| Activity |
|---|
| Catalytic type | Serine |
| Peplist | Included in the Peplist with identifier PL00365 |
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.14 (Dipeptidyl-peptidase and tripeptidyl-peptidases) >> Peptidase 3.4.14.10
|
| Enzymology | BRENDA database |
| Activity status | human: active (Tomkinson, 2004)
mouse: active (Tomkinson et al., 1997)
|
| Inhibitors | Butabindide is regarded as a highly specific inhibitor (Rose et al., 1996). |
| Physiology | Contributes to cytosolic degradation of oligopeptides, and to the late stages of processing of antigenic peptides for the MHC class I system (Levy et al., 2002). |
| Pharmaceutical relevance | Since tripeptidyl-peptidase II is responsible for much of the degradation of cholecystokinin-8, there is interest in inhibitors as drugs (Breslin et al., 2003). |
|
Other databases
| TREEFAM | http://www.treefam.org/family/TF105647 |
