Alignment for family N6

Family

Summary Holotypes Tree Genomes Literature

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   1 ------------------------------------------------------------------------------------------------MMVVLF---VSA-VFLNIVQV-GFMMTPDVLQLKWERLN---PIEGAKRIISIRGLVKLGVSLGKISLLVLIAVWFSYLVFPGFLGLM-GAPPETILRDIFNSTIELGLLLAL----ALIILGGL-----DYAFQKWKHEKDLMMSKQEIREEMKSMDGDPLIRQRRREAHRKLAM----SQELSKVESADVVITNPTHISIAIKYDPE-SMPAPVVVAKGAGEIAFQIRKIANEHGIPIIERKALARQMYRDVKTGQEIPFELYEVFVEIMAYV-------------   1
   2 ---EKTEEPTPKKLEKAREEGNVAKSKDMSDTA-VLFAGVMTLYFLHERMLEGFFAIMRNYL----DLTRNTFPTINEMPSFGITILLQMLHILWPLFLALT---LFA-LAINIGQI-GLLWSSKAVAPKWSKLN---PIKGIAQKFSLKNLIEVTKSLLKVSVFGPVAYFIAKDEFGSILMMM-HLTPIEIFATALMIIFKIWITIIL----IMLIVSAV-----DFYFQKYQHHEKLKMSKQEVKEERKQMDGNPEVKQRIRSLQREMAM----KRMMGDVPKSDVVITNPLFLAVALKYDTE-VKAAPYLVAKGQELVAQRIRDLALEHDIPIQQDPLLARQLYDSLEPGDEITHELYQAVAEILAEIYRQ----------   2
   3 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLAAL-----DYGYQWFRVFRELYMSRQELKDEHKDLEKDASVISRQRQMQKELAQ---MRSLGDKIPKATVVITNPTHYAVALRWNPR-EMSAPQVIAKGTDRVAQRIRELAQHHFVPLVENPPLAQALYKSVKIGQEISPEHYRAVSEVIRYVLR-----------   3
   4 ---EKTEEPTPRRREEARRRGQVAKSREITAVA-VLSGSMLVFTMAGTYMVSQILVIYREFF----IFSKPLI-DVNRAYELLVVSIKLGGKVLMPLLIILL---LVS-FLSAYLQV-GSVAAWEALKPKGERID---PIKGFKRLFSLPALFEFLKSLIKLIIISLVAYLVLMSEKDIVLYLA-EEGPAEIGKNIYILARSLVFKTLMA----LAVLAIL-----DFLFQRWETNRQLRMTKQELKEELKQTEGDPWVKSKIRQIQRTMAQ----RRMMAEVPKADVVITNPVHYAVALKYQAG-EMPAPQVLAKGEGLVAQRIKEVAEEAGVPIVENPPLAQALYKEVEIGEYVPAELYQAVAEVLAYVYR-----------   4
   5 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VILNERKKAAALKYEES--YTSPVVTAAGMGYVADKILEKASEEKVPIVYDKELAN-LLTNIDIGDSIPYELYDAVAKVIAYV-------------   5
   6 ----KTERATPYKRRKVREEGNVAKSHEIASSL-VVLLSLLLLLFLGTYIA---KEVILIFL----AVTGYVHADISELGSLYENFYENIVKVLTPLFFLAL---LVV-ILSHVAQF-GFIFTLKPLSFKWERIN---PFEGIKRLISLTTLFETVKNTLKAFLLIGIAVFVLKGSLYFFLSSS-TYPLAETLKSFIKTSAITLITLGV----VALLIAFL-----DYAFKRWQYEKKIMMSRRELKEEYKQLEGHPEVKSRIKARMRELAK----SRMMAEVPKATVVITNPTHIAIALKYNPE-KDKAPVVVAKGKGTIAQKIVEIAENYSIPVVRKPELARALYPAVEVGKEISPKFYKAVAEIIAYV-------------   6
