$VAR1 = undef;
Summary for peptidase S06.001: IgA1-specific serine peptidase (Neisseria-type)
| Names | |
|---|---|
| MEROPS Name | IgA1-specific serine peptidase (Neisseria-type) |
| Other names | IgA protease (Neisseria), igaB g.p. (nontypeable Haemophilus influenzae) |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan PA >> Subclan PA(S) >> Family S6 >> Subfamily (none) >> S06.001 |
| Holotype | IgA1-specific serine peptidase (Neisseria-type) (Neisseria gonorrhoeae), Uniprot accession P09790 (peptidase unit: 28-823), MERNUM MER0000278 |
| History | Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London. |
| Activity | |||
|---|---|---|---|
| Catalytic type | Serine | ||
| Peplist | Included in the Peplist with identifier PL00339 | ||
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.72 | ||
| Enzymology | BRENDA database | ||
| Proteolytic events | CutDB database (3 cleavages) | ||
| Pharmaceutical relevance | May allow organism to evade immune response by degrading host IgA1, particularly in meningitis. However, the role of the enzyme in allowing the organism to survive in the human host has been questioned. | ||
