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Binary enzyme-product complexes of human MMP12

X-ray diffraction
1.85Å resolution
PDB entry 1os9 coloured by chain, front view.
PDB entry 1os9 coloured by chain, side view.
PDB entry 1os9 coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
monomeric (preferred)
homo dimer
homo trimer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Macrophage metalloelastase
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Multimeric state: monomeric
Accessible surface area: 8707.43 Å2
Buried surface area: 278.1 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153971
Assembly 10
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Assembly Name: Macrophage metalloelastase
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Multimeric state: homo dimer
Accessible surface area: 16303.59 Å2
Buried surface area: 1524.87 Å2
Dissociation area: 488.33 Å2
Dissociation energy (ΔGdiss): 7.44 kcal/mol
Dissociation entropy (TΔSdiss): 11.54 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153975
Assembly 2
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Assembly Name: Macrophage metalloelastase
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Multimeric state: monomeric
Accessible surface area: 8618.15 Å2
Buried surface area: 277.13 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153971
Assembly 3
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Assembly Name: Macrophage metalloelastase
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Multimeric state: monomeric
Accessible surface area: 8671.99 Å2
Buried surface area: 279.74 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153971
Assembly 4
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Assembly Name: Macrophage metalloelastase
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Multimeric state: monomeric
Accessible surface area: 8768.82 Å2
Buried surface area: 278.39 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153971
Assembly 5
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Assembly Name: Macrophage metalloelastase
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Multimeric state: monomeric
Accessible surface area: 8596.47 Å2
Buried surface area: 277.1 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153971
Assembly 6
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Assembly Name: Macrophage metalloelastase
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Multimeric state: monomeric
Accessible surface area: 8626.08 Å2
Buried surface area: 278.38 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153971
Assembly 7
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Assembly Name: Macrophage metalloelastase
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Multimeric state: homo trimer
Accessible surface area: 23948.87 Å2
Buried surface area: 2983.03 Å2
Dissociation area: 1,082.84 Å2
Dissociation energy (ΔGdiss): 15.89 kcal/mol
Dissociation entropy (TΔSdiss): 23.91 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153976
Assembly 8
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Assembly Name: Macrophage metalloelastase
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Multimeric state: homo trimer
Accessible surface area: 23783.3 Å2
Buried surface area: 3027.52 Å2
Dissociation area: 1,104.71 Å2
Dissociation energy (ΔGdiss): 14.88 kcal/mol
Dissociation entropy (TΔSdiss): 23.91 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153976
Assembly 9
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Assembly Name: Macrophage metalloelastase
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Multimeric state: homo dimer
Accessible surface area: 16441.59 Å2
Buried surface area: 1511.87 Å2
Dissociation area: 482.59 Å2
Dissociation energy (ΔGdiss): 7.7 kcal/mol
Dissociation entropy (TΔSdiss): 11.54 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153975

Macromolecules

Macrophage metalloelastase
Chains: A, B, C, D, E, F
Length: 165 amino acids
Theoretical weight: 18.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P39900 (Residues: 106-268; Coverage: 36%)
Gene names: HME, MMP12
Pfam: Matrixin
InterPro:
CATH: Collagenase (Catalytic Domain)
SCOP: Matrix metalloproteases, catalytic domain
Macrophage metalloelastase in PDB entry 1os9, assembly 1, front view.
Macrophage metalloelastase in PDB entry 1os9, assembly 1, side view.
Macrophage metalloelastase in PDB entry 1os9, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P39900  
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