   7 -SDDKTEAPTPHRLEKAREEGQIPRSRELTSLL-ILLVGVSVIWFGGVSLARRLSGMLSAGL----HFDHSIINDPNLILGQIILLIREAMLALLPLISGVV---LVA-LISPVMLG-GLVFSGKSLQPKFSKLN---PLPGIKRMFSAQTGAELLKAILKTILVGSVTGFFLWHHWPQMMRLM-AESP------ITAMGNAMDLVGLCA---LLVVLGVIPMVGFDVFFQIFSHLKKLRMSRQDIRDEFKQSEGDPHVKGRIRQMQRARAR----RRMMADVPKADVIVNNPTHYSVALQYDEN-KMSAPKVVAKGAGLVALRIREIGAENNVPTLEAPRLARALYRHAEIGQQIPGQLYAAVAEVLAWV-------------   7
   8 --AERTERATPRKRRRVREEGRAPVSRELNMAV-TFLVFALALKIFGYQGVERITEDVQVFLSFEETEDLLMNA---------VNIFKDVLLIVGAFVVFSM---VAG-VMIGALQT-RFLFAPKALKPDLNRIN---PIEGFKRLFSLRSLVELLKSVLKVAIVGIVVYQVLKNRWDEMILLT-EMSVNDAFANFWDITSEITLKSGM----ILLALAVF-----DYFYQRWEFEKSIRMTKQEVKDELKEVEGNP----EIKRRQRQMMYDILRRRMLEEVPKADVVITNPTHFAVALKYDPD-TMNAPVVVAKGVDHLAFKIIEIAKENDVPVLRNPSLARALYYKTEIGEEIPVEFYRIVAEVL----------------   8
   9 -AGEKTEKATPKKRKDTRKKGQVAKSSDVNSAV-SLLVIFLSLIAIGPYMRDRLLSFIETFY----TESLTMKLSESNVHTLFVSLLKDMGMILAPILLVAL---VAG-VVSNYMQV-GFLFSAEVIQPKLEKLD---PIKGFKRIYSMRAIVELIKSILKIVVVGFAAFAVLWLHYGEILRLP-LLTPEEALS----FVSKLTLWMGLSGAGALLILAGL-----DYLYQRFDYEKNIKMSKQDIKDEYKKSEGDPIIKSKIKQRQREMAM----RRMMQEVPKADVIITNPTHYAIALKYDEE-KMDAPYIVAKGVDHLALKIRKIAKEHDVMMVENRPLARALYDQVEIDQAVPEEFFKVLAEILAYV-------------   9
  10 -SDDKTEEATPHKLSEARKKGQVPKSKEVNSAI-ILLTSTIILLTLGEYVANSFKKDIIEFF----TNYLNIELNSSSLISIIVTVLWRFMIVFLPVVVPLM---IMG-IGANLLQT-GYINSKEPLKPQLSKIN---PISGFKKMFSMRTVMELLKDIAVITIIGFAGYGFLKSNFKKVLSMT-NLRFPVIITSFLKLTTNIFFRVSL----IMFAIALT-----DFIYQKFQFKKDMRMSKQEVKEEFKQMEGDPQIKGKIKQKQREMAM----GRMMQNVPDASVVITNPTHIAVALKYEDGQD-NAPMLVAKGSDYIAIKIKQIAKENDVPIIENKPLARLIFKEVEIENEIPSDMYQAVAEIL----------------  10
  11 -SEEKTEEATPRKKMDARKKGQVAKSKELALAF-TLLACTLVLVALGEYGANELKETMAGFL----NNYLNMELNYNNLNSLAILTVLRVGKIVLPVALPIM---CFG-IAANYLQT-GFLFTKEPLKPDFKKLN---PINGFKRMFSLRTVMELLKDLTIITVVGIVGYKFLQDNYLKILNLG-TLRPWYMITGLLSLAISIFFRITL----IMLFIAVA-----DYVYQKYQYNKDLKMTKQEVKEEYKQDEGDPQIKSKIKQKQREMAM----QRMMQEVPKATVVVTNPTHIAVALRYEKG-D-TAPKVVAKGADYVAIKIKDIAKNNEVPVIENKPLARLIYEKVEIDSEVPQDMYEAVAEIL----------------  11
