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Structure of the A237F mutant of the pentameric ligand gated ion channel from Gloeobacter Violaceus

X-ray diffraction
3.15Å resolution
PDB entry 3lsv coloured by chain, front view.
PDB entry 3lsv coloured by chain, side view.
PDB entry 3lsv coloured by chain, top view.
Source organism: Gloeobacter violaceus
Assembly composition:
homo pentamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Proton-gated ion channel
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Multimeric state: homo pentamer
Accessible surface area: 62095.87 Å2
Buried surface area: 21879.24 Å2
Dissociation area: 10,939.62 Å2
Dissociation energy (ΔGdiss): 122.71 kcal/mol
Dissociation entropy (TΔSdiss): 60.29 kcal/mol
Symmetry number: 5
PDBe Complex ID: PDB-CPX-181806

Macromolecules

Proton-gated ion channel
Chains: A, B, C, D, E
Length: 317 amino acids
Theoretical weight: 36.37 KDa
Source organism: Gloeobacter violaceus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7NDN8 (Residues: 44-359; Coverage: 100%)
Gene names: glr4197, glvI
Pfam: Neurotransmitter-gated ion-channel ligand binding domain
InterPro:
CATH:
Proton-gated ion channel in PDB entry 3lsv, assembly 1, front view.
Proton-gated ion channel in PDB entry 3lsv, assembly 1, side view.
Proton-gated ion channel in PDB entry 3lsv, assembly 1, top view.
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