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Crystal structure of Hypoxic Response Protein I (HRPI) with two coordinated zinc ions

X-ray diffraction
1.9Å resolution
PDB entry 1xkf coloured by chain, front view.
PDB entry 1xkf coloured by chain, side view.
PDB entry 1xkf coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Hypoxic response protein 1
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Multimeric state: homo dimer
Accessible surface area: 12191.73 Å2
Buried surface area: 1593.35 Å2
Dissociation area: 712.41 Å2
Dissociation energy (ΔGdiss): 3.34 kcal/mol
Dissociation entropy (TΔSdiss): 11.37 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-161677
Assembly 2
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Assembly Name: Hypoxic response protein 1
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Multimeric state: homo dimer
Accessible surface area: 12335.19 Å2
Buried surface area: 1449.9 Å2
Dissociation area: 682 Å2
Dissociation energy (ΔGdiss): 27.4 kcal/mol
Dissociation entropy (TΔSdiss): 11.26 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-161677

Macromolecules

Hypoxic response protein 1
Chains: A, B
Length: 133 amino acids
Theoretical weight: 14.5 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P9WJA3 (Residues: 1-127; Coverage: 89%)
Gene names: Rv2626c, hrp1
Pfam: CBS domain
InterPro:
CATH: CBS-domain
SCOP: CBS-domain pair
Hypoxic response protein 1 in PDB entry 1xkf, assembly 1, front view.
Hypoxic response protein 1 in PDB entry 1xkf, assembly 1, side view.
Hypoxic response protein 1 in PDB entry 1xkf, assembly 1, top view.
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