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Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E72

Source organism: Homo sapiens
Biochemical function: histone H3K9 methyltransferase activity
Biological process: not assigned
Cellular component: nucleus

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EC 2.1.1.367: [Histone H3]-lysine(9) N-methyltransferase

Reaction catalysed:
S-adenosyl-L-methionine + a [histone H3]-L-lysine(9) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(9)
Systematic name:
S-adenosyl-L-methionine:[histone H3]-L-lysine(9) N(6)-methyltransferase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00856
Domain description: SET domain
Occurring in:
  1. Histone-lysine N-methyltransferase EHMT1
The deposited structure of PDB entry 3mo5 contains 4 copies of Pfam domain PF00856 (SET domain) in Histone-lysine N-methyltransferase EHMT1. Showing 1 copy in chain B.

PF05033
Domain description: Pre-SET motif
Occurring in:
  1. Histone-lysine N-methyltransferase EHMT1
The deposited structure of PDB entry 3mo5 contains 4 copies of Pfam domain PF05033 (Pre-SET motif) in Histone-lysine N-methyltransferase EHMT1. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR001214
Domain description: SET domain
Occurring in:
  1. Histone-lysine N-methyltransferase EHMT1
IPR007728
Domain description: Pre-SET domain
Occurring in:
  1. Histone-lysine N-methyltransferase EHMT1
IPR046341
Domain description: SET domain superfamily
Occurring in:
  1. Histone-lysine N-methyltransferase EHMT1
IPR038035
Domain description: Histone-lysine N-methyltransferase EHMT1, SET domain
Occurring in:
  1. Histone-lysine N-methyltransferase EHMT1
IPR043550
Domain description: Histone-lysine N-methyltransferase EHMT1/EHMT2
Occurring in:
  1. Histone-lysine N-methyltransferase EHMT1

Structure domain

CATH CATH domain
2.170.270.10
Class: Mainly Beta
Architecture: Beta Complex
Topology: Beta-clip-like
Homology: SET domain
Occurring in:
  1. Histone-lysine N-methyltransferase EHMT1
The deposited structure of PDB entry 3mo5 contains 4 copies of CATH domain 2.170.270.10 (Beta-clip-like) in Histone-lysine N-methyltransferase EHMT1. Showing 1 copy in chain B.

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