  12 -ADEKTEEATPKKKSDSKKKGQMARSKDVSVAI-TMAACTLAVSMLWGSLVDTFKGVLTYFL----VFPSLKDFNELTAMSLISFSLLKVATVFLPFALAIM---IAG-VASSIIQT-GFLITGEPLKPSLGKIN---PLKGLKNMFSKRSLVGLIKNVVVVTIISILAYKYVKNNYVDIINIS-NLYLPSLGDEIKNLVIGIFKQITL----ALVIIGAT-----DYFVQFRLHNKELKMTKQEIKDEYKQAEGDPQLKAKIKQKQREMGM----RRMMQSVSDATVVITNPTHLAIALKYEEGGNMEAPKVVAKGADNVALRLKTIAKDNDVPIVENKPLARLMYDRVEIDQDIPQDLYQGVAEVL----------------  12
  13 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ATFIVNNPTHISVVLRYNKHVD-AAPIVVAKGEDELALYIRTLAREQEIPMVENRPLARSLYYQVEEDMAIPEDLYVAVIEVMRYLIQTN---------  13
  14 ---NKTEKATPQKRKKSREEGNIARSKDLNNLF-SILVLAVVVYFFGDWLGFEIANSVAVLF-----DQIGKNTDSTEYFYLMGILLLKVSV---PILILVY---AFH-LFNYMIQV-GFLFSSKVIKPKASRIN---PKNYFTRLFSRKSLVDILKSLFYMGLIGYVSYVLFKKNLEKIVSMI-GFNWTASLTEIIRQIKFIFLAILI----ILIVLSII-----DFIYQKWEYEQDIKMKKEEVKREHKDNEGDPQVKGKRKNFMHAILQ----GTIAKKMDGATFIVNNPTHISVVLRYNKQVD-AAPIVVAKGEDELALYIRTLAREQEIPMVENRPLARSLYYQVEEDETIPEDLYVAVIEVMRYLIQTN---------  14
  15 ----KTEKPTAKKLDEAKKKG-VPHSRDLTSTV-TLIAAMVALYTTGGFMFTTLKRTSGELL----GSMGTFHLTEASVEHLLIKLFLVFLSVVMPFMLVVV---ISG-LATTMVQV-GFSMNSERITFKLDKLN---PVTNAQKLFNKDSLVEMLKAVLKIVIVGYMSYKIMRDEMDGLLFLA-DTD----LAGILEVFKHLAFKLVIHTCGVLLILGVL-----DLAFVKWRFIDNLKMTKQEVKDEHKESEGDPKVKGKIRQMQFQQAQ----KRLRKVIPTADVVVTNPTHYAVALKYERE-TMAAPLVLAKGVDHMAQTIKAIARENNVMLVENRFLARELYAQVKEGQPIPESLYTAVAEVLAYV-------------  15
  16 -GGEKTEEASGKRLEEAREKGQIAKSPEFATAA-FLLGFLLVFSFTGPQLWRFLLDTMGTSL----ATAGDSEHMGAGLIPWMQVISFRTIVAMLGAVAAMA---VVA-VAVQAAQT-GGLLTTKTLAPKFERLN---PMSNAGRILGKQSIVELAKALLKMMIVGYAVYMTVSDAWPDLQALALNASPMALLEVVQKYGFALIKNAGM----MFLVLAMA-----DYGYQRWKTMEDLKMTKQEVKEEHKSQEGNPEVKGRRRAIARERIR----RQMFAAVPKADVIIVNPVHIAIAIKYDPN-VAPAPYVVALGERKIAQRIKELAFQHGVPVIENKPLARALIKVAKVGTVIPVEMYLAVAEVLAFVMRQ----------  16
  17 MSGERTEKASPRRKQEAREKGDIPHSRDLTSAA-AMLAGTLVLGWAGPMWEARWAGSYSEML----DLSQPRSWLDGQMVEKMLAIRAAMMTVLWPLVVMFLACFAAA-VLAGVAQGRGVQFAGEAIAPKIERLN---PLTVLQQTFSSRGLTRMLKSALPVAALACFVAGKVREQ---------TAIPVFSLTRLPSLFTSMY-SLMVAAAAVLFVWSAI-----DYAVEWWSWEQRLRMSKQEVREEFKQTEGNPEVRRRIASIRRQLRR----KALRADVSRASVVITNPTHYAVALQFSLE-LMEAPRVLAKGRDLLAEQIKQEARWAGVPLVENPPLARALYRQVEVGQSIPFALYAAVAAILAWLYRRDMEER-----  17
