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Properties and crystal structure of methylenetetrahydrofolate reductase from Thermus thermophilus HB8

X-ray diffraction
2.8Å resolution
PDB entry 3apy coloured by chain, front view.
PDB entry 3apy coloured by chain, side view.
PDB entry 3apy coloured by chain, top view.
Source organism: Thermus thermophilus HB8
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Methylenetetrahydrofolate reductase
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Multimeric state: homo dimer
Accessible surface area: 25272.38 Å2
Buried surface area: 5193.04 Å2
Dissociation area: 1,210.37 Å2
Dissociation energy (ΔGdiss): 6.92 kcal/mol
Dissociation entropy (TΔSdiss): 13.47 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-178167
Assembly 2
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Assembly Name: Methylenetetrahydrofolate reductase
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Multimeric state: homo dimer
Accessible surface area: 25123.41 Å2
Buried surface area: 5149.25 Å2
Dissociation area: 1,169.31 Å2
Dissociation energy (ΔGdiss): 5 kcal/mol
Dissociation entropy (TΔSdiss): 13.46 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-178167
Assembly 3
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Assembly Name: Methylenetetrahydrofolate reductase
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Multimeric state: homo dimer
Accessible surface area: 25516.16 Å2
Buried surface area: 5247.86 Å2
Dissociation area: 1,188.31 Å2
Dissociation energy (ΔGdiss): 7.27 kcal/mol
Dissociation entropy (TΔSdiss): 13.47 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-178167
Assembly 4
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Assembly Name: Methylenetetrahydrofolate reductase
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Multimeric state: homo dimer
Accessible surface area: 25107.92 Å2
Buried surface area: 5240.3 Å2
Dissociation area: 1,180.74 Å2
Dissociation energy (ΔGdiss): 4.86 kcal/mol
Dissociation entropy (TΔSdiss): 13.46 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-178167

Macromolecules

Methylenetetrahydrofolate reductase
Chains: A, B, C, D, E, F, G, H
Length: 310 amino acids
Theoretical weight: 34.65 KDa
Source organism: Thermus thermophilus HB8
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5SLG6 (Residues: 1-296; Coverage: 100%)
Gene name: TTHA0327
Pfam: Methylenetetrahydrofolate reductase
InterPro:
CATH: TIM Barrel
Methylenetetrahydrofolate reductase in PDB entry 3apy, assembly 1, front view.
Methylenetetrahydrofolate reductase in PDB entry 3apy, assembly 1, side view.
Methylenetetrahydrofolate reductase in PDB entry 3apy, assembly 1, top view.
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