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Crystal structure of Mycobacterium tuberculosis S-Adenosyl-L-homocysteine hydrolase in ternary complex with NAD and 2-fluoroadenosine

X-ray diffraction
2.42Å resolution
PDB entry 2zj0 coloured by chain, front view.
PDB entry 2zj0 coloured by chain, side view.
PDB entry 2zj0 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Adenosylhomocysteinase
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Multimeric state: homo tetramer
Accessible surface area: 61434.67 Å2
Buried surface area: 28854.2 Å2
Dissociation area: 4,288.33 Å2
Dissociation energy (ΔGdiss): 37.75 kcal/mol
Dissociation entropy (TΔSdiss): 16.62 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-161521

Macromolecules

Adenosylhomocysteinase
Chains: A, B, C, D
Length: 495 amino acids
Theoretical weight: 54.39 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WGV3 (Residues: 2-495; Coverage: 100%)
Gene names: MTCY20B11.23c, Rv3248c, ahcY, sahH
Pfam:
InterPro:
CATH:
Adenosylhomocysteinase in PDB entry 2zj0, assembly 1, front view.
Adenosylhomocysteinase in PDB entry 2zj0, assembly 1, side view.
Adenosylhomocysteinase in PDB entry 2zj0, assembly 1, top view.
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