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Crystal structure of Anthrax Lethal Factor wild-type protein complexed with an optimised peptide substrate.

Source organism: Bacillus anthracis
Biochemical function: toxin activity
Biological process: modulation of process of another organism
Cellular component: host cell cytosol

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EC 3.4.24.83: Anthrax lethal factor endopeptidase

Reaction catalysed:
Preferred amino acids around the cleavage site can be denoted BBBBxHx-|-H, in which B denotes Arg or Lys, H denotes a hydrophobic amino acid, and x is any amino acid. The only known protein substrates are mitogen-activated protein (MAP) kinase kinases.
Systematic name:
-
Alternative Name(s):
  • Lethal toxin

GO terms

Sequence families

Pfam Protein families (Pfam)
PF07737
Domain description: Anthrax toxin lethal factor, N- and C-terminal domain
Occurring in:
  1. Lethal factor
The deposited structure of PDB entry 1pwv contains 4 copies of Pfam domain PF07737 (Anthrax toxin lethal factor, N- and C-terminal domain) in Lethal factor. Showing 2 copies in chain B.

PF09156
Domain description: Anthrax toxin lethal factor, middle domain
Occurring in:
  1. Lethal factor
The deposited structure of PDB entry 1pwv contains 2 copies of Pfam domain PF09156 (Anthrax toxin lethal factor, middle domain) in Lethal factor. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR003541
Domain description: Anthrax toxin, lethal/endema factor
Occurring in:
  1. Lethal factor
IPR047568
Domain description: Anthrax toxin lethal factor-like domain
Occurring in:
  1. Lethal factor
IPR014781
Domain description: Anthrax toxin, lethal/endema factor, N-/C-terminal
Occurring in:
  1. Lethal factor
IPR024079
Domain description: Metallopeptidase, catalytic domain superfamily
Occurring in:
  1. Lethal factor
IPR015239
Domain description: Anthrax toxin lethal factor, central domain
Occurring in:
  1. Lethal factor

Structure domains

CATH CATH domains
3.90.176.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Toxin ADP-ribosyltransferase; Chain A, domain 1
Homology: Toxin ADP-ribosyltransferase; Chain A, domain 1
Occurring in:
  1. Lethal factor
The deposited structure of PDB entry 1pwv contains 2 copies of CATH domain 3.90.176.10 (Toxin ADP-ribosyltransferase; Chain A, domain 1) in Lethal factor. Showing 1 copy in chain B.
3.40.390.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Collagenase (Catalytic Domain)
Homology: Collagenase (Catalytic Domain)
Occurring in:
  1. Lethal factor
The deposited structure of PDB entry 1pwv contains 4 copies of CATH domain 3.40.390.10 (Collagenase (Catalytic Domain)) in Lethal factor. Showing 2 copies in chain B.
1.10.2030.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Anthrax toxin lethal factor, domain 3, chain A
Homology: Anthrax toxin lethal factor, domain 3, chain A
Occurring in:
  1. Lethal factor
The deposited structure of PDB entry 1pwv contains 2 copies of CATH domain 1.10.2030.10 (Anthrax toxin lethal factor, domain 3, chain A) in Lethal factor. Showing 1 copy in chain B.
SCOP SCOP annotations
69775
Class: Alpha and beta proteins (a+b)
Fold: Zincin-like
Superfamily: Metalloproteases ("zincins"), catalytic domain
Occurring in:
  1. Lethal factor
The deposited structure of PDB entry 1pwv contains 4 copies of SCOP domain 69775 (Anthrax toxin lethal factor, N- and C-terminal domains) in Lethal factor. Showing 2 copies in chain B.
56400
Class: Alpha and beta proteins (a+b)
Fold: ADP-ribosylation
Superfamily: ADP-ribosylation
Occurring in:
  1. Lethal factor
The deposited structure of PDB entry 1pwv contains 2 copies of SCOP domain 56400 (ADP-ribosylating toxins) in Lethal factor. Showing 1 copy in chain B.

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