------D----Q-SFSH-Q-----YAGIFRFRFWQCG--QWVE----------------VVV---DDRLPVL-------------------------N--KE--------C-LF--------V-------------------------------------------------------------------------------------------------HPR-------K-----------------NNQEFWPCLLEK-----------AYAKFH----G-SYVNLH-----YGFLPDALVDLTGGVVTSI---------------NPN------------------------------------------------------------------------------------------------------------------------------------SIP---S---------------------------------------------------------------------------------------------------------------------------------------------------D-LVMM---------VKTAVKTGSLMACG-TL--------------------------------------------------AD-----VSERMENGLVTQHAYTVTGA----------ER------------------------------I----------------------------------QYGRGWEDLIRLWNP--WG--H-TEWIGRWSDRSP-EWQKIRSQHKR--LL------Y-KDKE-----DGEFWMS 186
187 WRRPKDI-----LE---G-KS---EPHFI--LEG----ASRFDIQQG-EAGDCWFLAA-LGSL--T-QNPQ---HLQKIL---M----------------D----Q-SFSC-H-----YAGIFRFRFWQCG--QWVE----------------VVV---DDRLPIL-------------------------N--RE--------Y-LF--------V-------------------------------------------------------------------------------------------------HPR-------N-----------------NNQEFWPCLLEK-----------AYAKFH----G-SYLNLH-----YGFLPDALVDLTGGVVTGI---------------DLH------------------------------------------------------------------------------------------------------------------------------------SFP---S---------------------------------------------------------------------------------------------------------------------------------------------------D-LVMI---------LKTAAKAGSLVTCG-TP--------------------------------------------------ASPTG--EARRMEDGLVSQHAYTVTGA----------ER------------------------------I----------------------------------QYRGSWEDLICLWNP--WG--N-TEWRGRWADGSP-EWQETHHQWRR--LL------Y-ENKD-----DGEFWMS 187
188 WKRPKDL-----SK---G-IS---EPHFI--LEG----ASRFDIQQG-QAGDCWFLAA-LGSL--T-QNPQ---HLQRIL---M----------------D----Q-SFSH-P-----YAGIFRFRFWQCG--QWVE----------------VVI---DDRLPVL-------------------------N--KD--------Y-LF--------V-------------------------------------------------------------------------------------------------HPR-------------------------KNQEFWPCLLEK-----------AYAKFR----G-SYLHLH-----YGHLPDAMVDLTGGVITTV---------------NLH------------------------------------------------------------------------------------------------------------------------------------SSP---S---------------------------------------------------------------------------------------------------------------------------------------------------D-LVMM---------VKMAAKAGSLMTCA-TP--------------------------------------------------AGPTG--EATRMPNGLVSQHAYTVTSA----------ER------------------------------I----------------------------------WYRNGWEDLIHLWNP--WG--N-TEWRGRWSDGSL-EWQEIHNQQKS--QL------FEEDKN-----DGEFWMS 188
189 -------------------KS---EPLFI--LEG----ASRFDIQQG-EAGDCWFLAA-LGAL--T-QSPQ---YLQKIL---I----------------D----Q-SFSY-Q-----YAGIFHFRFWRCG--QWVE----------------VVI---DDRLPVL-------------------------N--NE--------Y-LF--------V-------------------------------------------------------------------------------------------------KPR-------------------------NKREFWPCLLEK-----------AYAKFH----G-SYANLH-----YGYLPDALVDLTGGVVTNI---------------SLH------------------------------------------------------------------------------------------------------------------------------------SSS---S---------------------------------------------------------------------------------------------------------------------------------------------------D-LMTM---------VKTAAEAGSLMTCS-TL--------------------------------------------------AGPTS--ESVTMANGLVSRHAYTVTGA----------EQ------------------------------I----------------------------------EYRRSWEYLIRLWNP--WG--K-IEWRGRWSDWSP-EWQETHDQRKS--QL------Y-EDKD-----NGEFWMS 189
190 WMRPKDL-----LK---G-KS---EPLFI--LEG----ASRFDIQQG-EAGDCWFLAA-LGAL--T-QSPQ---YLQKIL---I----------------D----Q-SFSY-Q-----DAGIFHFRFWRCG--QWVE----------------VVI---DDRLPVL-------------------------N--NE--------Y-LF--------V-------------------------------------------------------------------------------------------------KPR-------------------------NKREFWPCLLEK-----------AYAKFH----G-SYANLH-----YGYLPDALVDLTGGVVTNI---------------SLH------------------------------------------------------------------------------------------------------------------------------------SSS---S---------------------------------------------------------------------------------------------------------------------------------------------------D-LMTM---------VKTAAEAGSLMTCS-TL--------------------------------------------------AGPTS--ESVTMANGLVSRHAYTVTGA----------EQ------------------------------I----------------------------------EYRRSWEYLIRLWNP--WG--K-IEWRGRWSDWSP-EWQETHDQRKS--QL------Y-EDKD-----NGEFWMS 190
191 WKRPKEI-----SD---S-------PSLL--VDG----ISRDDVVQG-ILGDCWFLSS-CASI--A-QHKR---FMEKVVP--T----------------D----Q-YLW----SSGKYCGLFHFRFWRFG--KWVD----------------VII---DDRIPVR-------------------------R--DQ--------V-IF--------A-------------------------------------------------------------------------------------------------KSS-------N-----------------S-KEFWVSLLEK-----------AYAKLH----G-SYEGLA-----GGQASDALIDMTGGLTERC---------------DL-------------------------------------------------------------------------------------------------------------------------------------KEP---R---------------------------------------------------------------------------------------------------------------------------------------------------AGLFRQ---------LLRNFKYGSFLTCN-KK--------------------------------------------GDWRAADEA--------DEHGLVSGHAYTVTSV----------RR------------------------------V---------QTR---------HG-----------DYVN----LLRVRNP--WGN-A-TEWNGNWSDESA-TWDLVSDEVKG--QL------ELKDKD-----DGEF--- 191
192 WKRPQEI-----MG-VTQ-------PRLL--VDG----ISRDDVIQG-MLGDCWFLVS-LAAI--C-RDSA---LMEKVVP--R----------------D----Q-YMWQEGEGEGSYVGMFHFKFWRYG--KWVD----------------TIV---DDMLPTM-------------------------A--GQ--------QPMY--------C-------------------------------------------------------------------------------------------------RSS-------D-----------------P-NEFWSALVEK-----------AYAKLR----G-SYEALN-----GGQAIDALEDLTGGMAESY---------------DL-------------------------------------------------------------------------------------------------------------------------------------KKA---P---------------------------------------------------------------------------------------------------------------------------------------------------GNLYQI---------MRRAFKKRAFFTTS-KK-------------------------------------------------TTQALT--QHGVTAQGLVGGHAYSITSV----------HI------------------------------V---------HSN---------FG-----------DF-P----LVRIRNP--WGD-G-TEWTGDWSDSSP-LWNRVPQHERD--RI------GFTDKD-----DGEFWM- 192
193 WKRPVDL-----VEEWQT-------PQLM--VDG----VTRDDIKQG-TLGDCWFLSA-CAAV--S-QKKE---FMKKIVP--S----------------D----Q-PLC----GPG-YKGVVHFRFWRFG--DWVD----------------VYI---DDLLPTV-------------------------N--GK--------L-VY--------G-------------------------------------------------------------------------------------------------RCT-------E-----------------P-QEFWVALIEK-----------AYAKLH----G-SYEAIE-----GGQSMDALVDLTGGIPRLY---------------EI-------------------------------------------------------------------------------------------------------------------------------------QDK---D---------------------------------------------------------------------------------------------------------------------------------------------------PFLYRM---------IEKAQQKGAFITCS-RK--------------------------------------------GNWKLSTKA--------DPNGLVSGHAYTVTEV----------RK------------------------------I---------KHV---------RG-----------ED-K----LVRIRNP--WGD-N-NEWKGSWSDSDV-NWTWVDDQTKK--EI------GLQAKD-----DGEFWMS 193
194 WKRPSQL-----VPEGKS-------PHML--VDG----ISRDDIKQG-VLGDCWFLSS-CAAV--S-QQEK---FMRKIIP--D----------------D----Q-PLC----GSA-YKGCVHFCFWRFG--SWVD----------------VVI---DDRLPVK-------------------------E--GE--------L-IY--------G-------------------------------------------------------------------------------------------------RCE-------D-----------------P-TEFWVALVEK-----------AYAKLH----G-SYEAIE-----GGQTMDALVDLTGGLAERY---------------EV-------------------------------------------------------------------------------------------------------------------------------------KGA---D---------------------------------------------------------------------------------------------------------------------------------------------------PNMYRY---------LLRAHKAGSFVACS-RK--------------------------------------------GDWRKATKA--------EANGLVSGHAYTITRV----------MR------------------------------I---------SHR---------MG-----------EE-R----LLRIRNP--WGN-E-TEWKGSWSDDDS-NWQWVDDDTKR--YM------EMTHRD-----DGEFWMS 194
195 WKRPFEL-----VF---N-------PRLG--VDG----FSRQDGVQG-NLGDCWFLAS-LSAI--A-KMPA---LIQKIIP--S----------------D----Q-SFT------DGYSGMFRFRFWRFG--RWIT----------------VVI---DDRLPVS-------------------------H--QG--------RRVF--------A-------------------------------------------------------------------------------------------------SSS-------D-----------------P-NEFWPSLVEK-----------AYAKLH----G-SYSGLS-----GGMAADAFVDLTGGLAEVY---------------DLT------------------------------------------------------------------------------------------------------------------------------------TEN---P---------------------------------------------------------------------------------------------------------------------------------------------------DDVYGI---------LYRGTRSGAFMCCS-RK--------------------------------------------GNWR-ANET--------NNLGIVTGHSYALNRV----------QT------------------------------G---------VLK---------DG-----------SKVR----LVKVRNP--WAN-S-TEWKGKWSDSSK-LWN----NLKN--KA------EFEEDEERSLSDGEFWMS 195
196 WKRPMDL-----SP---N-------PRLL--KNG----QSSEDIIQG-MLGNCWWLAS-SAAI--C-RSSK---HIQKVVP--G----------------D----Q-VMT----GPD-YVGMFHFRFWRFG--QWVD----------------VIV---DDNLPTL-------------------------R--GS--------L-CF--------G-------------------------------------------------------------------------------------------------RSA-------N-----------------P-DEFWLPLMEK-----------AYAKVH----G-SYQATE-----GGFTQDGMEDLTGGIAVTY---------------DLG------------------------------------------------------------------------------------------------------------------------------------SKT---P---------------------------------------------------------------------------------------------------------------------------------------------------SNLFRI---------MTKALRNDSFVCGG-IQ--------------------------------------------G----TTESVD------STTGLVSAHAYSVLKV----------AK------------------------------V---------NYR----------G-----------DTVK----LVKLRNP--WGG-K-NEWKGDWSDDSF-TWHYIPDDVKY--SM------GYENRD-----NGEWWM- 196
197 --RVQEF-----LD---H-------PVLF--AGG----TTRFDIEQG-GAGTCWFLSI-LSSL--A-DKPE---VLKQVC---N----------------H----SYNIGRED-----YDGVFHCRFWKFG--QWID----------------VYC---DDYLPVK----------------------------------------QWGDGFVPWGA-------------------------------------------------------------------------------------------------RS--------T-----------------NRNEVWVSLIEK-----------AFARFN----G-GYPQVY-----GGWAGDAFATMTGGVAERV---------------ESK------------D----------------------------------------------------------------------------------------------------------------------ITAP--------------------------------------------------------------------------------------------------------------------------------------------------------ALFAR---------MKNALNSGAVIACS-CP-------------------------------------------------------VGDAIDGQMGLVGDHAYTITGA----------IM------------------------------I----------------------------------EYRGSVKAMIRIRNP--WGSRK-GEWLGDWSDSSV-LWDEVTDDVKT--KM------KVSERQ-----DGEFWMA 197
198 WMRPVEF-----LD---H-------PVLF--ADG----TTRFDIEQG-GAGTCWFLSI-LSSL--A-DKPE---VLKQIIP--E----------------D----SYNIGRED-----YDGVFHCRFWKFG--QWID----------------VYC---DDYLPVK----------------------------------------QWGDGFVPWGA-------------------------------------------------------------------------------------------------RS--------T-----------------NRNEVWVSLMEK-----------AFARFN----G-GYPQVY-----GGWAGDAFVAMTGGVAERV---------------ESK------------D----------------------------------------------------------------------------------------------------------------------ITAP--------------------------------------------------------------------------------------------------------------------------------------------------------ALFAR---------VKNALNSGAVIACS-CP---------------------------------------------------------DAMDGQMGLVGGHAYTITGA----------IK------------------------------I----------------------------------EYQGSAKAMIRVRNP--WGVGK-GEWLGDWSDSSA-LWDEVTDDVKT--KM------KVSERQ-----DGEFWMT 198
199 -----EF-----CQ---Q-------PTLF--SDG----TTRFDVEQG-GAGTCWFLSI-LSSL--A-DNGE---AIKQIIP--D----------------D----AYPIGSDK-----YSGLFHCKLWRFG--QWVD----------------VYV---DDLLPVK----------------------------------------LYGSEFKLWGA-------------------------------------------------------------------------------------------------KS--------T-----------------DDREMWVSLMEK-----------AFARFK----G-GYANVY-----GGLPGDAFTTLTGGVAELV---------------EIQ------------D----------------------------------------------------------------------------------------------------------------------TDAA--------------------------------------------------------------------------------------------------------------------------------------------------------TLYSR---------MKNALSCGSIITCS-CP-----------------------------------------------------------VNGIKGLVGNHAYTITGT----------FR------------------------------I----------------------------------NHRAQSKMLLRLRNP--WGT-K-GEWKGDWSDKSY-LWNDVTDSVKE--KM------KVNKKM-----DGEFWMT 199
