› 2g0e

X-ray diffraction
2.88Å resolution

Structure of QacR Multidrug Transcriptional Regulator Bound to Trivalent and Bivalent Diamidine Drugs

Released:
DOI: 10.2210/pdb2g0e/pdb
PDB entry 2g0e coloured by chain, front view.
PDB entry 2g0e coloured by chain, side view.
PDB entry 2g0e coloured by chain, top view.
Source organism: Staphylococcus haemolyticus
Entry author: Schuman JT

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo hexadecamer
Assembly name:
PDBe Complex ID:
PDB-CPX-140961 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HTH-type transcriptional regulator QacR Chains: A, B, D, E
Molecule details ›
Chains: A, B, D, E
Length: 188 amino acids
Theoretical weight: 22.15 KDa
Source organism: Staphylococcus haemolyticus
Expression system: Escherichia coli
UniProt:
  • Canonical: P0A0N5 (Residues: 1-188; Coverage: 100%)
Gene name: qacR
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand SO4 21 x SO4
Ligand CGQ 1 x CGQ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P42212
Unit cell:
a: 170.47Å b: 170.47Å c: 94.05Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.237 0.299
Expression system: Escherichia coli

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