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Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E72

X-ray diffraction
2.14Å resolution
PDB entry 3mo5 coloured by chain, front view.
PDB entry 3mo5 coloured by chain, side view.
PDB entry 3mo5 coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Histone-lysine N-methyltransferase EHMT1
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Multimeric state: monomeric
Accessible surface area: 220.51 Å2
Buried surface area: 72.95 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-190698
Assembly 2
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Assembly Name: Histone-lysine N-methyltransferase EHMT1
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Multimeric state: monomeric
Accessible surface area: 219.91 Å2
Buried surface area: 73.54 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-190698
Assembly 3 (preferred)
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Assembly Name: Histone-lysine N-methyltransferase EHMT1
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Multimeric state: monomeric
Accessible surface area: 220.24 Å2
Buried surface area: 73.21 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-190698
Assembly 4
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Assembly Name: Histone-lysine N-methyltransferase EHMT1
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Multimeric state: monomeric
Accessible surface area: 223.01 Å2
Buried surface area: 70.44 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-190698
Assembly 5
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Assembly Name: Histone-lysine N-methyltransferase EHMT1
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Multimeric state: homo dimer
Accessible surface area: 24462.78 Å2
Buried surface area: 2250.09 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-190699
Assembly 6
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Assembly Name: Histone-lysine N-methyltransferase EHMT1
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Multimeric state: homo dimer
Accessible surface area: 23923.2 Å2
Buried surface area: 2260.4 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-190699

Macromolecules

Histone-lysine N-methyltransferase EHMT1
Chains: A, B, C, D
Length: 285 amino acids
Theoretical weight: 32.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H9B1 (Residues: 982-1266; Coverage: 22%)
Gene names: EHMT1, EUHMTASE1, GLP, KIAA1876, KMT1D
Pfam:
InterPro:
CATH: SET domain
Histone-lysine N-methyltransferase EHMT1 in PDB entry 3mo5, assembly 3, front view.
Histone-lysine N-methyltransferase EHMT1 in PDB entry 3mo5, assembly 3, side view.
Histone-lysine N-methyltransferase EHMT1 in PDB entry 3mo5, assembly 3, top view.
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