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Crystal structure of the human squalene synthase

Source organism: Homo sapiens
Biochemical function: transferase activity, transferring alkyl or aryl (other than methyl) groups
Biological process: biosynthetic process
Cellular component: not assigned

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EC 2.5.1.21: Squalene synthase

Reaction catalysed:
(1a) 2 farnesyl diphosphate = diphosphate + presqualene diphosphate
Systematic name:
Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase
Alternative Name(s):
  • Farnesyl-diphosphate farnesyltransferase
  • Farnesyltransferase
  • Presqualene synthase
  • Presqualene-diphosphate synthase
  • SQS
  • Squalene synthetase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00494
Domain description: Squalene/phytoene synthase
Occurring in:
  1. Squalene synthase
The deposited structure of PDB entry 3vj8 contains 1 copy of Pfam domain PF00494 (Squalene/phytoene synthase) in Squalene synthase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR019845
Domain description: Squalene/phytoene synthase, conserved site
Occurring in:
  1. Squalene synthase
IPR002060
Domain description: Squalene/phytoene synthase
Occurring in:
  1. Squalene synthase
IPR008949
Domain description: Isoprenoid synthase domain superfamily
Occurring in:
  1. Squalene synthase
IPR033904
Domain description: Trans-isoprenyl diphosphate synthases, head-to-head
Occurring in:
  1. Squalene synthase
IPR006449
Domain description: Squalene synthase-like
Occurring in:
  1. Squalene synthase
IPR044844
Domain description: Trans-isoprenyl diphosphate synthases, eukaryotic-type
Occurring in:
  1. Squalene synthase

Structure domain

CATH CATH domain
1.10.600.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Farnesyl Diphosphate Synthase
Homology: Farnesyl Diphosphate Synthase
Occurring in:
  1. Squalene synthase
The deposited structure of PDB entry 3vj8 contains 1 copy of CATH domain 1.10.600.10 (Farnesyl Diphosphate Synthase) in Squalene synthase. Showing 1 copy in chain A.

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