  18 -SEEKTEKPSAQKLRKAREEGQLPRSKDMGLAA-SLFAAFVVISSSFPWYADFVRESFIS------VHQYAQEINNPEVIGQFLRHHLLILGKFILTLLPMP---AAA-LLSSLVPG-GWLFLPKKILPDFSKIS---PLKGIGRLFSSEHLAETGKMTVKSVVVLVMLWVSLRNNFASFLGLQ-ALPFKLAMNEGLSLYACVMRNFVI----LFIFFALI-----DVPLAKALFTKGLKMTKQELKEEYKNQEGKPEVKARVRRLQRQLAM----GQIRKVVPKANVVITNPTHYAVALQYDSS-RAAAPFVVAKGTDEIALYIRQVAAENQVEVVEFPRLARSVYYTTQVNQQIPFQLYRAIAHVLTYV-------------  18
  19 MSEEKTEKPTEKKLRDARRDGEVPVSPDVTAAA-VLFGALMVMKSAGDYFSDHMRALMTIGF-----DFPENTRDATAINRALGHIGIQGLLLMLPLLVACL---VAG-VAGGAFQT-GLNASLKPVAPKFDSLN---PATGVKKLFSLRSLINLLKLIIKAILIGVVLWAGIRILMPMIIGLAYQTPPDIAQIAWRTLGMLFALGVLL-----FVLVGAA-----DWSVQHWLFIRDKRMSKDEQKREVKESEGDPEIKGKRKEFAKDMVF----GDPRERVAKAKVMVVNPTHYAVALAYEPD-DFGLPQVVAKGVDDGALELRAFAHNQGIPIVANPPLARALY-QVELGDAVPEPLFETVAVVLRWVDELGRDHSD----  19
  20 ----RTELPTDQKKQKAREEGRVLKSTEINTAV-SLLLLFALFFFMLSYFALDLIAVFKE------QAIKLPEVMRMSVYTMGFAYIRSIMGYVVLFFFASL---AVN-FFVNIIQV-GFFITFKSLEPRWDKISFNFSRWAKNSFFSAGAFFNLFKSLLKVVIICLIYYFIIENNIGKISKLS-----EYTLQSGISIVLVIAYKICFFSVMFLAIVGVF-----DYLFQRSQYIESLKMTKEEVKQERKEMEGDPLLRSRIKERMRVILS----TNLRVAIPQADVVITNPEHFAVAIKWDSE-TMLAPKVLAKGQDEIALTIKKIARENNVPLMENKLLARALYANVKVNEEIPREYWEIVSKIL----------------  20
  21 --GEKTEKATPKRLRDARKKGQVAKSQDFPSAI-TFIVSMFLTFSLASFFAEHLGSFLVSIF-----KTAPQNHDPHLAVYYLKNCLILILTVSLPLLGAVG---FVG-LLIGFLIV-GPTFSTEVFKPDLKKFN---PIDNLKQKFKVKTFIELLKSIFKISGAALILYIVLKNRVELVIETA-GIPPLVTAQVFKEILYKAVTSIGI----FFLVVAVI-----DLVYQRHSFAKELKMEKFEVKQEFKDTEGNPEIKGRRRQIAQEIAY----EDTSSQIKHASAVVSNPKDIAVAIGYMPE-KYKAPWIIAMGVNLRAKRIIAEAEKYGVPIMRNVPLAHQLLDEGKELKFIPETTYEAVGEILLYITSLNAQNLENKN-  21
  22 --GEKTEKATPKKLRDARNKGQVAKSQDLPSAF-TFIVSIWVTLAASKFLFDHLGSFTVMTF----HQIAKGSLDTAIPDLYIQG-LTEIFITSIPILGMVS---VIG-VLINFLVV-GPMFALEVFKFDIKKFD---PISNLKSKFKLKTLVELLKSVLKISIACYIVYDVMWKSLPVLIRAV-SLPIDASLMVFYAFLMEVVIKVGL----FFIIIAVA-----DFIYQKKTFASEMKMEKFEVKQEYKNSEGDPQIKSKRKQIAQEIAY---QEGPRGGVKRAQAVVTNPTHLAIAIGYKKD-YDAAPFVLAKGEDALAERIIKYAEEFNVPVVRNIKLAHKLWEEADVYEFVPEDTYELIAEILRWISSLNTDTQH----  22
  23 -MSEKTEKPTPKKLRDLKKKGDVTKSEEVMAAVQSLILFSFFSLYGMSFFVDIVG--LVNT------TIDSLNRPFLYAIREILGAVLNIFLLYILPISLIV---FVGTVTTGVSQI-GFIFAVEKIKPSAQKIS---VKNNLKNIFSVKSIFELLKSVFKLVIIVLIFYFMGHSYANEFANFT-GLNAYQALVVVAFFVFLLWKGVLF----GYLLFSVF-----DFWFQKHEGLKKMKMSKDEVKREAKDTDGNPEIKGERRRLHSEIQS----GSLANNIKKSTVIVKNPTHIAICLYYKLG-ETPLPLVIETGKDAKALQIIKLAELYDIPVIEDIPLARTLYKNIHKGQYITEDFFEPVAQLIRIAIDLDY--------  23
