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Crystal structure of the complex of JAML and Coxsackie and Adenovirus receptor, CAR

X-ray diffraction
2.8Å resolution
PDB entry 3mj7 coloured by chain, front view.
PDB entry 3mj7 coloured by chain, side view.
PDB entry 3mj7 coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Coxsackievirus and adenovirus receptor homolog and Junctional adhesion molecule-like
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Multimeric state: hetero dimer
Accessible surface area: 24552.98 Å2
Buried surface area: 3180.01 Å2
Dissociation area: 876.3 Å2
Dissociation energy (ΔGdiss): 1.83 kcal/mol
Dissociation entropy (TΔSdiss): 12.57 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-161325

Macromolecules

Junctional adhesion molecule-like
Chain: A
Length: 268 amino acids
Theoretical weight: 30.65 KDa
Source organism: Mus musculus
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q80UL9 (Residues: 21-280; Coverage: 72%)
Gene names: Amica1, Gm638, Jaml
Pfam: Immunoglobulin V-set domain
InterPro:
CATH: Immunoglobulins
Junctional adhesion molecule-like in PDB entry 3mj7, assembly 1, front view.
Junctional adhesion molecule-like in PDB entry 3mj7, assembly 1, side view.
Junctional adhesion molecule-like in PDB entry 3mj7, assembly 1, top view.
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Coxsackievirus and adenovirus receptor homolog
Chain: B
Length: 225 amino acids
Theoretical weight: 25.05 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P97792 (Residues: 18-236; Coverage: 63%)
Gene names: Car, Cxadr
Pfam:
InterPro:
CATH: Immunoglobulins
Coxsackievirus and adenovirus receptor homolog in PDB entry 3mj7, assembly 1, front view.
Coxsackievirus and adenovirus receptor homolog in PDB entry 3mj7, assembly 1, side view.
Coxsackievirus and adenovirus receptor homolog in PDB entry 3mj7, assembly 1, top view.
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