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USE OF AN N-TERMINAL FRAGMENT FROM MOLONEY MURINE LEUKEMIA VIRUS REVERSE TRANSCRIPTASE TO FACILITATE CRYSTALLIZATION AND ANALYSIS OF A PSEUDO-16-MER DNA MOLECULE CONTAINING G-A MISPAIRS

X-ray diffraction
2.3Å resolution
PDB entry 1d1u coloured by chain, front view.
PDB entry 1d1u coloured by chain, side view.
PDB entry 1d1u coloured by chain, top view.
Source organism: Moloney murine leukemia virus
Assembly composition:
hetero trimer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Reverse transcriptase/ribonuclease H and DNA
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Multimeric state: hetero trimer
Accessible surface area: 15565.86 Å2
Buried surface area: 1398.81 Å2
Dissociation area: 402.73 Å2
Dissociation energy (ΔGdiss): -9.15 kcal/mol
Dissociation entropy (TΔSdiss): 10.18 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-113580

Macromolecules

Reverse transcriptase/ribonuclease H
Chain: A
Length: 255 amino acids
Theoretical weight: 28.93 KDa
Source organism: Moloney murine leukemia virus
Expression system: Escherichia coli
UniProt:
  • Canonical: P03355 (Residues: 683-937; Coverage: 15%)
Gene name: gag-pol
Pfam: Reverse transcriptase (RNA-dependent DNA polymerase)
InterPro:
CATH:
SCOP: Reverse transcriptase
Reverse transcriptase/ribonuclease H in PDB entry 1d1u, assembly 1, front view.
Reverse transcriptase/ribonuclease H in PDB entry 1d1u, assembly 1, side view.
Reverse transcriptase/ribonuclease H in PDB entry 1d1u, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P03355  
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DNA chain B
Name: DNA (5'-D(*CP*TP*CP*GP*TP*G)-3')
Representative chains: B
Source organism: Moloney murine leukemia virus [11801]
Expression system: Not provided
Length: 6 nucleotides
Theoretical weight: 1.8 KDa
DNA (5'-D(*CP*TP*CP*GP*TP*G)-3') in PDB entry 1d1u, assembly 1, front view.
DNA (5'-D(*CP*TP*CP*GP*TP*G)-3') in PDB entry 1d1u, assembly 1, side view.
DNA (5'-D(*CP*TP*CP*GP*TP*G)-3') in PDB entry 1d1u, assembly 1, top view.
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DNA chain C
Name: DNA (5'-D(*AP*CP*GP*GP*CP*AP*CP*GP*AP*G)-3')
Representative chains: C
Source organism: Moloney murine leukemia virus [11801]
Expression system: Not provided
Length: 10 nucleotides
Theoretical weight: 3.08 KDa
DNA (5'-D(*AP*CP*GP*GP*CP*AP*CP*GP*AP*G)-3') in PDB entry 1d1u, assembly 1, front view.
DNA (5'-D(*AP*CP*GP*GP*CP*AP*CP*GP*AP*G)-3') in PDB entry 1d1u, assembly 1, side view.
DNA (5'-D(*AP*CP*GP*GP*CP*AP*CP*GP*AP*G)-3') in PDB entry 1d1u, assembly 1, top view.
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