$VAR1 = undef;
Summary for peptidase S01.162: kallikrein-related peptidase 3
Names | |
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MEROPS Name | kallikrein-related peptidase 3 |
Other names | APS g.p. [obs.] (Homo sapiens), hk3, kallikrein 3, kallikrein hK3, P-30 antigen, prostate-specific antigen, PSA, seminin, gamma-seminoprotein, KLK3 g.p. (Homo sapiens), semenogelase |
Domain architecture |
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![](/merops/cgi-bin/dbstore/merops/domain_image/unknown/120/mer0000115.png)
MEROPS Classification | |
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Classification | Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.162 |
Holotype | kallikrein-related peptidase 3 (Homo sapiens), Uniprot accession P07288 (peptidase unit: 25-260), MERNUM MER0000115 |
History | Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London. |
Activity | |||
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Catalytic type | Serine | ||
Peplist | Included in the Peplist with identifier PL00291 | ||
NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.77 | ||
Enzymology | BRENDA database | ||
Proteolytic events | CutDB database (37 cleavages) | ||
Biotechnology | Used in detection and assessment of prostate cancer. | ||
Pharmaceutical relevance | A potential drug target for prostatic and other cancers (Gygi et al., 2002). | ||
Other databases | WIKIPEDIA | http://en.wikipedia.org/wiki/KLK3 | |
Cleavage site specificity | Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here. | ||
Cleavage pattern | si/sq/-/yqr![]() |
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Specificity matrix | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Human genetics | ||||||
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Gene symbol | Locus | Megabases | Ensembl | Entrez gene | Gene Cards | OMIM |
KLK3 | 19q13.3-q13.4 | ENSG00000142515 | 354 | KLK3 | 176820 |