EC 3.4.24.83: Anthrax lethal factor endopeptidase
Reaction catalysed:
Preferred amino acids around the cleavage site can be denoted BBBBxHx-|-H, in which B denotes Arg or Lys, H denotes a hydrophobic amino acid, and x is any amino acid. The only known protein substrates are mitogen-activated protein (MAP) kinase kinases.
Systematic name:
-
Alternative Name(s):
- Lethal toxin
GO terms
Biochemical function:
Biological process:
Cellular component:
Sequence families
Structure domains
CATH domains
3.90.176.10
Class:
Alpha Beta
Architecture:
Alpha-Beta Complex
Topology:
Toxin ADP-ribosyltransferase; Chain A, domain 1
Homology:
Toxin ADP-ribosyltransferase; Chain A, domain 1
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>1pwv</span> contains 2 copies of CATH domain <span class='highlight'>3.90.176.10 (Toxin ADP-ribosyltransferase; Chain A, domain 1)</span> in <span class='highlight'>Lethal factor</span>. Showing 1 copy in chain <span class='highlight'>B</span>. The deposited structure of PDB entry 1pwv contains 2 copies of CATH domain 3.90.176.10 (Toxin ADP-ribosyltransferase; Chain A, domain 1) in Lethal factor. Showing 1 copy in chain B.](https://www.ebi.ac.uk/pdbe/static/entry/1pwv_1_B_CATH_3.90.176.10_image-200x200.png)
3.40.390.10
Class:
Alpha Beta
Architecture:
3-Layer(aba) Sandwich
Topology:
Collagenase (Catalytic Domain)
Homology:
Collagenase (Catalytic Domain)
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>1pwv</span> contains 4 copies of CATH domain <span class='highlight'>3.40.390.10 (Collagenase (Catalytic Domain))</span> in <span class='highlight'>Lethal factor</span>. Showing 2 copies in chain <span class='highlight'>B</span>. The deposited structure of PDB entry 1pwv contains 4 copies of CATH domain 3.40.390.10 (Collagenase (Catalytic Domain)) in Lethal factor. Showing 2 copies in chain B.](https://www.ebi.ac.uk/pdbe/static/entry/1pwv_1_B_CATH_3.40.390.10_image-200x200.png)