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Crystal structure of Oct-1 POU dimer bound to MORE

X-ray diffraction
1.9Å resolution
PDB entry 1e3o coloured by chain, front view.
PDB entry 1e3o coloured by chain, side view.
PDB entry 1e3o coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero hexamer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: POU domain, class 2, transcription factor 1 and DNA
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Multimeric state: hetero hexamer
PDBe Complex ID: PDB-CPX-113719

Macromolecules

POU domain, class 2, transcription factor 1
Chain: C
Length: 160 amino acids
Theoretical weight: 18.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P14859 (Residues: 280-355, 357-438; Coverage: 21%)
Gene names: OCT1, OTF1, POU2F1
Pfam:
InterPro:
CATH:
SCOP:
POU domain, class 2, transcription factor 1 in PDB entry 1e3o, assembly 1, front view.
POU domain, class 2, transcription factor 1 in PDB entry 1e3o, assembly 1, side view.
POU domain, class 2, transcription factor 1 in PDB entry 1e3o, assembly 1, top view.
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DNA chain A
Name: 5'-D(*AP*TP*GP*CP*AP*TP*GP*AP*GP*GP*A)-3'
Representative chains: A
Length: 11 nucleotides
Theoretical weight: 3.42 KDa
5'-D(*AP*TP*GP*CP*AP*TP*GP*AP*GP*GP*A)-3' in PDB entry 1e3o, assembly 1, front view.
5'-D(*AP*TP*GP*CP*AP*TP*GP*AP*GP*GP*A)-3' in PDB entry 1e3o, assembly 1, side view.
5'-D(*AP*TP*GP*CP*AP*TP*GP*AP*GP*GP*A)-3' in PDB entry 1e3o, assembly 1, top view.
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DNA chain B
Name: 5'-D(*TP*CP*CP*TP*CP*AP*TP*GP*CP*AP*T)-3'
Representative chains: B
Length: 11 nucleotides
Theoretical weight: 3.28 KDa
5'-D(*TP*CP*CP*TP*CP*AP*TP*GP*CP*AP*T)-3' in PDB entry 1e3o, assembly 1, front view.
5'-D(*TP*CP*CP*TP*CP*AP*TP*GP*CP*AP*T)-3' in PDB entry 1e3o, assembly 1, side view.
5'-D(*TP*CP*CP*TP*CP*AP*TP*GP*CP*AP*T)-3' in PDB entry 1e3o, assembly 1, top view.
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