200 WKRPKEF-----AE---K-------PCLF--SEG----TSRYDIGQG-SIGTCWFLAS-VANI--A-DKPK---LLRRIIP--R----------------D----SYPVEPQN-----YDGIFHCRFWRFG--IWDD----------------VFI---DDYLPI-----------------------------------------IYKKQI--YSA-------------------------------------------------------------------------------------------------HSV-------T-----------------DPNEMWVSLLEK-----------AFARMY----G-SYTEVS-----GGVSSDSYMALTGGVPEDF---------------DLRK----------LD----------------------------------------------------------------------------------------------------------------------MEPD--------------------------------------------------------------------------------------------------------------------------------------------------------QLHTR---------VRNALYSNAAVTCG-TP---------------------------------------------------------GTFVKKYGLLGSHEYTINGA----------VT--------------------------------------------------------------------AKGVRLFRLRNP--WG--K-TEWIGPYSDGSR-EW----QSIQG--II------KGPNKD-----DGEFYIS 200
201 WKRPPEF-----AS---S-------PCLF--SEG----TTRYDIGQG-SIGTCWFLSS-VANV--A-DKPK---LLRRIIP--S----------------D----SYPVGSPK-----YDGIFHCRFWRFG--IWDD----------------VFI---DDCLPI-----------------------------------------IYGNQI--YSA-------------------------------------------------------------------------------------------------HSN-------T-----------------DPNEMWVALLEK-----------AFARMY----G-SYTDVS-----GGMASDSYMALTGGVPEDI---------------NLRE----------LN----------------------------------------------------------------------------------------------------------------------MEPD--------------------------------------------------------------------------------------------------------------------------------------------------------QLHTR---------VRNALSSGAAVTCS-VP---------------------------------------------------------GEFDGQHGLVGGHEYTLTGA----------VT--------------------------------------------------------------------ANGVRLFRVRNP--WG--N-TEWTGPYSDGSP-EW----QSIQS--II------EGPNKD-----DGEFYIS 201
202 WKRPNEI-----GDP----SL---KPKVWS--GG----IDPDDVAQG-RLGNCYYLAA-ISAC--S-IGSSDILLHDLCI---E----------------D---------------GMDQGMFGVKFFLNG--KWVT----------------VLI---DDRFPC------------------------VRR--GSLW-----YP-IF--------C-------------------------------------------------------------------------------------------------GFKDHSGQEVN-----------------T-KELWPLVFEK-----------AWAKLH----L-SYEATA-----GGLTADTTNYLTGGTVQSI---------------SLD-----------EP----------------------------------------------------------------------------------------------------------------------DKAWSIAF---------------------------------------------------------------------------------------------------------------------------------------------------AALYPD---------ESGKDNSCFL----------------------------------------------------SCSVRSDAP-GNPQSM---GLVDGHAYSVLKM----------AE--V------------------------A-------------------------A-----------G------RFVQIRNP--WG--E-FEWNGRYSDKSE-LW---TPELKS--QL-----DH-EDEE-----DGSFWM- 202
203 WLRPQEI-----CS---L-------PRLF--SDN----HYEWQVKQG-MLGDCWFLCA-CAAL--Q-KSKY---LLAKVIP--P----------------G----QPGWRDEK-----YRGCFTCRIWQFG--HWVE----------------VTI---DDRLPCL-------------------------G--GK--------L-CF--------S-------------------------------------------------------------------------------------------------QCQ-------M-----------------E-DVFWLPLLEK-----------AYAKVH----G-SYEQLW-----AGQVADALVDLTGGLAERW---------------TLKD----------PG----------------------------------------------------------------------------------------------------------------------RSTERERA---------------------------------------------------------------------------------------------------------------------------------------------------GKVLEK-----SVFRRLMNLKEKCVMSCS-VF---------------------------------------------------------SSRQGTSELGEFHAFIVVDM----------QD------------------------------L----------------------S-----------KVSRKDVILLRIRNP--WG--R-RCWKGPWREGGP-GWSQLDPVVAA--EL-------LSQIQ------------ 203
204 WLRPQDI-----CS---T-------PRLF--SNS----LQDVQVKQG-ILGDCWFLCA-CVAL--Q-KSKY---LLNKVFP--P----------------G----QPSWADEL-----YQGRFTCHVWQFG--HWVE----------------VTI---DDRLPCL-------------------------G--GK--------L-CF--------S-------------------------------------------------------------------------------------------------QCQ-------T-----------------E-DLFWLPLLEK-----------AYAKVH----G-SYEQLW-----AGQVADALVDLTGGIAERW---------------ALKD----------PA----------------------------------------------------------------------------------------------------------------------RNTGKEKS---------------------------------------------------------------------------------------------------------------------------------------------------GMVLKK-----EVFRRLMVLKEQCVISCS-VL---------------------------------------------------------NSRQGASELGEFHAFIVTDM----------LN------------------------------L----------------------S-----------EVSGKEIILLRIRNP--WG--R-RCWRGPWCEGGE-GWSQLDPVVAS--EL-------LSQIQ-----EGEFWVD 204
205 ------------------------------------------QVKQG-LLGDCWLLCA-CAAL--Q-KSRR---LLDQVIP--P----------------G----QPSWLDPT-----YRGSFTCRVWRFG--RWVE----------------VTI---DDRLPCL-------------------------A--GR--------L-CF--------S-------------------------------------------------------------------------------------------------RCQ-------R-----------------E-DVFWLPLLEK-----------VYAKVY----G-SYEHLW-----AGQVADALVDLTGGLAERW---------------SLKD----------LA----------------------------------------------------------------------------------------------------------------------RTGGRQDR---------------------------------------------------------------------------------------------------------------------------------------------------PGGSEH-----RTCRQLLSLKDRCLISCS-VL---------------------------------------------------------SPRAGARELGEFHAFIVSDL----------RE------------------------------L----------------------R-----------GQTGQAILLLRIQNP--WG--R-RCWQGPWREGGE-GWSRVDPADEA--TL-------LSQLQ-----EGEFWVE 205
206 WRRPQEI-----CA---T-------PRLF--ADN----PREGQVKQG-LLGDCWLLCA-CAAL--Q-KSRR---LLDQVIP--P----------------G----QPSWLDPT-----YRGSFTCRVWRFG--RWVE----------------VTI---DDRLPCL-------------------------A--GR--------L-CF--------S-------------------------------------------------------------------------------------------------RCQ-------R-----------------E-DVFWLPLLEK-----------VYAKVY----G-SYEHLW-----AGQVADALVDLTGGLAERW---------------SLKD----------LA----------------------------------------------------------------------------------------------------------------------RTGGRQDR---------------------------------------------------------------------------------------------------------------------------------------------------PGGSEH-----RTCRQLLSLKDRCLISCS-VL---------------------------------------------------------SPRAGARELGEFHAFIVSDL----------RE------------------------------L----------------------R-----------GQTGQAILLLRIQNP--WG--R-RCWQGPWREGGE-GWSRVDPADEA--TL------------------------ 206
207 WRRPQEI-----CA---T-------PRLF--ADN----PQEGQVKQG-LLGDCWLLCA-CAAL--Q-KSQY---LLDQVFP--P----------------G----QPSWCDQT-----YRGSFTCRVWQFG--RWVE----------------VTI---DDRLPCL-------------------------A--GR--------L-CF--------S-------------------------------------------------------------------------------------------------RCQ-------R-----------------E-DVFWLPLLEK-----------VYAKVY----G-SYEHLW-----AGQVADALVDLTGGLAERW---------------NLKD----------LA----------------------------------------------------------------------------------------------------------------------RTSGQQAG---------------------------------------------------------------------------------------------------------------------------------------------------PGGSEH-----RTCRQLLSLKDRCLISCS-VL---------------------------------------------------------SPRAGAREEAEFHAFVVSDV----------RE------------------------------L----------------------P-----------GRAGQSILLLRIQNP--WG--R-RCWQGPWREGGE-GWSRVDPTDGS--EL-------LSQLQ-----EGEFWV- 207
208 WRRPQEI-----CA---T-------PRLF--ADN----PQEGQVKQG-LLGDCWLLCA-CAAL--Q-KSQY---LLDQVFP--P----------------G----QPSWCDQT-----YRGSFTCRVWQFG--RWVE----------------VTI---DDRLPCL-------------------------A--GR--------L-CF--------S-------------------------------------------------------------------------------------------------RCQ-------R-----------------E-DVFWLPLLEK-----------VYAKVY----G-SYEHLW-----AGQVADALVDLTGGLAERW---------------NLKD----------LA----------------------------------------------------------------------------------------------------------------------RTSGQQAG---------------------------------------------------------------------------------------------------------------------------------------------------PGGSEH-----RTCRQLLSLKDRCLISCS-VL---------------------------------------------------------SPRAGAREEAEFHAFVVSDV----------RE------------------------------L----------------------P-----------GRAGQSILLLRIQNP--WG--R-RCWQGPWREGGE-GWSRVDPTDGS--EL-------LSQLQ-----EGEFWVE 208
209 WRRPQEI-----CA---A-------PRLF--PDN----PQEGQVKQG-LLGDCWFLCA-CAAL--Q-KSRH---LLDQVIP--P----------------G----QPGWLDQT-----YRGSFTCRIWQFG--RWVE----------------VTI---DDRLPCL-------------------------T--GR--------L-CF--------S-------------------------------------------------------------------------------------------------RCQ-------R-----------------E-DVFWLPLLEK-----------AYAKIY----G-SYEHLW-----AGQVADALVDLTGGLAERW---------------NLKD----------LV----------------------------------------------------------------------------------------------------------------------RTSDRQDR---------------------------------------------------------------------------------------------------------------------------------------------------PGGSEH-----RTCRQLLDLKDRCLISCS-VL---------------------------------------------------------SPRAGARELGEFHAFIVADL----------RE------------------------------L----------------------R-----------GRAGQSVLLLRIHNP--WG--R-RCWQGPWKEGGP-GWSQVDPADAT--EL-------LSQLQ-----EGEFWVE 209
210 WRRPQEI-----CA---T-------PRLF--PDD----PREGQVKQG-LLGDCWFLCA-CAAL--Q-KSRH---LLDQVIP--P----------------G----QPSWADQE-----YRGSFTCRIWQFG--RWVE----------------VTT---DDRLPCL-------------------------A--GR--------L-CF--------S-------------------------------------------------------------------------------------------------RCQ-------R-----------------E-DVFWLPLLEK-----------VYAKVH----G-SYEHLW-----AGQVADALVDLTGGLAERW---------------NLKG----------VA----------------------------------------------------------------------------------------------------------------------GSGGQQDR---------------------------------------------------------------------------------------------------------------------------------------------------PGRWEH-----RTCRQLLHLKDQCLISCC-VL---------------------------------------------------------SPRAGARELGEFHAFIVSDL----------RE------------------------------L----------------------Q-----------GQAGQCILLLRIQNP--WG--R-RCWQGLWREGGE-GWSQVDAAVAS--EL-------LSQLQ-----EGEFWVE 210
211 WRRPQEI-----CA---M-------PRLF--AGS----PQEGQVKQG-LLGDCWFLCA-CAAL--Q-KSRH---LLDQVFP--P----------------G----QPSWLDQT-----YRGSFTCRVWQFG--RWVE----------------VTV---DDRLPCL-------------------------A--GR--------L-CF--------S-------------------------------------------------------------------------------------------------RCQ-------R-----------------E-DVFWLPLLEK-----------VYAKVH----G-SYEQLW-----AGQVADALVDLTGGLAERW---------------NLKD----------VA----------------------------------------------------------------------------------------------------------------------GSSGQQDG---------------------------------------------------------------------------------------------------------------------------------------------------PRGAER-----RTCRQLLSLKDRCLLSCS-VL---------------------------------------------------------SPRTGTRELGEFHAFIVSDL----------RE------------------------------L----------------------Q-----------DLAGRSVLLLRIQNP--WG--R-RCWQGPWREGGE-GWSQVEPAAQA--EL-------LSQLQ-----DGEFWV- 211
212 WRRPQEI-----CA---M-------PRLF--AGS----PQEGQVKQG-LLGDCWFLCA-CAAL--Q-KSRH---LLDQVFP--P----------------G----QPSWLDQT-----YRGSFTCRVWQFG--RWVE----------------VTV---DDRLPCL-------------------------A--GR--------L-CF--------S-------------------------------------------------------------------------------------------------RCQ-------R-----------------E-DVFWLPLLEK-----------VYAKVH----G-SYEQLW-----AGQVADALVDLTGGLAERW---------------NLKD----------VA----------------------------------------------------------------------------------------------------------------------GSSGQQDG---------------------------------------------------------------------------------------------------------------------------------------------------PRGAER-----RTCRQLLSLKDRCLLSCS-VL---------------------------------------------------------SPRTGTRELGEFHAFIVSDL----------RE------------------------------L----------------------Q-----------DLAGRSVLLLRIQNP--WG--R-RCWQGPWREGGE-GWSQVEPAAQA--EL-------LSQLQ-----DGEFWVE 212
213 WRRPQEI-----CA---T-------PQLF--PDN----PWEGQVKQG-LLGDCWFLCA-CAAL--Q-KSQH---LLDQVFP--P----------------G----QPGWSDQK-----YQGFFTCRIWQFG--HWEE----------------VTI---DDRLPCL-------------------------A--GR--------L-CF--------S-------------------------------------------------------------------------------------------------RCQ-------R-----------------E-DVFWLPLLEK-----------AYAKVH----G-SYEHLW-----AGQVADALVDLTGSLAERW---------------SLKD----------VT----------------------------------------------------------------------------------------------------------------------KASGQQDR---------------------------------------------------------------------------------------------------------------------------------------------------PSGGEH-----RTCRQLLHLKDRCLISCS-VL---------------------------------------------------------SPRAGARELGEFHAFIISDL----------QE------------------------------L----------------------R-----------SQTGQGILLLRIHNP--WG--R-RCWQGLWREGGE-GWNQVEPAKES--EL-------LAQLQ-----EGEFWVE 213
214 ------------------------------------------HPKQG-ILGDCWLLCA-CSML--L-KNQH---LLDKVFP--P----------------E----QPLWGDSA-----YRGEFLFRFWQNG--HWIE----------------VRV---DDRLPCI-------------------------N--DN--------L-CF--------S-------------------------------------------------------------------------------------------------RCQ-------S-----------------P-RAFWVALLEK-----------AYAKLH----G-SYEHLW-----AGQVCEAMVDLSGAVAVRW---------------SIKD----------P------------------------------------------------------------------------------------------------------------------------ESPQQPN---------------------------------------------------------------------------------------------------------------------------------------------------DSQIQHALHGLSVSDLPLELKERCAISCC-VH---------------------------------------------------------SATTGFPELGQFHAMCVMEW----------TS------------------------------V----------------------T-----------TITGEGVQLIRIRNP--WG--R-RSWAGVWRERGS-GWASLEASCAQ--TL-------LSRTA-----KGEFWMD 214
