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TATA BINDING PROTEIN (TBP)/DNA COMPLEX

X-ray diffraction
2.9Å resolution
PDB entry 1tgh coloured by chain, front view.
PDB entry 1tgh coloured by chain, side view.
PDB entry 1tgh coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 1 distinct polypeptide molecule
1 distinct DNA molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: TATA-box-binding protein and DNA
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Multimeric state: hetero trimer
Accessible surface area: 11106.2 Å2
Buried surface area: 4368.78 Å2
Dissociation area: 1,323.11 Å2
Dissociation energy (ΔGdiss): 1.85 kcal/mol
Dissociation entropy (TΔSdiss): 10.31 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-114644

Macromolecules

TATA-box-binding protein
Chain: A
Length: 185 amino acids
Theoretical weight: 20.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: P20226 (Residues: 155-339; Coverage: 55%)
Gene names: GTF2D1, TBP, TF2D, TFIID
Pfam: Transcription factor TFIID (or TATA-binding protein, TBP)
InterPro:
CATH: TATA-Binding Protein
SCOP: TATA-box binding protein (TBP), C-terminal domain
TATA-box-binding protein in PDB entry 1tgh, assembly 1, front view.
TATA-box-binding protein in PDB entry 1tgh, assembly 1, side view.
TATA-box-binding protein in PDB entry 1tgh, assembly 1, top view.
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DNA chains B, C
Name: DNA (5'-D(*CP*GP*TP*AP*TP*AP*TP*AP*TP*AP*CP*G)-3')
Representative chains: B, C
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 12 nucleotides
Theoretical weight: 3.66 KDa
DNA (5'-D(*CP*GP*TP*AP*TP*AP*TP*AP*TP*AP*CP*G)-3') in PDB entry 1tgh, assembly 1, front view.
DNA (5'-D(*CP*GP*TP*AP*TP*AP*TP*AP*TP*AP*CP*G)-3') in PDB entry 1tgh, assembly 1, side view.
DNA (5'-D(*CP*GP*TP*AP*TP*AP*TP*AP*TP*AP*CP*G)-3') in PDB entry 1tgh, assembly 1, top view.
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