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MURINE CD8AA ECTODOMAIN FRAGMENT IN COMPLEX WITH H-2KB/VSV8

X-ray diffraction
2.8Å resolution
PDB entry 1bqh coloured by chain, front view.
PDB entry 1bqh coloured by chain, side view.
PDB entry 1bqh coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
hetero pentamer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: CD8alpha-alpha complex
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Multimeric state: hetero pentamer
Accessible surface area: 29168.79 Å2
Buried surface area: 10456.13 Å2
Dissociation area: 1,557.64 Å2
Dissociation energy (ΔGdiss): -2.76 kcal/mol
Dissociation entropy (TΔSdiss): 13.11 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134573
Assembly 2
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Assembly Name: CD8alpha-alpha complex
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Multimeric state: hetero pentamer
Accessible surface area: 29214.69 Å2
Buried surface area: 10182.81 Å2
Dissociation area: 1,545.21 Å2
Dissociation energy (ΔGdiss): -1.96 kcal/mol
Dissociation entropy (TΔSdiss): 13.11 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134573

Macromolecules

H-2 class I histocompatibility antigen, K-B alpha chain
Chains: A, D
Length: 274 amino acids
Theoretical weight: 31.65 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P01901 (Residues: 22-295; Coverage: 79%)
Gene names: H2-K, H2-K1
Pfam:
InterPro:
CATH:
SCOP:
H-2 class I histocompatibility antigen, K-B alpha chain in PDB entry 1bqh, assembly 1, front view.
H-2 class I histocompatibility antigen, K-B alpha chain in PDB entry 1bqh, assembly 1, side view.
H-2 class I histocompatibility antigen, K-B alpha chain in PDB entry 1bqh, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P01901  
127420406080100120140160180200220240260
 
100200
UniProt
P01901
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
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Beta-2-microglobulin
Chains: B, E
Length: 99 amino acids
Theoretical weight: 11.7 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P01887 (Residues: 21-119; Coverage: 100%)
Gene name: B2m
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins
SCOP: C1 set domains (antibody constant domain-like)
Beta-2-microglobulin in PDB entry 1bqh, assembly 1, front view.
Beta-2-microglobulin in PDB entry 1bqh, assembly 1, side view.
Beta-2-microglobulin in PDB entry 1bqh, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P01887  
199102030405060708090
 
50100IQKTPQIQVYSRHPPENGKPNILNCYVTQFHPPHIEIQMLKNGKKIPKVEMSDMSFSKDWSFYILAHTEFTPTETDTYACRVKHDSMAEPKTVYWDRDM
UniProt
P01887
Chains
Domains
Secondary structure
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PROTEIN (VSV8)
Chains: C, F
Length: 8 amino acids
Theoretical weight: 956 Da
PROTEIN (VSV8) in PDB entry 1bqh, assembly 1, front view.
PROTEIN (VSV8) in PDB entry 1bqh, assembly 1, side view.
PROTEIN (VSV8) in PDB entry 1bqh, assembly 1, top view.
181.01.52.02.53.03.54.04.55.05.56.06.57.07.58.0
 
2468RGYVYQGL
Chains
Chain C (auth C)
Chain F (auth F)
Flexibility predictions
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T-cell surface glycoprotein CD8 alpha chain
Chains: G, H, I, K
Length: 129 amino acids
Theoretical weight: 14.51 KDa
Source organism: Mus musculus
Expression system: Mus musculus
UniProt:
  • Canonical: P01731 (Residues: 28-156; Coverage: 59%)
Gene names: Cd8a, Lyt-2, Lyt2
Pfam: Immunoglobulin V-set domain
InterPro:
CATH: Immunoglobulins
SCOP: V set domains (antibody variable domain-like)
T-cell surface glycoprotein CD8 alpha chain in PDB entry 1bqh, assembly 1, front view.
T-cell surface glycoprotein CD8 alpha chain in PDB entry 1bqh, assembly 1, side view.
T-cell surface glycoprotein CD8 alpha chain in PDB entry 1bqh, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P01731  
1129102030405060708090100110120
 
50100
UniProt
P01731
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
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