215 WLRPQEI-----CQ---Q-------PQLF--PDD----PLEAHPKQG-ILGDCWLLCA-CSML--L-KNQH---LLDKVFP--P----------------E----QPLWGDSA-----YRGEFLFRFWQNG--HWIE----------------VRV---DDRLPCI-------------------------N--DN--------L-CF--------S-------------------------------------------------------------------------------------------------RCQ-------S-----------------P-RAFWVALLEK-----------AYAKLH----G-SYEHLW-----AGQVCEAMVDLSGAVAVRW---------------SIKD----------P------------------------------------------------------------------------------------------------------------------------ESPQQPN---------------------------------------------------------------------------------------------------------------------------------------------------DSQIQHALHGLSVSDLPLELKERCAISCC-VH---------------------------------------------------------SATTGFPELGQFHAMCVMEW----------TS------------------------------V----------------------T-----------TITGEGVQLIRIRNP--WG--R-RSWAGVWRERGS-GWASLEASCAQ--TL-------LSRTA-----KGEFWMD 215
216 WMRPSDI-----AKEISI-SS---QPCLFS--GS----VNSSDVCQG-RLGDCWFLSA-VAVL--T-EMSR---ISEVII--TP----------------T---------------YNEEGIYTIRFCIQG--EWVA----------------VVV---DDWIPC------------------------ESP--GK--------P-AF--------A-------------------------------------------------------------------------------------------------TSR-------K-----------------Q-NELWVSILEK-----------AYAKLH----G-SYEALE-----GGLVQDALVDLTGGAGEEI---------------DMR-----------SP----------------------------------------------------------------------------------------------------------------------QAQIDLAS---------------------------------------------------------------------------------------------------------------------------------------------------GRLWSQ---------LLHFNQEGFLLGAG------------------------------------------------SP---SGSD-AHISSS---GIVQGHAYSVLQV----------RE--V------------------------D-------------------------G-----------H------KLVQIRNP--WAN-E-VEWNGPWSDSSQ-EW---TERMKH--KL-----KHVPQSK-----NGVFWMS 216
217 WMRPSDI-----AKDISI-SC---QPCLFS--GS----VNSSDVCQG-RLGDCWFLSA-VAVL--T-EMSR---ISEVII--TP----------------E---------------YNDEGIYTVRFCIQG--EWVA----------------VVV---DDWIPC------------------------ESP--GK--------P-AF--------A-------------------------------------------------------------------------------------------------TSR-------K-----------------Q-NELWVSILEK-----------AYAKLH----G-SYEALE-----GGLVQDALVDLTGGAGEEI---------------DMR-----------SP----------------------------------------------------------------------------------------------------------------------QAQLDLAS---------------------------------------------------------------------------------------------------------------------------------------------------GRLWSQ---------LLHFKQEGFLLGAG------------------------------------------------SP---SGSD-AHISSS---GIVQGHAYSILQV----------RE--V------------------------D-------------------------G-----------H------KLIQIRNP--WAN-E-VEWNGPWSDSSP-EW---TERMKH--KL-----MHVPQSK-----NGVFWMS 217
218 WMRPDSI-----VKENGS-DS---RPCLFS--GD----ANPSDVCQG-RLGDCWFLSA-VAVL--T-EVSR---ISEVII--TP----------------E---------------YNEEGIYTVRFCIQG--EWVP----------------VVI---DDWIPC------------------------ESP--GK--------P-AF--------A-------------------------------------------------------------------------------------------------TSR-------K-----------------L-NELWVSMVEK-----------AYAKLH----G-SYEALE-----GGLVQDALVDLTGGAGEEI---------------DLR-----------SA----------------------------------------------------------------------------------------------------------------------QAQIDLAS---------------------------------------------------------------------------------------------------------------------------------------------------GRLWSQ---------LLRFKQEGFLLGAG------------------------------------------------SP---SGSD-VHVSSS---GIVQGHAYSVLQV----------RE--V------------------------D-------------------------G-----------H------RLVQIRNP--WAN-E-VEWNGPWSDSSP-EW---TDRMKH--KL-----KHVPQSK-----EGIFWMS 218
219 -------------------AS---NAKLFA--DG----VSSGDVIQG-NLGDCWFLSA-LSVV--A-TRSD---LLEQTFWRRD----------------E---------------HKSKGLFVCKFMKNF--VWNY----------------VLI---DDRLPVFGF-------------------TDKKP--GK--------P-YF--------A-------------------------------------------------------------------------------------------------RCR-------N-----------------P-DELWVSLLEK-----------AYAKLH----G-SYEALI-----GGFVDCALNDLTGMCAEQI---------------ILKEGFPGFGENPYSP----------------------------------------------------------------------------------------------------------------------AKPLQKHG---------------------------------------------------------------------------------------------------------------------------------------------------DPFWEK---------ISRYKNSGTLMGCS-----------------------------------------------IQPPVTSSKE-VAVESSAGNGLYFKHAYALVDA----------AE--I------------------------K-------------------------T-----------AKGEIV-RLVKLRNP--WGM-G--EWTGPWSDSSD-E-------------------------------------- 219
220 WLRPSEF-----VPKLAHGRQ----PQLF--VDG----ANPSDVVQG-ALGDCWFLSA-LSCV--A-SRRD---LLRNLFA--S----------------TEYGSQ--------------GIYTIRFYKNG--RWKY----------------VSI---DDRIPC--------------------------SPSGE--------P-LY--------A-------------------------------------------------------------------------------------------------RCK-------------------------DVCEIWVMLIEK-----------AYAKMH----GRCYRNLE-----TGAMTYALKDLTGGDPHLV---------------NLM---------------------------------------------------------------------------------------------------------------------------------DPQTRDECEN---------------------------------------------------------------------------------------------------------------------------------------------------GFLWQK---------LKLWMKQNSLCGCS----------------------------------------------------YSVSKGEARHQESDGGILKGHAYSIVDL----------KE------------------------------Y----------------------------------RDLR----FLQVRNP--WG--R-KEWTGRWADFAP-EWEKLRERYP----------------------DAPDWM- 220
221 WFRPEEF-----VPADQK-------PILF--AAS----GAMSNVKQG-MLKNCHFLGA-LSVI--A-CRPD---MVEQIFGPLK----------------Q------VDPNVSHSYLLDRGIITVQLYKDC--AWHD----------------VTV---DTRIPCVIDPSS--------------------G--GF--------VPAF--------G-------------------------------------------------------------------------------------------------RCV-------------------------SPAQVWVQLLEK-----------AYAKLH----G-SYAAIE-----TGKISEALADLTGGVTETI---------------DTK---------------------------------------------------------------------------------------------------------------------------------GREGLERIKT---------------------------------------------------------------------------------------------------------------------------------------------------GSLWRQ---------LQEAKSEGHLLACS-----------------------------------------------------LSIRNAQPEAQGPCGLLVNHGYAILDV----------ET------------------------------I------------------------------------PDNGFRLVKVRNP--WGTNS-GVWDGDWGEDSA-LWSIYPEVSKHLGRM----------QE-----PGVFWMS 221
222 ------------------------PSFVLVTDFG----FSAQDLQQG-GIGDCWFLSA-LAVV--A-ERHD---LIAKLF-YDT----------------A---------------PNANGCYMIRLFLDG--SWQT----------------ILV---DDQLPCTRS------------------PRRPEH--ALET-----NL-AF--------S-------------------------------------------------------------------------------------------------R-G-------Q-----------------N-CQLWVSLLEK-----------AYAKAH----G-SYRAIS-----GGEIAEALLDLTGAPTLTI---------------NFDS----------PD---------------------------------------------------------------------------------------------------------------------------FSM---------------------------------------------------------------------------------------------------------------------------------------------------EHLWDQ---------LLYFKSQGFPMGCA-----------------------------------------------TGGD-------AELKEV---GLCGNHAYSILEC----------RE--V-----------------PDRRGRD------------------------------------------GMVRLVRIRNP--HG--V-GEWNGDWSDASE-KW---SGMICE--GL-----ERTGVND------GTFWM- 222
223 -----------------------------------------SQVRQG-AVGNCWFLSA-LAVV--A-EKSY---LVRQLL-PHD----------------K---------------LNPQGCYEVNLCLDG--AWTP----------------VRV---DSTLPVVLQDVNKTTGGSLLQSLRHGVPLNSCK--ELVA-----TP-AF--------C-------------------------------------------------------------------------------------------------S-A-------P-----------------D-LQLWPALVEK-----------AYAKAH----G-SYAQLS-----GGFIAEGLTDLTGAPTETI---------------IF-S----------DL---------------------------------------------------------------------------------------------------------------------------IDL---------------------------------------------------------------------------------------------------------------------------------------------------DELWAR---------LLSFHQAGFLVGVA-----------------------------------------------TSRG-------GE-------GLVGGHAYSLLDV----------IE--INNSLIGEQKKVTDYFSSPSKKHRKLTGP----------------------N-----------YDTCAPIRLVRIRNP--WG--K-REWKGDWSVDSE-RW---TRALRKKIGS-----DAFARGD------GTFFMS 223
224 WRRPNEI-----LCEGGN-QS---TAPQWAVFRT----PLPSDICQG-VLGNCWLLSA-LAVL--A-ERED---LVKEVL-LTK----------------E---------------ICPQGAYQVKLCKDG--RWTT----------------VLV---DDLLPC------------------------DKR--GH--------L-VY--------S-------------------------------------------------------------------------------------------------Q-A-------K-----------------R-KQLWVPLIEK-----------AVAKIH----G-CYEALV-----SGRAIEGLATLTGAPCESI---------------PLQA----------SS-----------------------LPLPS------------------------------------------------------------------------------------------EDD--LDR---------------------------------------------------------------------------------------------------------------------------------------------------DLIWAQ---------LLSSRLVKFLMGAS-----------------------------------------------CGGGNMKVDE-DEYQRK---GLRPRHAYSVLDV----------RD--I------------------------K-------------------------G-----------H------RLLKLRNP--WG--H-FSWQGDWSDDSE-LW---TDELRD--SL-----MPHGGSE------GVFWIS 224
225 WRRPHEI-----NCDGG-------AYPPWAVFRT----PLPSDICQG-VLGNCWLLSA-LAVL--A-ERED---LVKEVL-VTK----------------E---------------ICGQGAYQVRLCKDG--KWTT----------------VLV---DDLLPC------------------------DKR--GH--------L-VY--------S-------------------------------------------------------------------------------------------------Q-A-------K-----------------R-KQLWVPLIEK-----------AVAKIH----G-CYEALV-----SGRAIEGLATLTGAPCESI---------------PLQA----------SS-----------------------LPMPS------------------------------------------------------------------------------------------EDE--LDK---------------------------------------------------------------------------------------------------------------------------------------------------DLIWAQ---------LLSSRCVRFLMGAS-----------------------------------------------CGGGNMKVDE-EEYQQK---GLRPRHAYSVLDV----------KD--I------------------------Q-------------------------G-----------H------RLLKLRNP--WG--H-YSWRGDWSDDSS-LW---TDDLRD--AL-----MPHGASE------GVFWIS 225
226 WLRPSQI-----VSSAA-------SHVKWAVFRT----PLPSDISQG-ILGDCWLLSA-LAVL--A-ERDE---LVQNVM-VTR----------------E---------------VCNEGAYQIRLCKDG--MWRT----------------VLV---DDLLPC------------------------DQR--GH--------L-LY--------S-------------------------------------------------------------------------------------------------Q-A-------K-----------------R-KQLWVPLIEK-----------AMAKIH----G-GYGALV-----SGRSIEGLASLTGAPCESI---------------SLQP----------ST-----------------------NGSNR------------------------------------------------------------------------------------------EEAEVLDE---------------------------------------------------------------------------------------------------------------------------------------------------DLIWAR---------LLSSRTAGFLMGAS-----------------------------------------------CGGGTMKIDE-EEYRQK---GLRPRHAYSLLDV----------LD--F------------------------SSKG----------------------G-----------P------RLLRMRNP--WG--H-FSWRGDWADDSK-LW---NPELRA--IC-----MPHGDVE------GVFWIS 226
227 WLRPHQI-----T-DLS--QD---RGTKWVVFRT----PRPSDISQG-ILGNCWFLSA-LAVL--A-ERPE---LVERVM-ITR----------------E---------------ICPEGAYQVRLCKDG--EWMT----------------VLV---DDLLPC------------------------DHR--GF--------L-VY--------S-------------------------------------------------------------------------------------------------Q-A-------K-----------------R-RQLWVPLIEK-----------ALAKLH----G-CYEALI-----SGRSIEGLSTLTGAPCESV---------------QLHR----------AQ-----------------------TNNPD------------------------------------------------------------------------------------------EDP--VEP---------------------------------------------------------------------------------------------------------------------------------------------------DLIWAR---------LLSSKEAGFLMGAS-----------------------------------------------CGGGNMKVDD-AEYESK---GLRPRHAYSVLDV----------QD--V------------------------N-------------------------G-----------S------RLLRMRNP--WG--R-FSWKGDWSDSSP-LW---TPEMRD--RL-----LAHGASE------GVFWM- 227
228 WLRPTEI-----SCSTR--SE---MKTPWAVFRT----PFPSDISQG-ILGNCWFLSA-LSVL--A-ERPD---LIEKVL-ITK----------------E---------------YTPEGAYQLRLCKDG--IWQT----------------VLI---DDLFPC------------------------DQN--GF--------L-VY--------S-------------------------------------------------------------------------------------------------Q-A-------K-----------------R-RQLWVPLIEK-----------AMAKMH----G-CYEALV-----SGRCIEGLATLTGSPCESL---------------PLHS----------SS-----------------------L-NAN------------------------------------------------------------------------------------------DPV--VDK---------------------------------------------------------------------------------------------------------------------------------------------------DLIWAK---------LLSSKEAGFLMGAS-----------------------------------------------CGGGNMKVNN-KDYHDI---GLRPRHAYSVLDV----------QDILV------------------------C-------------------------G-----------H------RLIRLRNP--WG--T-YSWKGDWSDESP-LW---TPDLRD--AL-----MVHGAAE------GVFWMS 228
