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Crystal structure of the human two pore domain potassium ion channel K2P1 (TWIK-1)

X-ray diffraction
3.4Å resolution
PDB entry 3ukm coloured by chain, front view.
PDB entry 3ukm coloured by chain, side view.
PDB entry 3ukm coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Potassium channel subfamily K member 1
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Multimeric state: homo dimer
Accessible surface area: 22592.19 Å2
Buried surface area: 7560.68 Å2
Dissociation area: 3,555.6 Å2
Dissociation energy (ΔGdiss): 29.69 kcal/mol
Dissociation entropy (TΔSdiss): 20.54 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-126136
Assembly 2
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Assembly Name: Potassium channel subfamily K member 1
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Multimeric state: homo dimer
Accessible surface area: 22626.09 Å2
Buried surface area: 7547.49 Å2
Dissociation area: 3,547.87 Å2
Dissociation energy (ΔGdiss): 29.6 kcal/mol
Dissociation entropy (TΔSdiss): 20.53 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-126136

Macromolecules

Potassium channel subfamily K member 1
Chains: A, B, C, D
Length: 280 amino acids
Theoretical weight: 31.91 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: O00180 (Residues: 19-288; Coverage: 80%)
Gene names: HOHO1, KCNK1, KCNO1, TWIK1
Pfam: Ion channel
InterPro:
CATH: Helix Hairpins
Potassium channel subfamily K member 1 in PDB entry 3ukm, assembly 1, front view.
Potassium channel subfamily K member 1 in PDB entry 3ukm, assembly 1, side view.
Potassium channel subfamily K member 1 in PDB entry 3ukm, assembly 1, top view.
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