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Intact PPAR gamma - RXR alpha Nuclear Receptor Complex on DNA bound with GW9662, 9-cis Retinoic Acid and NCOA2 Peptide

X-ray diffraction
3.1Å resolution
PDB entry 3e00 coloured by chain, front view.
PDB entry 3e00 coloured by chain, side view.
PDB entry 3e00 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero hexamer (preferred)
Entry contents: 3 distinct polypeptide molecules
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero hexamer
Accessible surface area: 36861.35 Å2
Buried surface area: 11874.76 Å2
Dissociation area: 464.07 Å2
Dissociation energy (ΔGdiss): 2.67 kcal/mol
Dissociation entropy (TΔSdiss): 7.01 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-116190

Macromolecules

Retinoic acid receptor RXR-alpha
Chain: A
Length: 467 amino acids
Theoretical weight: 51.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19793 (Residues: 11-462; Coverage: 98%)
  • Best match: P19793-2 (Residues: 1-365)
Gene names: NR2B1, RXRA
Pfam:
InterPro:
CATH:
Retinoic acid receptor RXR-alpha in PDB entry 3e00, assembly 1, front view.
Retinoic acid receptor RXR-alpha in PDB entry 3e00, assembly 1, side view.
Retinoic acid receptor RXR-alpha in PDB entry 3e00, assembly 1, top view.
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Peroxisome proliferator-activated receptor gamma
Chain: D
Length: 419 amino acids
Theoretical weight: 48.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37231 (Residues: 102-505; Coverage: 80%)
Gene names: NR1C3, PPARG
Pfam:
InterPro:
CATH:
Peroxisome proliferator-activated receptor gamma in PDB entry 3e00, assembly 1, front view.
Peroxisome proliferator-activated receptor gamma in PDB entry 3e00, assembly 1, side view.
Peroxisome proliferator-activated receptor gamma in PDB entry 3e00, assembly 1, top view.
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Nuclear receptor coactivator 2
Chains: E, G
Length: 13 amino acids
Theoretical weight: 1.62 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15596 (Residues: 685-697; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2
Nuclear receptor coactivator 2 in PDB entry 3e00, assembly 1, front view.
Nuclear receptor coactivator 2 in PDB entry 3e00, assembly 1, side view.
Nuclear receptor coactivator 2 in PDB entry 3e00, assembly 1, top view.
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DNA chain C
Name: DNA (5'-D(*DCP*DAP*DAP*DAP*DCP*DTP*DAP*DGP*DGP*DTP*DCP*DAP*DAP*DAP*DGP*DGP*DTP*DCP*DAP*DG)-3')
Representative chains: C
Length: 20 nucleotides
Theoretical weight: 6.18 KDa
DNA (5'-D(*DCP*DAP*DAP*DAP*DCP*DTP*DAP*DGP*DGP*DTP*DCP*DAP*DAP*DAP*DGP*DGP*DTP*DCP*DAP*DG)-3') in PDB entry 3e00, assembly 1, front view.
DNA (5'-D(*DCP*DAP*DAP*DAP*DCP*DTP*DAP*DGP*DGP*DTP*DCP*DAP*DAP*DAP*DGP*DGP*DTP*DCP*DAP*DG)-3') in PDB entry 3e00, assembly 1, side view.
DNA (5'-D(*DCP*DAP*DAP*DAP*DCP*DTP*DAP*DGP*DGP*DTP*DCP*DAP*DAP*DAP*DGP*DGP*DTP*DCP*DAP*DG)-3') in PDB entry 3e00, assembly 1, top view.
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DNA chain F
Name: DNA (5'-D(*DCP*DTP*DGP*DAP*DCP*DCP*DTP*DTP*DTP*DGP*DAP*DCP*DCP*DTP*DAP*DGP*DTP*DTP*DTP*DG)-3')
Representative chains: F
Length: 20 nucleotides
Theoretical weight: 6.09 KDa
DNA (5'-D(*DCP*DTP*DGP*DAP*DCP*DCP*DTP*DTP*DTP*DGP*DAP*DCP*DCP*DTP*DAP*DGP*DTP*DTP*DTP*DG)-3') in PDB entry 3e00, assembly 1, front view.
DNA (5'-D(*DCP*DTP*DGP*DAP*DCP*DCP*DTP*DTP*DTP*DGP*DAP*DCP*DCP*DTP*DAP*DGP*DTP*DTP*DTP*DG)-3') in PDB entry 3e00, assembly 1, side view.
DNA (5'-D(*DCP*DTP*DGP*DAP*DCP*DCP*DTP*DTP*DTP*DGP*DAP*DCP*DCP*DTP*DAP*DGP*DTP*DTP*DTP*DG)-3') in PDB entry 3e00, assembly 1, top view.
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