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Crystal structure of Anthrax Lethal Factor wild-type protein complexed with an optimised peptide substrate.

X-ray diffraction
2.85Å resolution
PDB entry 1pwv coloured by chain, front view.
PDB entry 1pwv coloured by chain, side view.
PDB entry 1pwv coloured by chain, top view.
Source organism: Bacillus anthracis
Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Lethal factor
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Multimeric state: hetero dimer
Accessible surface area: 35603.61 Å2
Buried surface area: 1550.95 Å2
Dissociation area: 775.48 Å2
Dissociation energy (ΔGdiss): 12.26 kcal/mol
Dissociation entropy (TΔSdiss): 7.58 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-147527
Assembly 2
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Assembly Name: Lethal factor
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Multimeric state: hetero dimer
Accessible surface area: 35711.95 Å2
Buried surface area: 1493.22 Å2
Dissociation area: 746.61 Å2
Dissociation energy (ΔGdiss): 13.23 kcal/mol
Dissociation entropy (TΔSdiss): 7.57 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-147527
Assembly 3
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Assembly Name: Lethal factor
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Multimeric state: hetero tetramer
Accessible surface area: 68939.73 Å2
Buried surface area: 5420.0 Å2
Dissociation area: 1,187.92 Å2
Dissociation energy (ΔGdiss): 3.61 kcal/mol
Dissociation entropy (TΔSdiss): 16.06 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-147530

Macromolecules

Lethal factor
Chains: A, B
Length: 776 amino acids
Theoretical weight: 90.36 KDa
Source organism: Bacillus anthracis
Expression system: Bacillus anthracis
UniProt:
  • Canonical: P15917 (Residues: 34-809; Coverage: 100%)
Gene names: BXA0172, GBAA_pXO1_0172, lef, pXO1-107
Pfam:
InterPro:
CATH:
SCOP:
Lethal factor in PDB entry 1pwv, assembly 1, front view.
Lethal factor in PDB entry 1pwv, assembly 1, side view.
Lethal factor in PDB entry 1pwv, assembly 1, top view.
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LF20
Chains: C, D
Length: 20 amino acids
Theoretical weight: 2.35 KDa
Source organism: Bacillus anthracis
Expression system: Not provided
LF20 in PDB entry 1pwv, assembly 1, front view.
LF20 in PDB entry 1pwv, assembly 1, side view.
LF20 in PDB entry 1pwv, assembly 1, top view.
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