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Crystal structure of the human squalene synthase

X-ray diffraction
1.52Å resolution
PDB entry 3vj8 coloured by chain, front view.
PDB entry 3vj8 coloured by chain, side view.
PDB entry 3vj8 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Squalene synthase
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Multimeric state: monomeric
Accessible surface area: 14588.02 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153385

Macromolecules

Squalene synthase
Chain: A
Length: 343 amino acids
Theoretical weight: 39.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37268 (Residues: 31-370; Coverage: 82%)
Gene name: FDFT1
Pfam: Squalene/phytoene synthase
InterPro:
CATH: Farnesyl Diphosphate Synthase
Squalene synthase in PDB entry 3vj8, assembly 1, front view.
Squalene synthase in PDB entry 3vj8, assembly 1, side view.
Squalene synthase in PDB entry 3vj8, assembly 1, top view.
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