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LACTOSE BINDING TO HEAT-LABILE ENTEROTOXIN REVEALED BY X-RAY CRYSTALLOGRAPHY

X-ray diffraction
2.3Å resolution
PDB entry 1ltt coloured by chain, front view.
PDB entry 1ltt coloured by chain, side view.
PDB entry 1ltt coloured by chain, top view.
Source organism: Escherichia coli
Assembly composition:
hetero heptamer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Heat-labile enterotoxin
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Multimeric state: hetero heptamer
Accessible surface area: 27568.24 Å2
Buried surface area: 23258.37 Å2
Dissociation area: 2,260.97 Å2
Dissociation energy (ΔGdiss): -3.7 kcal/mol
Dissociation entropy (TΔSdiss): 12.9 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139157

Macromolecules

Heat-labile enterotoxin B chain
Chains: D, E, F, G, H
Length: 103 amino acids
Theoretical weight: 11.81 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: P32890 (Residues: 22-124; Coverage: 100%)
Gene names: eltB, ltpB
Pfam: Heat-labile enterotoxin beta chain
InterPro:
CATH: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
SCOP: Bacterial AB5 toxins, B-subunits
Heat-labile enterotoxin B chain in PDB entry 1ltt, assembly 1, front view.
Heat-labile enterotoxin B chain in PDB entry 1ltt, assembly 1, side view.
Heat-labile enterotoxin B chain in PDB entry 1ltt, assembly 1, top view.
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Heat-labile enterotoxin A chain
Chain: A
Length: 185 amino acids
Theoretical weight: 21.35 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: P06717 (Residues: 22-206; Coverage: 77%)
Gene names: eltA, ltpA
Pfam: Heat-labile enterotoxin alpha chain
InterPro: Heat-labile enterotoxin, A chain
CATH: Heat-Labile Enterotoxin, subunit A
SCOP: ADP-ribosylating toxins
Heat-labile enterotoxin A chain in PDB entry 1ltt, assembly 1, front view.
Heat-labile enterotoxin A chain in PDB entry 1ltt, assembly 1, side view.
Heat-labile enterotoxin A chain in PDB entry 1ltt, assembly 1, top view.
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Heat-labile enterotoxin A chain
Chain: C
Length: 41 amino acids
Theoretical weight: 4.95 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: P06717 (Residues: 214-254; Coverage: 17%)
Gene names: eltA, ltpA
InterPro: Heat-labile enterotoxin, A chain
CATH: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
SCOP: ADP-ribosylating toxins
Heat-labile enterotoxin A chain in PDB entry 1ltt, assembly 1, front view.
Heat-labile enterotoxin A chain in PDB entry 1ltt, assembly 1, side view.
Heat-labile enterotoxin A chain in PDB entry 1ltt, assembly 1, top view.
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