Structure analysis

NMR STRUCTURE OF THE FYN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PEPTIDE, 22 STRUCTURES

Solution NMR
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 7441.67 Å2
Buried surface area: 901.18 Å2
Dissociation area: 450.59 Å2
Dissociation energy (ΔGdiss): 2.5 kcal/mol
Dissociation entropy (TΔSdiss): 7.92 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-136550

Macromolecules

Chain: F
Length: 106 amino acids
Theoretical weight: 12.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P06241 (Residues: 143-248; Coverage: 20%)
  • Best match: P06241-3 (Residues: 143-232)
Gene name: FYN
Pfam: SH2 domain
InterPro:
CATH: SH2 domain
SCOP: SH2 domain

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Chain: P
Length: 11 amino acids
Theoretical weight: 1.47 KDa
Source organism: Mesocricetus auratus polyomavirus 1
UniProt:
  • Canonical: P03079 (Residues: 321-331; Coverage: 3%)

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