Structure for inhibitor I04.020: plasminogen activator inhibitor-1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Pharma

PDB	Organism	Resolution	Comment
1LJ5_A	Homo sapiens	1.80 Å	mature
The reactive site residue Thr369 is shown in ball-and-stick representation in pink.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Danio rerio
crystal structure of zebrafish plasminogen activator inhibitor-1 (pai-1)	1.96 Å	4DTE	4DTE	4DTE	4DTE	4DTE	4DTE
Homo sapiens
complex with reactive-centre loop pentapeptide	1.95 Å	1A7C	1A7C	1A7C	1A7C	1A7C	1A7C	Xue et al., 1998
mature inhibitor	2.99 Å	1B3K	1B3K	1B3K	1B3K	1B3K	1B3K	Sharp et al., 1999
mature inhibitor	2.60 Å	1C5G	1C5G	1C5G	1C5G	1C5G	1C5G	Tucker et al., 1995
mature inhibitor	2.70 Å	1DB2	1DB2	1DB2	1DB2	1DB2	1DB2	Nar et al., 2000
mature inhibitor	2.40 Å	1DVM	1DVM	1DVM	1DVM	1DVM	1DVM	Stout et al., 2000
latent form	2.10 Å	1DVN	1DVN	1DVN	1DVN	1DVN	1DVN	Stout et al., 2000
mature inhibitor	1.80 Å	1LJ5	1LJ5	1LJ5	1LJ5	1LJ5	1LJ5
plasminogen activator inhibitor-1 complex with somatomedin b domain of vitronectin	2.28 Å	1OC0	1OC0	1OC0	1OC0	1OC0	1OC0	Zhou et al., 2003
cleaved form	2.02 Å	3CVM	3CVM	3CVM	3CVM	3CVM	3CVM	Jensen & Gettins, 2008
cleaved pai-1-stab	2.61 Å	3EOX	3EOX	3EOX	3EOX	3EOX	3EOX	Dewilde et al., 2009
mature inhibitor	2.30 Å	3PB1	3PB1	3PB1	3PB1	3PB1	3PB1	Lin et al., 2011
mature inhibitor	2.30 Å	3Q02	3Q02	3Q02	3Q02	3Q02	3Q02	Jensen et al., 2011
mature inhibitor	2.64 Å	3Q03	3Q03	3Q03	3Q03	3Q03	3Q03	Jensen et al., 2011
mature inhibitor	2.70 Å	3R4L	3R4L	3R4L	3R4L	3R4L	3R4L	Jankun et al., 2012
mature inhibitor	2.42 Å	3UT3	3UT3	3UT3	3UT3	3UT3	3UT3
mature inhibitor	2.40 Å	4AQH	4AQH	4AQH	4AQH	4AQH	4AQH	Fjellstrom et al., 2013
mature inhibitor	2.71 Å	4G8O	4G8O	4G8O	4G8O	4G8O	4G8O	Li et al., 2013
mature inhibitor	2.19 Å	4G8R	4G8R	4G8R	4G8R	4G8R	4G8R	Li et al., 2013
mature inhibitor	2.32 Å	4IC0	4IC0	4IC0	4IC0	4IC0	4IC0
mature inhibitor	3.16 Å	5BRR	5BRR	5BRR	5BRR	5BRR	5BRR	Gong et al., 2015
structure of tpa and pai-1	3.58 Å	5ZLZ	5ZLZ	5ZLZ	5ZLZ	5ZLZ	5ZLZ
discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1	2.90 Å	6I8S	6I8S	6I8S	6I8S	6I8S	6I8S
cleaved substrate variant	2.70 Å	9PAI	9PAI	9PAI	9PAI	9PAI	9PAI	Aertgeerts et al., 1995
Mus musculus
mature inhibitor	1.93 Å	3LW2	3LW2	3LW2	3LW2	3LW2	3LW2	Dewilde et al., 2010
Oncorhynchus mykiss
crystal structure of latent rainbow trout plasminogen activator inhibitor 1 (pai-1)	1.67 Å	4KDS	4KDS	4KDS	4KDS	4KDS	4KDS