  24 MSGNKTEKPTRKRREEAARKGQSFRSRDFIVAC-LTLGGTAYLASVAS-----LRSLMEV------LGQAVSFHFQINIADYTEQVFCSGMKIILPFLALCL---FCS-ALPSILQT-GFVLATKALQPRLSALD---PTKGIKKIFSLRTVKEAVKAILYLGSFIISGMLFWFENKRLVFSQV-----NGNLFVVADVWRHLLFSLVALCLGCSVIILLL-----DALAEYFLVMKDMKMDKEEVKREMKETEGNPEVKSRRREIHMDILS----EQIKSDIDNSRLIIANPTHIAVGIYFKPE-IAPYPLISVREANQRALAVRQYAEKVGIPVVVDIRLARRIFKTHRRYDVVNLESVDEILRLLVWLEQ-----------  24
  25 MSSNKTEKPTKKRLEDSAKKGQSFKSKDLIIAC-LTLGGIAYLVSYGS-----FNEFMGI------IKIIIADNFEQSMADYSLAVFGIGLKYLIPFMLLCL---VCS-ALRALLQA-GFVLATEALKPNLSALN---PVEGAKKLFSMRTVKDTVKTLLYLSSFVVAAIICWKKYKVEIFLQL-----NGNVVGIAVIWRELLLALVLTCLACALIVLLL-----DAIAEYFLTMKDMKMDKEEVKREMKEQEGNPEVKSKRREVHMEILS----EQVKSDIENSRLIVANPTHITIGIYFKPE-LMPIPMISVYETNQRALAVRAYAEKVGVPVIVDIKLARSLFKTHRRYDLVSLEEIDEVLRLLVWLE------------  25
  26 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKSDVSNSRLMIANPTHIAIGIYFKPH-LSPIPLISVRETNEVALAVRKYAKEIGIPIITDKKLARKIYATHRRYDYVSFENIDEILRLLLWLE------------  26
  27 --ANKTEKPTQKKLQDASKKGQILKSRDLTVSV-IMLVGTLYLGYVFD-----VHHIMSI------LEYILDHNAKPDIWDYFKAMGIGWLKTIIPFLLVCM---FTT-ILVSWFQS-KMQLATEAVKLKFDSLN---PVNGLKRIFGLKTVKEFVKAILYIIFFALEIKVFWSNHKSLLFKTL-----DGDIISLLSDWGEMLFLLILYCLGSMIIVLIF-----DFIAEYFLFMKDMKMDKQEVKREYKEQEGNPEIKSKRRERHQEILS----EQLKSDVSNSRLMIANPTHIAIGIYFKPH-LSPIPLISVRETNEVALAVRKYAKEIGIPIITDKKLARKIYATHRRYDYVSFENIDEILRLLLWLEDVENAGQPVPDE  27
  28 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ISNPTHIAIGIYFKPH-LSPIPLISVRVTNEVALGVRKYAKEIGIPIITDKKLARKNYATHRRYDYVSFENIDEILRLL----------------  28
  29 MSGEKTEQPTPKKIRDARKKGQVAKSKEVVSTA-LIVALSAMLMGLSDYYFEHFSKLMLI------PAEQSYLPFSQALSYVVDNVLLEFFYLCFPLLTVAA---LMA-IASHVVQY-GFLISGEAIKPDIKKIN---PIEGAKRIFSIKSLVEFLKSILKVVLLSILIWIIIKGNLVTLLQLP-----TCGIECITPLLGQILRQLMVICTVGFVVISIA-----DYAFEYYQYIKELKMSKDEIKREYKEMEGSPEIKSKRRQFHQEIQS----RNMRENVKRSSVVVANPTHIAIGILYKRG-ETPLPLVTFKYTDAQVQTVRKIAEEEGVPILQRIPLARALYWDALVDHYIPAEQIEATAEVLRWLERQNIEKQHSEML  29

     Active site residue:           X

     Putative:              +

     Experimental:          #