$VAR1 = undef;
Summary for peptidase M03.002: neurolysin
Names | |
---|---|
MEROPS Name | neurolysin |
Other names | endopeptidase 24.16, microsomal endopeptidase, mitochondrial oligopeptidase, NLN g.p. (Homo sapiens), neurotensin-degrading enzyme, neurotensin endopeptidase, oligopeptidase M, soluble angiotensin II-binding protein, thimet oligopeptidase II |
Domain architecture |
---|
MEROPS Classification | |
---|---|
Classification | Clan MA >> Subclan MA(E) >> Family M3 >> Subfamily A >> M03.002 |
Holotype | neurolysin (Rattus norvegicus), Uniprot accession P42676 (peptidase unit: 26-704), MERNUM MER0001942 |
History | Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London. |
Activity | |||
---|---|---|---|
Catalytic type | Metallo | ||
Peplist | Included in the Peplist with identifier PL00137 | ||
NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.16 | ||
Enzymology | BRENDA database | ||
Proteolytic events | CutDB database (1 cleavage) | ||
Activity status | human: active (Barrett & Dando, 2004) mouse: active (by similarity to rat) (Serizawa et al., 1995) | ||
Physiology | Intracellular oligopeptide degradation. Proposed role in destruction of several bioactive peptides. | ||
Pathways | KEGG | Renin-angiotensin system | |
Other databases | TREEFAM | http://www.treefam.org/family/TF300459 | |
Cleavage site specificity | Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here. | ||
Cleavage pattern | G/F/spgr/PFsr/Rpi/Q/- (based on 128 cleavages) |
Specificity matrix | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Human genetics | ||||||
---|---|---|---|---|---|---|
Gene symbol | Locus | Megabases | Ensembl | Entrez gene | Gene Cards | OMIM |
NLN | 5q12.3 | ENSG00000123213 | 57486 | NLN | ||
Mouse genetics | ||||||
Gene symbol | Position | Megabases | Ensembl | Entrez gene | MGI | |
Nln | 13:D1 | ENSMUSG00000021710 | 75805 | MGI:1923055 |