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Intact PPAR gamma - RXR alpha Nuclear Receptor Complex on DNA bound with GW9662, 9-cis Retinoic Acid and NCOA2 Peptide

Source organism: Homo sapiens
Biochemical function: sequence-specific DNA binding
Biological process: regulation of DNA-templated transcription
Cellular component: nucleus

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF00104
Domain description: Ligand-binding domain of nuclear hormone receptor
Occurring in:
  1. Retinoic acid receptor RXR-alpha
  2. Peroxisome proliferator-activated receptor gamma
The deposited structure of PDB entry 3e00 contains 1 copy of Pfam domain PF00104 (Ligand-binding domain of nuclear hormone receptor) in Retinoic acid receptor RXR-alpha. Showing 1 copy in chain A.
The deposited structure of PDB entry 3e00 contains 1 copy of Pfam domain PF00104 (Ligand-binding domain of nuclear hormone receptor) in Peroxisome proliferator-activated receptor gamma. Showing 1 copy in chain B [auth D].

PF00105
Domain description: Zinc finger, C4 type (two domains)
Occurring in:
  1. Retinoic acid receptor RXR-alpha
  2. Peroxisome proliferator-activated receptor gamma
The deposited structure of PDB entry 3e00 contains 1 copy of Pfam domain PF00105 (Zinc finger, C4 type (two domains)) in Retinoic acid receptor RXR-alpha. Showing 1 copy in chain A.
The deposited structure of PDB entry 3e00 contains 1 copy of Pfam domain PF00105 (Zinc finger, C4 type (two domains)) in Peroxisome proliferator-activated receptor gamma. Showing 1 copy in chain B [auth D].

PF11825
Domain description: Nuclear/hormone receptor activator site AF-1
Occurring in:
  1. Retinoic acid receptor RXR-alpha
The deposited structure of PDB entry 3e00 contains 1 copy of Pfam domain PF11825 (Nuclear/hormone receptor activator site AF-1) in Retinoic acid receptor RXR-alpha. Showing 1 copy in chain A (this domain is out of the observed residue ranges!).

InterPro InterPro annotations
IPR001628
Domain description: Zinc finger, nuclear hormone receptor-type
Occurring in:
  1. Retinoic acid receptor RXR-alpha
  2. Peroxisome proliferator-activated receptor gamma
IPR001723
Domain description: Nuclear hormone receptor
Occurring in:
  1. Retinoic acid receptor RXR-alpha
  2. Peroxisome proliferator-activated receptor gamma
IPR003074
Domain description: Peroxisome proliferator-activated receptor
Occurring in:
  1. Peroxisome proliferator-activated receptor gamma
IPR000536
Domain description: Nuclear hormone receptor, ligand-binding domain
Occurring in:
  1. Retinoic acid receptor RXR-alpha
  2. Peroxisome proliferator-activated receptor gamma
IPR000003
Domain description: Retinoid X receptor/HNF4
Occurring in:
  1. Retinoic acid receptor RXR-alpha
IPR035500
Domain description: Nuclear hormone receptor-like domain superfamily
Occurring in:
  1. Retinoic acid receptor RXR-alpha
  2. Peroxisome proliferator-activated receptor gamma
IPR003077
Domain description: Peroxisome proliferator-activated receptor gamma
Occurring in:
  1. Peroxisome proliferator-activated receptor gamma
IPR013088
Domain description: Zinc finger, NHR/GATA-type
Occurring in:
  1. Retinoic acid receptor RXR-alpha
  2. Peroxisome proliferator-activated receptor gamma
IPR021780
Domain description: Nuclear/hormone receptor activator site AF-1
Occurring in:
  1. Retinoic acid receptor RXR-alpha

Structure domains

CATH CATH domains
1.10.565.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Retinoid X Receptor
Homology: Retinoid X Receptor
Occurring in:
  1. Retinoic acid receptor RXR-alpha
  2. Peroxisome proliferator-activated receptor gamma
The deposited structure of PDB entry 3e00 contains 1 copy of CATH domain 1.10.565.10 (Retinoid X Receptor) in Retinoic acid receptor RXR-alpha. Showing 1 copy in chain A.
The deposited structure of PDB entry 3e00 contains 1 copy of CATH domain 1.10.565.10 (Retinoid X Receptor) in Peroxisome proliferator-activated receptor gamma. Showing 1 copy in chain B [auth D].
3.30.50.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Erythroid Transcription Factor GATA-1; Chain A
Homology: Erythroid Transcription Factor GATA-1, subunit A
Occurring in:
  1. Retinoic acid receptor RXR-alpha
  2. Peroxisome proliferator-activated receptor gamma
The deposited structure of PDB entry 3e00 contains 1 copy of CATH domain 3.30.50.10 (Erythroid Transcription Factor GATA-1; Chain A) in Retinoic acid receptor RXR-alpha. Showing 1 copy in chain A.
The deposited structure of PDB entry 3e00 contains 1 copy of CATH domain 3.30.50.10 (Erythroid Transcription Factor GATA-1; Chain A) in Peroxisome proliferator-activated receptor gamma. Showing 1 copy in chain B [auth D].

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