$VAR1 = undef;
Summary for peptidase M09.002: collagenase G/A (Clostridium histolyticum)
Names | |
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MEROPS Name | collagenase G/A (Clostridium histolyticum) |
Other names | bacterial collagenase, class I, clostridiopeptidase A, Clostridium histolyticum collagenase, colA g.p. (Clostridium perfringens), collagenase A, collagenase Clostridium histolyticum, collagenase I, colG g.p. (Clostridium histolyticum), microbial collagenase, class I, Xiaflex |
Domain architecture |
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MEROPS Classification | |
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Classification | Clan MA >> Subclan MA(E) >> Family M9 >> Subfamily B >> M09.002 |
Holotype | collagenase G/A (Clostridium histolyticum) (Hathewaya histolytica), Uniprot accession Q9X721 (peptidase unit: 319-798), MERNUM MER0005663 |
History | Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London. |
Activity | |||
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Catalytic type | Metallo | ||
Peplist | Included in the Peplist with identifier PL00153 | ||
NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.3 | ||
Enzymology | BRENDA database | ||
Proteolytic events | CutDB database (2 cleavages) | ||
Biotechnology | Many uses, including tissue cell dispersion. | ||
Physiology | Required for bacterial nutrition; may act in tissue invasion by this pathogen. | ||
Pharmaceutical relevance | Agent under investigation for treatment of bed sores, and for chemonucleolysis of herniated intervertebral disks. | ||
Cleavage site specificity | Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here. | ||
Cleavage pattern | -/G/pa/-Ga/p/-/g (based on 167 cleavages) |
Specificity matrix | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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