$VAR1 = undef;
Summary for peptidase C01.076: CPA peptidase
| Names | |
|---|---|
| MEROPS Name | CPA peptidase |
| Other names | CPA protease, Lacys24 (L. amazonensis), lmcpa g.p. (Leishmania mexicana), lpcys1 g.p. (Leishmania pifanoi) |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan CA >> Subclan (none) >> Family C1 >> Subfamily A >> C01.076 |
| Holotype | CPA peptidase (Leishmania mexicana), Uniprot accession P25775 (peptidase unit: 128-342), MERNUM MER0000667 |
| History | Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London. |
| Activity | |||
|---|---|---|---|
| Catalytic type | Cysteine | ||
| NC-IUBMB | Not yet included in IUBMB recommendations. | ||
| Physiology | Immune avoidance. Invasion of macrophages. | ||
| Pharmaceutical relevance | Potential drug target for leishmaniasis. It is reported that immunisation with a cocktail of two plasmids expressing CPa and CPb induces a long lasting protective response in mice (Rafati et al., 2001). | ||
