Assemblies
Multimeric state:
hetero hexamer
Accessible surface area:
30799.5 Å2
Buried surface area:
9722.65 Å2
Dissociation area:
1,301.58
Å2
Dissociation energy (ΔGdiss):
-6.99
kcal/mol
Dissociation entropy (TΔSdiss):
23.66
kcal/mol
Symmetry number:
2
PDBe Complex ID:
PDB-CPX-146281
Macromolecules
Chain: A
Length: 114 amino acids
Theoretical weight: 12.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Pfam: Transforming growth factor beta like domain
InterPro:
SCOP: Transforming growth factor (TGF)-beta
Length: 114 amino acids
Theoretical weight: 12.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P12643 (Residues: 283-396; Coverage: 31%)
Pfam: Transforming growth factor beta like domain
InterPro:
- Transforming growth factor-beta, C-terminal
- Cystine-knot cytokine
- Transforming growth factor-beta-related
- Bone morphogenetic protein 2, TGF-beta-like domain
- Transforming growth factor beta, conserved site
SCOP: Transforming growth factor (TGF)-beta
Chain: B
Length: 129 amino acids
Theoretical weight: 14.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Pfam: Activin types I and II receptor domain
InterPro:
CATH: CD59
SCOP: Extracellular domain of cell surface receptors
Length: 129 amino acids
Theoretical weight: 14.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P36894 (Residues: 24-152; Coverage: 25%)
Pfam: Activin types I and II receptor domain
InterPro:
CATH: CD59
SCOP: Extracellular domain of cell surface receptors
Chain: C
Length: 99 amino acids
Theoretical weight: 11.65 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
Pfam: Activin types I and II receptor domain
InterPro:
SCOP: Extracellular domain of cell surface receptors
Length: 99 amino acids
Theoretical weight: 11.65 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
- Canonical:
P27040 (Residues: 19-117; Coverage: 19%)
Pfam: Activin types I and II receptor domain
InterPro:
- Snake toxin-like superfamily
- Activin types I and II receptor domain
- Ser/Thr protein kinase, TGFB receptor
SCOP: Extracellular domain of cell surface receptors