229 ------------NCNIF--KD---RSVKWSVFRT----PRPSDILQG-LLGNCWFLSA-LAVL--A-ERPE---LVERVM-ITR----------------T---------------LCPEGAYQVRLCKDG--TWTT----------------VLV---DDMLPC------------------------DEC--GY--------L-LF--------S-------------------------------------------------------------------------------------------------Q-A-------Q-----------------R-KQLWVALIEK-----------ALAKLH----G-SYFALQ-----AGRAIEGLATLTGAPCESL---------------MLQV----------SS-----------------------T-NPR------------------------------------------------------------------------------------------EEP--IDT---------------------------------------------------------------------------------------------------------------------------------------------------DLIWAK---------MLSSKEAGFLMGAS-----------------------------------------------CGGGNMKVDD-VAYESM---GLRPRHAYSILDV----------RD--V------------------------Q-------------------------G-----------F------RLLRLRNP--WG--R-FSWNGSWSDEWP-HW---PAPLRH--DL-----MPHGSSE------GVFWME 229
230 --------------------------------RT----PRPSDILQG-LLGNCWFLSA-LAVL--A-ERPE---LVERVM-ITR----------------T---------------LCPEGAYQVRLCKDG--TWTT----------------VLV---DDMLPC------------------------DEC--GY--------L-LF--------S-------------------------------------------------------------------------------------------------Q-A-------Q-----------------R-KQLWVALIEK-----------ALAKLH----G-SYFALQ-----AGRAIEGLATLTGAPCESL---------------MLQV----------SS-----------------------T-NPR------------------------------------------------------------------------------------------EEP--IDT---------------------------------------------------------------------------------------------------------------------------------------------------DLIWAK---------MLSSKEAGFLMGAS-----------------------------------------------CGGGNMKVDD-VAYESM---GLRPRHAYSILDV----------RD--V------------------------Q-------------------------G-----------F------RLLRLRNP--WG--R-FSWNGSWSDEWP-HW---PAPLRH--DL-----MPHGSSE------GVFWM- 230
231 WLRPHEI-----NCNIF--KD---RSVKWSVFRT----PRPSDILQG-LLGNCWFLSA-LAVL--A-ERPE---LVERVM-ITR----------------T---------------LCPEGAYQVRLCKDG--TWTT----------------VLV---DDMLPC------------------------DEC--GY--------L-LF--------S-------------------------------------------------------------------------------------------------Q-A-------Q-----------------R-KQLWVALIEK-----------ALAKLH----G-SYFALQ-----AGRAIEGLATLTGAPCESL---------------MLQV----------SS-----------------------T-NPR------------------------------------------------------------------------------------------EEP--IDT---------------------------------------------------------------------------------------------------------------------------------------------------DLIWAK---------MLSSKEAGFLMGAS-----------------------------------------------CGGGNMKVDD-VAYESM---GLRPRHAYSILDV----------RD--V------------------------Q-------------------------G-----------F------RLLRLRNP--WG--R-FSWNGSWSDEWP-HW---PAPLRH--DL-----MPHGSSE------GVFWME 231
232 -----------------------------------------SDILQG-LLGNCWFLSA-LAVL--A-ERPE---LVERVM-ITR----------------T---------------ICPEGAYQVRLCKDG--TWTT----------------VLV---DDMLPC------------------------DEF--GY--------L-LF--------S-------------------------------------------------------------------------------------------------Q-A-------Q-----------------R-KQLWVALIEK-----------ALAKLH----G-SYFALQ-----AGRAIEGLATLTGAPCESL---------------MLQV----------SS-----------------------T-NPR------------------------------------------------------------------------------------------EEP--IDT---------------------------------------------------------------------------------------------------------------------------------------------------DLIWAK---------MLSSKEAGFLMGAS-----------------------------------------------CGGGNMKVDD-AAYESM---GLRPRHAYSILDV----------RD--V------------------------Q-------------------------G-----------C------RLLRLRNP--WG--R-FSWNGSWSDEWS-HW---PTALRH--EL-----MPHGSSE------GVFWM- 232
233 WLRPHEI-----NCNNF--KD---RGVKWSVFRT----PRPSDILQG-LLGNCWFLSA-LAVL--A-ERPE---LVERVM-ITR----------------S---------------ICQEGAYQVRLCKDG--MWTT----------------VLV---DDMLPC------------------------DEY--GF--------L-LF--------S-------------------------------------------------------------------------------------------------Q-A-------Q-----------------R-RQLWVALIEK-----------ALAKLH----G-SYFALQ-----AGRAIEGLATLTGAPCESL---------------MLQV----------SS-----------------------T-NPR------------------------------------------------------------------------------------------EEP--IDT---------------------------------------------------------------------------------------------------------------------------------------------------DLIWAK---------MLSSKEAGFLMGAS-----------------------------------------------CGGGNMKVDD-AVYESL---GLRPRHAYSILDV----------RD--V------------------------Q-------------------------G-----------Y------RLLRLRNP--WG--R-FSWNGSWSDEWS-DW---PQHLRH--EL-----MAHGSSE------GVFWME 233
234 WLRPHEI-----NCSVS--RD---HNASWSVFHT----LRPSDILQG-LLGNCWFLSA-LAVL--A-ERPD---LVERVM-VTR----------------S---------------LCAEGAYQVRLCKDG--TWTT----------------VLV---DDMLPC------------------------DEA--GF--------L-LF--------S-------------------------------------------------------------------------------------------------Q-A-------Q-----------------R-KQLWVALIEK-----------ALAKLH----G-SYFALQ-----AGRAIEGLATLTGAPCESL---------------ALQV----------SS-----------------------T-NPR------------------------------------------------------------------------------------------EEP--VDT---------------------------------------------------------------------------------------------------------------------------------------------------DLIWAK---------MLSSKEAGFLMGAS-----------------------------------------------CGGGNMKVDD-AAYESL---GLRPRHAYSILDV----------RD--V------------------------Q-------------------------G-----------S------RLLRLRNP--WG--R-FSWNGSWSDEWP-HW---PGHLRS--EL-----MPHGSSE------GVFWME 234
235 WLRPHEI-----NCSVS--RD---HNASWSVFHT----LRPSDILQG-LLGNCWFLSA-LAVL--A-ERPD---LVERVM-VTR----------------S---------------LCAEGAYQVRLCKDG--TWTT----------------VLV---DDMLPC------------------------DEA--GF--------L-LF--------S-------------------------------------------------------------------------------------------------Q-A-------Q-----------------R-KQLWVALIEK-----------ALAKLH----G-SYFALQ-----AGRAIEGLATLTGAPCESL---------------ALQV----------SS-----------------------T-NPR------------------------------------------------------------------------------------------EEP--VDT---------------------------------------------------------------------------------------------------------------------------------------------------DLIWAK---------MLSSKEAGFLMGAS-----------------------------------------------CGGGNMKVDD-AAYESL---GLRPRHAYSILDV----------RD--V------------------------Q-------------------------G-----------S------RLLRLRNP--WG--R-FSWNGSWSDEWP-HW---PGHLRS--EL-----MPHGSSE------GVFWM- 235
236 --------------------------------HT----LRPSDILQG-LLGNCWFLSA-LAVL--A-ERPD---LVERVM-VTR----------------S---------------LCAEGAYQVRLCKDG--TWTT----------------VLV---DDMLPC------------------------DEA--GF--------L-LF--------S-------------------------------------------------------------------------------------------------Q-A-------Q-----------------R-KQLWVALIEK-----------ALAKLH----G-SYFALQ-----AGRAIEGLATLTGAPCESL---------------ALQV----------SS-----------------------T-NPR------------------------------------------------------------------------------------------EEP--VDT---------------------------------------------------------------------------------------------------------------------------------------------------DLIWAK---------MLSSKEAGFLMGAS-----------------------------------------------CGGGNMKVDD-AAYESL---GLRPRHAYSILDV----------RD--V------------------------Q-------------------------G-----------S------RLLRLRNP--WG--R-FSWNGSWSDEWP-HW---PGHLRS--EL-----MPHGSSE------GVFWM- 236
237 WLRPHEI-----NCSVF--RD---HSTSWSVFHT----LRPSDILQG-LLGNCWFLSA-LAVL--A-ERPD---LVERVM-VTR----------------S---------------LCAEGAYQVRLCKDG--TWTT----------------VLV---DDMLPC------------------------DEA--GF--------L-LF--------S-------------------------------------------------------------------------------------------------Q-A-------Q-----------------R-KQLWVALIEK-----------ALAKLH----G-SYFALQ-----AGRAIEGLATLTGAPCESL---------------ALQV----------SS-----------------------T-NPR------------------------------------------------------------------------------------------EEP--VDT---------------------------------------------------------------------------------------------------------------------------------------------------DLIWAK---------MLSSKEAGFLMGAS-----------------------------------------------CGGGNMKVDD-AAYESL---GLRPRHAYSILDV----------RD--V------------------------Q-------------------------G-----------S------RLLRLRNP--WG--R-FSWNGSWSDEWP-HW---PGHLRS--EL-----MPHGSSE------GVFWME 237
238 WLRPHEI-----NCSVS--RD---HSASWSVFHT----LRPSDILQG-LLGNCWFLSA-LAVL--A-ERPD---LVERVM-VTR----------------S---------------LCAEGAYQVRLCKDG--TWTT----------------VLV---DDMLPC------------------------DEA--GF--------L-LF--------S-------------------------------------------------------------------------------------------------Q-A-------Q-----------------R-KQLWVALIEK-----------ALAKLH----G-SYFALQ-----AGRAIEGLATLTGAPCESL---------------ALQV----------SS-----------------------T-NPR------------------------------------------------------------------------------------------EEP--VDT---------------------------------------------------------------------------------------------------------------------------------------------------DLIWAK---------MLSSKEAGFLMGAS-----------------------------------------------CGGGNMKVDD-AAYESL---GLRPRHAYSILDV----------RD--V------------------------Q-------------------------G-----------C------RLLRLRNP--WG--R-FSWNGSWSDEWP-HW---PGHLRG--EL-----MPHGSNE------GVFWME 238
239 WLRPHEI-----NCSVF--RD---HGTPWSVFHT----LRPSDILQG-LLGNCWFLSA-LAVL--A-ERPD---LVERVM-VTR----------------S---------------LCAEGAYQVRLCKDG--TWTT----------------VLV---DDMLPC------------------------DEA--GF--------L-LF--------S-------------------------------------------------------------------------------------------------Q-A-------Q-----------------R-KQLWVALIEK-----------ALAKLH----G-SYFALQ-----AGRAIEGLATLTGAPCESL---------------ALQV----------SS-----------------------T-NPR------------------------------------------------------------------------------------------EEP--VDT---------------------------------------------------------------------------------------------------------------------------------------------------DLIWAK---------MLSSKEAGFLMGAS-----------------------------------------------CGGGNMKVDD-AAYESL---GLRPRHAYSVLDV----------RD--V------------------------Q-------------------------G-----------S------RLLRLRNP--WG--R-FSWNGSWSDEWP-HW---PGHLRA--EL-----MPHGSSE------GVFWME 239
240 WLRPHEI-----NCSVF--RD---HSVSWSVFHT----LRPSDILQG-LLGNCWFLSA-LAVL--A-ERPD---LVERVM-VTR----------------S---------------LCAEGAYQVRLCKDG--TWTT----------------VLV---DDMLPC------------------------DEA--GF--------L-LF--------S-------------------------------------------------------------------------------------------------Q-A-------Q-----------------R-KQLWVALIEK-----------ALAKLH----G-SYFALQ-----AGRAIEGLATLTGAPCESL---------------ALQV----------SS-----------------------T-NPR------------------------------------------------------------------------------------------EEP--VDT---------------------------------------------------------------------------------------------------------------------------------------------------DLIWAK---------MLSSKEAGFLMGAS-----------------------------------------------CGGGNMKVDD-AIYESL---GLRPRHAYSVLDV----------RD--V------------------------P-------------------------G-----------L------RLLRLRNP--WG--R-FSWNGSWSDEWP-HW---PEHLRG--EL-----MPHGSSE------GVFWM- 240
241 WLRPQEI-----NCSVF--RD---HRATWSVFHT----LRPSDILQG-LLGNCWFLSA-LAVL--A-ERPD---LVERVM-VTR----------------S---------------LCAEGAYQVRLCKDG--TWTT----------------VLV---DDMLPC------------------------DEA--GC--------L-LF--------S-------------------------------------------------------------------------------------------------Q-A-------Q-----------------R-KQLWVALIEK-----------ALAKLH----G-SYFALQ-----AGRAIEGLATLTGAPCESL---------------ALQL----------SS-----------------------T-NPR------------------------------------------------------------------------------------------EEP--VDT---------------------------------------------------------------------------------------------------------------------------------------------------DLIWAK---------MLSSKEAGFLMGAS-----------------------------------------------CGGGNMKVDD-SAYESL---GLRPRHAYSILDV----------RD--V------------------------Q-------------------------G-----------T------RLLRLRNP--WG--R-FSWNGSWSDEWP-HW---PGHLRG--EL-----MPHGSSE------GVFWM- 241
242 WLRPTEI-----AAPRH--GD---EKVKWAVCRT----PLPDDISQG-LLGNCWFLSA-LAVL--A-ERPE---LVESII-LTK----------------D---------------YCPQGAYQVRLCKDG--KWQI----------------VLI---DDLLPC------------------------DHH--KR--------L-VF--------S-------------------------------------------------------------------------------------------------Q-A-------K-----------------R-KQLWVPLIEK-----------AMAKLH----G-SYESLV-----AGKCLEGLATLTGAPCDNI---------------ELQP-------------------------------------GPQ------------------------------------------------------------------------------------------KEE--IDP---------------------------------------------------------------------------------------------------------------------------------------------------NLIWAK---------LLSCRESRFLMGAS-----------------------------------------------CGGGNMKTED-KVYEEK---GLRPRHAYSILDV----------KD--I------------------------D-------------------------G-----------N------RLLRLRNP--WG--R-FSWNGDWSDDSA-RWANISTRAKQ--DL-----MLYGHTS------GVFWMA 242
