$VAR1 = undef;
Summary for peptidase S01.251: kallikrein-related peptidase 4
Names | |
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MEROPS Name | kallikrein-related peptidase 4 |
Other names | enamel matrix serine proteinase 1, EMSP1, kallikrein hK4, kallikrein 4 (Homo sapiens), kallikrein-like 1 protein (Homo sapiens), KLK4 g.p. (Homo sapiens), Klk4 g.p. (Mus musculus), prostase, PRSS17 [obs.] g.p. (Homo sapiens), serine protease 17 [obs.] |
Domain architecture |
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![](/merops/cgi-bin/dbstore/merops/domain_image/unknown/120/mer0005266.png)
MEROPS Classification | |
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Classification | Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.251 |
Holotype | kallikrein-related peptidase 4 (Homo sapiens), Uniprot accession Q9Y5K2 (peptidase unit: 31-254), MERNUM MER0005266 |
History | Identifier created: MEROPS 3.02 (25 June 1998) |
Activity | |||
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Catalytic type | Serine | ||
Peplist | Included in the Peplist with identifier PL00326 | ||
NC-IUBMB | Not yet included in IUBMB recommendations. | ||
Proteolytic events | CutDB database (10 cleavages) | ||
Activity status | human: active (Simmer, 2004) mouse: active (by similarity) (Hu et al., 2000) | ||
Physiology | Mutation in prostase causes autosomal recessive hypomaturation amelogenesis imperfecta (Hart et al., 2004). | ||
Pharmaceutical relevance | Proposed for use in vaccine strategies against prostate cancer (Hural et al., 2002). | ||
Other databases | WIKIPEDIA | http://en.wikipedia.org/wiki/KLK4 | |
Cleavage site specificity | Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here. | ||
Cleavage pattern | r/-/-/R![]() |
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Specificity matrix | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Specificity from combinatorial peptides | ||||||||||||||||||||||||||||||||||||||||
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Human genetics | ||||||
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Gene symbol | Locus | Megabases | Ensembl | Entrez gene | Gene Cards | OMIM |
KLK4 | 19q13.3-q13.4 | ENSG00000167749 | 9622 | KLK4 | 603767 | |
Mouse genetics | ||||||
Gene symbol | Position | Megabases | Ensembl | Entrez gene | MGI | |
Klk4 | 7:B2 | ENSMUSG00000006948 | 56640 | MGI:1861379 |