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Crystal structure of the ATP-gated P2X4 ion channel in the ATP-bound, open state at 2.8 Angstroms

X-ray diffraction
2.8Å resolution
PDB entry 4dw1 coloured by chain, front view.
PDB entry 4dw1 coloured by chain, side view.
PDB entry 4dw1 coloured by chain, top view.
Source organism: Danio rerio
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: P2X purinoceptor 4a
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Multimeric state: homo trimer
Accessible surface area: 44356.41 Å2
Buried surface area: 19802.72 Å2
Dissociation area: 6,183.54 Å2
Dissociation energy (ΔGdiss): 32.96 kcal/mol
Dissociation entropy (TΔSdiss): 30.38 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-244872

Macromolecules

P2X purinoceptor 4a
Chain: A
Length: 340 amino acids
Theoretical weight: 38.12 KDa
Source organism: Danio rerio
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: F8W463 (Residues: 28-365; Coverage: 87%)
Gene name: p2rx4a
Pfam: ATP P2X receptor
InterPro:
CATH:
P2X purinoceptor 4a in PDB entry 4dw1, assembly 1, front view.
P2X purinoceptor 4a in PDB entry 4dw1, assembly 1, side view.
P2X purinoceptor 4a in PDB entry 4dw1, assembly 1, top view.
PDBe-KB: UniProt Coverage View: F8W463  
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