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Crystal Structure of human SIRT3 with acetyl-lysine AceCS2 peptide

X-ray diffraction
1.8Å resolution
PDB entry 3glr coloured by chain, front view.
PDB entry 3glr coloured by chain, side view.
PDB entry 3glr coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Acetyl-coenzyme A synthetase 2-like, mitochondrial and NAD-dependent protein deacetylase sirtuin-3, mitochondrial
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Multimeric state: hetero tetramer
Accessible surface area: 24577.32 Å2
Buried surface area: 5020.08 Å2
Dissociation area: 1,647.68 Å2
Dissociation energy (ΔGdiss): 20.78 kcal/mol
Dissociation entropy (TΔSdiss): 13.55 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-192602

Macromolecules

NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Chain: A
Length: 285 amino acids
Theoretical weight: 31.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NTG7 (Residues: 118-399; Coverage: 71%)
Gene names: SIR2L3, SIRT3
Pfam: Sir2 family
InterPro:
CATH:
NAD-dependent protein deacetylase sirtuin-3, mitochondrial in PDB entry 3glr, assembly 1, front view.
NAD-dependent protein deacetylase sirtuin-3, mitochondrial in PDB entry 3glr, assembly 1, side view.
NAD-dependent protein deacetylase sirtuin-3, mitochondrial in PDB entry 3glr, assembly 1, top view.
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Acetyl-coenzyme A synthetase 2-like, mitochondrial
Chain: B
Length: 12 amino acids
Theoretical weight: 1.52 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9NUB1 (Residues: 638-649; Coverage: 2%)
Gene names: ACAS2L, ACSS1, KIAA1846
Acetyl-coenzyme A synthetase 2-like, mitochondrial in PDB entry 3glr, assembly 1, front view.
Acetyl-coenzyme A synthetase 2-like, mitochondrial in PDB entry 3glr, assembly 1, side view.
Acetyl-coenzyme A synthetase 2-like, mitochondrial in PDB entry 3glr, assembly 1, top view.
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