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Crystal structure of human Survivin bound to histone H3 phosphorylated on threonine-3.

X-ray diffraction
2.18Å resolution
PDB entry 3uec coloured by chain, front view.
PDB entry 3uec coloured by chain, side view.
PDB entry 3uec coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Survivin homodimer complex and peptide
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Multimeric state: hetero tetramer
Accessible surface area: 17674.7 Å2
Buried surface area: 5613.93 Å2
Dissociation area: 1,365.14 Å2
Dissociation energy (ΔGdiss): -0.92 kcal/mol
Dissociation entropy (TΔSdiss): 23.4 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-127462

Macromolecules

Baculoviral IAP repeat-containing protein 5
Chain: A
Length: 146 amino acids
Theoretical weight: 16.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O15392 (Residues: 1-142; Coverage: 100%)
Gene names: API4, BIRC5, IAP4
Pfam: Inhibitor of Apoptosis domain
InterPro: BIR repeat
CATH: Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A
Baculoviral IAP repeat-containing protein 5 in PDB entry 3uec, assembly 1, front view.
Baculoviral IAP repeat-containing protein 5 in PDB entry 3uec, assembly 1, side view.
Baculoviral IAP repeat-containing protein 5 in PDB entry 3uec, assembly 1, top view.
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N-TERMINAL FRAGMENT OF HISTONE H3
Chain: B
Length: 4 amino acids
Theoretical weight: 557 Da
Source organism: Homo sapiens
Expression system: Not provided
N-TERMINAL FRAGMENT OF HISTONE H3 in PDB entry 3uec, assembly 1, front view.
N-TERMINAL FRAGMENT OF HISTONE H3 in PDB entry 3uec, assembly 1, side view.
N-TERMINAL FRAGMENT OF HISTONE H3 in PDB entry 3uec, assembly 1, top view.
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