243 WLRPEKI-----SSMDR--SE---GSIRWTVSRN----PAPSDITQG-ILGNCWFLSA-LAVL--A-ERPE---LVEKVL-LTK----------------K---------------VNREGIYQVRLCKDG--QWQT----------------VLV---DDLLPC------------------------NSH--GL--------L-VY--------S-------------------------------------------------------------------------------------------------Q-A-------R-----------------R-RQLWVPLIEK-----------ALAKLH----G-CYEALI-----SGRCIEGLATLTGAPCETI---------------QLQG----------KT-----------------------S-----------------------------------------------------------------------------------------------ER--LDA---------------------------------------------------------------------------------------------------------------------------------------------------DLIWAR---------MLSSRESKYLMGAS-----------------------------------------------CGGGNMQTDD-DVYNEI---GLKARHAYSVLDI----------RS--V------------------------R-------------------------A-----------LSLTLFPRLVRLRNP--WG--R-FSWKRAWSDGSS-QWMEISQKERD--SL-----MPHGAEE------GVFWIS 243
244 WLRPSAV-----QLKAR--DD---SPLAWEVFRN----PKPSDISQG-LLGNCWFLSA-LSVL--A-GRAD---LLKRIM-ITH----------------E---------------VNPEGAYQVRLCRDG--IWDM----------------VLV---DDLLPC------------------------QEQ--GF--------L-VY--------S-------------------------------------------------------------------------------------------------K-A-------K-----------------R-KQLWVPLIEK-----------ALAKMS----G-CYEALT-----AGRCIEGLATLTGAPCESV---------------QLHA----------SGKFLSALSVLAERADLLKRIMITHEVNPEGAYQVRLCRDGIWDMVLVDDLLPCQEQGCLVYSKAKRKQLWVPLIEKALAKMSGCYEALTAGRCIEGLATLTGAPCESVQLHASGKYIVGRKP--ADP---------------------------------------------------------------------------------------------------------------------------------------------------DLVWAK---------LLSAKEAGYLMGAS-----------------------------------------------CGSGNMKIDP-QLYQDV---GLRPRHSYSVLDI----------QD--I------------------------C-------------------------G-----------K------RLIQLRNP--WG--H-FSWNGAWSDGSA-LW---TDIMKE--AL-----MAHGASE------GIFWMS 244
245 LRPQQIT-----FSSNDT-DW---RNREWSVFSN----PSPTDIKQG-VLGNCWFLSA-LAVL--A-ERPD---LLKRVM-VTK----------------N---------------YNKEGVYVVRLCKAG--VWQT----------------VFV---DDLLPC------------------------DEK--RR--------L-IY--------S-------------------------------------------------------------------------------------------------H-A-------R-----------------G-KQLWVPLVEK-----------ALAKLH----G-CYEALQ-----AGRSIEGLATLTGYPCESL---------------ALQQ----------SCP---------------------------------------------------------------------------------------------------------------------ETE--VEE---------------------------------------------------------------------------------------------------------------------------------------------------DMVWVK---------LLSSMEAGYLMGAS-----------------------------------------------CGGGNMDTND-EEYNQI---GLRPRHAYSVLRV----------TS-----------------------------------------------------E-----------YNIKFIFRLVQLRNP--WG--H-FSWKGDWSNESV-LWQQ-NPQLAN--QL-----FQRNADN------GTFWMC 245
246 -------------------------------FSN----PSPTDIKQG-VLGNCWFLSA-LAVL--A-ERPD---LLKRVM-VTK----------------N---------------YNKEGVYVVRLCKAG--VWQT----------------VFV---DDLLPC------------------------DEK--RR--------L-IY--------S-------------------------------------------------------------------------------------------------HVA-------R-----------------G-KQLWVPLVEK-----------ALAKLH----G-CYEALQ-----AGRSIEGLATLTGYPCESL---------------ALQQ----------SCP---------------------------------------------------------------------------------------------------------------------ETE--VEE---------------------------------------------------------------------------------------------------------------------------------------------------DMVWVK---------LLSSMEAGYLMGAS-----------------------------------------------CGGGNMDTND-EEYNQI---GLRPRHAYSVLRV----------T------------------------------------------------------------------YNIKFIFRLVQLRNP--WG--H-FSWKGDWSNESV-LWQQ-NPQLAN--QL-----FQRNADN------GTFWM- 246
247 --------------------W---RNREWSVFSN----PSPTDIKQG-VLGNCWFLSA-LAVL--A-ERPD---LLKRVM-VTK----------------N---------------YNKEGVYVVRLCKAG--VWQT----------------VFV---DDLLPC------------------------DEK--RR--------L-IY--------S-------------------------------------------------------------------------------------------------H-A-------R-----------------G-KQLWVPLVEK-----------ALAKLH----G-CYEALQ-----AGRSIEGLATLTGYPCESL---------------ALQQ----------SCP---------------------------------------------------------------------------------------------------------------------ETE--VEE---------------------------------------------------------------------------------------------------------------------------------------------------DMVWVK---------LLSSMEAGYLMGAS-----------------------------------------------CGGGNMDTND-EEYNQI---GLRPRHAYSVLRV----------TS-----------------------------------------------------E-----------YNIKFIFRLVQLRNP--WG--H-FSWKGDWSNESV-LWQQ-NPQLAN--QL-----FQRNADN------GTFWM- 247
248 WLRPKEI-----FR-----SN---TQTKWTMFRN----PRPSDILQG-TIGNCWFLSA-LAVV--C-ERPE---LLEKIM-VTR----------------E---------------ICDEGAYQIRICKNG--KWIV----------------VLV---DDLLPC------------------------DAN--GQ--------L-VF--------S-------------------------------------------------------------------------------------------------Q-A-------A-----------------R-NQLWVPIIEK-----------AVAKSV----G-CYEALV-----AGRCIEGLQLLTGCPCECI---------------LLSN----------H------------------------MDDAE------------------------------------------------------------------------------------------EDI--VDK---------------------------------------------------------------------------------------------------------------------------------------------------DLVWAK---------LLSSRNAGYLMGAS-----------------------------------------------CGGDITNQEAIDAYTKV---GLHAQHAYSVLDI----------QQ--F------------------------G-------------------------D-----------N------RLIRLRNP--WG--R-GSWTGRWSDSSF-LW---TNELRE--ML-----NAHGSEE------GVFWIS 248
249 WLRPSQM-----FTKDG-------RSFPWSVANN----PRPSDIEQGTLVGDCWLMSA-MALI--A-ERPD---VLDEII-PRK----------------Q---------------YSHYGVYQIRLCVEG--KWKV----------------VIV---DDFFPC------------------------YQH--TN--------S-IA--------M-------------------------------------------------------------------------------------------------AVG-------R-----------------R-NQLWVPLIEK-----------AMAKEL----G-SYSKLH-----GASLTQGLSMLTGASCVNY---------------NCPP----------VP----------------------------------------------------------------------------------------------------------------------INS--DDV---------------------------------------------------------------------------------------------------------------------------------------------------DTFWAL---------LVSSKESGFLMCCH-----------------------------------------------CGAFENAVAE-SEFRAM---GLLTNHAYSILDV----------VY--E------------------------H-------------------------G-----------H------RLLRIRNP--WG--Q-FVWKGKWSDGWP-GW---PVDLKQ--RL-----LNMRRDE-----TGAFWM- 249
250 WLRPSQM-----FTKDG-------RSSPWSVLNN----PRPSDIEQGTLVGDCWLMSA-MALI--A-ERPD---VLDDII-PKK----------------Q---------------YSHYGVYQIKLCVEG--KWEV----------------IIV---DDFFPC------------------------YSK--TN--------S-IA--------M-------------------------------------------------------------------------------------------------AVG-------R-----------------R-NQLWVPLIEK-----------AMAKVL----G-SYSKLH-----GASLAQGLSMLTGASCVNY---------------NCPP----------IP----------------------------------------------------------------------------------------------------------------------SSV--DDV---------------------------------------------------------------------------------------------------------------------------------------------------DTFWAQ---------LVSSKESGFLMCCH-----------------------------------------------CGAFENVVAE-AEFKAM---GLLTNHAYSILDV----------IY--E------------------------Q-------------------------G-----------Y------RLLRIRNP--WG--Q-FVWNGKWSDGWP-GW---PIGMKQ--KF-----LNQRKDE-----TGAFWM- 250
251 WLRPSQI-----RTKDG-------TSCAWSVFNN----PQPSDIEQGNLVGDCWLLSA-MALI--A-EKPE---VLDAII-PKK----------------Q---------------YSKHGVYQVKVCVEG--KWEV----------------IIV---DDFFPC------------------------YRN--TN--------S-IA--------I-------------------------------------------------------------------------------------------------AVG-------R-----------------R-NQLWVPLIEK-----------AMAKVL----G-SYSKLH-----GASLARGLSMLTGASCVRY---------------KCPQ----------TL----------------------------------------------------------------------------------------------------------------------KID--EEV---------------------------------------------------------------------------------------------------------------------------------------------------DTFWAQ---------LVSSQESGFLTCCH-----------------------------------------------CGPFESEEAE-AEFKAL---GLVTSHAYSILDV----------VH--E------------------------Q-------------------------G-----------H------RLLRIRNP--WG--Q-FVWNGKWSDGWL-EW---PIDMKR--AL-----LDKRSDE-----TGAFWM- 251
252 ---------------------------------------------QG-RLRDCWYLGA-LSIM--AGRRRE---RLEALVCFGW----------------V-----------------ARGVHAVRFFVEG--RWVV----------------VVV---DDLIPC--------------------------DRFGR--------P-IF--------G-------------------------------------------------------------------------------------------------RCR-------------------------KMEHCWVQIFEK-----------AFAKLC----G-SYADIE-----GGSEEEALVCLTGGMPKIV---------------DLR-----------------------------------------------------------------------------------------------------------------------------------EREELLLD---------------------------------------------------------------------------------------------------------------------------------------------------GQMWVK---------LVKYSDNGHLMGCA-----------------------------------------------------------NHVAATSGNIIRDHAYSILSV----------YS------------------------------VPHVPGDG-----------------------------------LLLLRNP--WG--K-HEWTGRYSRESP-SWEDVDDNILSMLGL------TREALRREVFEDGSFFM- 252
253 ------I-----FD---K-------PVFF--NAAELGKPKSEDIIQG-ALGDCWFLSA-LATI--A-SVPG---LIEEICVARD----------------E-----------------EVGVYGFVFHRDG--LWKP----------------VII---DDLLFTNIPK-YEELKEVEKELYHHDKDLYTKL--ARKGKK---IL-TY--------A-------------------------------------------------------------------------------------------------KSG-------------------------AQDETWVPLIEK-----------AYAKFY----C-NYDHLN-----GGWTGEAIEDLTGGIAKVI---------------EVK--------------------------------------------------------------------------------------------------------------------------------------DILNI---------------------------------------------------------------------------------------------------------------------------------------------------DQFWTE---------ELLNANRDRVFACA--------------------------------------------F----HQLDSSRNGV--GNARVQGLVGSHAYSVLRA----------VE------------------------------C----------------------------------KGRR----FLVVRNP--WGD---SEWTGPWADGSK-EWDSELVKILP--EL------GHQFGD-----DGQFVME 253
254 ------L-----FD---K-------PLFF--PPG--GAVSSNSIRQG-GLGDCWFLSA-LATV--S-TMPG---LIEKVCVARD----------------E-----------------EVGVYGFIFYGDN--GWDS----------------VII---DDMLFTNIPK-YEELTQQAKLTYHEDKSRYNQI--ARRGFKGGAHL-LY--------A-------------------------------------------------------------------------------------------------GAG-------------------------ADGETWVPLIEK-----------AYAKLN----G-NFAHLE-----GGYTCEGVEDLTGGVSTVF---------------LIK--------------------------------------------------------------------------------------------------------------------------------------DILDI---------------------------------------------------------------------------------------------------------------------------------------------------DKFWKE---------ELLMANKDRVLACS--------------------------------------------F----QRLRAPEDDWWGQSPDVEGLYGNHAYSIMRA----------VE------------------------------T----------------------------------RGKR----FVIVRNP--WGT---GEWKGAWSDGSK-EWTPEWLQVLP--EL------GHTFGD-----DGQFVME 254
255 -RRVTEI-----FD---K-------PKFF--NDK--GAAESSAIHQG-CIGDCYFLAG-LGTV--C-CIPG---LIEKICVARD----------------E-----------------EVGVYGFIFFQDD--GWCR----------------VIV---DDLLPIQNPRHFDSLDDGERQLFVEDRDLFHHV--QKNRGS---RL-TY--------A-------------------------------------------------------------------------------------------------KSG-------------------------SDGETWVPLIEK-----------AYAKLY----G-SYEHLD-----RGWTTEAIEDLSGGVSTTF---------------YTQ--------------------------------------------------------------------------------------------------------------------------------------DILDR---------------------------------------------------------------------------------------------------------------------------------------------------DRFWKE---------EMSKANTDRLLSAS--------------------------------------------F----------------FGDETQGLISEHAYSILKA----------IE------------------------------W----------------------------------NGKR----FVLVRNP--WGD---SEWGGPWSDGSK-EW------------------------------------- 255
256 -QRISEI-----FD---R-------PKFF--NEK--GAAESSAIVQG-GLGDCYFLAA-LATV--C-CLPG---LIEKICVARD----------------E-----------------EVGVYGFIFFQDD--GWAK----------------VIV---DDFVFTTQPPSFDSLGEEGKEAFLGDRELFHNV--HKNTGR---HL-VY--------A-------------------------------------------------------------------------------------------------RSG-------------------------SEGETWVPLIEK-----------AYAKLY----G-NFKHLD-----GGWTTEAIEDLSGGVSTTF---------------KTK--------------------------------------------------------------------------------------------------------------------------------------DILDR---------------------------------------------------------------------------------------------------------------------------------------------------DRFWNE---------EVLKVNHDRLLSAS--------------------------------------------F----------------SGTVTQGLIPNHAYSVLRA----------IE------------------------------W----------------------------------KGKR----FLVLRNP--WGQ---YEWTGRWSDGSK-EWTS----------------------------------- 256
