› 3iu2

X-ray diffraction
1.73Å resolution

Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90096

Released:
DOI: 10.2210/pdb3iu2/pdb
PDB entry 3iu2 coloured by chain, front view.
PDB entry 3iu2 coloured by chain, side view.
PDB entry 3iu2 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Qiu W, Hutchinson A, Wernimont A, Lin Y-H, Kania A, Ravichandran M, Kozieradzki I, Cossar D, Schapira M, Arrowsmith CH, Bountra C, Weigelt J, Edwards AM, Wyatt PG, Ferguson MAJ, Frearson JA, Brand SY, Robinson DA, Bochkarev A, Hui R, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
Tetradecanoyl-CoA + an N-terminal-glycyl-[protein] = CoA + an N-terminal-N-tetradecanoylglycyl-[protein]
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151725 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycylpeptide N-tetradecanoyltransferase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 383 amino acids
Theoretical weight: 44.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P30419 (Residues: 115-496; Coverage: 77%)
Gene names: NMT, NMT1
Sequence domains:
Structure domains: Aminopeptidase

Ligands and Environments


Cofactor: Ligand MYA 2 x MYA
1 bound ligand:
Ligand 096 2 x 096
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Unit cell:
a: 58.572Å b: 77.739Å c: 179.627Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.207 0.235
Expression system: Escherichia coli

Quick links