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Structure of native human PCNA

Electron Microscopy
22Å resolution
PDB entry 3ja9 coloured by chain, front view.
PDB entry 3ja9 coloured by chain, side view.
PDB entry 3ja9 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: PCNA homotrimer
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Multimeric state: homo trimer
Accessible surface area: 34543.41 Å2
Buried surface area: 4253.63 Å2
Dissociation area: 2,126.81 Å2
Dissociation energy (ΔGdiss): -3.69 kcal/mol
Dissociation entropy (TΔSdiss): 26.94 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-146041
Complex Portal ID: CPX-538

Macromolecules

Proliferating cell nuclear antigen
Chains: A, B, C
Length: 261 amino acids
Theoretical weight: 28.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P12004 (Residues: 1-261; Coverage: 100%)
Gene name: PCNA
Pfam:
InterPro:
Proliferating cell nuclear antigen in PDB entry 3ja9, assembly 1, front view.
Proliferating cell nuclear antigen in PDB entry 3ja9, assembly 1, side view.
Proliferating cell nuclear antigen in PDB entry 3ja9, assembly 1, top view.
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