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Structure of NAD-dependent protein deacetylase sirtuin-1 (open state, 2.64 A)

X-ray diffraction
2.64Å resolution
PDB entry 4ig9 coloured by chain, front view.
PDB entry 4ig9 coloured by chain, side view.
PDB entry 4ig9 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: SirtT1 75 kDa fragment
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Multimeric state: hetero dimer
Accessible surface area: 14007.81 Å2
Buried surface area: 1437.07 Å2
Dissociation area: 718.53 Å2
Dissociation energy (ΔGdiss): 1.61 kcal/mol
Dissociation entropy (TΔSdiss): 9.01 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-188452
Assembly 2
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Assembly Name: SirtT1 75 kDa fragment
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Multimeric state: hetero dimer
Accessible surface area: 13978.15 Å2
Buried surface area: 1118.87 Å2
Dissociation area: 559.44 Å2
Dissociation energy (ΔGdiss): -0.28 kcal/mol
Dissociation entropy (TΔSdiss): 8.42 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-188452
Assembly 3
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Assembly Name: SirtT1 75 kDa fragment
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Multimeric state: hetero dimer
Accessible surface area: 14392.4 Å2
Buried surface area: 1205.38 Å2
Dissociation area: 602.69 Å2
Dissociation energy (ΔGdiss): 0.5 kcal/mol
Dissociation entropy (TΔSdiss): 8.79 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-188452
Assembly 4
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Assembly Name: SirtT1 75 kDa fragment
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Multimeric state: hetero dimer
Accessible surface area: 14242.55 Å2
Buried surface area: 1505.05 Å2
Dissociation area: 752.53 Å2
Dissociation energy (ΔGdiss): 1.38 kcal/mol
Dissociation entropy (TΔSdiss): 9.18 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-188452

Macromolecules

SirtT1 75 kDa fragment
Chains: A, C, E, G
Length: 281 amino acids
Theoretical weight: 31.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96EB6 (Residues: 234-510; Coverage: 37%)
Gene names: SIR2L1, SIRT1
Pfam: Sir2 family
InterPro:
CATH:
SirtT1 75 kDa fragment in PDB entry 4ig9, assembly 1, front view.
SirtT1 75 kDa fragment in PDB entry 4ig9, assembly 1, side view.
SirtT1 75 kDa fragment in PDB entry 4ig9, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q96EB6  
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NAD-dependent protein deacetylase sirtuin-1
Chains: B, D, F, H
Length: 31 amino acids
Theoretical weight: 3.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96EB6 (Residues: 641-665; Coverage: 3%)
Gene names: SIR2L1, SIRT1
NAD-dependent protein deacetylase sirtuin-1 in PDB entry 4ig9, assembly 1, front view.
NAD-dependent protein deacetylase sirtuin-1 in PDB entry 4ig9, assembly 1, side view.
NAD-dependent protein deacetylase sirtuin-1 in PDB entry 4ig9, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q96EB6  
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Molecule details ›

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