257 --RITDL-----WE---H-------PKFF--ADH----ANPNDIRQG-TLGDCWFLSA-LSTI--S-GLKG---LVSKLCVARD----------------E-----------------EVGVYGFIFCKHG--IWTP----------------VIV---DDLLYSQMPI-YENLRTREQQICRQDKDAYNAM--ARKGGE---GL-FF--------A-------------------------------------------------------------------------------------------------KSG-------------------------YDGETWVPLIEK-----------AFAKLH----G-TYEALS-----GGQTAQALEDLTGGVNESW---------------KIM--------------------------------------------------------------------------------------------------------------------------------------DILDT---------------------------------------------------------------------------------------------------------------------------------------------------DRFWEE---------ELSKAGVDRFFDVS--------------------------------------------L----ARLTKNAS----QTYNTENLVFRHAYSVLRA----------RQ------------------------------V----------------------------------CGRR----FVVIRNP--WGKTI-AKWNGRWGDGSK-EWT----------EL------GREERE-----EILRVME 257
258 ------I-----FE---K-------PQFY--VNG----PTASDVRQG-RDGDCWFMAA-LCTM--G-NKAG---LIEKICVHRD----------------E-----------------EVGVYGFVFYRDG--EWQQ----------------CIV---DDKLYLRAADYDESIDERPVWDNINRKDTEEEY--RRAFQVGSRAL-YF--------A-------------------------------------------------------------------------------------------------QCV-------------------------DENETWLPLLEK-----------AYAKAH----G-DYSAIE-----GGFVGEAVEDLTGGVTSDL---------------LTS--------------------------------------------------------------------------------------------------------------------------------------NILNK---------------------------------------------------------------------------------------------------------------------------------------------------DKFWND---------ELMQVNKEFLFGCG--------------------------------------------TGLYSNWLTPNHRG---PPRDRKGISENHSYSIMDV----------KE------------------------------I----------------------------------DGVR----LVKLRNP--WGK---KEWNGAWSDGSE-QWTPQWME-----KL------NHKFGN-----DGFFWIS 258
259 WKRADLI----------KARDDDEPFHLF--NKG----VKAEDVKQG-ALGDCWLVAA-MATL--AGTMPG---AIKKLFGNSE----------------R----------------SYRGKYKVRLFDITQDRWRT----------------ITV---DDNIPT------------------------------------RHGNPIF--------A-------------------------------------------------------------------------------------------------KPN-------------------------G-KELWVVLLEK-----------AVAKFC----G-SYSNIA-----GGFEAWGLKVLTGNHVWTF------------------RRLKSARPGKPGQ----WRRYEFLFKPSADNKRDASSVGTEE-----------VHESD--KFWG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VL---------LTYAQGRKGAMCCS-------------------------------------------------------ITGPVSERVRKDGLIENHAYSIMRA------------------------------------------I----------------------D-----------MHGE---QLIQIRNP--WGKKG--EWKGRWADGTS-EWKTSPLISVAVGHE--------NNDN-----DGTFWM- 259
260 ---------------------------FL--ADG----VHYQDINQG-SLGNCWLLSS-LACL--A-TRSG---AIERLFLTPE----------------Y----------------NEDGRYQLRLWDKGSRQFKE----------------VVI---DDYIPVW----------------------------RQNGGGGTAGQPCF--------A-------------------------------------------------------------------------------------------------RPS-------------------------G-NEAWVLLLEK-----------AMAKHV----G-NYHYLN-----GGMASWALETLTGHYTCVF---------------LLERRYGPNRDAGPDQANWKWIRGE-LAQASKHADRIA-PVGESRPSPLNRAALYMLDEKDPAKFYAH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EELFMA---------ISYHLA-IGNLVAA-------------------------------------------------------ATVGTDDDEEVNGVVRAHAYTVLKA----------QP------------------------------V----------------------E-----------SNGRGQVLLVQLRNP--HGEGG-IEWSGDWSDKST-LWAKHREVAEAVGYSPPVSVTSAAARS-----DGLFWME 260
261 FLRPNEY-----ME---H-------PQLY--ENG----IEPLDIQQG-CLGDCYFLAA-LASL--S-EFPE---RIKTMIKSCG----------------N-------------------GKYEITLFYMG--KERH----------------IVI---DDLIPCN-------------------------N--GQ--------P-FF--------S-------------------------------------------------------------------------------------------------HNN-------------------------G-DELWVMLLEK-----------AYAKVV----G-SYGEIE-----GGIPFLALSDLTGMPVKRI---------------STR------------------------------------------------------------------------------------------------------------------------------------ETD---V---------------------------------------------------------------------------------------------------------------------------------------------------NRLFKK---------IADYDKKKYCMVAN-VP-----------------------------------------------------DTPGIDIEKEYGLVENHAYTLIGA----------YE------------------------------V----------------------------------DGIK----LLKIRNP--WG--C-CEWKGKWRDDDP-AW---TESMKK--KL------EVVEVN-----DGIYFM- 261
262 WVRPYDL-----SQ----------DPKIIHV-------ISSFSIRQT-IVSDCSFVAS-LAVSAAYERKFRKQIITSCIFP--------------------------QD-KQKRPIVNPCGKYLVRLNING--IQRK----------------IAI---DDTLPLG------------------------ND--GQ--------L-LC--------S-------------------------------------------------------------------------------------------------FSH-------------------------NRDEFWVSLMEK-----------AYMKVM----G-GYD-FP-----GSNSNIDLHALTGWIPERI---------------ATKN----------------------------------------------------------------------------------------------------------------------------------E--ESFKA---------------------------------------------------------------------------------------------------------------------------------------------------NSVFAR---------IKDGLERGDVLVTV------------------------------------------------------ATGALSNTDTERTGLVSSHAYALLDA----------KQ------------------------------I----------------------------------KDIK----LFQLKNP--WS--H-LRWKGKYSE------------------------------------------- 262
263 WVRVSEL-----CE----------QPQLIVGDH-----ADFYSIRQT-VVSDCSFVAS-LAVASQFEKKFRRRILTSIIYP--------------------------RN-SKDEPIYNPSGKYTIRMHVNG--IPRK----------------VVI---DDYLPLG------------------------RY--NQ--------L-LC--------S-------------------------------------------------------------------------------------------------YSS-------------------------NKSEFWVSLLEK-----------AYMKLM----G-GYD-FP-----GSNSNIDLHALTGWIPERA---------------LVKS----------------------------------------------------------------------------------------------------------------------------------D-EPDFNA---------------------------------------------------------------------------------------------------------------------------------------------------DAVFNR---------LQEGLSMGRCLVTV------------------------------------------------------ATGELTDAEAERTGLVSTHAYAVLDM----------RE------------------------------V----------------------------------DGVK----LLQLKNP--WS--H-LRWRGNYSELDVVHW---TPELQRTLGYD---PKLAATYD-----NGVFWI- 263
264 WVRPEQF-----CD----------NPQIIYT-------VSCYSIKQT-IVSDCSFVSS-LAISAQYERRFKKKLITSIIYP--------------------------QN-RNGDPVYNPCGKYMVKLNING--VPRK----------------VII---DDFFPMG------------------------RG--GE--------L-LC--------S-------------------------------------------------------------------------------------------------FSN-------------------------NKNELWISLLEK-----------AYMKVM----G-GYD-FP-----GSNSNIDLHALTGWIPERV---------------AIKR----------------------------------------------------------------------------------------------------------------------------------N-SEDFDR---------------------------------------------------------------------------------------------------------------------------------------------------DKEFKR---------IHDRFHKGHCLITI------------------------------------------------------ATGEMHDSEADRAGLVPTHAYAMLDI----------RD------------------------------V----------------------------------KGKK----LFMLKNP--WS-------------------------------------------------------- 264
265 WVRPEQF-----CD----------NPQIIYT-------VSCYSIKQT-IVSDCSFVSS-LAISAQYERRFKKKLIT-----------------------------------------------------------RS----------------VII---DDFFPMG------------------------RG--GE--------L-LC--------SFSNNKNELWISLLEKAYMKTIVSDCSFVSSLAISAQYERRFKKKLITSIIYPQNRNGDPVYNPCGKYMVKLNINGVPRKVVIDDFFPMGRGGELLCSFSN-------------------------NKNELWISLLEK-----------AYMKVM----G-GYD-FP-----GSNSNIDLHALTGWIPERV---------------AIKR----------------------------------------------------------------------------------------------------------------------------------N-SEDFDR---------------------------------------------------------------------------------------------------------------------------------------------------DKEFKR---------IHDRFHKGHCLITI------------------------------------------------------ATGEMHDSEADRAGLVPTHAYAMLDI----------RD------------------------------V----------------------------------KGKK----LFMLKNP--WS--H-LRWKGNFSEKDVMNW---TPDLQKLLNYD---PKSAQQYD-----NGVFWID 265
266 WVRPSDY-----IS----------GPKMILA-------ISCFSICQT-VVTDCSFVAS-MAIAAQYERRFKKKLITNVIYP--------------------------QG-INGEAIYNPCGKYMVRLNFNG--VPRK----------------VII---DDFLPMG------------------------KD--GK--------L-LC--------C-------------------------------------------------------------------------------------------------YSN-------------------------NQNELWVSLLEK-----------AYMKVM----G-GYD-FP-----GSNSNIDLHALTGWIPERI---------------SIRS----------------------------------------------------------------------------------------------------------------------------------S-SSSFNK---------------------------------------------------------------------------------------------------------------------------------------------------DREFRR---------LLSRFHKGHCLVTI------------------------------------------------------ATGQLSDDESERSGLVPTHAYAMLDI----------RE------------------------------V----------------------------------EGYR----LFLLKNP--WS-------------------------------------------------------- 266
267 WVRPSDY-----IS----------GPKMILA-------ISCFSICQT-VVTDCSFVAS-MAIAAQYERRFKKKLITNVIYP--------------------------QG-INGEAIYNPCGKYMVRLNFNG--VPRK----------------VII---DDFLPMG------------------------KD--GK--------L-LC--------C-------------------------------------------------------------------------------------------------YSN-------------------------NQNELWVSLLEK-----------AYMKVM----G-GYD-FP-----GSNSNIDLHALTGWIPERI---------------SIRS----------------------------------------------------------------------------------------------------------------------------------S-SSSFNK---------------------------------------------------------------------------------------------------------------------------------------------------DREFRR---------LLSRFHKGHCLVTI------------------------------------------------------ATGQLSDDESERSGLVPTHAYAMLDI----------RE------------------------------V----------------------------------EGYR----LFLLKNP--WS-------------------------------------------------------- 267
268 WARPDEY-----MS----------DPSMVYA-------VSPLAIKQS-IVSDCSFVAS-LAIAAQYERRFNTKLITSIIYP--------------------------QN-RKGDPQYNPCGKYMVKLNLNG--VPRK----------------VVI---DDLLPIG------------------------HH--GE--------L-LC--------S-------------------------------------------------------------------------------------------------YSI-------------------------NRNELWVSLLEK-----------AYLKVM----G-GYD-FP-----GSNSNIDLHALTGWIPERV---------------DLQD----------------------------------------------------------------------------------------------------------------------------------P--EEFDP---------------------------------------------------------------------------------------------------------------------------------------------------DKEFLK---------IQSRFHKGDCLVTT------------------------------------------------------GTGELSDDEADRAGLVSTHAYAMLNI----------ME------------------------------V----------------------------------KGHR----LFQLKNP--WN--V-KRWKGNFSDFDTVHW---TPEMEKALSYN---RKVAVDND-----NGIFWI- 268
269 WVRPDDI-----TN----------NPTMIYT-------VSSFSIKQT-IVSDCSFVAS-LAISAAYERRYNKKLITSIIYP--------------------------QN-KKGEPEYNPCGKYMVKLHING--VPRK----------------VII---DDFLPVD------------------------HS--GE--------L-LC--------S-------------------------------------------------------------------------------------------------YSN-------------------------NKNELWVSLIEK-----------AYMKVM----G-GYD-FP-----GSNSNIDLHALTGWIPERI---------------AMHS----------------------------------------------------------------------------------------------------------------------------------D-NQTFNK---------------------------------------------------------------------------------------------------------------------------------------------------DSSFRM---------LYQRFHKGDVLITT------------------------------------------------------ATGMMTEEEGERWGLVPTHAYAVLDI----------RE------------------------------Y----------------------------------KGLR----FLQLKNP--WS--H-LRWKGRYSENDMKNW---TPELQKYLNFD---PRTAQKID-----NGIFWIS 269
270 WVRPDDI-----TN----------NPTMIYT-------VSSFSIKQT-IVSDCSFVAS-LAISAAYERRYNKKLITSIIYP--------------------------QN-KKGEPEYNPCGKYMVKLHING--VPRK----------------VII---DDQLPVD------------------------HS--GE--------L-LC--------S-------------------------------------------------------------------------------------------------YSN-------------------------NKNELWVSLIEK-----------AYMKVM----G-GYD-FP-----GSNSNIDLHALTGWIPERI---------------AMHS----------------------------------------------------------------------------------------------------------------------------------D-NQAFDR---------------------------------------------------------------------------------------------------------------------------------------------------DSTFRM---------LYQRFHKGDVLITT------------------------------------------------------ATGVMSEEEGEKWGLVPTHAYAVLDI----------RE------------------------------H----------------------------------KGLR----FLQLKNP--WS--H-LRWKGRYSENDTRSW---TPDLQKYLNFD---PRTAQKID-----NGIFWIA 270
271 ---------------------------------------------QT-IVSDCSFVAS-LAISAAYERRFNKKLITGIIYP--------------------------QN-KDGEPEYNPCGKYMVKLHLNG--VPRKNTYKLNISNLKIQNTPVII---DDQLPVD------------------------HK--GE--------L-LC--------S-------------------------------------------------------------------------------------------------YSN-------------------------NKSELWVSLIEK-----------AYMKVM----G-GYD-FP-----GSNSNIDLHALTGWIPERI---------------AMHS----------------------------------------------------------------------------------------------------------------------------------D-SQTFSK---------------------------------------------------------------------------------------------------------------------------------------------------DNSFRM---------LYQRFHKGDVLITA------------------------------------------------------STGMMTEAEGEKWGLVPTHAYAVLDI----------RE------------------------------F----------------------------------KGLR----FIQLKNP--WS-------------------------------------------------------- 271
