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crystal structure of human insulin degrading enzyme in complex with iodinated insulin

X-ray diffraction
2.8Å resolution
PDB entry 2wc0 coloured by chain, front view.
PDB entry 2wc0 coloured by chain, side view.
PDB entry 2wc0 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Insulin complex and Insulin-degrading enzyme
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Multimeric state: hetero trimer
Accessible surface area: 38286.01 Å2
Buried surface area: 5486.96 Å2
Dissociation area: 1,363.67 Å2
Dissociation energy (ΔGdiss): 13.43 kcal/mol
Dissociation entropy (TΔSdiss): 9.06 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134191
Assembly 2
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Assembly Name: Insulin complex and Insulin-degrading enzyme
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Multimeric state: hetero trimer
Accessible surface area: 38279.07 Å2
Buried surface area: 5742.08 Å2
Dissociation area: 1,432.02 Å2
Dissociation energy (ΔGdiss): 9.34 kcal/mol
Dissociation entropy (TΔSdiss): 9.18 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134191

Macromolecules

Insulin-degrading enzyme
Chains: A, B
Length: 990 amino acids
Theoretical weight: 114.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P14735 (Residues: 42-1019; Coverage: 96%)
Gene name: IDE
Pfam:
InterPro:
CATH: Metalloenzyme, LuxS/M16 peptidase-like
Insulin-degrading enzyme in PDB entry 2wc0, assembly 1, front view.
Insulin-degrading enzyme in PDB entry 2wc0, assembly 1, side view.
Insulin-degrading enzyme in PDB entry 2wc0, assembly 1, top view.
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Insulin A chain
Chains: C, E
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 90-110; Coverage: 24%)
Gene name: INS
InterPro:
Insulin A chain in PDB entry 2wc0, assembly 1, front view.
Insulin A chain in PDB entry 2wc0, assembly 1, side view.
Insulin A chain in PDB entry 2wc0, assembly 1, top view.
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Insulin B chain
Chains: D, F
Length: 30 amino acids
Theoretical weight: 3.43 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 25-54; Coverage: 35%)
Gene name: INS
Pfam: Insulin/IGF/Relaxin family
InterPro:
Insulin B chain in PDB entry 2wc0, assembly 1, front view.
Insulin B chain in PDB entry 2wc0, assembly 1, side view.
Insulin B chain in PDB entry 2wc0, assembly 1, top view.
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