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Structural and Functional insights into the human Upf1 helicase core

X-ray diffraction
2.4Å resolution
PDB entry 2gk6 coloured by chain, front view.
PDB entry 2gk6 coloured by chain, side view.
PDB entry 2gk6 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Regulator of nonsense transcripts 1
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Multimeric state: monomeric
Accessible surface area: 28000.13 Å2
Buried surface area: 1047.71 Å2
Dissociation area: 83.17 Å2
Dissociation energy (ΔGdiss): 12.6 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-187805
Assembly 2
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Assembly Name: Regulator of nonsense transcripts 1
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Multimeric state: monomeric
Accessible surface area: 27931.72 Å2
Buried surface area: 1041.15 Å2
Dissociation area: 81.91 Å2
Dissociation energy (ΔGdiss): 12.72 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-187805

Macromolecules

Regulator of nonsense transcripts 1
Chains: A, B
Length: 624 amino acids
Theoretical weight: 70.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92900 (Residues: 295-925; Coverage: 55%)
  • Best match: Q92900-2 (Residues: 295-914)
Gene names: KIAA0221, RENT1, UPF1
Pfam:
InterPro:
CATH:
Regulator of nonsense transcripts 1 in PDB entry 2gk6, assembly 1, front view.
Regulator of nonsense transcripts 1 in PDB entry 2gk6, assembly 1, side view.
Regulator of nonsense transcripts 1 in PDB entry 2gk6, assembly 1, top view.
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