272 WVRPEDL-----TN----------NPTMIYT-------VSSFSIKQT-IVSDCSFVAS-LAISAAYERRFNKKLITGIIYP--------------------------QN-KDGEPEYNPCGKYMVKLHLNG--VPRK----------------VII---DDQLPVD------------------------HK--GE--------L-LC--------S-------------------------------------------------------------------------------------------------YSN-------------------------NKSELWVSLIEK-----------AYMKVM----G-GYD-FP-----GSNSNIDLHALTGWIPERI---------------AMHS----------------------------------------------------------------------------------------------------------------------------------D-SQTFSK---------------------------------------------------------------------------------------------------------------------------------------------------DNSFRM---------LYQRFHKGDVLITA------------------------------------------------------STGMMTEAEGEKWGLVPTHAYAVLDI----------RE------------------------------F----------------------------------KGLR----FIQLKNP--WS--H-LRWKGRYSENDVKNW---TPELQKYLNFD---PRTAQKID-----NGIFWIS 272
273 WVRPEDL-----TN----------NPTMIYT-------VSSFSIKQT-IVSDCSFVAS-LAISAAYERRFNKKLITSIIYP--------------------------QN-KDGEPEYNPCGKYMVKLHLNG--VPRK----------------VII---DDQLPVD------------------------HK--GE--------L-LC--------S-------------------------------------------------------------------------------------------------YSN-------------------------NKSELWVSLIEK-----------AYMKVM----G-GYD-FP-----GSNSNIDLHALTGWIPERI---------------AMHS----------------------------------------------------------------------------------------------------------------------------------D-SQTFSK---------------------------------------------------------------------------------------------------------------------------------------------------DNSFRM---------LYQRFHKGDVLITA------------------------------------------------------STGMMTEAEGEKWGLVPTHAYAVLDI----------RE------------------------------F----------------------------------KGLR----FIQLKNP--WS--H-LRWKGRYSENDVKNW---TPELQKYLNFD---PRTAQKID-----NGIFWIS 273
274 WVRPEDL-----TN----------NPTMIYT-------VSSFSIKQT-IVSDCSFVAS-LAISAAYERRFNKKLITSIIYP--------------------------QN-KDGEPEYNPCGKYMVKLHLNG--VPRK----------------VII---DDQLPVD------------------------HK--GE--------L-LC--------S-------------------------------------------------------------------------------------------------YSN-------------------------NKSELWVSLIEK-----------AYMKVM----G-GYD-FP-----GSNSNIDLHALTGWIPERI---------------AMHS----------------------------------------------------------------------------------------------------------------------------------D-SQTFSK---------------------------------------------------------------------------------------------------------------------------------------------------DNSFRM---------LYQRFHKGDVLITA------------------------------------------------------STGMMTEAEGEKWGLVPTHAYAVLDI----------RE------------------------------F----------------------------------KGLR----FIQLKNP--WS--H-LRWKGRYSENDVKNW---TPELQKYLNFD---PRTAQKID-----NGIFWIS 274
275 WVRPEDL-----TN----------NPTMIYT-------VSSFSIKQT-IVSDCSFVAS-LAISAAYERRFNKKLITSIIYP--------------------------QN-KDGEPEYNPCGKYMVKLHLNG--VPRK----------------VII---DDQLPVD------------------------HK--GE--------L-LC--------S-------------------------------------------------------------------------------------------------YSN-------------------------NKSELWVSLIEK-----------AYMKVM----G-GYD-FP-----GSNSNIDLHALTGWIPERI---------------AMHS----------------------------------------------------------------------------------------------------------------------------------D-SQTFSK---------------------------------------------------------------------------------------------------------------------------------------------------DNSFRM---------LYQRFHKGDVLITA------------------------------------------------------STGMMTEAEGEKWGLVPTHAYAVLDI----------RE------------------------------F----------------------------------KGLR----FIQLKNP--WS--H-LRWKGRYSENDVKNW---TPELQKYLNFD---PRTAQKID-----NGIFWIS 275
276 -VRPEDL-----TN----------NPTMIYT-------VSSFSIKQT-IVSDCSFVAS-LAISAAYERRFNKKLITSIIYP--------------------------QN-KDGEPEYNPCGKYMVKLHLNG--VPRK----------------VII---DDQLPVD------------------------HK--GE--------L-LC--------S-------------------------------------------------------------------------------------------------YSN-------------------------NKSELWVSLIEK-----------AYMKVM----G-GYD-FP-----GSNSNIDLHALTGWIPERI---------------AMHS----------------------------------------------------------------------------------------------------------------------------------D-SQAFSK---------------------------------------------------------------------------------------------------------------------------------------------------DNSFRM---------LYQRFHKGDVLITA------------------------------------------------------STGVMTEAEGEKWGLVPTHAYAVLDI----------RE------------------------------F----------------------------------KGLR----FIQLKNP--WS--H-LRWKGRYSENDVKNW---TPELQKYLNFD---PRTAQKID-----NGIFWIS 276
277 WVRPEDL-----TN----------NPTMIYT-------VSSFSIKQT-IVSDCSFVAS-LAISAAYERRFNKKL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FHKGDVLITA------------------------------------------------------STGVMTEAEGEKWGLVPTHAYAVLDI----------RE------------------------------F----------------------------------KGLR----FIQLKNP--WS--H-LRWKGRYSENDVKNW---TPELQKYLNFD---PRTAQKID-----NGIFWIS 277
278 WVRPEDL-----TN----------NPTMIYT-------VSSFSIKQT-IVSDCSFVAS-LAISAAYERRFNKKLITSIIYP--------------------------QN-KDGEPEYNPCGKYMVKLHLNG--VPRK----------------VII---DDQLPVD------------------------HK--GE--------L-LC--------S-------------------------------------------------------------------------------------------------YSN-------------------------NKSELWVSLIEK-----------AYMKVM----G-GYD-FP-----GSNSNIDLHALTGWIPERI---------------AMHS----------------------------------------------------------------------------------------------------------------------------------D-SQTFSK---------------------------------------------------------------------------------------------------------------------------------------------------DNSFRM---------LYQRFHKGDVLITA------------------------------------------------------STGVMTEAEGEKWGLVPTHAYAVLDI----------RE------------------------------F----------------------------------KGLR----FIQLKNP--WS--H-LRWKGRYSENDVKNW---TPELQKYLNFD---PRTAQKID-----NGIFWIS 278
279 WVRPDDI-----CN----------NPTMIFT-------VSSFSIKQT-VVSDCSFVAS-LAISAAYERRYSKKLITSIIYP--------------------------QN-RKGEPEYNPCGKYMVKLHING--VPRK----------------VII---DDFLPVD------------------------RN--GE--------L-LC--------S-------------------------------------------------------------------------------------------------YSS-------------------------NRNELWVSLIEK-----------AYMKVM----G-GYD-FP-----GSNSNIDLHALTGWIPERI---------------AMHS----------------------------------------------------------------------------------------------------------------------------------D-NQSFNK---------------------------------------------------------------------------------------------------------------------------------------------------DDTFRM---------LYQRFHRGDVLITT------------------------------------------------------ATGVMTEEEGERWGLVPTHAYAVLDI----------RQ------------------------------Y----------------------------------KDKR----FLQLKNP--WS--H-LRWKGSYSERDEKNW---TPDLLKYLNFD---PKTAQKFD-----NGVFWII 279
280 -KRPDEF-----MN----------EPQMILT-------VSSLSIMQT-VVSDCSFVAS-LAISAAYERKYNKKLITSIIYP--------------------------QN-RKGDPIYNPCGKYMVKLHLNG--VFRK----------------VVI---DDRLPVD------------------------RQ--GK--------L-LC--------S-------------------------------------------------------------------------------------------------YSA-------------------------NRNELWVSLVEK-----------AYMKVM----G-GYD-FP-----GSNSNIDLHSLTGWIPERQ---------------SLRD----------------------------------------------------------------------------------------------------------------------------------K-N--FDY---------------------------------------------------------------------------------------------------------------------------------------------------DGFFQK---------VRDRFHKGHCLATI------------------------------------------------------STGMISEAEADRAGLVPTHAYAVLDV----------QV------------------------------V----------------------------------YGIK----LLQLKNP--WS--H-LRWKGNYSAHDDAHW---TPELRKALNYD---NKYAQEFD-----NGVFWID 280
281 WKRPDEF-----MN----------EPQMILT-------VSSLSIMQT-VVSDCSFVAS-LAISAAYERKYNKKLITSIIYP--------------------------QN-RKGDPIYNPCGKYMVKLHLNG--VFRK----------------VVI---DDRLPVD------------------------RQ--GK--------L-LC--------S-------------------------------------------------------------------------------------------------YSA-------------------------NRNELWVSLVEK-----------AYMKVM----G-GYD-FP-----GSNSNIDLHSLTGWIPERQ---------------SLRD----------------------------------------------------------------------------------------------------------------------------------K-N--FDY---------------------------------------------------------------------------------------------------------------------------------------------------DGFFQK---------VRDRFHKGHCLATI------------------------------------------------------STGMISEAEADRAGLVPTHAYAVLDV----------QV------------------------------V----------------------------------YGIK----LLQLKNP--WS--H-LRWKGNYSAHDDAHW---TPELRKALNYD---NKYAQEFD-----NGVFWI- 281
282 WVRPSDI-----CE----------NPQMIFA-------VSSLSIKQT-IVSDCSFVAS-LAISAAYERQFQRKLITSIIFP--------------------------QQ-KDGTPFINPCGKYMVKLHFNG--VARK----------------VII---DDLLPMG------------------------KD--GQ--------L-LC--------S-------------------------------------------------------------------------------------------------FSQ-------------------------NCNEFWVSLLEK-----------AYMKVM----G-GYD-FP-----GSNSNIDLNALTGWIPERA---------------SLKS----------------------------------------------------------------------------------------------------------------------------------K---DISF---------------------------------------------------------------------------------------------------------------------------------------------------DVLFDR---------MLNGLEKGDVLITA------------------------------------------------------ATGVMSDAEADRAGLVPTHAYAVLNL----------KK------------------------------V----------------------------------QGKR----LCLLKNP--WS--H-LRWKGNYSDSDTVNW---TLSLENALGYN---REKAAQND-----NGVFWIN 282
283 WARAEEI-----SA----------DPKVIEN-------IDCFSIKQT-VVSDCSFVAS-LAVSAQYEKRFNKKLITNIIYP--------------------------QN-KSGMPVYNSCGKYMIRLRING--VSRK----------------VVI---DDYLPMG------------------------RH--GE--------L-LC--------S-------------------------------------------------------------------------------------------------YSV-------------------------NRNELWVSLLEK-----------AYMKVM----G-GYD-FP-----GSNSNIDLHALTGWIPERV---------------ALKS----------------------------------------------------------------------------------------------------------------------------------SGGEEFKK---------------------------------------------------------------------------------------------------------------------------------------------------EELFKK---------LYDRFHKGDVIVTV------------------------------------------------------ATGEMSEAAEVRTGLVSAHAYALLNI----------QE------------------------------V----------------------------------KGIR----LIMLKNP--WS--H-VRWKGNYSELDANHW---TEDLKKQLNYN---PESAANFD-----NGVFWI- 283
284 WQRPGEI-----CD----------NPKMCHL-------ISSLSIKQT-MIGDCSFVAS-LGVCADYERRFKRKLITSCIFP--------------------------QN-RHKEPIINPNGKYLIKLFLNG--CRRK----------------VVI---DDLLPVD------------------------GY--SN--------I-LG--------S-------------------------------------------------------------------------------------------------YSN-------------------------SRDEFWVSLLEK-----------AYMKVM----G-GYD-FP-----GSSSNNDLHALTGWIPERI---------------DIKE----------------------------------------------------------------------------------------------------------------------------------S-----NK---------------------------------------------------------------------------------------------------------------------------------------------------DKTFKM---------LEAKLKAGSALVTM------------------------------------------------------GTGPLTKEESERTGLVPTHAYAVLRV----------TE------------------------------T----------------------------------CGVR----LLQLKNP--WS--E-KRWKGSFSERDATNW---TPELKRALNYD---QSLALQVD-----NGVFWI- 284
285 WKRVSDL-----FE----------HPTIISS-------IDCNTIKQT-VISDCSFISS-LSIAALYEKRFKKQLVTSIIYP--------------------------QD-AHGKPIYNPAGKYMIKFHING--VWRK----------------VVI---DDYFPVD------------------------EN--NR--------M-MC--------S-------------------------------------------------------------------------------------------------QTE-------------------------NKGELWVSLLEK-----------AYMKVM----G-GYD-FP-----GSNSNIDLNALTGWIPERI---------------ELNE----------------------------------------------------------------------------------------------------------------------------------S--NKADP---------------------------------------------------------------------------------------------------------------------------------------------------DAIFRK---------LFDRFHRGDCLITL------------------------------------------------------ATGKMTEEMQKRSGLVETHAYAVIDI----------RS------------------------------V----------------------------------ENKR----LLKVKNP--WT--H-SRWKGNFSEKDKLNW---TTKMKSSLVYD---PEVAATKD-----DGIFWID 285
286 WKRVSEL-----FE----------NPTIIFS-------IDCHTIKQT-VISDCSFISS-LSIAALYEKRFKKQLVTSIIFP--------------------------QD-ANGKPIYNPAGKYMFKFHLNG--AWRK----------------VLI---DDYFPVD------------------------EN--NR--------M-MC--------S-------------------------------------------------------------------------------------------------QTE-------------------------NKGELWVSLLEK-----------AYMKVM----G-GYD-FP-----GSNSNIDLNALTGWIPERI---------------ELSD----------------------------------------------------------------------------------------------------------------------------------T--SKADP---------------------------------------------------------------------------------------------------------------------------------------------------DEVFRK---------LFDRFHRGDCLITL------------------------------------------------------ATGKMTEDMQKRSGLVETHAYAVIDI----------RC------------------------------V----------------------------------ETKR----LLKVKNP--WT--H-SRWKGNFSDKDKVNW---TAKMKNALAFD---PEVAAEKD-----DGIFWID 286
