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Crystal structure of a ternary ligand-receptor complex of BMP-2

X-ray diffraction
1.92Å resolution
PDB entry 2h64 coloured by chain, front view.
PDB entry 2h64 coloured by chain, side view.
PDB entry 2h64 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero hexamer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero hexamer
Accessible surface area: 30799.5 Å2
Buried surface area: 9722.65 Å2
Dissociation area: 1,301.58 Å2
Dissociation energy (ΔGdiss): -6.99 kcal/mol
Dissociation entropy (TΔSdiss): 23.66 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-146281

Macromolecules

Bone morphogenetic protein 2
Chain: A
Length: 114 amino acids
Theoretical weight: 12.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P12643 (Residues: 283-396; Coverage: 31%)
Gene names: BMP2, BMP2A
Pfam: Transforming growth factor beta like domain
InterPro:
CATH: Cystine-knot cytokines
SCOP: Transforming growth factor (TGF)-beta
Bone morphogenetic protein 2 in PDB entry 2h64, assembly 1, front view.
Bone morphogenetic protein 2 in PDB entry 2h64, assembly 1, side view.
Bone morphogenetic protein 2 in PDB entry 2h64, assembly 1, top view.
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Bone morphogenetic protein receptor type-1A
Chain: B
Length: 129 amino acids
Theoretical weight: 14.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P36894 (Residues: 24-152; Coverage: 25%)
Gene names: ACVRLK3, ALK3, BMPR1A
Pfam: Activin types I and II receptor domain
InterPro:
CATH: CD59
SCOP: Extracellular domain of cell surface receptors
Bone morphogenetic protein receptor type-1A in PDB entry 2h64, assembly 1, front view.
Bone morphogenetic protein receptor type-1A in PDB entry 2h64, assembly 1, side view.
Bone morphogenetic protein receptor type-1A in PDB entry 2h64, assembly 1, top view.
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Activin receptor type-2B
Chain: C
Length: 99 amino acids
Theoretical weight: 11.65 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P27040 (Residues: 19-117; Coverage: 19%)
Gene name: Acvr2b
Pfam: Activin types I and II receptor domain
InterPro:
CATH: CD59
SCOP: Extracellular domain of cell surface receptors
Activin receptor type-2B in PDB entry 2h64, assembly 1, front view.
Activin receptor type-2B in PDB entry 2h64, assembly 1, side view.
Activin receptor type-2B in PDB entry 2h64, assembly 1, top view.
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