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Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90096

X-ray diffraction
1.73Å resolution
PDB entry 3iu2 coloured by chain, front view.
PDB entry 3iu2 coloured by chain, side view.
PDB entry 3iu2 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Glycylpeptide N-tetradecanoyltransferase 1
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Multimeric state: monomeric
Accessible surface area: 17378.09 Å2
Buried surface area: 1625.73 Å2
Dissociation area: 812.87 Å2
Dissociation energy (ΔGdiss): 16.91 kcal/mol
Dissociation entropy (TΔSdiss): 7.2 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-151725
Assembly 2
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Assembly Name: Glycylpeptide N-tetradecanoyltransferase 1
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Multimeric state: monomeric
Accessible surface area: 17286.15 Å2
Buried surface area: 1634.26 Å2
Dissociation area: 817.13 Å2
Dissociation energy (ΔGdiss): 15.61 kcal/mol
Dissociation entropy (TΔSdiss): 7.21 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-151725

Macromolecules

Glycylpeptide N-tetradecanoyltransferase 1
Chains: A, B
Length: 383 amino acids
Theoretical weight: 44.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P30419 (Residues: 115-496; Coverage: 77%)
Gene names: NMT, NMT1
Pfam:
InterPro:
CATH: Aminopeptidase
Glycylpeptide N-tetradecanoyltransferase 1 in PDB entry 3iu2, assembly 1, front view.
Glycylpeptide N-tetradecanoyltransferase 1 in PDB entry 3iu2, assembly 1, side view.
Glycylpeptide N-tetradecanoyltransferase 1 in PDB entry 3iu2, assembly 1, top view.
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