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Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90096

Source organism: Homo sapiens
Biochemical function: glycylpeptide N-tetradecanoyltransferase activity
Biological process: N-terminal protein myristoylation
Cellular component: not assigned

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EC 2.3.1.97: Glycylpeptide N-tetradecanoyltransferase

Reaction catalysed:
Tetradecanoyl-CoA + an N-terminal-glycyl-[protein] = CoA + an N-terminal-N-tetradecanoylglycyl-[protein]
Systematic name:
Tetradecanoyl-CoA:N-terminal glycyl-[protein] N-tetradecanoyltransferase
Alternative Name(s):
  • Myristoyl-CoA-protein N-myristoyltransferase
  • Myristoyl-coenzyme A:protein N-myristoyl transferase
  • Myristoylating enzymes
  • NMT (gene name)
  • Peptide N-myristoyltransferase
  • Peptide N-tetradecanoyltransferase
  • Protein N-myristoyltransferase
  • Tetradecanoyl-CoA:glycylpeptide N-tetradecanoyltransferase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF02799
Domain description: Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
Occurring in:
  1. Glycylpeptide N-tetradecanoyltransferase 1
The deposited structure of PDB entry 3iu2 contains 2 copies of Pfam domain PF02799 (Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain) in Glycylpeptide N-tetradecanoyltransferase 1. Showing 1 copy in chain A.

PF01233
Domain description: Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
Occurring in:
  1. Glycylpeptide N-tetradecanoyltransferase 1
The deposited structure of PDB entry 3iu2 contains 2 copies of Pfam domain PF01233 (Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain) in Glycylpeptide N-tetradecanoyltransferase 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR022678
Domain description: Glycylpeptide N-tetradecanoyltransferase, conserved site
Occurring in:
  1. Glycylpeptide N-tetradecanoyltransferase 1
IPR016181
Domain description: Acyl-CoA N-acyltransferase
Occurring in:
  1. Glycylpeptide N-tetradecanoyltransferase 1
IPR000903
Domain description: Glycylpeptide N-tetradecanoyltransferase
Occurring in:
  1. Glycylpeptide N-tetradecanoyltransferase 1
IPR022677
Domain description: Glycylpeptide N-tetradecanoyltransferase, C-terminal
Occurring in:
  1. Glycylpeptide N-tetradecanoyltransferase 1
IPR022676
Domain description: Glycylpeptide N-tetradecanoyltransferase, N-terminal
Occurring in:
  1. Glycylpeptide N-tetradecanoyltransferase 1

Structure domain

CATH CATH domain
3.40.630.170
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aminopeptidase
Homology: Aminopeptidase
Occurring in:
  1. Glycylpeptide N-tetradecanoyltransferase 1
The deposited structure of PDB entry 3iu2 contains 2 copies of CATH domain 3.40.630.170 (Aminopeptidase) in Glycylpeptide N-tetradecanoyltransferase 1. Showing 1 copy in chain A.

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