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Crystal structure of the lactate dehydrogenase from cryptosporidium parvum complexed with substrate (lactic acid) and cofactor (b-nicotinamide adenine dinucleotide)

X-ray diffraction
2.3Å resolution
PDB entry 2fn7 coloured by chain, front view.
PDB entry 2fn7 coloured by chain, side view.
PDB entry 2fn7 coloured by chain, top view.
Source organism: Cryptosporidium parvum
Assemblies composition:
homo dimer (preferred)
homo tetramer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: L-lactate dehydrogenase
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Multimeric state: homo dimer
Accessible surface area: 24215.97 Å2
Buried surface area: 7167.52 Å2
Dissociation area: 1,966.57 Å2
Dissociation energy (ΔGdiss): 23.08 kcal/mol
Dissociation entropy (TΔSdiss): 13.81 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-176952
Assembly 2
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Assembly Name: L-lactate dehydrogenase
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Multimeric state: homo tetramer
Accessible surface area: 41554.77 Å2
Buried surface area: 21203.34 Å2
Dissociation area: 3,438.43 Å2
Dissociation energy (ΔGdiss): 20.94 kcal/mol
Dissociation entropy (TΔSdiss): 15.44 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-176953

Macromolecules

L-lactate dehydrogenase
Chains: A, B
Length: 321 amino acids
Theoretical weight: 33.88 KDa
Source organism: Cryptosporidium parvum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5CYZ2 (Residues: 17-337; Coverage: 95%)
Gene name: cgd7_480
Pfam:
InterPro:
CATH:
L-lactate dehydrogenase in PDB entry 2fn7, assembly 1, front view.
L-lactate dehydrogenase in PDB entry 2fn7, assembly 1, side view.
L-lactate dehydrogenase in PDB entry 2fn7, assembly 1, top view.
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