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hPPARgamma Ligand binding domain in complex with 5-HEPA

X-ray diffraction
2.75Å resolution
PDB entry 2vv2 coloured by chain, front view.
PDB entry 2vv2 coloured by chain, side view.
PDB entry 2vv2 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Peroxisome proliferator-activated receptor gamma
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Multimeric state: monomeric
Accessible surface area: 12982.92 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153368
Monomeric assembly 1 of PDB entry 2vv2 coloured by chemically distinct molecules, front view.
Monomeric assembly 1 of PDB entry 2vv2 coloured by chemically distinct molecules, side view.
Monomeric assembly 1 of PDB entry 2vv2 coloured by chemically distinct molecules, top view.
    Assembly 1
Confidence : 12%
No. subunits : 1
Symmetry : None
More details
3DComplex & QSbio predictionx
No. subunits : 2
Symmetry : C2
Evidence : Sequence is/are identical to 4pwl_1 (which is supposedly correct) suggesting that interface(s) is/are missing
Assembly 2
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Assembly Name: Peroxisome proliferator-activated receptor gamma
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 13890.72 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153368
Monomeric assembly 2 of PDB entry 2vv2 coloured by chemically distinct molecules, front view.
Monomeric assembly 2 of PDB entry 2vv2 coloured by chemically distinct molecules, side view.
Monomeric assembly 2 of PDB entry 2vv2 coloured by chemically distinct molecules, top view.
    Assembly 2
Confidence : 12%
No. subunits : 1
Symmetry : None
More details
3DComplex & QSbio predictionx
No. subunits : 2
Symmetry : C2
Evidence : Sequence is/are identical to 4pwl_1 (which is supposedly correct) suggesting that interface(s) is/are missing

Macromolecules

Peroxisome proliferator-activated receptor gamma
Chains: A, B
Length: 276 amino acids
Theoretical weight: 31.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P37231 (Residues: 232-505; Coverage: 54%)
Gene names: NR1C3, PPARG
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
CATH: Retinoid X Receptor
SCOP: Nuclear receptor ligand-binding domain
Peroxisome proliferator-activated receptor gamma in PDB entry 2vv2, assembly 1, front view.
Peroxisome proliferator-activated receptor gamma in PDB entry 2vv2, assembly 1, side view.
Peroxisome proliferator-activated receptor gamma in PDB entry 2vv2, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P37231  
127620406080100120140160180200220240260
 
100200
UniProt
P37231
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Sequence conservation
Molecule details ›

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