| Activity |
|---|
| Catalytic type | Serine |
| Peplist | Included in the Peplist with identifier PL00336 |
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.117
|
| Enzymology | BRENDA database |
| Proteolytic events | CutDB database (6 cleavages) |
| Activity status | human: active (Egelrud, 2004)
mouse: active (by similarity to human) (Backman et al., 1999)
|
| Physiology | May play a role in desquamation of stratum corneum. Enhanced expression in inflammatory skin disease may be of etiological significance (Hansson et al., 2002). |
| Pharmaceutical relevance | A genetic association between an AACC insertion in the 3"UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis has been reported by Vasilopoulos et al., 2004, suggesting that the enzyme could have an important role in the development of atopic dermatitis. |
|
Other databases
| WIKIPEDIA | http://en.wikipedia.org/wiki/KLK7 |
| Cleavage site specificity |
Explanations of how to interpret the
following cleavage site sequence logo and specificity matrix can be found here. |
|---|
| Cleavage pattern | -/-/-/Yfr -/-/-/- (based on 43 cleavages) |