287 WKRPSDI-----MR----------DPKLIC--C-----ISSTSIIQD-IVTDCSFVAS-LCVAAAYEQKFKKQLITSCVYP--------------------------QN-KQGQPCYNPNGKYVVKLVYNG--ITRK----------------VVV---DDLLPVS------------------------RE--GT--------L-MC--------T-------------------------------------------------------------------------------------------------FST-------------------------NKGELWASIIEK-----------A---LM----G-GYD-FP-----GSNSGIDLHCLTGWIPEHI---------------FIHD----------------------------------------------------------------------------------------------------------------------------------KYFVP------------------------------------------------------------------------------------------------------------------------------------------------------DNVWDR---------IFDGMKYGDALVTI------------------------------------------------------ATGEMTEEEATQLGLVPTHAYAVIDI-------KMTPD------------------------------G----------------------------------K--R----LLQVKNP--WS--H-KRWRGPYSHLDSNIW---TSELMEALCFD---PDAAEKND-----DGIFWI- 287
288 WMRPSDCAAKCGYE----------APVMIADGG-----VNPLVVKQD-IVTDCSFVAS-LCIAAAYEQRFQKHLITNIIFP--------------------------ADPRTKQPVYNPFGKYVVKLWANG--VPRK----------------VVI---DDLLPVS-----------------------ATS--GQ--------L-LS--------S-------------------------------------------------------------------------------------------------CTT-------------------------RKNELWVSLIEK-----------AYLKLN----G-GYD-FP-----GGNSGIDLFALTGWVPERV---------------PVSE----------------------------------------------------------------------------------------------------------------------------------LIDAPSKE---------------------------------------------------------------------------------------------------------------------------------------------------ERLWEQ---------LKSAFHYGDCIITM------------------------------------------------------STGDITKQEAKAIGLVPMHVYAVLNVYELANNSVASKE------------------------------G----------------------------------KKIR----LLQVKNP--WR--K-MSWKGPYS-------------------------------------------- 288
289 WARISQI-----YS----------NPVVIKQ-------FTYENITQT-LVGDCSFVSS-LAVCASWERRYGRTLISRNIYP--------------------------Q--KNNVPVISPSGKYMIKMYLNG--AVRK----------------IVI---DDYLPVV------------------------QSMPPQ--------L-LC--------S-------------------------------------------------------------------------------------------------YSR-------------------------IGEEAWLPLYEK-----------AYMKLH----G-GYD-FP-----GSTSSIDLHALCGWIPETF---------------HLKE----------------------------------------------------------------------------------------------------------------------------------DSKSRSDP---------------------------------------------------------------------------------------------------------------------------------------------------EEAWRR---------LEQGQKKGTALFTM------------------------------------------------------GTKSLSADEEERSGLASQHAYAVLEV----------VM------------------------------A----------------------------------GGRR----LVKLMNP--WR--R-MRWRGEFS-------------------------------------------- 289
290 WKRPSEL-----LAKDTEDVYTKVVPVMSVP--------GKTDLVQD-MLTDCSVVAS-LCATTSMLERGQCTHFLPMIYP-----------------------------SRGSSQPSPSGKYIFRFYFNG--CFRK----------------VII---DDRLPSS-----------------------KTS--RS--------L-HV--------I-------------------------------------------------------------------------------------------------DRK-------------------------NPNFLWPALVEK-----------AYLKLR----G-GYD-FP-----GSNSGTDLWVLTGWIPEQV---------------FLHN----------------------------------------------------------------------------------------------------------------------------------D---DVTG---------------------------------------------------------------------------------------------------------------------------------------------------DQLWKR---------LYRSFHQGDVLLTI------------------------------------------------------GTGELTEREQRELGLVSEHDYAILDM----------KE------------------------------S----------------------------------KGRR----QLLVKNP--WA--------GADTA----------PGDNGSLSASQDLPHNPPSFE-----PGTFWM- 290
291 WKRPHEL-----LSGQVDDAGMPLNPVMTVS--------GNTDLVQD-VLTDCSVVAS-LCATTSRSERGLDDTLLPIVYP--------------------------CIHNSMKSDISPSGKYIFRFYFNG--CFRK----------------VVI---DDRLPSS-----------------------KTS--RS--------L-YM--------I-------------------------------------------------------------------------------------------------DRN-------------------------HRNFMWPALVEK-----------AYLKLR----G-GYE-FP-----GSNSGTDLWVLTGWIPEQV---------------FLHS----------------------------------------------------------------------------------------------------------------------------------D---EVTA---------------------------------------------------------------------------------------------------------------------------------------------------DQIWSD---------LFKSFHSGDVLLTI------------------------------------------------------GTGKLTEREQKELGLVSEHDYAILDM----------KE------------------------------L----------------------------------KGRR----QFLIKNP--WA--------GTDAVYPALFA---DPG---------PFP-NSPFLS-----PGTFWMD 291
292 WKRLSEL----------YENPIVMSPYLY-----------NNCIRQG-FVADCSFLSS-LTVLIEYEKKHKIPVISSIITPCSW----------------NYLCINKTWPIFN-----PCGMYICRLHCNG--IQRK----------------III---DDYVPVK------------------------NN--NS--------L-LV--------A-------------------------------------------------------------------------------------------------YSN-------------------------NQKELWVTLLEK-----------AFVKLM----GGSYS-MF-----GSNPGSDLYYLTGWIPVTI---------------SLK-------------------------------------------------------------------------------------------------------------------------------SKISSSPPSFDKHSTHSLIRDERIDELVYETNEVMINKKHGYVNSVEFVEDTKYNHNNNNNNNKNNTDHDQYMCDDNICFNNYNFCYKDDYEVRNKLQKQFLKEELATMDFAKYMNGSVDNYSDLIKRGGHKTLGINCEEGKYEPYEQYEQYEEYDEKWDSVWNN---------IYDGIKKGKCVVCL--------------------------------------------GTLELKDAAPSGLDYPEGVSISTGIVTRHAYSILNI----------EN------------------------------Y----------------------------------NGDK----LLYIKNP--WG--C-IRWKGRYSHNDYETW---TKELQK--KL------NYSLEKAISKDDGCFWI- 292
293 WVRPEDL-----SN----------NPTMIYT-------VSSFSIKQT-IVSDCSFVAS-LAISAAYE-RVNKKI-TXXXXX--------------------------XX-XXXXXXXXXXXXXXXXXXXXX--XXXX----------------XXX---XXXXXXX------------------------XX--XX--------X-XX--------X-------------------------------------------------------------------------------------------------XXX-------------------------XXXXXXXXXXXX-----------XXXXXX----X-XXX-XX-----XXXXXXXXXXXXXXXXXXX---------------XXXX----------------------------------------------------------------------------------------------------------------------------------X-XXXXXX---------------------------------------------------------------------------------------------------------------------------------------------------XXXXXX---------XXXXFHKGDVLITA------------------------------------------------------STGMMTEAEGEKWGLVPTHAYAVLDI----------RE------------------------------F----------------------------------KGLR----FIQLKNP--WS--H-LRWKGRYSENDVKNW---TPELQKYLNFD---PRTAQKID-----NGIFWIS 293
294 -------------------------------------------LYQD-ILPNCSFVSSFLAIIDA------NIPIIDTITP--------------------------QK---------SSQKYKVSLRFNG--ALRN----------------VIV---DSKFPIM-----------------------PNS--RN--------L-II--------K-------------------------------------------------------------------------------------------------SYS-------------------------DTELYWPALIEK-----------AYLTIM----GNGYN-FS-----GSNMANDAYVLSGWLPQII---------------KLSN----------------------------------------------------------------------------------------------------------------------------------G-QLPSNI---------------------------------------------------------------------------------------------------------------------------------------------------NDLWRL---------RTQ----GKVTMGI------------------------------------------------------GTGTLSKQLSSQLHLVSGHDYVIDNI----------KD--------------------------------------------------------------------G----VITVKNP--WL--D----------------------------------------------------- 294
295 --------------------------------------------CQA-GVGNCWLMAS-LMAI--A-QRKD---ILEIVLP-------------------------------KRDYALDCGLVQVRLFVDG--RWQV----------------IKI---DFYLPH-----------------------------EN----GIERC-SK--------M-----------------------------------------------------------------------------------------------------------------------------PKKQMWVAMIEK-----------AYAKVK----G-SFGGLN-----GGQSHLAFKCLTGAGGKQI---------------M--------------------------------------------------------------------------------------------------------------------------------------INKDTNT---------------------------------------------------------------------------------------------------------------------------------------------------EQLWED---------LIKYYSCGNLLAAG--------------------------------------------------TPNIKDNEEELKRYEAIKIDYNHGYAILGF----------KE------------------------------H----------------------------------NGYR----LINLGNP---G--P-TKFTGRFSELPG-YD-DRETVSNF-----------CPVDY-YLYHHKIFWMD 295
296 ----------------------------------------PFHVCQG-VVGDCWLLGP-LMTI--C-RRRE---LMEQIIP-------------------------------RNEYAMEQGLVQVRLLIDG--QWQV----------------FRL---DSYIPN-----------------------------ID----GVEQC-VM--------M-----------------------------------------------------------------------------------------------------------------------------TRKQAWAGFIEK-----------AFAKKR----G-SYGALN-----GGCANHTFHCLT------V---------------W--------------------------------------------------------------------------------------------------------------------------------------VRDKMNE---------------------------------------------------------------------------------------------------------------------------------------------------DQLWED---------MMKYFSAGFLMTAS--------------------------------------------------AYPLKEGTEKWEFFKTNNMVHSHAYAVLDF----------KQ------------------------------Y----------------------------------DDHR----LIKFGNN---N--I-KPWKGNFASMKS-YEFEEENFENL-----------AFIDL-YLSDLKIFWM- 296
297 ----------------------------TAY-----------EVFQR-KVGDCGLVAA-LSAI--S-TKPE---VIMNIF-DSL-------------------------------QLSKYGVYKVKLFVDG--QWKT----------------III---DDYFP------------------------------YTTDDMRIGAT-------------------------------------------------------------------------------------------------------------SGK-------------------------Q---IWAALIEK-----------ALAKER----G-NYKGIT-----GFQNQSAFSALTGSPVLSILTTRILK--------ELR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KHWKIL---------MDYKYEFLKILIGV-----------------------------------------------VIFQKNQYPMACETTIQRRNGILSKHVYTIMDI------------------------------------------V------------------------------------ERDGHKLLLLRNP--SG--G-SVWTGN---WSK-EWEWWPENMKD----------LLEGMI-----RGSFWIS 297
298 WRRITPP-----STDVSSSLSVYNPLTFTAY-----------EVFQR-KVGDCGLVAA-LSAI--S-TKPE---VIMNIF-DSL-------------------------------QLSKYGVYKVKLFVDG--QWKT----------------III---DDYFP------------------------------YTTDGIRIGAT-------------------------------------------------------------------------------------------------------------SGY-------------------------Q---IWAALIEK-----------ALVKEC----G-NYKGIH-----GFQSLSAFSALTGSPVLLIPVAKMFN--------NLR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KYWKTL---------ME-------------------------------------------------------------FRNNQYPMACGTLNREVNGILPQHAYTIMDI------------------------------------------V------------------------------------ERDGHKLLLLRNP--SG--G-SVWTRN---WSK-EWEWWPENMKD----------LLEGMI-----RGSFWIS 298
299 -----------------------------MS-----------DVNQR-WVGDCCACAV-IASM--AYLYPR---FVKHIIKDNM-------------------------------D----KTYTVTMY-DP--KGKQ----------------ISVGVGGDYFI------------------------------GNSGDL--GAL-------------------------------------------------------------------------------------------------------------GGR-------------------------NKEVTWATILEK-----------AMIKWN----Q-IYQGSSNVGGIGTEYVSAIFTGDGESVGFGANALIAE--------DLQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R----A---------VEVSLKQGRLVIGG-----------------------------------------------FTRSGEQVDQNWQTT--------SGHAFTF--I------------------------------------------L------------------------------------PDDNTHLFKMRNP--WG-------------------------------------------------------- 299
300 ---PTKN-----LRDDNNTVHQYREVGFQSNGAH----NLWDTVVQG-IAGDCYMLAA-LSAI--AWVWPA---LL-NMDVDIMSNQDEWRLYRYFIGRSKQTYARPSGSGTSTNEILQEGYYKVPIFARS--RY--------------------------WFN------------------------------GE------------------------------------------------------------------------------------------------------------------------------------------------------YWPALFEQ-----------AYANWKFPNDS-KYNAILQIG--GGWPEEALCELSGDSWFTSSGKLMLSSFTDLSLLNFM----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K----S---------MCYSWKTIKPMV-------------------------------------------------------IVTPCWEPLPPMMPGIAAYHAYTVLGY------------------------------------------T------------------------------------VSNGAYYLIIRNP--WG--V-TEPTGDGVLSKR-DWVIHFDNMKW----------FNLSKD-----DGIF--- 300
301 WAKPLML-----PT---HISTTAYGPALYDPSTG----PTCADIKQT-TAPDCWLASV-MCAL----AKCNGGFITSLIVAKTQ----------------VHPATSLSVTGAT-----------FKIWDPD--TLVETDQA------------VVL---ADTVTGD----------------------------GN----------------------------------------------------------------------------------------------------------------------DDS-------------------------SIYVWWPSALQA-----------AVKKHG----G-SGITDGKFDINGGFGFKALSYLTGLEASC----------------DMNS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STWWGN---------LVAHVDSTPIVICT--------------------------------------------------------------NSDTDVLVNSHCYTAMTI----------ID-----------------------------------------------------------------NGDSDDTRTVQLHNP--WG-------------------------------------------------------- 301
Active site residue: X
Putative: +
Experimental: #
